Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis

Nutrition

Volumn 28, Issue 2, 2012, Pages 148-153

  Ingenbleek, Yves ^a   McCully, Kilmer S ^b,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cardiovascular disease; Homocysteine; Lean body mass; Protein malnutrition; Sulfur deficiency; Transthyretin

Indexed keywords

ALBUMIN; CREATININE; CYANOCOBALAMIN; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; LIPID; METHIONINE; NITROGEN; PREALBUMIN; PYRIDOXINE; SULFUR AMINO ACID; VITAMIN B GROUP;

ADULT; ARTICLE; ATHEROGENESIS; BLOOD LEVEL; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHEMICAL MODIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FOOD INTAKE; FRAMINGHAM RISK SCORE; HEALTH STATUS; HUMAN; HYPERHOMOCYSTEINEMIA; INHIBITION KINETICS; LEAN BODY WEIGHT; MALE; MALNUTRITION; MEDICAL ASSESSMENT; MORBIDITY; MORTALITY; NUTRITIONAL REQUIREMENT; PRIORITY JOURNAL; PROTEIN RESTRICTION; QUESTIONNAIRE; RISK FACTOR; SULFURATION; UNITED STATES; URBAN RURAL DIFFERENCE; URINE LEVEL; VEGETARIAN DIET;

ADOLESCENT; ADULT; AMINO ACIDS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; CARDIOVASCULAR DISEASES; CHAD; DIET SURVEYS; DIET, VEGETARIAN; DIETARY PROTEINS; HEALTH STATUS; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; NUTRITION POLICY; NUTRITIONAL STATUS; PROTEIN DEFICIENCY; QUESTIONNAIRES; RISK FACTORS; RURAL POPULATION; SULFUR; VITAMIN B COMPLEX; YOUNG ADULT;

EID: 82855180997     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2011.04.009     Document Type: Article

References (45)

1. The world health report 2001. Health systems: improving performance 2001, World Health Organization, World Health Organization, Geneva.
2. McDermott M.M. The international pandemic of chronic cardiovascular disease. JAMA 2007, 297:1253-1255.
3. Walter P. Effects of vegetarian diets on aging and longevity. Nutr Rev 1997, 55:S61-S68.
4. Key T.J., Appleby P.N., Rosell M.S. Health effects of vegetarian and vegan diets. Proc Nutr Soc 2006, 65:35-41.
5. Position of the American Dietetic Association and Dieticians of Canada: vegetarian diets. ADA Rep 2003, 6:106. American Dietetic Association.
6. Reddy S. Vegetarian diets. The Encyclopedia of human nutrition 2005, 131-137. Academic Press, London. 2nd ed. B. Caballero, I. Allen, A. Prentice (Eds.).
7. Hung C.J., Huang P.C., Lu S.C., Li Y.H., Huang H.B., Lin B.F., et al. Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores. J Nutr 2002, 132:152-158.
8. 12 deficiency and hyperhomocysteinemia in rural and urban Indians. J Assoc Phys India 2006, 54:775-782.
9. Christopher R., Nagaraja D., Shankar S.K. Homocysteine and cerebral stroke in developing countries. Curr Med Chem 2007, 14:2393-2401.
10. McCully K.S. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969, 56:111-128.
11. McCully K.S. Homocysteine and vascular disease. Nat Med 1996, 2:386-389.
12. 12 deficiency as a worldwide problem. Annu Rev Nutr 2004, 24:299-326.
13. Glew R.H., Williams M., Conn C.A., Cadena S.M., Crossey M., Okolo S.N., VanderJagt D.J. Cardiovascular disease risk factors and diet of Fulani pastoralists of northern Nigeria. Am J Clin Nutr 2001, 74:730-736.
14. Young V.R., Pellett P.L. Plant proteins in relation to human protein and amino acid nutrition. Am J Clin Nutr 1994, 59:S1203-S1212.
15. Ingenbleek Y. The nutritional relationship linking sulfur to nitrogen in living organisms. J Nutr 2006, 136:S1641-S1651.
16. Ingenbleek Y., Barclay D., Dirren H. Nutritional significance of alterations in serum amino acid patterns in goitrous patients. Am J Clin Nutr 1986, 43:310-319.
17. Ingenbleek Y., Hardillier E., Jung L. Subclinical malnutrition is a determinant of hyperhomocysteinemia. Nutrition 2002, 18:40-46.
18. Tang B., Mustafa A., Gupta S., Melnyk S., James S.J., Kruger W.D. Methionine-deficient diet induces post-transcriptional down-regulation of cystathionine β-synthase. Nutrition 2010, 26:1170-1175.
19. Elshorbagy A.K., Valdivia-Garcia M., Refsum H., Smith A.D., Mattocks D.A., Perrone C.E. Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition 2010, 26:1201-1204.
20. Ingenbleek Y., Carpentier Y.A. A prognostic inflammatory and nutritional index scoring critically ill patients. Int J Vitam Nutr Res 1985, 55:91-101.
21. Amino-acid content of foods and biological data on proteins 1970, Food and Agriculture Organization, Food and Agriculture Organization, Rome.
22. McCance R.A., Widdowson E.M. The composition of foods 1991, Royal Society of Chemistry, Cambridge. 5th ed.
23. Araki A., Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987, 422:43-52.
24. Toyo'oka T., Uchiyama S., Saito Y., Imai K. Simultaneous determination of thiols and disulfides by high-performance liquid chromatography with fluorescence detection. Anal Chim Acta 1988, 205:29-41.
25. Battezzatti A., Bertoli S., San Romerio A., Testolin G. Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals. Nutr Metab Cardiovasc Dis 2007, 17:525-534.
26. Ingenbleek Y. Plasma transthyretin reflects the fluctuations of lean body mass in health and disease. Recent advances in transthyretin evolution, structure and biological functions 2009, 329-357. Springer Verlag, Berlin. S.J. Richardson, V. Cody (Eds.).
27. Ingenbleek Y., De Visscher M., De Nayer P. Measurement of prealbumin as index of protein-calorie malnutrition. Lancet 1972, 300:106-109.
28. Ingenbleek Y., Young V.R. The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinemia. Nutr Res Rev 2004, 17:135-153.
29. Finkelstein J.D., Kyle W.E., Martin J.J., Pick A.M. Activation of cystathionine synthase by adenosylmethionine and adenosylethionine. Biochem Biophys Res Commun 1975, 66:81-87.
30. Jahoor F., Badaloo A., Reid M., Forrester T. Sulfur amino acid metabolism in children with severe childhood undernutrition: cysteine kinetics. Am J Clin Nutr 2006, 84:1393-1399.
31. Jones D.P., Coates R.J., Flagg E.W., Eley J.W., Block G., Greensberg R.S., et al. Glutathione in foods listed in the National Cancer Institute's health habits and history food frequency questionnaire. Nutr Cancer 1992, 17:57-75.
32. Lyons J., Rauh-Pfeiffer A., Yu Y.M., Lu X.M., Zurakowski D., Tompkins R.G., et al. Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc Natl Acad Sci U S A 2000, 97:5071-5076.
33. Stipanuk M.H., Ueki I. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J Inherit Metab Dis 2011, 34:17-32.
34. 2S be the third endogenous gaseous transmitter?. FASEB J 2002, 16:1792-1798.
35. Chang L., Geng B., Yu F., Zhao J., Jiang H., Du J., Tang C. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 2008, 34:573-585.
36. Searcy D.G., Lee S.H. Sulfur reduction by human erythrocytes. J Exp Zool 1998, 282:310-322.
37. Sulfur: a missing link between soils, crops, and nutrition. Agriculture monograph no. 50 2008, American Society of Agronomy, Crop Science Society of America, Soil Science Society of America, Madison, WI. J.M. Jez (Ed.).
38. Das S.K., Chhabra P., Chatterjee S.R., Abrol Y.P., Deb D.L. Influence of sulphur fertilization on yield of maize and protein quality of cereals. Fertil News 1975, 20:30-32.
39. Ingenbleek Y. Hyperhomocysteinemia is a biomarker of sulfur-deficiency in human morbidities. Open Clin Chem J 2009, 2:49-60.
40. Khurana M.P.S., Sadana U.S., Bijay-Singh Sulfur nutrition of crops in the Indo-Gangetic plains of South Asia. Sulfur: a missing link between soils, crops and nutrition 2008, 11-24. American Society of Agronomy, Crop Science Society of America, Soil Science Society of America, Madison, WI. J.M. Jez (Ed.).
41. Ghosh K., Khare A., Shetty S. Fasting plasma homocysteine levels in Indian patients with acute myocardial infarction from Western India. Indian Heart J 2007, 59:242-245.
42. McCully K.S. Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr 2007, 74:S1563-S1568.
43. Ahmad U., Frossard P.M. Coronary heart diseases in South Asia: need to redefine risk. Int J Cardiol 2006, 107:289-290.
44. Srivastava R. South Asia's governments exhorted to focus on CVD. Lancet 2002, 359:858.
45. Alkali N.H., Watt H., Bwala S.A., Gadzama A. Association of plasma homocysteine and ischaemic stroke in a Nigerian population. Pak J Med Sci 2006, 22:405-408.