Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells

Journal of Cellular Biochemistry

Volumn 101, Issue 4, 2007, Pages 1011-1022

  Huang, Shih Horng ^a   Chen, Ying ^b   Tung, Po Yuan ^b   Wu, Jiahn Chun ^b   Chen, Kuo Hsin ^a   Wu, Jiann Ming ^a   Wang, Seu Mei ^b  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Magnolol; Necrosis; Signaling mechanism; Thyroid carcinoma cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; DIMETHYL SULFOXIDE; MAGNOLOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAGNOLIACEAE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; THYROID CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CYTOCHROMES C; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LIGNANS; NECROSIS; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; THYROID NEOPLASMS;

MAGNOLIA;

EID: 34447277695     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21100     Document Type: Article

References (45)

1. Ali IU, Schriml LM, Dean M. 1999. Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91:1922-1932.
2. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. 1999. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274:22932-22940.
3. Cantley LC, Neel BG. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245.
4. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 13:1318-1321.
5. Chen JS, Chen YL, Greenberg AS, Chen YJ, Wang SM. 2005a. Magnolol stimulates lipolysis in lipid-laden RAW 264.7 macrophages. Cell Biochem 94:1028-1037.
6. Chen YC, Chang MF, Chen Y, Wang SM. 2005b. Signaling pathways of magnolol-induced adrenal steroidogenesis. FEBS Lett 579:4337-4343.
7. Chen JH, Wu CC, Hsiao G, Yen MH. 2003. Magnolol induces apoptosis in vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 368:127-133.
8. Clark RS, Nathaniel PD, Zhang X, Dixon CE, Alber SM, Watkins SC, Melick JA, Kochanek PM, Graham SH. 2006. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab (Online published).
9. Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: A play in three Akts. Genes Dev 15:2905-2927.
10. D'Amours D, Sallmann FR, Dixit VM, Poirier GG. 2001. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: Implications for apoptosis. J Cell Sci 114:3771-3778.
11. Decker P, Muller S. 2002. Modulating poly (ADP-ribose) polymerase activity: Potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr Pharm Biotechnol 3:275-283.
12. Fagin JA. 2002. Minireview: Branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid. Mol Endocrinol 6:903-911.
13. Farrow B, Evers BM. 2003. Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. Biochem Biophys Res Commun 301:50-53.
14. Ferrer I, Planas AM. 2003. Signaling of cell death and cell survival following focal cerebral ischemia: Life and death struggle in the penumbra. J Neuropathol Exp Neurol 62: 329-339.
15. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. 2005. PI3K/Akt and apoptosis: Size matters. Oncogene 22:8983-8998.
16. Garcia-Rostan G, Costa AM, Pereira-Castro I, Salvatore G, Hernandez R, Hermsem MJ, Herrero A, Fusco A, Camaselle-Teijeiro J, Santoro M. 2005. Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Res 15:10199-10207.
17. Ha HC, Snyder SH. 1999. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 96:13978-13982.
18. Herceg Z, Wang ZQ. 1999. Failure of poly (ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 19:5124-5133.
19. Huang SH, Shen WJ, Yeo HL, Wang SM. 2004. Signaling pathway of magnolol-stimulated lipolysis in sterol esterloaded 3T3-L1 preadipocytes. J Cell Biochem 91:1021-1029.
20. Ikeda K, Nagase H. 2002. Magnolol has the ability to induce apoptosis in tumor cells. Biol Pharm Bull 25:1546-1549.
21. Kada F, Saji M, Ringel MD. 2004. Akt: A potential target for thyroid cancer therapy. Curr Drug Targets Immune Endocr Metabol Disord 4:181-185.
22. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. 2001. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20:6669-6678.
23. Lee SY, Hur GY, Jung KH, Jung HC, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH. 2006. PPAR-gamma agonist increase gefitinib's antitumor activity through PTEN expression. Lung Cancer 51:297-301.
24. Lin JD, Jeng LB, Chao TC, Weng HF, Huang HS. 1996. Surgical treatment of papillary and follicular thyroid carcinoma. Int Surg 81:61-66.
25. Lin SY, Chang YT, Liu JD, Yu CH, Ho YS, Lee YH, Lee WS. 2001. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. Mol Carcinog 32: 73-83.
26. Lin SY, Lau JD, Chang HC, Yeh SD, Lin CH, Lee WS. 2002. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 84:532-544.
27. Mitsiades CS, Mitsiades N, Koutsilieris M. 2004. The Akt pathway: Molecular targets for anti-cancer drug development. Curr Cancer Drug Targets 4:235-256.
28. Motti ML, Califano D, Troncone G, De Marco C, Migliaccio I, Palmieri E, Pezzullo L, Palombini L, Fusco A, Viglietto G. 2005. Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: Regulation of p27kip1 expression and localization. Am J Pathol 166:737-749.
29. Nagase H, Ikeda K, Sakai Y. 2001. Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro. Planta Med 67:705-708.
30. Proskuryakov SY, Konoplyannikov AG, Gabai VL. 2003. Necrosis: A specific form of programmed cell death? Exp Cell Res 1:1-16.
31. Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A. 2004. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303: 1179-1181.
32. Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H, Hla T. 2005. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci USA 102:4312-4317.
33. Smaili SS, Hsu YT, Youle RJ, Russell JT. 2000. Mitochondria in Ca2+ signaling and apoptosis. J Bioenerg Biomembr 32:35-46.
34. Stewart J, Siavash H, Hebert C, Norris K, Nikitakis NG, Sauk JJ. 2003. Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells. Oral Oncol 39:862-869.
35. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446.
36. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF. 1988. Two anti-platelet agents from Magnolia officinalis. Thromb Res 50:757-765.
37. van Wijk SJ, Hageman GJ. 2005. Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic Biol Med 1: 81-90.
38. Virag L. 2005. Structure and function of poly (ADP-ribose) polymerase-1: Role in oxidative stress-related pathologies. Curr Vasc Pharmacol 3:209-214.
39. Wang SM, Lee LJ, Huang YT, Chen JJ, Chen YL. 2000. Magnolol stimulates steroidogenesis in rat adrenal cells. Br J Pharmacol 131:1172-1178.
40. Wu X, Obata T, Khan Q, Highshaw RA, De Vere White R, Sweeney C. 2004. The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. BJU Int 93:143-150.
41. Yang SE, Hsieh MT, Tsai TH, Hsu SL. 2003. Effector mechanism of magnolol-induced apoptosis in human squamous carcinoma CH27 cells. Br J Pharmacol 138: 193-201.
42. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. 2002. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297:259-263.
43. Yu SW, Wang H, Dawson TM, Dawson VL. 2003. Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol Dis 14:303-317.
44. Zhang Y, Zhang X, Park TS, Gidday JM. 2005. Cerebral endothelial cell apoptosis after ischemia-reperfusion: Role of PARP activation and AIF translocation. J Cereb Blood Flow Metab 25:868-877.
45. Zhong WB, Wang CY, Ho KJ, Lu FJ, Chang TC, Lee WS. 2003. Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation. Anticancer drugs 14:211-217.