The in vitro drug interaction potential of dietary supplements containing multiple herbal components

Drug Metabolism and Disposition

Volumn 35, Issue 2, 2007, Pages 185-188

  Foti, Robert S ^a,b   Wahlstrom, Jan L ^a   Wienkers, Larry C ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; ASCORBIC ACID; CARYOPHYLLENE; CHLOROGENIC ACID; CHLORZOXAZONE; CICHORIC ACID; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DICLOFENAC; HERBACEOUS AGENT; KETOCONAZOLE; LUTEOLIN; MENTHONE; PARACETAMOL; PHENACETIN; RIBOFLAVIN; TOLBUTAMIDE;

ARTICLE; COMMON COLD; CONTROLLED STUDY; DEMETHYLATION; DIET SUPPLEMENTATION; DRUG HYDROXYLATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME INHIBITION; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL;

COMPLEMENTARY THERAPIES; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY SUPPLEMENTS; HERB-DRUG INTERACTIONS;

EID: 33846435706     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.012724     Document Type: Article

References (16)

1. Bachmann KA, Ring BJ, and Wrighton SA (2003) Drug-drug interactions and cytochromes P450, in Drug Metabolizing Enzymes (Lee JS, Obach RS, and Fisher MB eds) pp 311-336, Marcel Dekker, New York.
2. Delgoda R and Westlake AC (2004) Herbal interactions involving cytochrome P450 enzymes: a mini review. Toxicol Rev 23:239-249.
3. Echizen H, Kawasaki H, Chiba K, Tani M, and Ishizaki T (1993) A potent inhibitory effect of erythromycin and other macrolide antibiotics on the mono-N-dealkylation metabolism of disopyramide with human liver microsomes. J Pharmacol Exp Ther 264:1425-1431.
4. Fugh-Berman A and Ernst E (2001) Herb-drug interactions: review and assessment of report reliability. Br J Clin Pharmacol 52:587-595.
5. Greco WR, Bravo G, and Parsons JC (1995) The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 47:331-385.
6. Ioannides C (2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:451-478.
7. Kent UM, Aviram M, Rosenblat M, and Hollenberg PF (2002) The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450s 3A4, 2B6 and 2C9. Drug Metab Dispos 30:709-715.
8. Kim HJ, Lee SB, Park SK, Kim HM, Park YI, and Dong MS (2005) Effects of hydroxyl group numbers on the B-ring of 5,7-hydroxyflavones on the differential inhibition of human CYP1A and CYP1B1 enzymes. Arch Pharm Res 28:1114-1121.
9. Komoroski BJ, Zhang S, Cai H, Hutzler JM, Frye R, Tracy TS, Strom SC, Lehmann T, Ang CYW, Cui YY, et al. (2004) Induction and inhibition of cytochrome P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos 32:512-518.
10. Lazarou J, Pomeranz BH, and Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies J Am Med Assoc 279:1200-1205.
11. Lo AC, Chan K, Yeung JH, and Woo KS (1992) The effects of Danshen (Salvia miltiorrhize) on pharmacokinetics and pharmacodynamics of warfarin in rats. Eur J Drug Metab Pharmacokinet 17:257-262.
12. Obach RS (2000) Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294:88-95.
13. Saruwatari J, Nakagawa K, Shindo J, Shinobu N, Echizen H, and Ishizaki T (2003) The in-vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in man. J Pharm Pharmacol 55: 1553-1559.
14. Subehan, Usia T, Kadota S, and Tezuka Y (2005) Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity. Chem Pharm Bull (Tokyo) 53:333-335.
15. Walsky RL and Obach RS (2004) Validated assays for human cytochrome P450 activities. Drug Metab Dispos 32:647-660.
16. Zhou S, Gao Y, Jiang W, Huang M, Xu A, and Paxton JW (2003) Interactions of herbs with cytochrome P450. Drug Metab Rev 35:35-98.