Historical origins of transdifferentiation and reprogramming

Cell Stem Cell

Volumn 9, Issue 6, 2011, Pages 504-516

  Graf, Thomas ^a  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; MYOD PROTEIN; NUCLEAR FACTOR; RNA DIRECTED DNA POLYMERASE; TRANSCRIPTION FACTOR;

B LYMPHOCYTE; BLASTOCYST; BONE MARROW CELL; CELL CLONING; CELL DEATH; CELL DIFFERENTIATION; CELL FATE; CELL LINE; CELL NUCLEUS TRANSPLANTATION; CELL TRANSDIFFERENTIATION; CELL TYPE; DNA BINDING; DNA SEQUENCE; DROSOPHILA; EMBRYONIC STEM CELL; ENUCLEATION; EPITHELIUM CELL; FIBROBLAST; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GERM LAYER; GRANULOCYTE; HATCHING; HEMATOPOIETIC STEM CELL; HETEROKARYON; HUMAN; INTESTINE CELL; MAMMAL CELL; MUSCLE CELL; MYELOBLAST; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; POINT MUTATION; PRIORITY JOURNAL; RETROVIRUS; REVIEW; SALAMANDER; SOMATIC CELL; STEM CELL; STROMA CELL; TADPOLE; TISSUE CULTURE; XENOPUS LAEVIS; ZYGOTE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL TRANSDIFFERENTIATION; EMBRYO, MAMMALIAN; EMBRYO, NONMAMMALIAN; GENETIC ENGINEERING; HUMANS; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS; TISSUE THERAPY;

EID: 82755182204     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2011.11.012     Document Type: Review

References (132)

1. N. Arber, Y. Doki, E.K. Han, A. Sgambato, P. Zhou, N.H. Kim, T. Delohery, M.G. Klein, P.R. Holt, and I.B. Weinstein Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells Cancer Res. 57 1997 1569 1574 (Pubitemid 27175576)
2. D. Baltimore RNA-dependent DNA polymerase in virions of RNA tumour viruses Nature 226 1970 1209 1211
3. H. Beug, A. von Kirchbach, G. Doderlein, J.F. Conscience, and T. Graf Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation Cell 18 1979 375 390 (Pubitemid 10248363)
4. H. Beug, A. Leutz, P. Kahn, and T. Graf Ts mutants of E26 leukemia virus allow transformed myeloblasts, but not erythroblasts or fibroblasts, to differentiate at the nonpermissive temperature Cell 39 1984 579 588 (Pubitemid 15198596)
5. H. Beug, P.A. Blundell, and T. Graf Reversibility of differentiation and proliferative capacity in avian myelomonocytic cells transformed by tsE26 leukemia virus Genes Dev. 1 1987 277 286
6. H.M. Blau, and D. Baltimore Differentiation requires continuous regulation J. Cell Biol. 112 1991 781 783 (Pubitemid 21909626)
7. H.M. Blau, C.P. Chiu, and C. Webster Cytoplasmic activation of human nuclear genes in stable heterocaryons Cell 32 1983 1171 1180 (Pubitemid 13033052)
8. H.M. Blau, G.K. Pavlath, E.C. Hardeman, C.P. Chiu, L. Silberstein, S.G. Webster, S.C. Miller, and C. Webster Plasticity of the differentiated state Science 230 1985 758 766 (Pubitemid 16193964)
9. R. Briggs, and T.J. King Transplantation of living nuclei from blastula cells into enucleated frogs' eggs Proc. Natl. Acad. Sci. USA 38 1952 455 463
10. L.H. Bussmann, A. Schubert, T.P. Vu Manh, L. De Andres, S.C. Desbordes, M. Parra, T. Zimmermann, F. Rapino, J. Rodriguez-Ubreva, and E. Ballestar A robust and highly efficient immune cell reprogramming system Cell Stem Cell 5 2009 554 566
11. M.R. Capecchi Altering the genome by homologous recombination Science 244 1989 1288 1292 (Pubitemid 19170497)
12. C.L. Cepko, B.E. Roberts, and R.C. Mulligan Construction and applications of a highly transmissible murine retrovirus shuttle vector Cell 37 1984 1053 1062 (Pubitemid 15139296)
13. C. Cobaleda, W. Jochum, and M. Busslinger Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors Nature 449 2007 473 477 (Pubitemid 47509547)
14. D.E. Cohen, and D. Melton Turning straw into gold: directing cell fate for regenerative medicine Nat. Rev. Genet. 12 2011 243 252
15. E.H. Davidson Emerging properties of animal gene regulatory networks Nature 468 2010 911 920
16. R.L. Davis, H. Weintraub, and A.B. Lassar Expression of a single transfected cDNA converts fibroblasts to myoblasts Cell 51 1987 987 1000
17. A. Di Tullio, T.P. Manh, A. Schubert, R. Mansson, and T. Graf CCAAT/enhancer binding protein {alpha} (C/EBP{alpha})-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation Proc. Natl. Acad. Sci. USA 108 2011 17016 17021
18. D. Egli, J. Rosains, G. Birkhoff, and K. Eggan Developmental reprogramming after chromosome transfer into mitotic mouse zygotes Nature 447 2007 679 685 (Pubitemid 46889733)
19. H.M. Eilken, S. Nishikawa, and T. Schroeder Continuous single-cell imaging of blood generation from haemogenic endothelium Nature 457 2009 896 900
20. T. Enver, C.M. Heyworth, and T.M. Dexter Do stem cells play dice? Blood 92 1998 348 351 discussion 352
21. M. Evans Discovering pluripotency: 30 years of mouse embryonic stem cells Nat. Rev. Mol. Cell Biol. 12 2011 680 686
22. M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156 (Pubitemid 11050741)
23. R. Feng, S.C. Desbordes, H. Xie, E.S. Tillo, F. Pixley, E.R. Stanley, and T. Graf PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells Proc. Natl. Acad. Sci. USA 105 2008 6057 6062 (Pubitemid 351758398)
24. B. Feng, J. Jiang, P. Kraus, J.H. Ng, J.C. Heng, Y.S. Chan, L.P. Yaw, W. Zhang, Y.H. Loh, and J. Han Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb Nat. Cell Biol. 11 2009 197 203
25. L. Frykberg, T. Metz, G. Brady, M. Introna, H. Beug, B. Vennstrom, and T. Graf A point mutation in the DNA binding domain of the v-myb oncogene of E26 virus confers temperature sensitivity for transformation of myelomonocytic cells Oncogene Res. 3 1988 313 322 (Pubitemid 19049215)
26. M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, and H. Bujard Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766 1769
27. T. Graf Differentiation plasticity of hematopoietic cells Blood 99 2002 3089 3101 (Pubitemid 34525285)
28. T. Graf, and T. Enver Forcing cells to change lineages Nature 462 2009 587 594
29. T. Graf, N. Ade, and H. Beug Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesis Nature 275 1978 496 501 (Pubitemid 9020556)
30. T. Graf, K. McNagny, G. Brady, and J. Frampton Chicken "erythroid" cells transformed by the Gag-Myb-Ets-encoding E26 leukemia virus are multipotent Cell 70 1992 201 213
31. F.L. Graham, and A.J. van der Eb A new technique for the assay of infectivity of human adenovirus 5 DNA Virology 52 1973 456 467
32. H. Gu, J.D. Marth, P.C. Orban, H. Mossmann, and K. Rajewsky Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting Science 265 1994 103 106
33. J.B. Gurdon, and J.A. Byrne The first half-century of nuclear transplantation Proc. Natl. Acad. Sci. USA 100 2003 8048 8052 (Pubitemid 36842495)
34. J.B. Gurdon, and V. Uehlinger "Fertile" intestine nuclei Nature 210 1966 1240 1241
35. J.B. Gurdon, T.R. Elsdale, and M. Fischberg Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei Nature 182 1958 64 65
36. E. Hadorn Transdetermination in cells Sci. Am. 219 1968 110 114 passim
37. G. Halder, P. Callaerts, and W.J. Gehring Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila Science 267 1995 1788 1792
38. J. Han, P. Yuan, H. Yang, J. Zhang, B.S. Soh, P. Li, S.L. Lim, S. Cao, J. Tay, and Y.L. Orlov Tbx3 improves the germ-line competency of induced pluripotent stem cells Nature 463 2010 1096 1100
39. H. Harris, and J.F. Watkins Hybrid cells derived from mouse and man: artificial heterokaryons of mammalian cells from different species Nature 205 1965 640 646
40. C. Heyworth, S. Pearson, G. May, and T. Enver Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells EMBO J. 21 2002 3770 3781 (Pubitemid 34787050)
41. K. Hochedlinger, and R. Jaenisch Monoclonal mice generated by nuclear transfer from mature B and T donor cells Nature 415 2002 1035 1038 (Pubitemid 34193452)
42. K. Hochedlinger, and K. Plath Epigenetic reprogramming and induced pluripotency Development 136 2009 509 523
43. P. Huang, Z. He, S. Ji, H. Sun, D. Xiang, C. Liu, Y. Hu, X. Wang, and L. Hui Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors Nature 475 2011 386 389
44. M. Ieda, J.D. Fu, P. Delgado-Olguin, V. Vedantham, Y. Hayashi, B.G. Bruneau, and D. Srivastava Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors Cell 142 2010 375 386
45. M. Introna, J. Golay, J. Frampton, T. Nakano, S.A. Ness, and T. Graf Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene Cell 63 1990 1289 1297
46. F. Jacob, and J. Monod Genetic regulatory mechanisms in the synthesis of proteins J. Mol. Biol. 3 1961 318 356
47. R. Jaenisch Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus Proc. Natl. Acad. Sci. USA 73 1976 1260 1264
48. M. Jain, C. Arvanitis, K. Chu, W. Dewey, E. Leonhardt, M. Trinh, C.D. Sundberg, J.M. Bishop, and D.W. Felsher Sustained loss of a neoplastic phenotype by brief inactivation of MYC Science 297 2002 102 104 (Pubitemid 34743102)
49. P. Jones Out of Africa and into epigenetics: discovering reprogramming drugs Nat. Cell Biol. 13 2011 2
50. P.A. Jones, and S.M. Taylor Cellular differentiation, cytidine analogs and DNA methylation Cell 20 1980 85 93 (Pubitemid 10117303)
51. D.L. Jones, and A.J. Wagers No place like home: anatomy and function of the stem cell niche Nat. Rev. Mol. Cell Biol. 9 2008 11 21
52. S. Kajimura, P. Seale, K. Kubota, E. Lunsford, J.V. Frangioni, S.P. Gygi, and B.M. Spiegelman Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex Nature 460 2009 1154 1158
53. K. Kim, A. Doi, B. Wen, K. Ng, R. Zhao, P. Cahan, J. Kim, M.J. Aryee, H. Ji, and L.I. Ehrlich Epigenetic memory in induced pluripotent stem cells Nature 467 2010 285 290
54. T.J. King, and R. Briggs Changes in the nuclei of differentiating gastrula cells, as demonstrated by nuclear transplantation Proc. Natl. Acad. Sci. USA 41 1955 321 325
55. L.J. Kleinsmith, and G.B. Pierce Jr. Multipotentiality of single embryonal carcinoma cells Cancer Res. 24 1964 1544 1551
56. B.H. Koller, and O. Smithies Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination Proc. Natl. Acad. Sci. USA 86 1989 8932 8935 (Pubitemid 20010339)
57. M. Kondo, D.C. Scherer, T. Miyamoto, A.G. King, K. Akashi, K. Sugamura, and I.L. Weissman Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines Nature 407 2000 383 386
58. H. Kulessa, J. Frampton, and T. Graf GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts Genes Dev. 9 1995 1250 1262
59. A.B. Lassar, B.M. Paterson, and H. Weintraub Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts Cell 47 1986 649 656 (Pubitemid 17011408)
60. R. Levi-Montalcini, and V. Hamburger Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo J. Exp. Zool. 116 1951 321 361
61. L. Li, M. Leid, and E.V. Rothenberg An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b Science 329 2010 89 93
62. P. Li, S. Burke, J. Wang, X. Chen, M. Ortiz, S.C. Lee, D. Lu, L. Campos, D. Goulding, and B.L. Ng Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion Science 329 2010 85 89
63. N. Maherali, T. Ahfeldt, A. Rigamonti, J. Utikal, C. Cowan, and K. Hochedlinger A high-efficiency system for the generation and study of human induced pluripotent stem cells Cell Stem Cell 3 2008 340 345
64. S. Marro, Z.P. Pang, N. Yang, M.C. Tsai, K. Qu, H.Y. Chang, T.C. Sudhof, and M. Wernig Direct lineage conversion of terminally differentiated hepatocytes to functional neurons Cell Stem Cell 9 2011 374 382
65. G.R. Martin Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc. Natl. Acad. Sci. USA 78 1981 7634 7638 (Pubitemid 12186197)
66. L. Maves, and G. Schubiger Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance Curr. Opin. Genet. Dev. 13 2003 472 479 (Pubitemid 37204922)
67. J. McGrath, and D. Solter Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro Science 226 1984 1317 1319 (Pubitemid 15215583)
68. D. Metcalf Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation Blood 92 1998 345 347 discussion 352
69. T. Metz, and T. Graf v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes Genes Dev. 5 1991 369 380 (Pubitemid 21905960)
70. R.A. Miller, and F.H. Ruddle Pluripotent teratocarcinoma-thymus somatic cell hybrids Cell 9 1976 45 55
71. M.L. Mucenski, K. McLain, A.B. Kier, S.H. Swerdlow, C.M. Schreiner, T.A. Miller, D.W. Pietryga, W.J. Scott Jr., and S.S. Potter A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis Cell 65 1991 677 689
72. A. Nagy, E. Gocza, E.M. Diaz, V.R. Prideaux, E. Ivanyi, M. Markkula, and J. Rossant Embryonic stem cells alone are able to support fetal development in the mouse Development 110 1990 815 821
73. L. Naldini, U. Blömer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, and D. Trono In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272 1996 263 267 (Pubitemid 26119138)
74. C. Nerlov, and T. Graf PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors Genes Dev. 12 1998 2403 2412 (Pubitemid 28371359)
75. S.A. Ness, H. Beug, and T. Graf v-myb dominance over v-myc in doubly transformed chick myelomonocytic cells Cell 51 1987 41 50
76. J. Nichols, B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius, I. Chambers, H. Schöler, and A. Smith Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 Cell 95 1998 379 391 (Pubitemid 28507326)
77. S. Noggle, H.L. Fung, A. Gore, H. Martinez, K.C. Satriani, R. Prosser, K. Oum, D. Paull, S. Druckenmiller, and M. Freeby Human oocytes reprogram somatic cells to a pluripotent state Nature 478 2011 70 75
78. S.L. Nutt, B. Heavey, A.G. Rolink, and M. Busslinger Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 Nature 401 1999 556 562
79. S.H. Orkin Globin gene regulation and switching: circa 1990 Cell 63 1990 665 672 (Pubitemid 120035040)
80. S.H. Orkin, and K. Hochedlinger Chromatin connections to pluripotency and cellular reprogramming Cell 145 2011 835 850
81. Z.P. Pang, N. Yang, T. Vierbuchen, A. Ostermeier, D.R. Fuentes, T.Q. Yang, A. Citri, V. Sebastiano, S. Marro, and T.C. Sudhof Induction of human neuronal cells by defined transcription factors Nature 476 2011 220 223
82. D. Picard, S.J. Salser, and K.R. Yamamoto A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor Cell 54 1988 1073 1080
83. F.M. Piccolo, C.F. Pereira, I. Cantone, K. Brown, T. Tsubouchi, J. Soza-Ried, M. Merkenschlager, and A.G. Fisher Using heterokaryons to understand pluripotency and reprogramming Philos. Trans. R. Soc. Lond. B Biol. Sci. 366 2011 2260 2265
84. M. Ptashne Specific binding of the lambda phage repressor to lambda DNA Nature 214 1967 232 234
85. M. Ptashne Principles of a switch Nat. Chem. Biol. 7 2011 484 487
86. M.A. Rieger, P.S. Hoppe, B.M. Smejkal, A.C. Eitelhuber, and T. Schroeder Hematopoietic cytokines can instruct lineage choice Science 325 2009 217 218
87. A.G. Rolink, S.L. Nutt, F. Melchers, and M. Busslinger Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors Nature 401 1999 603 606
88. M. Roussel, S. Saule, C. Lagrou, C. Rommens, H. Beug, T. Graf, and D. Stehelin Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation Nature 281 1979 452 455 (Pubitemid 10244265)
89. H.R. Scholer, S. Ruppert, N. Suzuki, K. Chowdhury, and P. Gruss New type of POU domain in germ line-specific protein Oct-4 Nature 344 1990 435 439
90. P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scime, S. Devarakonda, H.M. Conroe, and H. Erdjument-Bromage PRDM16 controls a brown fat/skeletal muscle switch Nature 454 2008 961 967
91. S. Sekiya, and A. Suzuki Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors Nature 475 2011 390 393
92. J. Silva, and A. Smith Capturing pluripotency Cell 132 2008 532 536 (Pubitemid 351253697)
93. J.M. Slack Metaplasia and transdifferentiation: from pure biology to the clinic Nat. Rev. Mol. Cell Biol. 8 2007 369 378 (Pubitemid 46643236)
94. A.G. Smith, J.K. Heath, D.D. Donaldson, G.G. Wong, J. Moreau, M. Stahl, and D. Rogers Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides Nature 336 1988 688 690 (Pubitemid 19007952)
95. P. Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain Nat. Genet. 21 1999 70 71 (Pubitemid 29036285)
96. M. Stadtfeld, and T. Graf Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing Development 132 2005 203 213 (Pubitemid 40207979)
97. M. Stadtfeld, and K. Hochedlinger Induced pluripotency: history, mechanisms, and applications Genes Dev. 24 2010 2239 2263
98. M. Stadtfeld, N. Maherali, D.T. Breault, and K. Hochedlinger Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse Cell Stem Cell 2 2008 230 240
99. M. Stadtfeld, N. Maherali, M. Borkent, and K. Hochedlinger A reprogrammable mouse strain from gene-targeted embryonic stem cells Nat. Methods 7 2010 53 55
100. D. Stehelin, H.E. Varmus, J.M. Bishop, and P.K. Vogt DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA Nature 260 1976 170 173
101. J. Sterneckert, S. Hoing, and H.R. Scholer Oct4 and more: the reprogramming expressway Stem Cells 2011 10.1002/stem.765 in press. Published online October 18, 2011
102. M. Tada, Y. Takahama, K. Abe, N. Nakatsuji, and T. Tada Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells Curr. Biol. 11 2001 1553 1558 (Pubitemid 32931020)
103. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
104. K. Takahashi, K. Okita, M. Nakagawa, and S. Yamanaka Induction of pluripotent stem cells from fibroblast cultures Nat. Protoc. 2 2007 3081 3089
105. S.J. Tapscott The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription Development 132 2005 2685 2695 (Pubitemid 40932860)
106. S.M. Taylor, and P.A. Jones Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine Cell 17 1979 771 779 (Pubitemid 9252286)
107. H.M. Temin, and S. Mizutani RNA-dependent DNA polymerase in virions of Rous sarcoma virus Nature 226 1970 1211 1213
108. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147 (Pubitemid 28516247)
109. H. Ursprung, and E. Hadorn [Further research on model growth in combination with partly dissociated wing imaginal disks of Drosophila melanogaster] Dev. Biol. 4 1962 40 66
110. T. Vierbuchen, A. Ostermeier, Z.P. Pang, Y. Kokubu, T.C. Sudhof, and M. Wernig Direct conversion of fibroblasts to functional neurons by defined factors Nature 463 2010 1035 1041
111. A.J. Wagers, and I.L. Weissman Plasticity of adult stem cells Cell 116 2004 639 648 (Pubitemid 38326723)
112. T. Wakayama, A.C. Perry, M. Zuccotti, K.R. Johnson, and R. Yanagimachi Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei Nature 394 1998 369 374 (Pubitemid 28373832)
113. H. Weintraub, H. Beug, M. Groudine, and T. Graf Temperature-sensitive changes in the structure of globin chromatin in lines of red cell precursors transformed by ts-AEV Cell 28 1982 931 940 (Pubitemid 12084339)
114. H. Weintraub, S.J. Tapscott, R.L. Davis, M.J. Thayer, M.A. Adam, A.B. Lassar, and A.D. Miller Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD Proc. Natl. Acad. Sci. USA 86 1989 5434 5438 (Pubitemid 19185563)
115. M. Wernig, C.J. Lengner, J. Hanna, M.A. Lodato, E. Steine, R. Foreman, J. Staerk, S. Markoulaki, and R. Jaenisch A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types Nat. Biotechnol. 26 2008 916 924
116. R.L. Williams, D.J. Hilton, S. Pease, T.A. Willson, C.L. Stewart, D.P. Gearing, E.F. Wagner, D. Metcalf, N.A. Nicola, and N.M. Gough Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells Nature 336 1988 684 687 (Pubitemid 19007951)
117. I. Wilmut, A.E. Schnieke, J. McWhir, A.J. Kind, and K.H. Campbell Viable offspring derived from fetal and adult mammalian cells Nature 385 1997 810 813 (Pubitemid 27106068)
118. B.J. Wouters, B. Lowenberg, C.A. Erpelinck-Verschueren, W.L. van Putten, P.J. Valk, and R. Delwel Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression that is uniquely associated with a favorable outcome Blood 113 2009 3088 3091
119. H. Xie, M. Ye, R. Feng, and T. Graf Stepwise reprogramming of B cells into macrophages Cell 117 2004 663 676 (Pubitemid 38692531)
120. S. Yamanaka A fresh look at iPS cells Cell 137 2009 13 17
121. S. Yamanaka Elite and stochastic models for induced pluripotent stem cell generation Nature 460 2009 49 52
122. S. Yamanaka, and H.M. Blau Nuclear reprogramming to a pluripotent state by three approaches Nature 465 2010 704 712
123. J. Yang, and R.A. Weinberg Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis Dev. Cell 14 2008 818 829 (Pubitemid 351757205)
124. N. Yang, Y.H. Ng, Z.P. Pang, T.C. Südhof, and M. Wernig Induced neuronal cells: how to make and define a neuron Cell Stem Cell 9 2011 517 525 this issue
125. Q.L. Ying, J. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, and A. Smith The ground state of embryonic stem cell self-renewal Nature 453 2008 519 523 (Pubitemid 351733324)
126. J. Yu, M.A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J.L. Frane, S. Tian, J. Nie, G.A. Jonsdottir, V. Ruotti, and R. Stewart Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
127. J. Yu, K. Hu, K. Smuga-Otto, S. Tian, R. Stewart, I.I. Slukvin, and J.A. Thomson Human induced pluripotent stem cells free of vector and transgene sequences Science 324 2009 797 801
128. P. Zhang, J. Iwasaki-Arai, H. Iwasaki, M.L. Fenyus, T. Dayaram, B.M. Owens, H. Shigematsu, E. Levantini, C.S. Huettner, and J.A. Lekstrom-Himes Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα Immunity 21 2004 853 863 (Pubitemid 39642186)
129. Q. Zhou, and D.A. Melton Extreme makeover: converting one cell into another Cell Stem Cell 3 2008 382 388
130. Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D.A. Melton In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632
131. D.L. Zinyk, E.H. Mercer, E. Harris, D.J. Anderson, and A.L. Joyner Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system Curr. Biol. 8 1998 665 668 (Pubitemid 28257972)
132. A.C. Zovein, J.J. Hofmann, M. Lynch, W.J. French, K.A. Turlo, Y. Yang, M.S. Becker, L. Zanetta, E. Dejana, and J.C. Gasson Fate tracing reveals the endothelial origin of hematopoietic stem cells Cell Stem Cell 3 2008 625 636