Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 10, 1998, Pages 813-817

  Hsieh, M T ^a   Chueh, F Y ^a   Lin, M T ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Hypothalamus; Hypothermia; Magnolol; Serotonin

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; INTERLEUKIN 1BETA; MAGNOLOL; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; FEVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTHALAMUS; HYPOTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METABOLIC RATE; MICRODIALYSIS; NONHUMAN; RAT; SEROTONIN RELEASE; SKIN TEMPERATURE; THERMOREGULATION;

EID: 0031687045     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02158.x     Document Type: Article

References (37)

1. Fujita M, Itokawa H, Sashida Y. Honokiol, a new phenolic compound isolated from the bark of Magnolia obovata Thunb. Chem. Bull. 1972; 20: 212-13.
2. Kawai T, Kinoshita K, Koyama K, Takahashi K. Anti-emetic principles of Magnolia obovata bark and Zingiber officinalis rhizome. Planta Med. 1994; 60: 17-20.
3. Ito K, Iida T, Ichino K, Tsunezuka M, Mattori M, Namba T. Obovatol and obovatal, novel biphenyl ether ligands from the leaves of Magnolia obovata Thunb. Chem. Pharm. Bull. 1982; 30: 3347-53.
4. Wang JP, Hsu MF, Raung SL, Chen CC, Kuo JS, Teng CM. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch. Pharmacol. 1992; 346: 707-12.
5. Wang JP, Ho TF, Chang LC, Chen CC. Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J. Pharm. Pharmacol. 1995; 47: 857-60.
6. Watanabe K, Watanabe H, Goto Y, Yamamoto N, Yoshizaki M. Studies on the active principles of magnolia bark: Centrally acting muscle relaxant activity of magnolol and honokiol. Jpn. J. Pharmacol. 1975; 25: 605-7.
7. Teng CM, Ko FN, Wang JP et al. Antihaemostatic, antithrombotic effect of some antiplatelet agents isolated from Chinese herbs. J. Pharm. Pharmacol. 1991; 43: 667-9.
8. Teng CM, Chen CC, Ko FN et al. Two antiplatelet agents from Magnolia officinalis. Thromb. Res. 1988; 50: 757-65.
9. Lin MH, Chao HT, Hong CY. Magnolol protects human sperm motility against lipid peroxidation: A sperm head fixation method. Arch. Androl. 1995; 34: 151-6.
10. Tsai TH, Lee TF, Chen CF, Wang LC. Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices. Neurosci. Lett. 1995; 186: 49-52.
11. Gemma C, Ghezzi P, De Simoni MG. Activation of the hypothalamic serotoninergic system by central interleukin-1. Eur. J. Pharmacol. 1991; 209: 139-40.
12. Shintani F, Kanba S, Nakaki T et al. Interleukin-1β augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. J. Neurosci. 1993; 13: 3574-81.
13. Lin MT, Tsay HJ, Su WH, Chueh FY. Changes in extracellular serotonin in the rat hypothalamus affect thermoregulatory function. Am. J. Physiol. 1998; 274: R1260-7.
14. Lin MT, Chern YF, Liu GG, Chang TC. Studies on thermoregulation in the rat. Proc. Natl Sci. Council ROC 1979; 3: 46-52.
15. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York. 1982.
16. Yang YK, Lin MT. Brain serotonin depletion attenuates diabetogenic effects of streptozotocin. Am. J. Physiol. 1995; 268: E839-44.
17. Lin MT, Hang WN, Ho LT. Somatostatin: A hypothalamic transmitter for thermoregulation in rats. Pflügers Arch. 1989; 413: 528-32.
18. Auerbach SB, Minzenberg MJ, Wilkinson LO. Extracellular serotonin and 5-hydroxyindoleacetic acid in hypothalamus of the unanesthetized rat measured by in vivo dialysis coupled to high-performance liquid chromatography with electrochemical detection: Dialysate serotonin reflects neuronal release. Brain Res. 1989; 499: 281-90.
19. Cooper JR, Bloom FE, Roth RH. The Biochemical Basis of Neuropharmacology. Oxford University Press, New York. 1996; 353-407.
20. Gudelsky GA, Koenig JI, Meltzer HY. Altered responses to serotonergic agents in Fawn-Hooded rats. Pharmacol. Biochem. Behav. 1985; 22: 489-92.
21. 1A receptors. Neuropharmacology 1986; 25: 1307-13.
22. Hjorth S. Hypothermia in the rat induced by the potent serotonergic agent 8-OH-DPAT. J. Neural Transm. 1985; 61: 131-5.
23. Koenig JI, Gudelsky GA, Meltzer HY. Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur. J. Pharmacol. 1987; 37: 1-8.
24. Lee HS, Bastani B, Friedman L, Ramirez L, Meltzer HY. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol. Psychiatry 1992; 31: 460-70.
25. 1A) receptor-mediated hypothermie response to ipsapirone in unipolar depression. Life Sci. 1990; 46: 1271-7.
26. Murphy DL, Mueller EA, Hill JL, Tolliver TJ, Jacobson FM. Comparative anxiogenic, neuroendocrine, other physiologic effects of m-chlorophenyl piperazine given intravenously or orally to healthy volunteers. Psychopharmacology 1989; 98: 275-82.
27. Nash JF, Meltzer HY, Gudelsky GA. Selective cross-tolerance to 5-HT1A, 5-HT2 receptor-mediated temperature, corticosterone responses. Pharmacol. Biochem. Behav. 1989; 33: 781-5.
28. Wilkinson LO, Auerback SB, Jacobs BL. Relationship between dialysate serotonin, raphe unit activity. Soc. Neurosci. Abstr. 1988; 14: 25.
29. Clement HW, Ruwl C, Gemsa D, Wesemann W. The effect of exo- and endopyrogens on serotonin metabolism in the nucleus raphe dorsalis of the rat. In: Lomax P, Schönbaum E (eds). Thermal Balance in Health and Disease. Advances in Pharmacological Sciences. Birk Hauser Verlag, Basel. 1994; 373-8.
30. Ruwe WD, Myers RD. 5-HT receptors and hyper-or hypothermia: Elucidation by catecholamine antagonists injected into the cat hypothalamus. Brain Res. Bull. 1982; 8: 79-86.
31. Myers RD, Beleslin DB. Change in serotonin release in hypothalamus during cooling or warming of the monkey. Am. J. Physiol. 1971; 220: 1746-54.
32. Huttunen P, Lapinlampi T, Myers RDT, Myers RD. Temperature-related release of serotonin from unrestrained rat's pre-optic area perfused with ethanol. Alcohol 1988; 5: 189-93.
33. Myers RD. Hypothalamic control of thermoregulation. In: Morgane PJ, Panksepp J (eds). Behavioral Studies of the Hypothalamus, Vol. 3. Marcel Dekker, New York. 1980; 83-210.
34. Myers RD, Waller MB. 5-HT and norepinephrine-induced release of ACh from the thalamus and mesencephalon of the monkey during thermoregulation. Brain Res. 1975; 84: 47-61.
35. Tsai TH, Chou CJ, Chen CF. Glucuronidation of magnolol assessed using HPLC/fluorescence. Planta Med. 1995; 61: 491-2.
36. Tsai TH, Chou CJ, Chen CF. Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection. J. Pharm. Pharmacol. 1996; 48: 57-9.
37. Vanherweghem JL, Depierreux M, Tielemans C et al. Rapid progressive interstitial renal fibrosis in young women: Associated with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-91.