Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho -benzoquinone metabolites in human liver microsomes

Chemical Research in Toxicology

Volumn 23, Issue 10, 2010, Pages 1617-1628

  Deng, Pan ^a   Zhong, Dafang ^a   Nan, Fajun ^a   Liu, Sheng ^a   Li, Dan ^a   Yuan, Tao ^a   Chen, Xiaoyan ^a   Zheng, Jiang ^b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZOQUINONE; 4 NONYLPHENOL; BENZOQUINONE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; GLUTATHIONE; QUINONE DERIVATIVE; QUINONE METHIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; HUMAN; HUMAN CELL; ISOMERISM; LIVER MICROSOME; LIVER MICROSOME METABOLISM; METABOLITE;

BENZOQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HUMANS; INDOLEQUINONES; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; PHENOLS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77958094800     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100223h     Document Type: Article

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