Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia

Journal of Neurochemistry

Volumn 100, Issue 4, 2007, Pages 1121-1128

  Hu, Li Fang ^a   Wong, Peter T H ^a   Moore, Philip K ^a   Bian, Jin Song ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Hydrogen sulfide; Microglia; Neuroinflammation; Nitric oxide; p38 MAPK; Tumor necrosis factor

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HYDROGEN SULFIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; ENCEPHALITIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN SULFIDE; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 33846817478     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04283.x     Document Type: Article

References (39)

1. Abe K. and Kimura H. (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci. 16, 1066-1071.
2. Bhatia M., Wong F. L., Fu D., Lau H. Y., Moochhala S. M. and Moore P. K. (2005) Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J. 19, 623-625.
3. Blasi E., Barluzzi R., Bocchini V., Mazzolla R. and Bistoni F. (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 27, 229-237.
4. Boehning D. and Snyder S. H. (2003) Novel neural modulators. Annu. Rev. Neurosci. 26, 105-131.
5. Chahl L. A. (2004) Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons? Br. J. Pharmacol. 142, 1-2.
6. Craft J. M., Watterson D. M. and Van Eldik L. J. (2005) Neuroinflammation: a potential therapeutic target. Expert Opin. Ther. Targets 9, 887-900.
7. Eto K., Asada T., Arima K., Makifuchi T. and Kimura H. (2002) Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem. Biophys. Res. Commun. 293, 1485-1488.
8. Ferdinandy P., Danial H., Ambrus I., Rothery R. A. and Schulz R. (2000) Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ. Res. 87, 241-247.
9. Gad M. Z. and Khattab M. (2000) Modulation of nitric oxide synthesis in inflammation. Relationship to oxygen-derived free radicals and prostaglandin synthesis. Arzneimittelforschung 50, 449-455.
10. Gao H. M., Hong J. S., Zhang W. and Liu B. (2002) Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 22, 782-790.
11. + on SH-SY5Y cells by decreasing extracellular glutamate level. J. Neurochem. 94, 1570-1579.
12. Jung K. K., Lee H. S., Cho J. Y., Shin W. C., Rhee M. H., Kim T. G., Kang J. H., Kim S. H., Hong S. and Kang S. Y. (2006) Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 79, 2022-2031.
13. Kaminska B. (2005) MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754, 253-262.
14. Kim Y. J., Hwang S. Y. and Han I. O. (2006) Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochem. Biophys. Res. Commun. 347, 731-738.
15. Kim Y. S. and Joh T. H. (2006) Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp. Mol. Med. 38, 333-347.
16. Kimura H. (2002) Hydrogen sulfide as a neuromodulator. Mol. Neurobiol. 26, 13-19.
17. Kimura H., Nagai Y., Umemura K. and Kimura Y. (2005) Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxid. Redox Signal. 7, 795-803.
18. Kimura Y. and Kimura H. (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J. 18, 1165-1167.
19. Lee S. W., Hu Y. S., Hu L. F., Lu Q., Dawe G. S., Moore P. K., Wong P. T. and Bian J. S. (2006) Hydrogen sulphide regulates calcium homeostasis in microglial cells. Glia 54, 116-124.
20. Lee Y. B., Schrader J. W. and Kim S. U. (2000) p38 MAP kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms. Cytokine 12, 874-880.
21. Li L., Bhatia M. and Moore P. K. (2006) Hydrogen sulphide - a novel mediator of inflammation? Curr. Opin. Pharmacol. 6, 125-129.
22. Li L., Bhatia M., Zhu Y. Z., Zhu Y. C., Ramnath R. D., Wang Z. J., Anuar F. B., Whiteman M., Salto-Tellez M. and Moore P. K. (2005) Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J. 19, 1196-1198.
23. Mok Y. Y., Atan M. S., Yoke Ping C., Zhong Jing W., Bhatia M., Moochhala S. and Moore P. K. (2004) Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. Br. J. Pharmacol. 143, 881-889.
24. Moore A. H. and O'Banion M. K. (2002) Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv. Drug Deliv. Rev. 54, 1627-1656.
25. Morale M. C., Serra P. A., L'Episcopo F. et al. (2006) Estrogen, neuro-inflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration. Neuroscience 138, 869-878.
26. Myers R. R., Campana W. M. and Shubayev V. I. (2006) The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov. Today 11, 8-20.
27. Nagai Y., Tsugane M., Oka J. and Kimura H. (2004) Hydrogen sulfide induces calcium waves in astrocytes. FASEB J. 18, 557-559.
28. Oh G. S., Pae H. O., Lee B. S., Kim B. N., Kim J. M., Kim H. R., Jeon S. B., Jeon W. K., Chae H. J. and Chung H. T. (2006) Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic. Biol. Med. 41, 106-119.
29. Qu K., Chen C. P., Halliwell B., Moore P. K. and Wong P. T. (2006) Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 37, 889-893.
30. Reiffenstein R. J., Hulbert W. C. and Roth S. H. (1992) Toxicology of hydrogen sulfide. Annu. Rev. Pharmacol. Toxicol. 32, 109-134.
31. Rinaldi L., Gobbi G., Pambianco M., Micheloni C., Mirandola P. and Vitale M. (2006) Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3. Lab. Invest. 86, 391-397.
32. Shen S., Yu S., Binek J. et al. (2005) Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem. Int. 47, 298-307.
33. Teismann P. and Schulz J. B. (2004) Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 318, 149-161.
34. 2S be the third endogenous gaseous transmitter? FASEB J. 16, 1792-1798.
35. Wang R. (2003) The gasotransmitter role of hydrogen sulfide. Antioxid. Redox Signal. 5, 493-501.
36. Watters J. J., Sommer J. A., Pfeiffer Z. A., Prabhu U., Guerra A. N. and Bertics P. J. (2002) A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production. J. Biol. Chem. 277, 9077-9087.
37. Whiteman M., Armstrong J. S., Chu S. H., Jia-Ling S., Wong B. S., Cheung N. S., Halliwell B. and Moore P. K. (2004) The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? J. Neurochem. 90, 765-768.
38. Wojtera M., Sikorska B., Sobow T. and Liberski P. P. (2005) Microglial cells in neurodegenerative disorders. Folia Neuropathol. 43, 311-321.
39. Zhang H., Zhi L., Moore P. K. and Bhatia M. (2006) The role of hydrogen sulfide in cecal ligation and puncture induced sepsis in the mouse. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L1193-1201.