A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: Role of Trp129 and Leu324

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Syed, Khajamohiddin ^a   Porollo, Aleksey ^a   Lam, Ying Wai ^a   Yadav, Jagjit S ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ALKYLPHENOL; CYTOCHROME P450; CYTOCHROME P450 5136A3; CYTOSINE; GLYCINE; GUANINE; LEUCINE; LEUCINE 324; NONYLPHENOL; PHENANTHRENE; PHENYLALANINE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; THYMINE; TRYPTOPHAN; TRYPTOPHAN 129; UNCLASSIFIED DRUG; AMINO ACID; ENDOCRINE DISRUPTOR; LIGAND; OXYGEN; PHENOL DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME METABOLISM; GENE MUTATION; HYDROXYLATION; NONHUMAN; PHANEROCHAETE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MUTATION; PHYSIOLOGY; PICHIA; PROTEIN SECONDARY STRUCTURE;

AMINO ACIDS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENDOCRINE DISRUPTORS; LEUCINE; LIGANDS; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; PHANEROCHAETE; PHENOLS; PICHIA; POLYCYCLIC HYDROCARBONS, AROMATIC; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPTOPHAN;

EID: 82555175839     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028286     Document Type: Article

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