Therapeutic Targeting of Astrocytes After Traumatic Brain Injury

Translational Stroke Research

Volumn 2, Issue 4, 2011, Pages 633-642

  Shields, Jessica ^a   Kimbler, Donald E ^a   Radwan, Walid ^a   Yanasak, Nathan ^a   Sukumari Ramesh, Sangeetha ^a   Dhandapani, Krishnan M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Aquaporin; Cerebral blood flow; ICP; Inflammation; Intracranial pressure; Neurotrauma

Indexed keywords

AQUAPORIN; AQUAPORIN 4; BARBITURIC ACID DERIVATIVE; PROTEIN S100B;

ASTROCYTE; BRAIN EDEMA; CEREBROSPINAL FLUID DRAINAGE; DECOMPRESSIVE CRANIECTOMY; EXTERNAL VENTRICULAR DRAINAGE; GLIA; HUMAN; INTRACRANIAL PRESSURE; OSMOTHERAPY; PRIORITY JOURNAL; REVIEW; THERAPY; TRAUMATIC BRAIN INJURY;

EID: 83355163225     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-011-0129-6     Document Type: Review

References (182)

1. Bramlett HM, Dietrich WD. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab. 2004; 24(2): 133-50.
2. Nortje J, Menon DK. Traumatic brain injury: physiology, mechanisms, and outcome. Curr Opin Neurol. 2004; 17(6): 711-8.
3. Langlois JA, Rutland-Brown W, Thomas KE. Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2004.
4. Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, et al. Clinical trials in head injury. J Neurotrauma. 2002; 19(5): 503-57.
5. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus. 2007; 22(5): E1.
6. Verweij BH, Amelink GJ, Muizelaar JP. Current concepts of cerebral oxygen transport and energy metabolism after severe traumatic brain injury. Prog Brain Res. 2007; 161: 111-24.
7. Sarabia R, Lobato RD, Rivas JJ, Cordobes F, Rubio J, Cabrera A, et al. Cerebral hemisphere swelling in severe head injury patients. Acta Neurochir Suppl (Wien). 1988; 42: 40-6.
8. Saul TG, Ducker TB. Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg. 1982; 56(4): 498-503.
9. Levin HS, Eisenberg HM, Gary HE, Marmarou A, Foulkes MA, Jane JA, et al. Intracranial hypertension in relation to memory functioning during the first year after severe head injury. Neurosurgery. 1991; 28(2): 196-9. discussion 200.
10. Miller JD, Becker DP, Ward JD, Sullivan HG, Adams WE, Rosner MJ. Significance of intracranial hypertension in severe head injury. J Neurosurg. 1977; 47(4): 503-16.
11. Eisenberg HM, Gary Jr HE, Aldrich EF, Saydjari C, Turner B, Foulkes MA, et al. Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg. 1990; 73(5): 688-98.
12. Matsuno A, Katayama H, Wada H, Morikawa K, Tanaka K, Tanaka H, et al. Significance of consecutive bilateral surgeries for patients with acute subdural hematoma who develop contralateral acute epi- or subdural hematoma. Surg Neurol. 2003; 60(1): 23-30. discussion.
13. Bruce DA, Langfitt TW, Miller JD, Schutz H, Vapalahti MP, Stanek A, et al. Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J Neurosurg. 1973; 38(2): 131-44.
14. Cold GE, Jensen FT. Cerebral autoregulation in unconscious patients with brain injury. Acta Anaesthesiol Scand. 1978; 22(3): 270-80.
15. Cold GE, Jensen FT. Cerebral blood flow in the acute phase after head injury. Part 1: correlation to age of the patients, clinical outcome and localisation of the injured region. Acta Anaesthesiol Scand. 1980; 24(3): 245-51.
16. Enevoldsen EM, Jensen FT. Autoregulation and CO2 responses of cerebral blood flow in patients with acute severe head injury. J Neurosurg. 1978; 48(5): 689-703.
17. Overgaard J, Tweed WA. Cerebral circulation after head injury. 1. Cerebral blood flow and its regulation after closed head injury with emphasis on clinical correlations. J Neurosurg. 1974; 41(5): 531-41.
18. Cremer OL, van Dijk GW, van Wensen E, Brekelmans GJ, Moons KG, Leenen LP, et al. Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury. Crit Care Med. 2005; 33(10): 2207-13.
19. Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring. J Neurosurg. 1979; 50(1): 20-5.
20. Narayan RK, Kishore PR, Becker DP, Ward JD, Enas GG, Greenberg RP, et al. Intracranial pressure: to monitor or not to monitor? A review of our experience with severe head injury. J Neurosurg. 1982; 56(5): 650-9.
21. Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, et al. Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg. 2008; 109(4): 678-84.
22. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, et al. Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma. 2007; 24 Suppl 1: S37-44.
23. Burke AM, Quest DO, Chien S, Cerri C. The effects of mannitol on blood viscosity. J Neurosurg. 1981; 55(4): 550-3.
24. Jafar JJ, Johns LM, Mullan SF. The effect of mannitol on cerebral blood flow. J Neurosurg. 1986; 64(5): 754-9.
25. Cruz J, Miner ME, Allen SJ, Alves WM, Gennarelli TA. Continuous monitoring of cerebral oxygenation in acute brain injury: injection of mannitol during hyperventilation. J Neurosurg. 1990; 73(5): 725-30.
26. Muizelaar JP, Wei EP, Kontos HA, Becker DP. Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes. J Neurosurg. 1983; 59(5): 822-8.
27. Donato T, Shapira Y, Artru A, Powers K. Effect of mannitol on cerebrospinal fluid dynamics and brain tissue edema. Anesth Analg. 1994; 78(1): 58-66.
28. Node Y, Nakazawa S. Clinical study of mannitol and glycerol on raised intracranial pressure and on their rebound phenomenon. Adv Neurol. 1990; 52: 359-63.
29. Manno EM, Adams RE, Derdeyn CP, Powers WJ, Diringer MN. The effects of mannitol on cerebral edema after large hemispheric cerebral infarct. Neurology. 1999; 52(3): 583-7.
30. Kaufmann AM, Cardoso ER. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992; 77(4): 584-9.
31. Kotwica Z, Persson L. Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat. Mater Med Pol. 1991; 23(4): 280-4.
32. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Use of barbiturates in the control of intracranial hypertension. J Neurotrauma. 2000; 17(6-7): 527-30.
33. Cormio M, Gopinath SP, Valadka A, Robertson CS. Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. J Neurotrauma. 1999; 16(10): 927-36.
34. Lee SJ, Lee S. Toll-like receptors and inflammation in the CNS. Curr Drug Targets Inflamm Allergy. 2002; 1(2): 181-91.
35. Nordstrom CH, Messeter K, Sundbarg G, Schalen W, Werner M, Ryding E. Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions. J Neurosurg. 1988; 68(3): 424-31.
36. Nordby HK, Nesbakken R. The effect of high dose barbiturate decompression after severe head injury. A controlled clinical trial. Acta Neurochir (Wien). 1984; 72(3-4): 157-66.
37. Allen CH, Ward JD. An evidence-based approach to management of increased intracranial pressure. Crit Care Clin. 1998; 14(3): 485-95.
38. Schalen W, Messeter K, Nordstrom CH. Complications and side effects during thiopentone therapy in patients with severe head injuries. Acta Anaesthesiol Scand. 1992; 36(4): 369-77.
39. Roberts I. Barbiturates for acute traumatic brain injury. Cochrane Database Syst Rev. 2000;(2): CD000033.
40. Woster PS, LeBlanc KL. Management of elevated intracranial pressure. Clin Pharm. 1990; 9(10): 762-72.
41. Schwab S, Spranger M, Schwarz S, Hacke W. Barbiturate coma in severe hemispheric stroke: useful or obsolete? Neurology. 1997; 48(6): 1608-13.
42. Mansfield RT, Schiding JK, Hamilton RL, Kochanek PM. Effects of hypothermia on traumatic brain injury in immature rats. J Cereb Blood Flow Metab. 1996; 16(2): 244-52.
43. Szczygielski J, Mautes AE, Schwerdtfeger K, Steudel WI. The effects of selective brain hypothermia and decompressive craniectomy on brain edema after closed head injury in mice. Acta Neurochir Suppl. 2010; 106: 225-9.
44. Bao YH, Liang YM, Gao GY, Jiang JY. Lack of effect of moderate hypothermia on brain tissue oxygenation after acute intracranial hypertension in pigs. J Neurotrauma. 2010; 27(2): 433-8.
45. Lee HC, Chuang HC, Cho DY, Cheng KF, Lin PH, Chen CC. Applying cerebral hypothermia and brain oxygen monitoring in treating severe traumatic brain injury. World Neurosurg. 2010; 74(6): 654-60.
46. Fox JL, Vu EN, Doyle-Waters M, Brubacher JR, Abu-Laban R, Hu Z. Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review. CJEM. 2010; 12(4): 355-64.
47. Sinclair HL, Andrews PJ. Bench-to-bedside review: hypothermia in traumatic brain injury. Crit Care. 2010; 14(1): 204.
48. Sahuquillo J, Arikan F. Decompressive craniectomy for the treatment of refractory high intracranial pressure in traumatic brain injury. Cochrane Database Syst Rev. 2006;(1): CD003983.
49. Aarabi B, Hesdorffer DC, Ahn ES, Aresco C, Scalea TM, Eisenberg HM. Outcome following decompressive craniectomy for malignant swelling due to severe head injury. J Neurosurg. 2006; 104(4): 469-79.
50. Guerra WK, Gaab MR, Dietz H, Mueller JU, Piek J, Fritsch MJ. Surgical decompression for traumatic brain swelling: indications and results. J Neurosurg. 1999; 90(2): 187-96.
51. Kontopoulos V, Foroglou N, Patsalas J, Magras J, Foroglou G, Yiannakou-Pephtoulidou M, et al. Decompressive craniectomy for the management of patients with refractory hypertension: should it be reconsidered? Acta Neurochir (Wien). 2002; 144(8): 791-6.
52. Morgalla MH, Will BE, Roser F, Tatagiba M. Do long-term results justify decompressive craniectomy after severe traumatic brain injury? J Neurosurg. 2008; 109(4): 685-90.
53. Polin RS, Shaffrey ME, Bogaev CA, Tisdale N, Germanson T, Bocchicchio B, et al. Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema. Neurosurgery. 1997; 41(1): 84-92. discussion 92-4.
54. De Bonis P, Pompucci A, Mangiola A, Paternoster G, Festa R, Nucci CG, et al. Decompressive craniectomy for elderly patients with traumatic brain injury: it's probably not worth the while. J Neurotrauma. 2011; 28(10): 2043-8.
55. Honeybul S. Complications of decompressive craniectomy for head injury. J Clin Neurosci. 2010; 17(4): 430-5.
56. Stiver SI. Complications of decompressive craniectomy for traumatic brain injury. Neurosurg Focus. 2009; 26(6): E7.
57. Yang XF, Wen L, Shen F, Li G, Lou R, Liu WG, et al. Surgical complications secondary to decompressive craniectomy in patients with a head injury: a series of 108 consecutive cases. Acta Neurochir (Wien). 2008; 150(12): 1241-7. discussion 8.
58. Gooch MR, Gin GE, Kenning TJ, German JW. Complications of cranioplasty following decompressive craniectomy: analysis of 62 cases. Neurosurg Focus. 2009; 26(6): E9.
59. Rish BL, Dillon JD, Meirowsky AM, Caveness WF, Mohr JP, Kistler JP, et al. Cranioplasty: a review of 1030 cases of penetrating head injury. Neurosurgery. 1979; 4(5): 381-5.
60. Ho KM, Honeybul S, Litton E. Delayed neurological recovery after decompressive craniectomy for severe nonpenetrating traumatic brain injury. Crit Care Med. 2011; 39(11): 2495-500.
61. Honeybul S, Ho KM. Long-term complications of decompressive craniectomy for head injury. J Neurotrauma. 2011; 28(6): 929-35.
62. Chang EF, Meeker M, Holland MC. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery. 2006; 58(4): 647-56. discussion 647-56.
63. Oertel M, Kelly DF, McArthur D, Boscardin WJ, Glenn TC, Lee JH, et al. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J Neurosurg. 2002; 96(1): 109-16.
64. Smith JS, Chang EF, Rosenthal G, Meeker M, von Koch C, Manley GT, et al. The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage. J Trauma. 2007; 63(1): 75-82.
65. Cohen JE, Rajz G, Itshayek E, Umansky F. Bilateral acute epidural hematoma after evacuation of acute subdural hematoma: brain shift and the dynamics of extraaxial collections. Neurol Res. 2004; 26(7): 763-6.
66. Piepmeier JM, Wagner Jr FC. Delayed post-traumatic extracerebral hematomas. J Trauma. 1982; 22(6): 455-60.
67. Liu K, Mori S, Takahashi HK, Tomono Y, Wake H, Kanke T, et al. Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats. FASEB J. 2007; 21(14): 3904-16.
68. Howard JL, Cipolle MD, Anderson M, Sabella V, Shollenberger D, Li PM, et al. Outcome after decompressive craniectomy for the treatment of severe traumatic brain injury. J Trauma. 2008; 65(2): 380-5. discussion 5-6.
69. Grant FC, Norcross NC. Repair of cranial defects by cranioplasty. Ann Surg. 1939; 110(4): 488-512.
70. Sviri GE, Aaslid R, Douville CM, Moore A, Newell DW. Time course for autoregulation recovery following severe traumatic brain injury. J Neurosurg. 2009; 111(4): 695-700.
71. Grant GA, Jolley M, Ellenbogen RG, Roberts TS, Gruss JR, Loeser JD. Failure of autologous bone-assisted cranioplasty following decompressive craniectomy in children and adolescents. J Neurosurg. 2004; 100(2 Suppl Pediatrics): 163-8.
72. Stiefel MF, Spiotta A, Gracias VH, Garuffe AM, Guillamondegui O, Maloney-Wilensky E, et al. Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring. J Neurosurg. 2005; 103(5): 805-11.
73. Spiotta AM, Stiefel MF, Gracias VH, Garuffe AM, Kofke WA, Maloney-Wilensky E, et al. Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury. J Neurosurg. 2010; 113(3): 571-80.
74. Narotam PK, Morrison JF, Nathoo N. Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy. J Neurosurg. 2009; 111(4): 672-82.
75. Pandya JD, Pauly JR, Nukala VN, Sebastian AH, Day KM, Korde AS, et al. Post-injury administration of mitochondrial uncouplers increases tissue sparing and improves behavioral outcome following traumatic brain injury in rodents. J Neurotrauma. 2007; 24(5): 798-811.
76. Kawamata T, Katayama Y. Cerebral contusion: a role model for lesion progression. Prog Brain Res. 2007; 161: 235-41.
77. Kawamata T, Katayama Y. Surgical management of early massive edema caused by cerebral contusion in head trauma patients. Acta Neurochir Suppl. 2006; 96: 3-6.
78. Palmer AM, Marion DW, Botscheller ML, Swedlow PE, Styren SD, DeKosky ST. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J Neurochem. 1993; 61(6): 2015-24.
79. Obrenovitch TP, Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J Neurotrauma. 1997; 14(10): 677-98.
80. Faden AI, Demediuk P, Panter SS, Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science. 1989; 244(4906): 798-800.
81. Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, et al. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol. 2008; 75(2): 494-502.
82. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995; 15(4): 961-73.
83. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA. 1995; 92(16): 7162-6.
84. Yamamoto T, Rossi S, Stiefel M, Doppenberg E, Zauner A, Bullock R, et al. CSF and ECF glutamate concentrations in head injured patients. Acta Neurochir Suppl. 1999; 75: 17-9.
85. Faden AI, O'Leary DM, Fan L, Bao W, Mullins PG, Movsesyan VA. Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma. Exp Neurol. 2001; 167(2): 435-44.
86. Phillips LL, Lyeth BG, Hamm RJ, Reeves TM, Povlishock JT. Glutamate antagonism during secondary deafferentation enhances cognition and axo-dendritic integrity after traumatic brain injury. Hippocampus. 1998; 8(4): 390-401.
87. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, et al. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999; 23(2): 297-308.
88. Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. Neuroscience. 2004; 129(4): 1021-9.
89. Smith DH, Okiyama K, Thomas MJ, McIntosh TK. Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J Neurosci. 1993; 13(12): 5383-92.
90. Okiyama K, Smith DH, White WF, McIntosh TK. Effects of the NMDA antagonist CP-98, 113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. Brain Res. 1998; 792(2): 291-8.
91. Dempsey RJ, Baskaya MK, Dogan A. Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-d-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery. 2000; 47(2): 399-404. discussion 404-6.
92. Caso JR, Pradillo JM, Hurtado O, Lorenzo P, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation. 2007; 115(12): 1599-608.
93. Muir KW. Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol. 2006; 6(1): 53-60.
94. Roesler R, Quevedo J, Schroder N. Is it time to conclude that NMDA antagonists have failed? Lancet Neurol. 2003; 2(1): 13. discussion.
95. Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol. 2002; 1(6): 383-6.
96. Hoyte L, Barber PA, Buchan AM, Hill MD. The rise and fall of NMDA antagonists for ischemic stroke. Curr Mol Med. 2004; 4(2): 131-6.
97. Klatzo I. Presidental address. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol. 1967; 26(1): 1-14.
98. Ito J, Marmarou A, Barzo P, Fatouros P, Corwin F. Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury. J Neurosurg. 1996; 84(1): 97-103.
99. Bignami A. Glial cells in the central nervous system. In: Magistretti PJ, editor. Discussions in neuroscience. Amsterdam: Elsevier; 1991. p. 1-45.
100. Abbott NJ, Revest PA, Romero IA. Astrocyte-endothelial interaction: physiology and pathology. Neuropathol Appl Neurobiol. 1992; 18(5): 424-33.
101. Hayashi Y, Nomura M, Yamagishi S, Harada S, Yamashita J, Yamamoto H. Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes. Glia. 1997; 19(1): 13-26.
102. Janzer RC, Raff MC. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature. 1987; 325(6101): 253-7.
103. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 2004; 5(5): 347-60.
104. Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, et al. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci. 2006; 9(2): 260-7.
105. Wilson JX. Antioxidant defense of the brain: a role for astrocytes. Can J Physiol Pharmacol. 1997; 75(10-11): 1149-63.
106. Dhandapani KM, Hadman M, De Sevilla L, Wade MF, Mahesh VB, Brann DW. Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway. J Biol Chem. 2003; 278(44): 43329-39.
107. Laird MD, Sukumari-Ramesh S, Swift AE, Meiler SE, Vender JR, Dhandapani KM. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem. 2010; 113(3): 637-48.
108. Mahesh VB, Dhandapani KM, Brann DW. Role of astrocytes in reproduction and neuroprotection. Mol Cell Endocrinol. 2006; 246(1-2): 1-9.
109. Pfrieger FW, Barres BA. Synaptic efficacy enhanced by glial cells in vitro. Science. 1997; 277(5332): 1684-7.
110. Ullian EM, Christopherson KS, Barres BA. Role for glia in synaptogenesis. Glia. 2004; 47(3): 209-16.
111. Ullian EM, Sapperstein SK, Christopherson KS, Barres BA. Control of synapse number by glia. Science. 2001; 291(5504): 657-61.
112. Cortez SC, McIntosh TK, Noble LJ. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res. 1989; 482(2): 271-82.
113. Clausen F, Hanell A, Bjork M, Hillered L, Mir AK, Gram H, et al. Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice. Eur J Neurosci. 2009; 30(3): 385-96.
114. Dietrich WD, Truettner J, Zhao W, Alonso OF, Busto R, Ginsberg MD. Sequential changes in glial fibrillary acidic protein and gene expression following parasagittal fluid-percussion brain injury in rats. J Neurotrauma. 1999; 16(7): 567-81.
115. Castejon OJ. Morphological astrocytic changes in complicated human brain trauma. A light and electron microscopic study. Brain Inj. 1998; 12(5): 409-27. discussion 7.
116. Ridet JL, Malhotra SK, Privat A, Gage FH. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997; 20(12): 570-7.
117. Eddleston M, Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience. 1993; 54(1): 15-36.
118. Norenberg MD. Astrocyte responses to CNS injury. J Neuropathol Exp Neurol. 1994; 53(3): 213-20.
119. Baldwin SA, Scheff SW. Intermediate filament change in astrocytes following mild cortical contusion. Glia. 1996; 16(3): 266-75.
120. Amaducci L, Forno KI, Eng LF. Glial fibrillary acidic protein in cryogenic lesions of the rat brain. Neurosci Lett. 1981; 21(1): 27-32.
121. Laird MD, Vender JR, Dhandapani KM. Opposing roles for reactive astrocytes following traumatic brain injury. Neurosignals. 2008; 16(2-3): 154-64.
122. Floyd CL, Lyeth BG. Astroglia: important mediators of traumatic brain injury. Prog Brain Res. 2007; 161: 61-79.
123. Pelinka LE, Toegel E, Mauritz W, Redl H. Serum S 100 B: a marker of brain damage in traumatic brain injury with and without multiple trauma. Shock. 2003; 19(3): 195-200.
124. Pelinka LE, Kroepfl A, Schmidhammer R, Krenn M, Buchinger W, Redl H, et al. Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma. J Trauma. 2004; 57(5): 1006-12.
125. Pelinka LE, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H. GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J Neurotrauma. 2004; 21(11): 1553-61.
126. Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, et al. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock. 2004; 22(2): 102-7.
127. Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M, et al. Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J Trauma. 2010; 69(1): 104-9.
128. Lumpkins KM, Bochicchio GV, Keledjian K, Simard JM, McCunn M, Scalea T. Glial fibrillary acidic protein is highly correlated with brain injury. J Trauma. 2008; 65(4): 778-82. discussion 82-4.
129. Kimelberg HK. Astrocytic edema in CNS trauma. J Neurotrauma. 1992; 9 Suppl 1: S71-81.
130. Gotoh O, Asano T, Koide T, Takakura K. Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: the time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin. Stroke. 1985; 16(1): 101-9.
131. Betz AL. Transport of ions across the blood-brain barrier. Fed Proc. 1986; 45(7): 2050-4.
132. Nilsson P, Hillered L, Olsson Y, Sheardown MJ, Hansen AJ. Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats. J Cereb Blood Flow Metab. 1993; 13(2): 183-92.
133. Kimelberg HK, Rutledge E, Goderie S, Charniga C. Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release. J Cereb Blood Flow Metab. 1995; 15(3): 409-16.
134. Barron KD, Dentinger MP, Kimelberg HK, Nelson LR, Bourke RS, Keegan S, et al. Ultrastructural features of a brain injury model in cat. I. Vascular and neuroglial changes and the prevention of astroglial swelling by a fluorenyl (aryloxy) alkanoic acid derivative (L-644, 711). Acta Neuropathol (Berl). 1988; 75(3): 295-307.
135. Kimelberg HK, Barron KD, Bourke RS, Nelson LR, Cragoe EJ. Brain anti-cytoxic edema agents. Prog Clin Biol Res. 1990; 361: 363-85.
136. Borgnia M, Nielsen S, Engel A, Agre P. Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem. 1999; 68: 425-58.
137. Verkman AS, Mitra AK. Structure and function of aquaporin water channels. Am J Physiol Renal Physiol. 2000; 278(1): F13-28.
138. Badaut J, Lasbennes F, Magistretti PJ, Regli L. Aquaporins in brain: distribution, physiology, and pathophysiology. J Cereb Blood Flow Metab. 2002; 22(4): 367-78.
139. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci. 1997; 17(1): 171-80.
140. Kokiko ON, Murashov AK, Hoane MR. Administration of raloxifene reduces sensorimotor and working memory deficits following traumatic brain injury. Behav Brain Res. 2006; 170(2): 233-40.
141. Nicchia GP, Frigeri A, Liuzzi GM, Santacroce MP, Nico B, Procino G, et al. Aquaporin-4-containing astrocytes sustain a temperature- and mercury-insensitive swelling in vitro. Glia. 2000; 31(1): 29-38.
142. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007; 22(6): 778-84.
143. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004; 18(11): 1291-3.
144. Zhao J, Moore AN, Clifton GL, Dash PK. Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. J Neurosci Res. 2005; 82(4): 499-506.
145. Kiening KL, van Landeghem FK, Schreiber S, Thomale UW, von Deimling A, Unterberg AW, et al. Decreased hemispheric aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats. Neurosci Lett. 2002; 324(2): 105-8.
146. Ghabriel MN, Thomas A, Vink R. Magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury state. Acta Neurochir Suppl. 2006; 96: 402-6.
147. Guo Q, Sayeed I, Baronne LM, Hoffman SW, Guennoun R, Stein DG. Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp Neurol. 2006; 198(2): 469-78.
148. Amorini AM, Dunbar JG, Marmarou A. Modulation of aquaporin-4 water transport in a model of TBI. Acta Neurochir Suppl. 2003; 86: 261-3.
149. Sun MC, Honey CR, Berk C, Wong NL, Tsui JK. Regulation of aquaporin-4 in a traumatic brain injury model in rats. J Neurosurg. 2003; 98(3): 565-9.
150. Vizuete ML, Venero JL, Vargas C, Ilundain AA, Echevarria M, Machado A, et al. Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. Neurobiol Dis. 1999; 6(4): 245-58.
151. Verkman AS, Yang B, Song Y, Manley GT, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000; 85 Spec No: 233S-41S.
152. Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, et al. Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J. 2004; 18(3): 542-4.
153. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000; 6(2): 159-63.
154. Vajda Z, Pedersen M, Fuchtbauer EM, Wertz K, Stodkilde-Jorgensen H, Sulyok E, et al. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci USA. 2002; 99(20): 13131-6.
155. Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, et al. An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA. 2003; 100(4): 2106-11.
156. Taya K, Gulsen S, Okuno K, Prieto R, Marmarou CR, Marmarou A. Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema. Acta Neurochir Suppl. 2008; 102: 425-9.
157. Hu H, Yao HT, Zhang WP, Zhang L, Ding W, Zhang SH, et al. Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors. J Zhejiang Univ Sci B. 2005; 6(1): 33-7.
158. Pleines UE, Morganti-Kossmann MC, Rancan M, Joller H, Trentz O, Kossmann T. S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma. 2001; 18(5): 491-8.
159. Hinkle DA, Baldwin SA, Scheff SW, Wise PM. GFAP and S100beta expression in the cortex and hippocampus in response to mild cortical contusion. J Neurotrauma. 1997; 14(10): 729-38.
160. Bae MK, Kim SR, Lee HJ, Wee HJ, Yoo MA, Ock Oh S, et al. Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006; 1763(3): 282-9.
161. Lam AG, Koppal T, Akama KT, Guo L, Craft JM, Samy B, et al. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiol Aging. 2001; 22(5): 765-72.
162. Sinke AP, Jayakumar AR, Panickar KS, Moriyama M, Reddy PV, Norenberg MD. NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture. J Neurochem. 2008; 106(6): 2302-11.
163. Aoki-Yoshino K, Uchihara T, Duyckaerts C, Nakamura A, Hauw JJ, Wakayama Y. Enhanced expression of aquaporin 4 in human brain with inflammatory diseases. Acta Neuropathol. 2005; 110(3): 281-8.
164. Nonaka M, Chen XH, Pierce JE, Leoni MJ, McIntosh TK, Wolf JA, et al. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J Neurotrauma. 1999; 16(11): 1023-34.
165. Sanz O, Acarin L, Gonzalez B, Castellano B. NF-kappaB and IkappaBalpha expression following traumatic brain injury to the immature rat brain. J Neurosci Res. 2002; 67(6): 772-80.
166. Laird MD, Sukumari-Ramesh S, Swift AE, Meiler SE, Vender JR, Dhandapani KM. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem. 2010; 113(3): 637-48.
167. Thiyagarajan M, Sharma SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci. 2004; 74(8): 969-85.
168. Pan DS, Liu WG, Yang XF, Cao F. Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury. Biomed Environ Sci. 2007; 20(5): 432-8.
169. Pettus EH, Wright DW, Stein DG, Hoffman SW. Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res. 2005; 1049(1): 112-9.
170. Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, et al. Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma. 2007; 24(10): 1545-57.
171. Singhal A, Baker AJ, Hare GM, Reinders FX, Schlichter LC, Moulton RJ. Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma. 2002; 19(8): 929-37.
172. Chiaretti A, Genovese O, Aloe L, Antonelli A, Piastra M, Polidori G, et al. Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv Syst. 2005; 21(3): 185-93. discussion 94.
173. Lin HW, Basu A, Druckman C, Cicchese M, Krady JK, Levison SW. Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury. J Neuroinflammation. 2006; 3: 15.
174. Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol. 1993; 42(2): 177-85.
175. Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK. Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain. Brain Res Mol Brain Res. 1995; 30(1): 125-30.
176. Nieto-Sampedro M, Berman MA. Interleukin-1-like activity in rat brain: sources, targets, and effect of injury. J Neurosci Res. 1987; 17(3): 214-9.
177. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci. 2001; 2(10): 734-44.
178. Kinoshita K, Chatzipanteli K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD. Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature. Neurosurgery. 2002; 51(1): 195-203. discussion.
179. Tehranian R, Andell-Jonsson S, Beni SM, Yatsiv I, Shohami E, Bartfai T, et al. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma. 2002; 19(8): 939-51.
180. Clausen F, Hanell A, Israelsson C, Hedin J, Ebendal T, Mir AK, et al. Neutralization of interleukin-1beta reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice. Eur J Neurosci. 2011; 34(1): 110-23.
181. Lazovic J, Basu A, Lin HW, Rothstein RP, Krady JK, Smith MB, et al. Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke. 2005; 36(10): 2226-31.
182. Ito H, Yamamoto N, Arima H, Hirate H, Morishima T, Umenishi F, et al. Interleukin-1beta induces the expression of aquaporin-4 through a nuclear factor-kappaB pathway in rat astrocytes. J Neurochem. 2006; 99(1): 107-18.