메뉴 건너뛰기




Volumn 3, Issue 4, 2011, Pages e317-e324

Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

Author keywords

Antioxidant; Chinese medicine; Inflammation; Integrative medicine; Magnolol

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; HYDROXYL RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MAGNOLIA OFFICINALIS EXTRACT; MAGNOLOL; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 82455208877     PISSN: 18763820     EISSN: 18763839     Source Type: Journal    
DOI: 10.1016/j.eujim.2011.09.002     Document Type: Review
Times cited : (41)

References (84)
  • 1
    • 77957318362 scopus 로고    scopus 로고
    • Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders
    • Shen J.L., Man K.M., Huang P.H., Chen W.C., Chen D.C., Cheng Y.W., et al. Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders. Molecules 2010, 15:6452-6465.
    • (2010) Molecules , vol.15 , pp. 6452-6465
    • Shen, J.L.1    Man, K.M.2    Huang, P.H.3    Chen, W.C.4    Chen, D.C.5    Cheng, Y.W.6
  • 2
    • 0020577654 scopus 로고
    • Chemostructural requirement for centrally acting muscle relaxant effect of magnolol and honokiol, neolignane derivatives
    • Watanabe H., Watanabe K., Hagino K. Chemostructural requirement for centrally acting muscle relaxant effect of magnolol and honokiol, neolignane derivatives. J Pharmacobiodyn 1983, 6:184-190.
    • (1983) J Pharmacobiodyn , vol.6 , pp. 184-190
    • Watanabe, H.1    Watanabe, K.2    Hagino, K.3
  • 4
    • 0028029275 scopus 로고
    • Biphenyl compounds are hydroxyl radical scavengers: their effective inhibition for UV-induced mutation in Salmonella typhimurium TA102
    • Fujita S., Taira J. Biphenyl compounds are hydroxyl radical scavengers: their effective inhibition for UV-induced mutation in Salmonella typhimurium TA102. Free Radic Biol Med 1994, 17:273-277.
    • (1994) Free Radic Biol Med , vol.17 , pp. 273-277
    • Fujita, S.1    Taira, J.2
  • 5
    • 0028289204 scopus 로고
    • Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation
    • Lo Y.C., Teng C.M., Chen C.F., Chen C.C., Hong C.Y. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 1994, 47:549-553.
    • (1994) Biochem Pharmacol , vol.47 , pp. 549-553
    • Lo, Y.C.1    Teng, C.M.2    Chen, C.F.3    Chen, C.C.4    Hong, C.Y.5
  • 7
    • 64749084915 scopus 로고    scopus 로고
    • Honokiol, a multifunctional antiangiogenic and antitumor agent
    • Fried L.E., Arbiser J.L. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid Redox Signal 2009, 11:1139-1148.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1139-1148
    • Fried, L.E.1    Arbiser, J.L.2
  • 8
    • 0032865634 scopus 로고    scopus 로고
    • Effect of magnolol on in vitro mitochondrial lipid peroxidation and isolated cold-preserved warm-reperfused rat livers
    • Chiu J.H., Wang J.C., Lui W.Y., Wu C.W., Hong C.Y. Effect of magnolol on in vitro mitochondrial lipid peroxidation and isolated cold-preserved warm-reperfused rat livers. J Surg Res 1999, 82:11-16.
    • (1999) J Surg Res , vol.82 , pp. 11-16
    • Chiu, J.H.1    Wang, J.C.2    Lui, W.Y.3    Wu, C.W.4    Hong, C.Y.5
  • 9
    • 0029828414 scopus 로고    scopus 로고
    • Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation
    • Hong C.Y., Huang S.S., Tsai S.K. Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation. Clin Exp Pharmacol Physiol 1996, 23:660-664.
    • (1996) Clin Exp Pharmacol Physiol , vol.23 , pp. 660-664
    • Hong, C.Y.1    Huang, S.S.2    Tsai, S.K.3
  • 10
    • 0037794540 scopus 로고    scopus 로고
    • Magnolol protects against cerebral ischaemic injury of rat heatstroke
    • Chang C.P., Hsu Y.C., Lin M.T. Magnolol protects against cerebral ischaemic injury of rat heatstroke. Clin Exp Pharmacol Physiol 2003, 30:387-392.
    • (2003) Clin Exp Pharmacol Physiol , vol.30 , pp. 387-392
    • Chang, C.P.1    Hsu, Y.C.2    Lin, M.T.3
  • 11
    • 34547632395 scopus 로고    scopus 로고
    • Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism
    • Li H.B., Gao J.M., Ying X.X., Wang S.P., Li J.C. Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism. Arch Pharm Res 2007, 30:850-857.
    • (2007) Arch Pharm Res , vol.30 , pp. 850-857
    • Li, H.B.1    Gao, J.M.2    Ying, X.X.3    Wang, S.P.4    Li, J.C.5
  • 12
    • 0035672013 scopus 로고    scopus 로고
    • Pretreatment with magnolol attenuates ischemia-reperfusion injury in rat small intestine
    • Loong C.C., Chiu J.H., Tiao R.C., Chiu Y.Y., Wu C.W., Lui W.Y. Pretreatment with magnolol attenuates ischemia-reperfusion injury in rat small intestine. Transplant Proc 2001, 33:3737-3738.
    • (2001) Transplant Proc , vol.33 , pp. 3737-3738
    • Loong, C.C.1    Chiu, J.H.2    Tiao, R.C.3    Chiu, Y.Y.4    Wu, C.W.5    Lui, W.Y.6
  • 13
    • 0036843880 scopus 로고    scopus 로고
    • Protective effect of magnolol on the small intestinal ischemia-reperfusion injury
    • Loong C.C., Chiu J.H., Tiao R.C., Chiu Y.Y., Wu C.W., Lui W.Y. Protective effect of magnolol on the small intestinal ischemia-reperfusion injury. Transplant Proc 2002, 34:2679-2680.
    • (2002) Transplant Proc , vol.34 , pp. 2679-2680
    • Loong, C.C.1    Chiu, J.H.2    Tiao, R.C.3    Chiu, Y.Y.4    Wu, C.W.5    Lui, W.Y.6
  • 15
    • 1042298770 scopus 로고    scopus 로고
    • Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils
    • Hsu M.F., Lu M.C., Tsao L.T., Kuan Y.H., Chen C.C., Wang J.P. Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Biochem Pharmacol 2004, 67:831-840.
    • (2004) Biochem Pharmacol , vol.67 , pp. 831-840
    • Hsu, M.F.1    Lu, M.C.2    Tsao, L.T.3    Kuan, Y.H.4    Chen, C.C.5    Wang, J.P.6
  • 16
    • 0028862360 scopus 로고
    • Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice
    • Wang J.P., Ho T.F., Chang L.C., Chen C.C. Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J Pharm Pharmacol 1995, 47:857-860.
    • (1995) J Pharm Pharmacol , vol.47 , pp. 857-860
    • Wang, J.P.1    Ho, T.F.2    Chang, L.C.3    Chen, C.C.4
  • 17
    • 0028326546 scopus 로고
    • Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex
    • Yamazaki R., Sugatani J., Fujii I., Kuroyanagi M., Umehara K., Ueno A., et al. Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex. Biochem Pharmacol 1994, 47:995-1006.
    • (1994) Biochem Pharmacol , vol.47 , pp. 995-1006
    • Yamazaki, R.1    Sugatani, J.2    Fujii, I.3    Kuroyanagi, M.4    Umehara, K.5    Ueno, A.6
  • 18
    • 0033974928 scopus 로고    scopus 로고
    • Inhibitory effects of lignans and flavonoids in saiboku-to, a herbal medicine for bronchial asthma, on the release of leukotrienes from human polymorphonuclear leukocytes
    • Homma M., Minami M., Taniguchi C., Oka K., Morita S., Niitsuma T., et al. Inhibitory effects of lignans and flavonoids in saiboku-to, a herbal medicine for bronchial asthma, on the release of leukotrienes from human polymorphonuclear leukocytes. Planta Med 2000, 66:88-91.
    • (2000) Planta Med , vol.66 , pp. 88-91
    • Homma, M.1    Minami, M.2    Taniguchi, C.3    Oka, K.4    Morita, S.5    Niitsuma, T.6
  • 19
    • 0028208573 scopus 로고
    • A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma
    • Homma M., Oka K., Niitsuma T., Itoh H. A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma. J Pharm Pharmacol 1994, 46:305-309.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 305-309
    • Homma, M.1    Oka, K.2    Niitsuma, T.3    Itoh, H.4
  • 20
    • 0026529471 scopus 로고
    • A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma
    • Homma M., Oka K., Yamada T., Niitsuma T., Ihto H., Takahashi N. A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma. Anal Biochem 1992, 202:179-187.
    • (1992) Anal Biochem , vol.202 , pp. 179-187
    • Homma, M.1    Oka, K.2    Yamada, T.3    Niitsuma, T.4    Ihto, H.5    Takahashi, N.6
  • 21
    • 0034767744 scopus 로고    scopus 로고
    • Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats
    • Ikarashi Y., Yuzurihara M., Sakakibara I., Nakai Y., Hattori N., Maruyama Y. Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats. Planta Med 2001, 67:709-713.
    • (2001) Planta Med , vol.67 , pp. 709-713
    • Ikarashi, Y.1    Yuzurihara, M.2    Sakakibara, I.3    Nakai, Y.4    Hattori, N.5    Maruyama, Y.6
  • 22
    • 0034951726 scopus 로고    scopus 로고
    • Effects of absorbed components of saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma
    • Niitsuma T., Morita S., Hayashi T., Homma M., Oka K. Effects of absorbed components of saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma. Methods Find Exp Clin Pharmacol 2001, 23:99-104.
    • (2001) Methods Find Exp Clin Pharmacol , vol.23 , pp. 99-104
    • Niitsuma, T.1    Morita, S.2    Hayashi, T.3    Homma, M.4    Oka, K.5
  • 23
    • 0033755751 scopus 로고    scopus 로고
    • Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction
    • Taniguchi C., Homma M., Takano O., Hirano T., Oka K., Aoyagi Y., et al. Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction. Planta Med 2000, 66:607-611.
    • (2000) Planta Med , vol.66 , pp. 607-611
    • Taniguchi, C.1    Homma, M.2    Takano, O.3    Hirano, T.4    Oka, K.5    Aoyagi, Y.6
  • 24
    • 0033005108 scopus 로고    scopus 로고
    • Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells
    • Hamasaki Y., Kobayashi I., Zaitu M., Tsuji K., Kita M., Hayasaki R., et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. Planta Med 1999, 65:222-226.
    • (1999) Planta Med , vol.65 , pp. 222-226
    • Hamasaki, Y.1    Kobayashi, I.2    Zaitu, M.3    Tsuji, K.4    Kita, M.5    Hayasaki, R.6
  • 25
    • 36049006615 scopus 로고    scopus 로고
    • Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors
    • Han S.J., Bae E.A., Trinh H.T., Yang J.H., Youn U.J., Bae K.H., et al. Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors. Biol Pharm Bull 2007, 30:2201-2203.
    • (2007) Biol Pharm Bull , vol.30 , pp. 2201-2203
    • Han, S.J.1    Bae, E.A.2    Trinh, H.T.3    Yang, J.H.4    Youn, U.J.5    Bae, K.H.6
  • 26
    • 0034047190 scopus 로고    scopus 로고
    • Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages
    • Son H.J., Lee H.J., Yun-Choi H.S., Ryu J.H. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Planta Med 2000, 66:469-471.
    • (2000) Planta Med , vol.66 , pp. 469-471
    • Son, H.J.1    Lee, H.J.2    Yun-Choi, H.S.3    Ryu, J.H.4
  • 27
    • 34248996892 scopus 로고    scopus 로고
    • Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB
    • Tanaka K., Hasegawa J., Asamitsu K., Okamoto T. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB. Eur J Pharmacol 2007, 565:212-219.
    • (2007) Eur J Pharmacol , vol.565 , pp. 212-219
    • Tanaka, K.1    Hasegawa, J.2    Asamitsu, K.3    Okamoto, T.4
  • 28
    • 0027732267 scopus 로고
    • The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators
    • Wang J.P., Raung S.L., Chen C.C., Kuo J.S., Teng C.M. The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators. Naunyn Schmiedebergs Arch Pharmacol 1993, 348:663-669.
    • (1993) Naunyn Schmiedebergs Arch Pharmacol , vol.348 , pp. 663-669
    • Wang, J.P.1    Raung, S.L.2    Chen, C.C.3    Kuo, J.S.4    Teng, C.M.5
  • 29
    • 0037826019 scopus 로고    scopus 로고
    • Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea
    • Ko C.H., Chen H.H., Lin Y.R., Chan M.H. Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. Planta Med 2003, 69:532-536.
    • (2003) Planta Med , vol.69 , pp. 532-536
    • Ko, C.H.1    Chen, H.H.2    Lin, Y.R.3    Chan, M.H.4
  • 30
    • 0036143510 scopus 로고    scopus 로고
    • Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol
    • Wu S.N., Chen C.C., Li H.F., Lo Y.K., Chen S.A., Chiang H.T. Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol. Thorax 2002, 57:67-74.
    • (2002) Thorax , vol.57 , pp. 67-74
    • Wu, S.N.1    Chen, C.C.2    Li, H.F.3    Lo, Y.K.4    Chen, S.A.5    Chiang, H.T.6
  • 31
    • 0025983001 scopus 로고
    • Studies on inhibitors of skin tumor promotion, IX Neolignans from Magnolia officinalis
    • Konoshima T., Kozuka M., Tokuda H., Nishino H., Iwashima A., Haruna M., et al. Studies on inhibitors of skin tumor promotion, IX Neolignans from Magnolia officinalis. J Nat Prod 1991, 54:816-822.
    • (1991) J Nat Prod , vol.54 , pp. 816-822
    • Konoshima, T.1    Kozuka, M.2    Tokuda, H.3    Nishino, H.4    Iwashima, A.5    Haruna, M.6
  • 32
    • 0035168066 scopus 로고    scopus 로고
    • Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
    • Lin S.Y., Chang Y.T., Liu J.D., Yu C.H., Ho Y.S., Lee Y.H., et al. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. Mol Carcinog 2001, 32:73-83.
    • (2001) Mol Carcinog , vol.32 , pp. 73-83
    • Lin, S.Y.1    Chang, Y.T.2    Liu, J.D.3    Yu, C.H.4    Ho, Y.S.5    Lee, Y.H.6
  • 33
    • 0037275601 scopus 로고    scopus 로고
    • Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells
    • Yang S.E., Hsieh M.T., Tsai T.H., Hsu S.L. Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. Br J Pharmacol 2003, 138:193-201.
    • (2003) Br J Pharmacol , vol.138 , pp. 193-201
    • Yang, S.E.1    Hsieh, M.T.2    Tsai, T.H.3    Hsu, S.L.4
  • 34
    • 34447277695 scopus 로고    scopus 로고
    • Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells
    • Huang S.H., Chen Y., Tung P.Y., Wu J.C., Chen K.H., Wu J.M., et al. Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells. J Cell Biochem 2007, 101:1011-1022.
    • (2007) J Cell Biochem , vol.101 , pp. 1011-1022
    • Huang, S.H.1    Chen, Y.2    Tung, P.Y.3    Wu, J.C.4    Chen, K.H.5    Wu, J.M.6
  • 35
    • 1542281527 scopus 로고    scopus 로고
    • Magnolol has the ability to induce apoptosis in tumor cells
    • Ikeda K., Nagase H. Magnolol has the ability to induce apoptosis in tumor cells. Biol Pharm Bull 2002, 25:1546-1549.
    • (2002) Biol Pharm Bull , vol.25 , pp. 1546-1549
    • Ikeda, K.1    Nagase, H.2
  • 36
    • 77249164164 scopus 로고    scopus 로고
    • Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells
    • You Q., Li M., Jiao G. Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells. Arch Pharm Res 2009, 32:1789-1794.
    • (2009) Arch Pharm Res , vol.32 , pp. 1789-1794
    • You, Q.1    Li, M.2    Jiao, G.3
  • 37
    • 33845373014 scopus 로고    scopus 로고
    • Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells
    • Ikai T., Akao Y., Nakagawa Y., Ohguchi K., Sakai Y., Nozawa Y. Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells. Biol Pharm Bull 2006, 29:2498-2501.
    • (2006) Biol Pharm Bull , vol.29 , pp. 2498-2501
    • Ikai, T.1    Akao, Y.2    Nakagawa, Y.3    Ohguchi, K.4    Sakai, Y.5    Nozawa, Y.6
  • 38
    • 0037357959 scopus 로고    scopus 로고
    • Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation
    • Zhong W.B., Wang C.Y., Ho K.J., Lu F.J., Chang T.C., Lee W.S. Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation. Anticancer Drugs 2003, 14:211-217.
    • (2003) Anticancer Drugs , vol.14 , pp. 211-217
    • Zhong, W.B.1    Wang, C.Y.2    Ho, K.J.3    Lu, F.J.4    Chang, T.C.5    Lee, W.S.6
  • 39
    • 66149089933 scopus 로고    scopus 로고
    • Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
    • Lee D.H., Szczepanski M.J., Lee Y.J. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. J Cell Biochem 2009, 106:1113-1122.
    • (2009) J Cell Biochem , vol.106 , pp. 1113-1122
    • Lee, D.H.1    Szczepanski, M.J.2    Lee, Y.J.3
  • 40
    • 33644785160 scopus 로고    scopus 로고
    • Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis
    • Syu W.J., Shen C.C., Lu J.J., Lee G.H., Sun C.M. Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis. Chem Biodivers 2004, 1:530-537.
    • (2004) Chem Biodivers , vol.1 , pp. 530-537
    • Syu, W.J.1    Shen, C.C.2    Lu, J.J.3    Lee, G.H.4    Sun, C.M.5
  • 41
    • 38049125764 scopus 로고    scopus 로고
    • Magnolol-induced H460 cells death via autophagy but not apoptosis
    • Li H.B., Yi X., Gao J.M., Ying X.X., Guan H.Q., Li J.C. Magnolol-induced H460 cells death via autophagy but not apoptosis. Arch Pharm Res 2007, 30:1566-1574.
    • (2007) Arch Pharm Res , vol.30 , pp. 1566-1574
    • Li, H.B.1    Yi, X.2    Gao, J.M.3    Ying, X.X.4    Guan, H.Q.5    Li, J.C.6
  • 42
    • 0141514775 scopus 로고    scopus 로고
    • Inhibitory effect of magnolol on tumour metastasis in mice
    • Ikeda K., Sakai Y., Nagase H. Inhibitory effect of magnolol on tumour metastasis in mice. Phytother Res 2003, 17:933-937.
    • (2003) Phytother Res , vol.17 , pp. 933-937
    • Ikeda, K.1    Sakai, Y.2    Nagase, H.3
  • 44
    • 0025894809 scopus 로고
    • Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs
    • Teng C.M., Ko F.N., Wang J.P., Lin C.N., Wu T.S., Chen C.C., et al. Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs. J Pharm Pharmacol 1991, 43:667-669.
    • (1991) J Pharm Pharmacol , vol.43 , pp. 667-669
    • Teng, C.M.1    Ko, F.N.2    Wang, J.P.3    Lin, C.N.4    Wu, T.S.5    Chen, C.C.6
  • 45
    • 33845405725 scopus 로고    scopus 로고
    • Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules
    • Chen Y.H., Lin S.J., Chen Y.L., Liu P.L., Chen J.W. Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules. Cardiovasc Hematol Disord Drug Targets 2006, 6:279-304.
    • (2006) Cardiovasc Hematol Disord Drug Targets , vol.6 , pp. 279-304
    • Chen, Y.H.1    Lin, S.J.2    Chen, Y.L.3    Liu, P.L.4    Chen, J.W.5
  • 47
    • 29144460129 scopus 로고    scopus 로고
    • Elucidating the inhibitory mechanisms of magnolol on rat smooth muscle cell proliferation
    • Wu C.H., Chen C.W., Chen H.C., Chang W.C., Shu M.J., Hung J.S. Elucidating the inhibitory mechanisms of magnolol on rat smooth muscle cell proliferation. J Pharmacol Sci 2005, 99:392-399.
    • (2005) J Pharmacol Sci , vol.99 , pp. 392-399
    • Wu, C.H.1    Chen, C.W.2    Chen, H.C.3    Chang, W.C.4    Shu, M.J.5    Hung, J.S.6
  • 48
    • 0034927255 scopus 로고    scopus 로고
    • Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits
    • Chen Y.L., Lin K.F., Shiao M.S., Chen Y.T., Hong C.Y., Lin S.J. Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res Cardiol 2001, 96:353-363.
    • (2001) Basic Res Cardiol , vol.96 , pp. 353-363
    • Chen, Y.L.1    Lin, K.F.2    Shiao, M.S.3    Chen, Y.T.4    Hong, C.Y.5    Lin, S.J.6
  • 49
    • 34250821328 scopus 로고    scopus 로고
    • Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells
    • Ou H.C., Chou F.P., Sheu W.H., Hsu S.L., Lee W.J. Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells. Arch Toxicol 2007, 81:421-432.
    • (2007) Arch Toxicol , vol.81 , pp. 421-432
    • Ou, H.C.1    Chou, F.P.2    Sheu, W.H.3    Hsu, S.L.4    Lee, W.J.5
  • 50
    • 63849097233 scopus 로고    scopus 로고
    • Anti-inflammatory strategies for homocysteine-related cardiovascular disease
    • Lin C.P., Chen Y.H., Leu H.B., Lin S.J., Chen Y.L., Huang S.L., et al. Anti-inflammatory strategies for homocysteine-related cardiovascular disease. Front Biosci 2009, 14:3836-3845.
    • (2009) Front Biosci , vol.14 , pp. 3836-3845
    • Lin, C.P.1    Chen, Y.H.2    Leu, H.B.3    Lin, S.J.4    Chen, Y.L.5    Huang, S.L.6
  • 51
    • 0036157197 scopus 로고    scopus 로고
    • Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits
    • Chen Y.H., Lin S.J., Chen J.W., Ku H.H., Chen Y.L. Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br J Pharmacol 2002, 135:37-47.
    • (2002) Br J Pharmacol , vol.135 , pp. 37-47
    • Chen, Y.H.1    Lin, S.J.2    Chen, J.W.3    Ku, H.H.4    Chen, Y.L.5
  • 52
  • 53
    • 0032569621 scopus 로고    scopus 로고
    • Magnolol protects cortical neuronal cells from chemical hypoxia in rats
    • Lee M.M., Hseih M.T., Kuo J.S., Yeh F.T., Huang H.M. Magnolol protects cortical neuronal cells from chemical hypoxia in rats. Neuroreport 1998, 9:3451-3456.
    • (1998) Neuroreport , vol.9 , pp. 3451-3456
    • Lee, M.M.1    Hseih, M.T.2    Kuo, J.S.3    Yeh, F.T.4    Huang, H.M.5
  • 54
    • 0033921894 scopus 로고    scopus 로고
    • Anti-inflammatory and neuroprotective effects of magnolol in chemical hypoxia in rat cultured cortical cells in hypoglycemic media
    • Lee M.M., Huang H.M., Hsieh M.T., Chen C.S., Yeh F.T., Kuo J.S. Anti-inflammatory and neuroprotective effects of magnolol in chemical hypoxia in rat cultured cortical cells in hypoglycemic media. Chin J Physiol 2000, 43:61-67.
    • (2000) Chin J Physiol , vol.43 , pp. 61-67
    • Lee, M.M.1    Huang, H.M.2    Hsieh, M.T.3    Chen, C.S.4    Yeh, F.T.5    Kuo, J.S.6
  • 55
    • 33646135325 scopus 로고    scopus 로고
    • Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage
    • Lin Y.R., Chen H.H., Ko C.H., Chan M.H. Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage. Eur J Pharmacol 2006, 537:64-69.
    • (2006) Eur J Pharmacol , vol.537 , pp. 64-69
    • Lin, Y.R.1    Chen, H.H.2    Ko, C.H.3    Chan, M.H.4
  • 56
    • 0034931851 scopus 로고    scopus 로고
    • Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro
    • Ai J., Wang X., Nielsen M. Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro. Pharmacology 2001, 63:34-41.
    • (2001) Pharmacology , vol.63 , pp. 34-41
    • Ai, J.1    Wang, X.2    Nielsen, M.3
  • 57
    • 0016784993 scopus 로고
    • Studies on the active principles of magnolia bark. Centrally acting muscle relaxant activity of magnolol and honokiol
    • Watanabe K., Watanabe H.Y., Goto Y., Yamamoto N., Yoshizaki M. Studies on the active principles of magnolia bark. Centrally acting muscle relaxant activity of magnolol and honokiol. Jpn J Pharmacol 1975, 25:605-607.
    • (1975) Jpn J Pharmacol , vol.25 , pp. 605-607
    • Watanabe, K.1    Watanabe, H.Y.2    Goto, Y.3    Yamamoto, N.4    Yoshizaki, M.5
  • 58
    • 0021069340 scopus 로고
    • Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects
    • Watanabe K., Watanabe H., Goto Y., Yamaguchi M., Yamamoto N., Hagino K. Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects. Planta Med 1983, 49:103-108.
    • (1983) Planta Med , vol.49 , pp. 103-108
    • Watanabe, K.1    Watanabe, H.2    Goto, Y.3    Yamaguchi, M.4    Yamamoto, N.5    Hagino, K.6
  • 59
    • 0028852724 scopus 로고
    • Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices
    • Tsai T.H., Lee T.F., Chen C.F., Wang L.C. Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices. Neurosci Lett 1995, 186:49-52.
    • (1995) Neurosci Lett , vol.186 , pp. 49-52
    • Tsai, T.H.1    Lee, T.F.2    Chen, C.F.3    Wang, L.C.4
  • 60
    • 0344876575 scopus 로고    scopus 로고
    • Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice
    • Nakazawa T., Yasuda T., Ohsawa K. Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J Pharm Pharmacol 2003, 55:1583-1591.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 1583-1591
    • Nakazawa, T.1    Yasuda, T.2    Ohsawa, K.3
  • 61
    • 39749181656 scopus 로고    scopus 로고
    • Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents
    • Xu Q., Yi L.T., Pan Y., Wang X., Li Y.C., Li J.M., et al. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:715-725.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 715-725
    • Xu, Q.1    Yi, L.T.2    Pan, Y.3    Wang, X.4    Li, Y.C.5    Li, J.M.6
  • 63
    • 23244452574 scopus 로고    scopus 로고
    • Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement
    • Zhang W.W., Li Y., Wang X.Q., Tian F., Cao H., Wang M.W., et al. Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement. World J Gastroenterol 2005, 11:4414-4418.
    • (2005) World J Gastroenterol , vol.11 , pp. 4414-4418
    • Zhang, W.W.1    Li, Y.2    Wang, X.Q.3    Tian, F.4    Cao, H.5    Wang, M.W.6
  • 64
    • 33645553617 scopus 로고    scopus 로고
    • Inhibitory effects of magnolol on distal colon of guinea pig in vitro
    • Bian Z.X., Zhang G.S., Wong K.L., Hu X.G., Liu L., Yang Z., et al. Inhibitory effects of magnolol on distal colon of guinea pig in vitro. Biol Pharm Bull 2006, 29:790-795.
    • (2006) Biol Pharm Bull , vol.29 , pp. 790-795
    • Bian, Z.X.1    Zhang, G.S.2    Wong, K.L.3    Hu, X.G.4    Liu, L.5    Yang, Z.6
  • 65
    • 42549088040 scopus 로고    scopus 로고
    • Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum
    • Chan S.S., Zhao M., Lao L., Fong H.H., Che C.T. Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum. Planta Med 2008, 74:381-384.
    • (2008) Planta Med , vol.74 , pp. 381-384
    • Chan, S.S.1    Zhao, M.2    Lao, L.3    Fong, H.H.4    Che, C.T.5
  • 66
    • 85042587277 scopus 로고    scopus 로고
    • Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators
    • Yang T.C., Zhang S.W., Sun L.N., Wang H., Ren A.M. Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators. World J Gastroenterol 2008, 14:7353-7360.
    • (2008) World J Gastroenterol , vol.14 , pp. 7353-7360
    • Yang, T.C.1    Zhang, S.W.2    Sun, L.N.3    Wang, H.4    Ren, A.M.5
  • 67
    • 62449271208 scopus 로고    scopus 로고
    • Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats
    • Chen Y.H., Lin F.Y., Liu P.L., Huang Y.T., Chiu J.H., Chang Y.C., et al. Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats. Arch Pharm Res 2009, 32:221-228.
    • (2009) Arch Pharm Res , vol.32 , pp. 221-228
    • Chen, Y.H.1    Lin, F.Y.2    Liu, P.L.3    Huang, Y.T.4    Chiu, J.H.5    Chang, Y.C.6
  • 68
    • 0037285908 scopus 로고    scopus 로고
    • Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or d-galactosamine-induced toxicity in rat primary hepatocytes
    • Park E.J., Zhao Y.Z., Na M., Bae K., Kim Y.H., Lee B.H., et al. Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or d-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med 2003, 69:33-37.
    • (2003) Planta Med , vol.69 , pp. 33-37
    • Park, E.J.1    Zhao, Y.Z.2    Na, M.3    Bae, K.4    Kim, Y.H.5    Lee, B.H.6
  • 69
    • 0037533739 scopus 로고    scopus 로고
    • The protective mechanism of magnolol, a Chinese herb drug, against warm ischemia-reperfusion injury of rat liver
    • Jawan B., Goto S., Pan T.L., Lai C.Y., Luk H.N., Eng H.L., et al. The protective mechanism of magnolol, a Chinese herb drug, against warm ischemia-reperfusion injury of rat liver. J Surg Res 2003, 110:378-382.
    • (2003) J Surg Res , vol.110 , pp. 378-382
    • Jawan, B.1    Goto, S.2    Pan, T.L.3    Lai, C.Y.4    Luk, H.N.5    Eng, H.L.6
  • 70
    • 66249124259 scopus 로고    scopus 로고
    • Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c
    • Yin H.Q., Je Y.T., Kim Y.C., Shin Y.K., Sung S., Lee K., et al. Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c. J Pharmacol Sci 2009, 109:486-495.
    • (2009) J Pharmacol Sci , vol.109 , pp. 486-495
    • Yin, H.Q.1    Je, Y.T.2    Kim, Y.C.3    Shin, Y.K.4    Sung, S.5    Lee, K.6
  • 71
    • 33845764758 scopus 로고    scopus 로고
    • Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats
    • Sohn E.J., Kim C.S., Kim Y.S., Jung D.H., Jang D.S., Lee Y.M., et al. Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Life Sci 2007, 80:468-475.
    • (2007) Life Sci , vol.80 , pp. 468-475
    • Sohn, E.J.1    Kim, C.S.2    Kim, Y.S.3    Jung, D.H.4    Jang, D.S.5    Lee, Y.M.6
  • 72
    • 67349146720 scopus 로고    scopus 로고
    • Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells
    • Choi S.S., Cha B.Y., Lee Y.S., Yonezawa T., Teruya T., Nagai K., et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci 2009, 84:908-914.
    • (2009) Life Sci , vol.84 , pp. 908-914
    • Choi, S.S.1    Cha, B.Y.2    Lee, Y.S.3    Yonezawa, T.4    Teruya, T.5    Nagai, K.6
  • 73
    • 0031687045 scopus 로고    scopus 로고
    • Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus
    • Hsieh M.T., Chueh F.Y., Lin M.T. Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus. Clin Exp Pharmacol Physiol 1998, 25:813-817.
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 813-817
    • Hsieh, M.T.1    Chueh, F.Y.2    Lin, M.T.3
  • 74
    • 0034256988 scopus 로고    scopus 로고
    • Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells
    • Tachikawa E., Takahashi M., Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000, 60:433-440.
    • (2000) Biochem Pharmacol , vol.60 , pp. 433-440
    • Tachikawa, E.1    Takahashi, M.2    Kashimoto, T.3
  • 75
    • 23644456701 scopus 로고    scopus 로고
    • Signaling pathways of magnolol-induced adrenal steroidogensis
    • Chen Y.C., Chang M.F., Chen Y., Wang S.M. Signaling pathways of magnolol-induced adrenal steroidogensis. FEBS Lett 2005, 579:4337-4343.
    • (2005) FEBS Lett , vol.579 , pp. 4337-4343
    • Chen, Y.C.1    Chang, M.F.2    Chen, Y.3    Wang, S.M.4
  • 76
    • 34548699687 scopus 로고    scopus 로고
    • Effects of honokiol and magnolol on acute and inflammatory pain models in mice
    • Lin Y.R., Chen H.H., Ko C.H., Chan M.H. Effects of honokiol and magnolol on acute and inflammatory pain models in mice. Life Sci 2007, 81:1071-1078.
    • (2007) Life Sci , vol.81 , pp. 1071-1078
    • Lin, Y.R.1    Chen, H.H.2    Ko, C.H.3    Chan, M.H.4
  • 77
    • 70449447656 scopus 로고    scopus 로고
    • Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
    • Lin Y.R., Chen H.H., Lin Y.C., Ko C.H., Chan M.H. Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. J Biomed Sci 2009, 16:94.
    • (2009) J Biomed Sci , vol.16 , pp. 94
    • Lin, Y.R.1    Chen, H.H.2    Lin, Y.C.3    Ko, C.H.4    Chan, M.H.5
  • 79
    • 0019408245 scopus 로고
    • Antimicrobial activity of phenolic constituents of Magnolia grandiflora L
    • Clark A.M., El-Feraly F.S., Li W.S. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci 1981, 70:951-952.
    • (1981) J Pharm Sci , vol.70 , pp. 951-952
    • Clark, A.M.1    El-Feraly, F.S.2    Li, W.S.3
  • 80
    • 0031683979 scopus 로고    scopus 로고
    • Anti-Helicobacter pylori activity of herbal medicines
    • Bae E.A., Han M.J., Kim N.J., Kim D.H. Anti-Helicobacter pylori activity of herbal medicines. Biol Pharm Bull 1998, 21:990-992.
    • (1998) Biol Pharm Bull , vol.21 , pp. 990-992
    • Bae, E.A.1    Han, M.J.2    Kim, N.J.3    Kim, D.H.4
  • 81
    • 21044435937 scopus 로고    scopus 로고
    • Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling
    • Lee J., Jung E., Park J., Jung K., Lee S., Hong S., et al. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta Med 2005, 71:338-343.
    • (2005) Planta Med , vol.71 , pp. 338-343
    • Lee, J.1    Jung, E.2    Park, J.3    Jung, K.4    Lee, S.5    Hong, S.6
  • 83
    • 70349210557 scopus 로고    scopus 로고
    • Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1
    • Chen L.C., Liu Y.C., Liang Y.C., Ho Y.S., Lee W.S. Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. J Agric Food Chem 2009, 57:7331-7337.
    • (2009) J Agric Food Chem , vol.57 , pp. 7331-7337
    • Chen, L.C.1    Liu, Y.C.2    Liang, Y.C.3    Ho, Y.S.4    Lee, W.S.5
  • 84
    • 73949084866 scopus 로고    scopus 로고
    • Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice
    • Matsui N., Takahashi K., Takeichi M., Kuroshita T., Noguchi K., Yamazaki K., et al. Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice. Brain Res 2009, 1305:108-117.
    • (2009) Brain Res , vol.1305 , pp. 108-117
    • Matsui, N.1    Takahashi, K.2    Takeichi, M.3    Kuroshita, T.4    Noguchi, K.5    Yamazaki, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.