Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 128-137

  Li, Xiaoyan ^a,b   Chen, Xiaoyan ^a   Li, Qiang ^a   Wang, Linling ^a,b   Zhong, Dafang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

1 Hydroxymidazolam; 3 Methyoxymorphinan; 4 Hydroxymephenytoin; 4 Hydroxytolbutamide; 6 Hydroxychlorzoxazone; Acetaminophen; Dextrorphan

Indexed keywords

DRUG INTERACTIONS; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS; SCREENING; SUBSTRATES;

ACETAMINOPHEN; DEXTRORPHAN; HYDROXYMEPHENYTOIN;

ENZYMES;

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; MEPHENYTOIN; MIDAZOLAM; PHENACETIN; TOLBUTAMIDE;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SCREENING; TANDEM MASS SPECTROMETRY;

CALIBRATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 34249673435     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.01.006     Document Type: Article

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