Magnolol induces apoptosis in vascular smooth muscle

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 2, 2003, Pages 127-133

  Chen, Jiun Han ^a   Wu, Chin Chen ^a   Hsiao, George ^b   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aorta; Apoptosis; Bcl 2; Caspase; Magnolol; Rat; Re stenosis

Indexed keywords

ANTIOXIDANT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; MAGNOLOL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; INTIMA; MAGNOLIA OFFICINALIS; MALE; MITOCHONDRION; NICK END LABELING; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PLANT; RAT; RESTENOSIS; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CAROTID ARTERY DISEASES; CASPASE 3; CASPASE 9; CASPASES; CELLS, CULTURED; CONSTRICTION, PATHOLOGIC; DOWN-REGULATION; ENZYME ACTIVATION; LIGNANS; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, MUSCLE; MUSCLE, SMOOTH, VASCULAR; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0041375666     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0779-3     Document Type: Article

References (28)

1. Brown MR, Miller FJ Jr, Li WG, Ellingson AN, Mozena JD, Chatterjee P, Engelhardt JF, Zwacka RM, Oberley LW, Fang X, Spector AA, Weintraub NL (1999) Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. Circ Res 85:524-533
2. Chen YL, Lin KF, Shiao MS, Chen YT, Hong CY, Lin SJ (2001) Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbit. Basic Res Cardiol 96:353-363
3. Chen YH, Lin SJ, Chen JW, Ku HH, Chen YL (2002) Magnolol attenuates VCAM-1 expression in vitro in TNF-α-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br J Pharmacol 135:37-47
4. Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, Coffey RJ (1997) Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21 WAF1/CIP1 via C/EBPβ. Nat Med 3:1233-1241
5. Chiu JH, Wang JC, Lui WY, Wu CW, Hong CY (1999) Effect of magnolol on in vitro mitochondrial lipid peroxidation and isolated cold-preserved warm-reperfused rat livers. J Surg Res 82:11-16
6. Deuel TF, Huang JS (1984) Platelet-derived growth factor: structure, function and roles in normal and transformed cells. J Clin Invest 74:669-676
7. ++. Am J Physiol 278:C1116-C1125
8. Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch KR (1990) Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res 67:651-659
9. Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88:85-89
10. Kyprianou N, Benning CM (2000) Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res 60:4550-4555
11. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997a) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
12. Li PF, Dietz R, Von Harsdorf R (1997b) Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation 96:3602-3609
13. Libby P, Warner SJC, Friedman GB (1988) Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest 81:487-498
14. Lin SY, Liu JD, Chang HC, Yeh SD, Lin CH, Lee WS (2001) Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 84:532-544
15. Loeffler M, Kroemer G (2000) The mitochondrion in cell death control: certainties and incognita. Exp Cell Res 256:19-26
16. Mooberry S, Tien G, Hernandez AH, Plubrukarn A, Davidson BS (1999) Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents. Cancer Res 59:653-660
17. Nagata S (1997) Apoptosis by death factor. Cell 88:355-365
18. Nobel CI, Kinland M, Lind B, Orrenius S, Slater AF (1995) Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J Biol Chem 270:26202-26208
19. Pauly RR, Bilato C, Cheng L, Monticone R, Crow MT (1997) Vascular smooth muscle cell cultures. Methods Cell Biol 52:133-152
20. Perlman H, Sata M, Krasinski K, Dorai T, Buttyan R, Walsh K (2000) Adenovirus-encoded hammerhead ribozyme to Bcl-2 inhibits neointimal hyperplasia and induces smooth muscle cell apoptosis. Cardiovasc Res 45:570-578
21. Picketing JG, Weir L, Jekanowski J, Kearney MA, Isner JM (1993) Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularisation. J Clin Invest 91:1469-1480
22. Sandstrom PA, Mannie MD, Buttke TM (1994) Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J Leukoc Biol 55:221-226
23. Srivastava IK, Rottenberg H, Vaidya AB (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J Biol Chem 272:3967-3962
24. Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perrella MA, Cooke C, Wang H, Haber E, Schlegel R, Lee ME (1996) Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem 271:3667-3670
25. Walsh K, Isner JM (2000) Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall. Cardiovasc Res 45:756-765
26. Wang JP, Ho TF, Chang LC, Chen CC (1995) Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J Pharm Pharmacol 47:857-860
27. Yonemitsu Y, Kaneda Y, Tanaka S, Nakashima Y, Komori K, Sugimachi K, Sueishi K (1998) Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo. Circ Res 82:147-156
28. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, Kroemer G (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182:367-377