Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1828-1833

  Han, Yong Long ^a,c   Yu, Hong Liang ^b,c   Li, Dan ^a,d   Meng, Xiang Le ^a,d   Zhou, Zhi Yong ^a   Yu, Qi ^a   Zhang, Xiao You ^c   Wang, Fu Jing ^b   Guo, Cheng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c DAQING OILFIELD CO LTD   (China)

^d SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cytochrome P450; Food drug interactions; Inhibition; Limonin; P glycoprotein

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GLYCOPROTEIN P; LIMONIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLUOROMETRY; HUMAN; IC 50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MELANOMA; PROTEIN FUNCTION; TANDEM MASS SPECTROMETRY;

CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FOOD-DRUG INTERACTIONS; HUMANS; LIMONINS; MICROSOMES, LIVER; P-GLYCOPROTEIN; TANDEM MASS SPECTROMETRY;

CITRUS;

EID: 82655184203     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.09.023     Document Type: Article

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