Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction

Circulation: Cardiovascular Interventions

Volumn 4, Issue 4, 2011, Pages 327-335

  O'Sullivan, John F ^a   Leblond, Anne Laure ^a   Kelly, Geraldine ^a   Kumar, Arun H S ^a   Metharom, Pat ^a   Büneker, Chirlei K ^a   Alizadeh Vikali, Niki ^a   Hristova, Ivalina ^a   Hynes, Brian G ^a   O'Connor, Rosemary ^a   Caplice, Noel M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Myocardial contraction; Myocardial infarction; Myocytes; Proteins; Remodeling

Indexed keywords

COLLAGEN; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RECOMBINANT SOMATOMEDIN C; SODIUM CHLORIDE; SOMATOMEDIN C RECEPTOR; TRIPHENYLTETRAZOLIUM;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKENING; CELL COUNT; CELL DEATH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRESSLER SYNDROME; EXPERIMENTAL PIG; FEMALE; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE VOLUME; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE REMODELING; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LOW DRUG DOSE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

ANIMALS; APOPTOSIS; CLINICAL PROTOCOLS; FEMALE; HEMODYNAMICS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MODELS, ANIMAL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RECEPTOR, IGF TYPE 1; STROKE VOLUME; SWINE; TETRAZOLIUM SALTS; TIME FACTORS;

EID: 82955169620     PISSN: 19417640     EISSN: 19417632     Source Type: Journal    
DOI: 10.1161/CIRCINTERVENTIONS.110.960765     Document Type: Review

References (29)

1. Li Q, Ren J. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging Cell. 2007;6:799-806. (Pubitemid 350131048)
2. Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR. Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol. 2007;27:1649-1664.
3. Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, Schmitz W, Dietz R, von Harsdorf R. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3- OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation. 2001;104:2088-2094. (Pubitemid 33027051)
4. Song HP, Yan H, Zhang DX, Chu ZG, Zhang Q, Huang YS. [The influence of insulin growth factor-I on the apoptosis of cardiomyocytes subjected to ischemia and hypoxia]. Zhonghua Shao Shang Za Zhi. 2007;23:436-439. (Pubitemid 351265863)
5. Song HP, Zhang L, Dang YM, Yan H, Chu ZG, Huang YS. The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clin Exp Pharmacol Physiol. 2010;37:598-604.
6. Duerr RL, McKirnan MD, Gim RD, Clark RG, Chien KR, Ross J Jr. Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat. Circulation. 1996;93:2188-2196. (Pubitemid 26187109)
7. Osterziel KJ, Strohm O, Schuler J, Friedrich M, Hanlein D, Willenbrock R, Anker SD, Poole-Wilson PA, Ranke MB, Dietz R. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet. 1998;351:1233-1237. (Pubitemid 28181962)
8. Fazio S, Sabatini D, Capaldo B, Vigorito C, Giordano A, Guida R, Pardo F, Biondi B, Sacca L. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med. 1996;334:809-814. (Pubitemid 26099602)
9. Tong H, Imahashi K, Steenbergen C, Murphy E. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3- kinase-dependent pathway is cardioprotective. Circ Res. 2002;90:377-379. (Pubitemid 34633905)
10. Nishihara M, Miura T, Miki T, Tanno M, Yano T, Naitoh K, Ohori K, Hotta H, Terashima Y, Shimamoto K. Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection. J Mol Cell Cardiol. 2007;43:564-570. (Pubitemid 47615050)
11. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121-1135.
12. Feng J, Lucchinetti E, Ahuja P, Pasch T, Perriard JC, Zaugg M. Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta. Anesthesiology. 2005;103:987-995. (Pubitemid 41552054)
13. Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J. Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res. 2010;106:1635-1645.
14. Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S, Sollott SJ. Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res. 2009;104: 1240-1252.
15. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005;434:658-662. (Pubitemid 40488559)
16. Yang X, Cohen MV, Downey JM. Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther. 2010;24:225-234.
17. Pop C, Salvesen GS. Human caspases: activation, specificity, and regulation. J Biol Chem. 2009;284:21777-21781.
18. Doyle B, Sorajja P, Hynes B, Kumar AH, Araoz PA, Stalboerger PG, Miller D, Reed C, Schmeckpeper J, Wang S, Liu C, Terzic A, Kruger D, Riederer S, Caplice NM. Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1. Stem Cells Dev. 2008;17:941-951.
19. Klein HH, Schubothe M, Nebendahl K, Kreuzer H. Temporal and spatial development of infarcts in porcine hearts. Basic Res Cardiol. 1984;79: 440-447. (Pubitemid 14053181)
20. Kondo K, Shibata R, Unno K, Shimano M, Ishii M, Kito T, Shintani S, Walsh K, Ouchi N, Murohara T. Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model. Circ Cardiovasc Interv. 2010;3:166-173.
21. Kiely PA, Sant A, O'Connor R. Rack1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J Biol Chem. 2002;277: 22581-22589. (Pubitemid 34967235)
22. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
23. Hammerman H, Schoen FJ, Braunwald E, Kloner RA. Drug-induced expansion of infarct: morphologic and functional correlations. Circulation. 1984;69:611-617. (Pubitemid 14192275)
24. Gomez L, Paillard M, Thibault H, Derumeaux G, Ovize M. Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. Circulation. 2008;117:2761-2768. (Pubitemid 351770456)
25. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci U S A. 1995;92:8031-8035.
26. Keyes KT, Xu J, Long B, Zhang C, Hu Z, Ye Y. Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. Am J Physiol Heart Circ Physiol. 2010;298:H1198-H1208.
27. Jeong JJ, Ha YM, Jin YC, Lee EJ, Kim JS, Kim HJ, Seo HG, Lee JH, Kang SS, Kim YS, Chang KC. Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Food Chem Toxicol. 2009;47:1569-1576.
28. Miyamoto S, Howes AL, Adams JW, Dorn GW II, Brown JH. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and Akt. J Biol Chem. 2005;280:38505-38512. (Pubitemid 43853749)
29. St John Sutton M, Lee D, Rouleau JL, Goldman S, Plappert T, Braunwald E, Pfeffer MA. Left ventricular remodeling and ventricular arrhythmias after myocardial infarction. Circulation. 2003;107:2577-2582. (Pubitemid 36628939)