Novel metabolic pathways of p-n-nonylphenol catalyzed by cytochrome P450 and estrogen receptor binding activity of new metabolites

Journal of Health Science

Volumn 53, Issue 5, 2007, Pages 552-561

  Tezuka, Yoshito ^a   Takahashi, Kyoko ^a   Suzuki, Tomoharu ^b   Kitamura, Shigeyuki ^b,c   Ohta, Shigeru ^b   Nakamura, Shigeo ^a   Mashino, Tadahiko ^a  

^a KEIO UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Endocrine disruptor; Estrogenic activity; Metabolism; Nonylphenol

Indexed keywords

4 NONYLPHENOL; 4' HYDOXYNONANOPHENONE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 4A11; ESTROGEN RECEPTOR; HYDROQUINONE; NONYLPHENOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ESTROGEN ACTIVITY; HUMAN; HYDROXYLATION; LIVER MICROSOME; NONHUMAN; RAT; RECEPTOR BINDING; SYNTHESIS;

RATTUS;

EID: 35148848734     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.53.552     Document Type: Article

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