Aquaporin-4 and brain edema

Pediatric Nephrology

Volumn 22, Issue 6, 2007, Pages 778-784

  Papadopoulos, Marios C ^a,b   Verkman, Alan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

AQP4; Brain swelling; Hydrocephalus; Hyponatremia; Water channel

Indexed keywords

AQUAPORIN 4; CORTICOSTEROID; MANNITOL; SODIUM CHLORIDE;

ASTROCYTE; BLOOD; BRAIN DISEASE; BRAIN EDEMA; BRAIN INFECTION; BRAIN ISCHEMIA; BRAIN TUMOR; BRAIN WATER; CELL MIGRATION; CEREBROSPINAL FLUID; CYTOTOXICITY; FLUID BALANCE; HUMAN; HYDROCEPHALUS; HYPONATREMIA; MENINGITIS; NERVE CELL EXCITABILITY; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; STROKE; TRAUMATIC BRAIN INJURY; WATER INTOXICATION; WATER TRANSPORT;

ANIMALS; AQUAPORIN 4; BRAIN EDEMA; DISEASE MODELS, ANIMAL; HUMANS; HYDROCEPHALUS; HYPONATREMIA; MICE; MICE, KNOCKOUT; WATER; WATER INTOXICATION;

EID: 34247399026     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-006-0411-0     Document Type: Review

References (37)

1. Agre P (2004) Nobel Lecture. Aquaporin water channels. Biosci Rep 24:127-163
2. Verkman AS (2005) More than just water channels: Unexpected cellular roles of aquaporins. J Cell Sci 118:3225-3232
3. Verkman AS (2006) Roles of aquaporins in kidney revealed by transgenic mice. Semin Nephrol 26:200-208
4. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT (2005) Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J 19:76-78
5. Badaut J, Hirt L, Granziera C, Bogousslavsky J, Magistretti PJ, Regli L (2001) Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. J Cereb Blood Flow Metab 21:477-482
6. Elkjaer M, Vajda Z, Nejsum LN, Kwon T, Jensen UB, Amiry-Moghaddam M, Frokiaer J, Nielsen S (2000) Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain. Biochem Biophys Res Commun 276:1118-1128
7. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997) Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17:171-180
8. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S (1998) Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci USA 95:11981-11986
9. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1997) Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 100:957-962
10. Wen H, Nagelhus EA, Amiry-Moghaddam M, Agre P, Ottersen OP, Nielsen S (1999) Ontogeny of water transport in rat brain: Postnatal expression of the aquaporin-4 water channel. Eur J Neurosci 11:935-945
11. Saunders NR (1977) Ontogeny of the blood-brain barrier. Exp Eye Res 25(Suppl):523-550
12. Rodier PM (1995) Developing brain as a target of toxicity. Environ Health Perspect 103(Suppl 6):73-76
13. Wenzel D, Felgenhauer K (1976) The development of the blood-CSF barrier after birth. Neuropadiatrie 7:175-181
14. Lehmenkuhler A, Sykova E, Svoboda J, Zilles K, Nicholson C (1993) Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis. Neuroscience 55:339-351
15. Klatzo I (1994) Evolution of brain edema concepts. Acta Neurochir Suppl (Wien) 60:3-6
16. Kimelberg HK (1995) Current concepts of brain edema. Review of laboratory investigations. J Neurosurg 83:1051-1059
17. Prough DS, Lang J (1997) Therapy of patients with head injuries: Key parameters for management. J Trauma 42:S10-S18
18. Roberts I, Schierhout G, Alderson P (1998) Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: A systematic review. J Neurol Neurosurg Psychiatry 65:729-733
19. Rash JE, Yasumura T (1999) Direct immunogold labeling of connexins and aquaporin-4 in freeze-fracture replicas of liver, brain, and spinal cord: Factors limiting quantitative analysis. Cell Tissue Res 296:307-321
20. Papadopoulos MC, Binder DK, Verkman AS (2005) Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB J 19:425-427
21. Reulen HJ, Graham R, Spatz M, Klatzo I (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg 46:24-35
22. Papadopoulos MC, Manley GT, Krishna S, Verkman AS (2004) Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18:1291-1293
23. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163
24. Papadopoulos MC, Verkman AS (2005) Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem 280:13906-13912
25. Amiry-Moghaddam M, Frydenlund DS, Ottersen OP (2004) Anchoring of aquaporin-4 in brain: Molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience 129:999-1010
26. Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A (2003) An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA 100:2106-2111
27. Bloch O, Manley GT, Verkman AS (2006) Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4 deficient mice. J Cereb Blood Flow Metab 26:1527-1537
28. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786-792
29. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS (2006) Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci 118:5691-5698
30. Hu J, Verkman AS (2006) Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J 20:1892-1894
31. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS (2007) Greatly impaired migration of aquaporin-4 deficient astroglial cells after implantation into mouse brain. FASEB J 21:108-116
32. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT (2004) Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport 15:259-262
33. Binder DK, Yao X, Sick TJ, Verkman AS, Manley GT (2006) Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53:631-636
34. Li J, Verkman AS (2001) Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem 276:31233-31237
35. Li J, Patil RV, Verkman AS (2002) Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels. Invest Ophthalmol Vis Sci 43:573-579
36. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS (2005) K+ waves in brain cortex visualized using a long-wavelength K+sensing fluorescent indicator. Nat Methods 2:825-827
37. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS (2004) In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci 24:8049-8056