The oxidative stress of hyperhomocysteinemia results from reduced bioavailability of sulfur-containing reductants

Open Clinical Chemistry Journal

Volumn 4, Issue 1, 2011, Pages 34-44

  Ingenbleek, Yves ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Asia; cardiovascular diseases; developing countries; hydrogen sulfide; hyperhomocysteinemia; malnutrition; oxidative stress; sulfur deficiency; Vegetarianism

Indexed keywords

CASPASE 3; CATALASE; CYSTATHIONINE BETA SYNTHASE; CYSTEINE; GELATINASE A; GELATINASE B; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HYDROGEN SULFIDE; MALONALDEHYDE; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PREALBUMIN; REACTIVE OXYGEN METABOLITE; REDUCING AGENT; SULFATE; SULFUR; SUPEROXIDE DISMUTASE; VITAMIN B GROUP;

ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; BIOGENESIS; BODY FLUID; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CROP PRODUCTION; DIETARY INTAKE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD COMPOSITION; FOOD INTAKE; GLOMERULUS FILTRATION; HEART PROTECTION; HIGH FIBER DIET; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY BLOOD FLOW; LEAN BODY WEIGHT; LOW FAT DIET; MALABSORPTION; MALNUTRITION; NEUROPROTECTION; NUTRITION EDUCATION; NUTRITIONAL REQUIREMENT; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; REDUCTION; RISK ASSESSMENT; SODIUM EXCRETION; SOIL TREATMENT; STROKE; ULCER HEALING; VEGETARIAN; WOUND HEALING;

EID: 82855162709     PISSN: None     EISSN: 18742416     Source Type: Journal    
DOI: 10.2174/1874241601104010034     Document Type: Article

References (164)

1. McCully, K.S. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am. J. Pathol., 1969, 56, 111-128.
2. Ubbink, J.B.; van der Merwe, A.; Delport, R.; Allen, R.H.; Stabler, S.P.; Riezler, R.; Vermaak, W.J. The effect of subnormal vitamin B-6 status on homocysteine metabolism. J. Clin. Invest., 1996, 98, 177-184.
3. Kang, S.S.; Wong, P.W.; Norusis, M. Homocysteinemia due to folate deficiency. Metabolism, 1987, 36, 458-462.
4. Stabler, S.P.; Allen, R.H.; Savage, D.G.; Lindenbaum, J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood, 1990, 76, 871-881.
5. Yan, S.K.; Chang, T.; Wang, H.; Wu, L.; Wang, R.; Meng, Q.H. Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 2006, 351, 485-491.
6. Cheng, Z.; Yang, X.; Wang, H. Hyperhomocysteinemia and endothelial dysfunction. Curr. Hypertens. Rev., 2009, 5,158-165.
7. Loscalzo, J. The oxidant stress of hyperhomocyst(e)inemia. J. Clin. Invest., 1996, 98, 5-7.
8. Jacobsen, D.W. Hyperhomocysteinemia and oxidative stress: Time for a reality check? Arterioscler. Thromb. Vasc. Biol., 2000, 20, 1182-1184.
9. Packer, L.; Cadenas, E. Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Rad. Res., 2007, 41, 951-952.
10. McCully, K.S. Chemical pathology of homocysteine: IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation. Annals Clin. Lab. Sci., 2009, 39, 219-232.
11. Bautista, L.E.; Arenas, I.A.; Penuela, A.; Martinez, I.X. Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies. J. Clin. Epidemiol., 2002, 55, 882-887.
12. Furie, K.L.; Kelly, P. J. Homocyst(e)ine and stroke. Semin. Neurol., 2006, 26, 24-32.
13. Van Guldener, C. Homocysteine and the kidney. Curr. Drug Metab., 2005, 6, 23-26.
14. McCaddon, A.; Davies, G.; Hudson, P.; Tandy, S.; Cattell, H. Total serum homocysteine in senile dementia of Alzheimer type. Int. J. Geriatr. Psychiatry 1998, 13, 235-239.
15. Troen, A.M.; Rosenberg, I.H. Homocysteine and cognitive function. Semin. Vasc. Med., 2005, 5, 209-214.
16. Danese, S.; Sgambato, A.; Papa, A.; Scaldaferri, F.; Pola, R.; Sans, M.; Lovecchio M. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am. J. Gastroenterol., 2005, 100, 886-895.
17. van Meurs, J.B.; Dhonukshe-Rutten, R.A.; Plum, S.M.; van der Klift, M.; de Jonge, R.; Lindemans, J.; de Groot, L.; Hofman, A.; Witteman, J.; van Leeuwen, J.; Breteler, M.; Lips, P.K; Pols, H.; Uitterlinden, A.G. Homocysteine levels and the risk of osteoporotic fracture. N. Engl. J. Med., 2004, 350, 2033-2041.
18. Wang, R. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J., 2002, 16, 1792-1798.
19. Sen, U.; Basu, P.; Abe, O.A.; Givvimani, S.; Tyagi, N.; Metreveli, N.; Shah, K.S.; Passmore, J.C.; Tyagi S.C. Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure. Am. J. Physiol. Renal Physiol., 2009, 297, F410-419.
20. Elrod, J.W.; Calvert, J.W.; Morrison, J.; Doeller, J.E.; Kraus, D.W.; Tao, L.; Jiao, X.; Scalia, R.; Kiss, L.; Szabó, C.; Kimura, H.; Chow, C.W.; Lefer, D.J. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc. Natl. Acad. Sci. USA, 2007, 104, 15560-15565.
21. Chang, L.; Geng, B.; Yu, F.; Zhao, J.; Jiang, H.; Du, J.; Tang C. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids, 2008, 34, 573-585.
22. Yonezawa, D.; Sekiguchi, F.; Miyamoto, M.; Taniguchi, E.; Honjo, M.; Masuko, T.; Nishikawa, H.; Kawabata, A. A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology, 2007, 241, 11-18.
23. Dominy, J.E.; Stipanuk, M.H. New roles for cysteine and transulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr. Rev. 2004, 62, 348-353.
24. Singh, S.; Padovani, D.; Leslie, R.A.; Chiku, T.; Banerjee, R. Relative contributions of cystathionine -synthase and -cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J. Biol. Chem., 2009, 284, 22457-22466.
25. Searcy, D.G.; Lee, S.H. Sulfur reduction by human erythrocytes. J. Exp. Zool. 1998, 282, 310-322.
26. Benavides, G.A.; Squadrito, G.L.; Mills, R.W.; Patel, H.D.; Isbell, T.S.; Patel, R.P.; Darley-Usmar, V.M.; Doeller, J.E.; Kraus, D.W. Hydrogen sulfide mediates the vasoactivity of garlic. Proc. Natl. Acad. Sci. USA, 2007, 104, 17977-19982.
27. th August 2011.
28. Battezzatti, A.; Bertoli, S.; San Romerio, A.; Testolin, G. Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals. Nutr. Metab. Cardiovasc. Dis., 2007, 17, 525-534.
29. Ingenbleek, Y. Plasma Transthyretin Reflects the Fluctuations of Lean Body Mass in Health and Disease. In: Recent Advances in Transthyretin Evolution, Structure and Biological Functions; Richardson, S.J. and Cody, V., Eds.; Springer Verlag: Berlin, 2009, pp. 329-357.
30. Ingenbleek, Y. The nutritional relationship linking sulfur to nitrogen in living organisms. J. Nutr., 2006, 136, S1641-S1651.
31. Cuthbertson, D.P. The distribution of nitrogen and sulphur in the urine during conditions of increased catabolism. Biochem. J., 1931, 25, 236-244.
32. th ed., Royal Society of Chemistry: Cambridge, 1991.
33. Food and Agriculture Organization. Amino-acid Content of Foods and Biological Data on Proteins, FAO: Rome, 1970.
34. th ed., CRC Press: Boca Raton, 1994.
35. Ingenbleek, Y.; Young, V.R. Significance of transthyretin in protein metabolism. Clin. Chem. Lab. Med., 2002, 40, 1281-1291.
36. th ed.; Ziegler, E.E. and Filer L.J, Eds.; ILSI Press: Washington D.C. 1996; pp. 7-12.
37. Walter, P. Effects of the vegetarian diets on aging and longevity. Nutr. Rev., 1997, 55, S61-S65.
38. Key, T.J.; Appleby, P.N.; Rosell, M.S. Health effects of vegetarian and vegan diets. Proc. Nutr. Soc., 2006, 65, 35-41.
39. Young, V.R.; Pellet, P.L. Plant proteins in relation to human protein and amino acid nutrition. Am. J. Clin. Nutr., 1994, 59, S1203-S1212.
40. Friedman, M. Dietary impact of food processing. Annu. Rev. Nutr., 1992, 12, 119-137.
41. Gilani, G.S.; Cockell, K.A.; Sepehr, E. Effects of antinutritional factors on protein digestibility and amino acid availability in foods. J. AOAC Int., 2005, 88, 967-987.
42. Ingenbleek, Y.; Barclay, D.; Dirren, H. Nutritional significance of alterations in serum amino acid patterns in goitrous patients. Am. J. Clin. Nutr., 1986, 43, 310-319.
43. Ingenbleek, Y.; Hardillier, E.; Jung, L. Subclinical protein malnutrition is a determinant of hyperhomocysteinemia. Nutrition, 2002, 18, 40-46.
44. Ingenbleek, Y.; Young, V.R. The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinemia. Nutr. Res. Rev., 2004, 17, 135-153.
45. Tang, B.; Mustafa, A.; Gupta, S.; Melnyk, S.; James S.J.; Kruger, W.D. Methionine-deficient diet induces post-transcriptional down-regulation of cystathionine--synthase. Nutrition, 2010, 26, 1170-1175.
46. Elshorbagy, A.K.; Valdivia-Garcia, M.; Refsum, H.; Smith, A.D.; Mattocks, D.A.; Perrone, C.E. Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia. Nutrition, 2010, 26, 1201-1204.
47. Owens, F.N.; Bergen, W.G. Nitrogen metabolism in ruminant animals: historical perspective, current understanding and future implications. J. Anim. Sci., 1983, 57 (Suppl. 2), 498-518.
48. Fuller, M.F.; McWilliam, R.; Wang, T.C.; Giles, L.R. The optimum dietary amino acid pattern for growing pigs. 2. Requirements for maintenance and for tissue protein accretion. Br. J. Nutr., 1989, 62, 255-267.
49. Finkelstein, J.D.; Kyle, W.E.; Martin, J.J.; Pick, A.M. Activation of cystathionine synthase by adenosylmethionine and adenosylethionine. Biochem. Biophys. Res. Commun., 1975, 66, 81-87.
50. Janosik, M.; Kery, V.; Gaustadnes, M.; Maclean, K.N.; Kraus, J.P. Regulation of human cystathionine beta-synthase by Sadenosyl-Lmethionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal group. Biochemistry (Mosc.), 2001, 40, 10625-10633.
51. Jahoor, F.; Badaloo, A.; Reid, M.; Forrester, T. Sulfur amino acid metabolism in children with severe childhood undernutrition: cysteine kinetics. Am. J. Clin. Nutr., 2006, 84, 1400-1405.
52. Jones, D.P.; Coates, R.J.; Flagg, E.W.; Eley, J.W.; Block, G.; Greenberg, R.S.; Gunter, E.W.; Jackson, B. Glutathione in foods listed in the National Cancer Institute's health habits and history food frequency questionnaire. Nutr. Cancer, 1992, 17, 57-75.
53. Lyons, J.; Rauh-Pfeiffer, A.; Yu, Y.M.; Lu, X.M.; Zurakowski, D.; Tompkins R.G.; Ajami, A.M.; Young, V.R.; Castillo, L. Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc. Natl. Acad. Sci. USA, 2000, 97, 5071-5076.
54. Chen, X.; Jhee, K.H.; Kruger, W.D. Production of the neuromodulator H2S by cystathionine -synthase via the condensation of cysteine and homocysteine. J. Biol. Chem., 2004, 279, 52082-52086.
55. Stipanuk, M.H. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu. Rev. Nutr., 2004, 24, 539-577.
56. Stipanuk, M.H.; Ueki, I. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J. Inherit. Metab. Dis., 2011, 34, 17-32.
57. Kamoun, P. Endogenous production of hydrogen sulfide in mammals. Amino Acids, 2004, 26, 243-254.
58. Kimura, H. Hydrogen sulfide: its production, release and functions. Amino Acids, 2011, 41, 113-121.
59. Enokido, Y.; Suzuki, E.; Iwasawa, K.; Namekata, K.; Okazawa, H.; Kimura, H. Cystathionine-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J., 2005, 19, 1854-1856.
60. Zhao, W.; Ndisang, J.F.; Wang, R. Modulation of endogenous production of H2S in rat tissues. Can. J. Physiol. Pharmacol., 2003, 81, 848-853.
61. House, J.D.; Brosnan, M.E.; Brosnan, J.T. Characterization of homocysteine metabolism in the rat kidney. Biochem. J., 1997, 328, 287-292.
62. Dorman, D.C.; Moulin, F.J.; McManus, B.E.; Mahle, K.C.; James, R.A.; Struve, M.F. Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium. Toxicol. Sci., 2002, 65, 18-25.
63. Barañano, D.E.; Ferris, C.D.; Snyder, S.H. Atypical neural messengers. Trends Neurosci., 2001, 24, 99-106.
64. Mancardi, D.; Penna, C.; Merlino, A.; Del Soldato, P.; Wink, D.A.; Pagliaro, P. Physiological and pharmacological features of the novel gasotransmitter: Hydrogen sulfide. Biochim. Biophys. Acta, 2009, 1787, 864-872.
65. Zhao, W.; Zhang, J.; Lu, Y.; Wang, R. The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J., 2001, 20, 6008-6016.
66. Hosoki, R.; Matsuki, N.; Kimura, H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem. Biophys. Res. Commun., 1997, 237, 527-531.
67. Geng, B.; Yang, J.; Qi, Y.; Zhao, J.; Pang, Y.; Du, J.; Tang C. H2S generated by heart in rat and its effects on cardiac function. Biochem. Biophys. Res. Commun., 2004, 313, 362-368.
68. Klimmek, O. The biological cycle of sulfur. Met. Ions Biol. Syst., 2005, 105-130.
69. Vennesland, B.V.; Castric, P.A.; Conn, E.E.; Solomonson, L.P.; Volini, M.; Westley, J. Cyanide metabolism. Fed. Proc. Fed. Am. Soc. Exp. Biol., 1982, 41, 2639-2648.
70. Wood, J.L. Sulfane sulfur. Methods Enzymol., 1987, 143, 25-29.
71. Toohey, J.I. Sulphane sulphur in biological systems: a possible regulatory role. Biochem. J., 1989, 264, 625-632.
72. Ogasawara, Y.; Isoda, S.; Tanabe, S. Tissue and subcellular distribution of bound and acid-labile sulfur, and the enzymic capacity for sulfide production in the rat. Biol. Pharm. Bull., 1994, 17, 1535-1542.
73. Bonomi, F.; Pagani, S.; Cerletti, P.; Cannella, C. Rhodanese-mediated sulfur transfer to succinate dehydrogenase. Eur. J. Biochem., 1977, 72, 17-24.
74. Pagani, S.; Galante, Y.M. Interaction of rhodanese with mitochondrial NADH dehydrogenase. Biochim. Biophys. Acta, 1983, 742, 278-284.
75. Russell, P.J.; Conner, J.; Sisson, S. Sulfur specifically inhibits adenylate kinase in assays for creatine kinase. Clin. Chem., 1984, 30, 1555-1557.
76. Hargrove, J.L.; Wichman, R.D. A cystine-dependent inactivator of tyrosine aminotransferase co-purifies with -cystathionase (cysteine desulfurase). J. Biol. Chem., 1987, 262, 7351-7357.
77. Xia, M.; Chen, L.; Muh, R.W.; Li, P.L.; Li, N. Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys. J. Pharmacol. Exp. Ther., 2009, 329, 1056-1062.
78. Monaghan, W.J.; Garai, F. Treatment of acute and chronic polyarthritis, arthritis deformans, and septicemias, with activated colloid sulphur. Med. J. Record, 1924, 120, 24-26.
79. Fiorucci, S.; Distrutti, E.; Cirino, G.; Wallace, J.L. The emerging role of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology, 2006, 131, 259-271.
80. Goubern, M.; Andriamihaja, M.; Nubel, T.; Blachier, F.; Bouillaud, F. Sulfide, the first inorganic substrate for human cells. FASEB J., 2007, 21, 1699-1706.
81. Furne, J.; Springfield, J.; Koenig, T.; DeMaster, E.; Levitt, MD. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem. Pharmacol., 2001, 62, 255-259.
82. Chen, YH.; Yao, W.Z.; Geng, B.; Ding, Y.L.; Lu, M.; Zhao, M.W.; Tang, C.S. Endogenous hydrogen sulfide in patients with COPD. Chest, 2005, 128, 3205-3211.
83. Whiteman, M.; Moore, P.K. Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? J. Cell. Mol. Med., 2009, 13, 488-507.
84. Breitkreutz, R.; Holm, S.; Pittack, N.; Beichert, M.; Babylon, A.; Yodoi, J.; Dröge, W. Massive loss of sulfur in HIV infection. AIDS Res. Hum. Retroviruses, 2000, 16, 203-209.
85. Ingenbleek, Y.; Bernstein, L. The stressful condition as a nutritionally dependent adaptive dichotomy. Nutrition, 1999, 15, 305-320.
86. Whitfield, N.L.; Kreimier, E.L.; Verdial, F.C.; Skovgaard, N.; Olson, K.R. A reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2008, 294, R1930-1937.
87. Eto, K.; Asada, T.; Arima, K.; Makifuchi, T.; Kimura, H. Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem. Biophys. Res. Commun., 2002, 293, 1485-1488.
88. Liu, X.Q.; Liu, X.Q.; Jiang, P.; Huang, H.; Yan, Y. Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer's disease and vascular dementia and the significance thereof. Zhonghua Yi Xue Za Zhi, 2008, 88, 2246-2249.
89. Chen, L.; Ingrid, S.; Ding, Y.G.; Liu, Y.; Qi, J.G.; Tang, J.B. Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children. Chin. Med. J., 2007, 120, 389-393.
90. Sun, N.L.; Xi, Y.; Yang, S.N.; Ma, Z.; Tang, C.S. Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications. Zonghua Xin Xue Guan Bing Za Zhi, 2007, 35, 1145-1148.
91. Lin, M.T.; Beal, M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 2006, 443, 787-795.
92. Abe, K.; Kimura, H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci., 1996, 16, 1066-1071.
93. Eto, K.; Ogasawara, M.; Umemara, K.; Nagai, Y.; Kimura, H. Hydrogen sulfide is produced in response to neuronal excitation. J. Neurosci., 2002, 22, 3386-3391.
94. Qu, K.; Lee, S.W.; Bian, J.S.; Low, C.M.; Wong, P.T. Hydrogen sulfide: neurochemistry and neurobiology. Neurochem. Int., 2007, 52, 155-165.
95. Tyagi, N.; Moshal, K.S.; Sen, U.; Vacek, T.P.; Kumar, M.; Hughes, W.M. Jr.; Kundu, S.; Tyagi, S.C. H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid. Redox. Signal, 2009, 11, 25-33.
96. Lee, S.W.; Hu, Y.S.; Hu, L.F.; Lu, O.; Dawe, G.S.; Moore, P.K.; Wong, P.T.; Bian, J.S. Hydrogen sulfide regulates calcium homeostasis in microglial cells. Glia, 2006, 54, 116-124.
97. Hu, L.F.; Wong, P.T.; Moore, P.K.; Bian, J.S. Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. J. Neurochem., 2007, 100, 1121-1128.
98. Tang, X.Q.; Shen, X.T.; Huang, Y.E.; Ren, Y.K.; Chen, R.Q.; Hu, B.; He, J.Q.; Yin, W.L.; Xu, J.H.; Jiang, Z.S. Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells. Neurosci. Res., 2010, 68, 241-249.
99. Yang, G.; Wu, L.; Jiang, B.; Yang, W.; Qi, J.; Cao, K.; Meng, Q.; Mustafa, A.K.; Mu, W.; Zhang, S. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gammalyase. Science, 2008, 322, 587-590.
100. Zanardo, R.C.; Brancaleone, V.; Distrutti, E.; Fiorucci, S.; Cirino, G.; Wallace, J.L. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J., 2006, 20, 2118-2120.
101. Tang, G.; Wu, L.; Liang, W.; Wang, R. Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol. Pharmacol., 2005, 68, 1757-1764.
102. Rinaldi, L.; Gobbi, G.; Pambianco, M.; Micheloni, C.; Mirandola, P.; Vitale, M. Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3. Lab. Invest., 2006, 86, 391-397.
103. Papapetropoulos, A.; Pyriochou, A.; Altaany, Z.; Yang, G.; Marazioti, A.; Zhou, Z.; Jeschke, M.G.; Branski, L.K.; Herndon, D.N.; Szabó, C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc. Natl. Acad. Sci. USA, 2009, 106, 21972-21977.
104. Bos, E.M.; Leuvenink, H.G.; Snijder, P.M.; Kloosterhuis, N.J.; Hillebrands, J.L.; Leemans, J.C.; Florquin, S.; van Goor, H. Hydrogen sulfide-induced hypometabolism prevents ischemia/reperfusion injury. J. Am. Soc. Nephrol., 2009, 20, 1901-1905.
105. Tripatara, P.; Patel, N.S.; Collino, M.; Gallichio, M.; Kieswich, J.; Castiglia, S.; Benetti, E.; Stewart, K.N.; Brown, P.A.; Yaqoob, M.M.; Fantozzi, R.; Thiemermann, C. Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Lab. Invest., 2008, 88, 1038-1048.
106. Sen, U.; Munjal, C.; Qipshidze, N.; Abe, O.; Gargoum, R.; Tyagi, S.C. Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis. Am. J. Nephrol., 2010, 31, 442-455.
107. Wallace, J.L.; Dicay, M.; McKnight, W.; Martin, G.R. Hydrogen sulfide enhances ulcer healing in rats. FASEB J., 2007, 21, 4070-4076.
108. Fiorucci, S.; Antonelli, E.; Distrutti, E.; Rizzo, G.; Mencarelli, A.; Orlandi S.; Zanardo, R.; Renga, B.; Di Sante, M.; Morelli, A.; Cirino, G.; Wallace, J.L. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology, 2005, 129, 1210-1224.
109. Liu, H.; Bai, X.B.; Shi, S.; Cao, Y.X. Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. J. Pharm. Pharmacol., 2009, 61, 207-212.
110. Yang, W.; Yang, G.; Jia, X.; Wu, L.; Wang, R. Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanism. J. Physiol., 2005, 569, 519-531.
111. Tamizhselvi, R.; Moore, P.K.; Bhatia, M. Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells. J. Cell. Mol. Med., 2007, 11, 315-326.
112. Kang, K.; Zhao, M.; Jiang, H.; Tan, G.; Pan, S.; Sun, X. Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats. Liver Transpl., 2009, 15, 1306-1314.
113. Wei, H.L.; Zhang, C.Y.; Jin, H.F.; Tang, C.S.; Du, J.B. Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic pulmonary hypertensive rats. Acta Pharmacol. Sin., 2008, 29, 670-679.
114. Fu, Z.; Liu, X.; Geng, B.; Fang, L.; Tang, C. Hydrogen sulfide protects rat lung from ischemia-reperfusion injury. Life Sci., 2008, 82, 1196-1202.
115. Chen, Y.H.; Wu, R.; Geng, B.; Qi, Y.F.; Wang, P.P.; Yao, W.Z.; Tang, C.S. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine 2009, 45, 117-123.
116. Li, X.; Jin, H.; Bin, G.; Wang, L.; Tang, C.; Du, J. Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Exp. Biol. Med. (Maywood), 2009, 234, 504-512.
117. Dombkowski, R.A.; Russell, M.J.; Olson, K.R. Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2004, 286, R678-R685.
118. Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol. Sci., 2007, 28, 501-505.
119. Ingenbleek, Y. Hyperhomocysteinemia is a biomarker of sulfur-deficiency in human morbidities. Open Clin. Chem. J., 2009, 2, 49-60.
120. Steed, M.M.; Tyagi, S.C. Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxid. Redox. Signal., 2011, 15, 1927-1943.
121. Black, R.E.; Morris, S.S.; Bryce, J. Where and why are 10 millions children dying every year? Lancet, 2003, 361, 2226-2234.
122. El-Ghannam, A.R. The global problems of child malnutrition and mortality in different world regions. J. Health Soc. Policy, 2003, 16, 1-26.
123. Ferro-Luzzi, A.; James, W.P.T. Adult malnutrition: simple assessment techniques for use in emergencies. Br. J. Nutr., 1996, 75, 3-10.
124. Waterlow, J.C. Protein-energy malnutrition: the nature and extent of the problem. Clin. Nutr. 1997, 16 (Suppl 1), S3-S9.
125. de Onis, M.; Monteiro, C.; Akré, J.; Clugston, G. The world magnitude of protein-energy malnutrition: an overview from the WHO global database on child growth. Bull. WHO, 1993, 71, 703-712.
126. Stephenson, L.S.; Latham, M.C.; Ottesen, E.A. Global malnutrition. Parasitology, 2000, 121, S5-S22.
127. Khan, N.C.; Tuyen, le D.; Ngoc, T.X.; Duong, P.H.; Khoi, H.H. Reduction in childhood malnutrition in Vietnam from 1990 to 2004. Asia Pac. J. Clin. Nutr., 2007, 16, 274-278.
128. Faruque, A.S.; Shamsir Ahmed, A.M.; Tahmeed Ahmed.; Munirul M.; Iqbal Hossain, M.; Roy, S.K.; Nurul Alam; Iqbal Kabir; Sack, D.A. Nutrition: Basis for healthy children and mothers in Bangladesh. J. Health Popul. Nutr., 2008, 26, 325-339.
129. Wang, X.; Wang, Y.; Kang, C. Feeding practices in 105 countries of rural China. Child Care Health Dev., 2005, 31, 417-423.
130. Antony, G.M.; Laxmaiah, A. Human development, poverty, health & nutrition situation in India. Indian J. Med. Res., 2008, 128, 198-205.
131. Kumar, S. South Asia fails to reduce malnutrition burden. Lancet, 2001, 357, 1511.
132. Ngare, D.K.; Muttunga, J.N. Prevalence of malnutrition in Kenya. East Afr. Med. J., 1999, 76, 376-380.
133. World Health Organization. Physical status: The use and interpretation of anthropometry. WHO Techn Rep Ser 854; WHO: Geneva, 1995.
134. Ingenbleek, Y.; De Visscher, M; De Nayer, P. Measurement of prealbumin as index of protein-calorie malnutrition. Lancet, 1972, 106-109.
135. Shenkin, A.; Cederblad, G.; Elia, M.; Isaksson, B. International Federation of Clinical Chemistry. Laboratory assessment of protein-energy status. Clin. Chim. Acta, 1996, 253, S5-S59.
136. Hung, C.J.; Huang, P.C.; Lu, S.C.; Li, Y.H.; Huang, H.B.; Lin, B.F.; Chang, S.J.; Chou, H.F. Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores. J. Nutr., 2002, 132, 152-158.
137. Yajnik, C.S.; Deshpande, S.S.; Lubree, H.G.; Naik, S.S.; Bhat, D.S.; Uradey, B.S.; Deshpande, J.A.; Rege, S.S.; Refsum, H.; Yudkin, J.S. Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians. J. Assoc. Physicians India, 2006, 54, 775-782.
138. Benzie, I.F.; Wachtel-Galor, S. Biomarkers in long-term vegetarian diets. Adv. Clin. Chem., 2009, 47, 171-222.
139. Must, A.; Jacques, P.F.; Rogers, G.; Rosenberg, I.H.; Selhub, J. Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III). J. Nutr., 2003, 133, 2643-2649.
140. Rauh, M.; Verwied, S.; Knerr, I.; Dörr, H.G.; Sönnichsen, A.; Koletzko, B. Homocysteine concentrations in a German cohort of 500 individuals: Reference ranges and determinants of plasma levels in healthy children and their parents. Amino Acids, 2001, 20, 409-418.
141. Abdel, G.A.; Abdullah, S.H.; Kordofani, A.Y. Plasma homocysteine levels in cardiovascular disease, malaria and protein-energy malnutrition in Sudan. East Mediterr. Health J., 2009, 15, 1432-1439.
142. Moyano, D.; Vilaseca, M.A.; Artuch, R.; Valls, C.; Lambruschini, N. Plasma total-homocysteinemia in anorexia nervosa. Eur. J. Clin. Nutr., 1998, 52, 172-175.
143. Gallistl, S.; Sudi, K.M.; Erwa, W.; Aigner, R.; Borkenstein, M. Determinants of homocysteine during weight reduction in obese children and adolescents. Metabolism, 2001, 50, 1220-1223.
144. Borzon-Chazot, F.; Harthe, C.; Teboul, F.; Labrousse, F.; Gaume, C.; Guadagnino, L.; Claustrat, B.; Berthezène, F.; Moulin, P. Occurrence of hyperhomocysteinemia 1 year after gastroplasty for severe obesity. J. Clin. Endocrinol. Metab., 1999, 84, 541-545.
145. Sheu, W.H.; Wu, H.S.; Wang, C.W.; Wan, C.J.; Lee, W.J. Elevated plasma homocysteine concentrations after gastroplasty in morbidly obese subjects. Intern. Med., 2001, 40, 584-588.
146. Faintuch, J.; Matsuda, M.; Cruz, M.E.; Silva, M.M.; Teivelis, M.P.; Garrido, A.B. Jr.; Gama-Rodriguez, J.J. Severe protein-calorie malnutrition after bariatric procedures. Obes. Surg., 2004, 14, 175-181.
147. Chandalia, M.; Abate, N.; Cabo-Chan, A.V. Jr.; Devaraj, S.; Jialal, I.; Grundy, S.M. Hyperhomocysteinemia in Asian Indians living in the United States. J. Clin. Endocrinol. Metab., 2003, 88, 1089-1095.
148. Koebnick, C.; Garcia, A.L.; Dagnelie, P.C.; Strassner, C.; Lindemans, J.; Katz, N.; Leitzmann, C.; Hoffmann, I. Long-term consumption of a raw food diet is associated with favorable serum LDL cholesterol and triglycerides but also with elevated plasma homocysteine and low HDL cholesterol in humans. J. Nutr., 2005, 135, 2372-2375.
149. Coleman, R. The importance of sulfur as a plant nutrient in world crop production. Soil Sci., 1966, 101, 230-239.
150. Dijkshoorn, W.; Van Wijk, A.L. The sulphur requirements of plants as evidenced by the sulphur-nitrogen ratio in the organic matter: a review of published data. Plant Soil, 1967, 26, 129-157.
151. Tisdale, S.L.; Reneau, R.B. Jr.; Platou, J.S. Atlas of Sulfur Deficiency. In: Sulfur in Agriculture; Tabatabai, M.A., Ed.; American Society of Agronomy, Crop Science Society of America, Soil Science Society of America: Madison, 1986; Vol. 27, pp. 295-322.
152. Jez, J.M. Sulfur: A Missing Link between Soils, Crops, and Nutrition; American Society of Agronomy, Crop Science Society of America, Soil Science Society of America: Madison, 2008.
153. Beaton, J.D.; White, M. Occurrence and correction of S-deficiencies in the Asian and Pacific region: a review and update. The Sulphur Institute: Washington D.C., 1997, pp. 31-46.
154. Khurana, M.P.S.; Sadana, U.S.; Bijay-Singh. Sulfur-Nutrition of Crops in the Indo-Gangetic Plains of South Asia. In: Sulfur: A Missing Link between Soils, Crops, and Nutrition; Jez, J.M., Ed.; American Society of Agronomy, Crop Science Society of America, Soil Science Society of America: Madison, 2008; Vol. 50, pp. 11-24.
155. Surridge, C. Rice cultivation: Feast or famine? Nature 2004, 432, 814.
156. Fox, R.L.; Blair, G.J. Plant responses to sulfur in tropical soils. In: Sulfur in Agriculture; Tabatabai, M.A., Ed., American Society of Agronomy, Crop Science Society of America, Soil Science Society of America: Madison, 1986; Vol. 27, pp. 405-434.
157. Galili, G.; Amir, R.; Hoefgen, R.; Hesse, H. Improving the levels of essential amino acids and sulfur metabolites in plants. Biol. Chem., 2005, 386, 817-831.
158. Fageria, N.K.; Baligar, V.C.; Jones, C.A. Growth and Mineral Nutrition of Field Crops, Taylor & Francis: London, 2010.
159. Kumar, Y.; Das, R.; Garewal, G.; Bali, H.K. High prevalence of hyperhomocysteinemia in young population of North India a potential risk factor for coronary artery disease? Thromb. Res., 2009, 123, 800-802.
160. Ghosh, K.; Khare, A.; Shetty, S. Fasting plasma homocysteine levels are increased in young patients with acute myocardial infarction in Western India. Indian Heart J., 2007, 59, 242-245.
161. Christopher, R.; Nagaraja, D.; Shankar, S.K. Homocysteine and cerebral stroke in developing countries. Curr. Med. Chem., 2007, 14, 2393-2401.
162. Ahmad, U.; Frossard, P.M. Letter to the Editor. Coronary heart diseases in South Asia: Need to redefine risk. Int. J. Cardiol., 2006, 107, 289-290.
163. Lee, J.; Heng, D.; Chia, K.S.; Chew, S.K.; Tan, B.Y.; Hughes, K. Risk factors and incident coronary heart disease in Chinese, Malay and Asian Indian males: the Singapore Cardiovascular Cohort Study. Int. J. Epidemiol., 2001, 30, 983-988.
164. Srivastava, R. South Asia's governments exhorted to focus on CVD. Lancet, 2002, 359, 858.