The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 4, 2003, Pages 262-269

  Lu, Yu Cheng ^a,b   Chen, Hwei Hsien ^b   Ko, Chien Hsin ^a   Lin, Yi Ruu ^b   Chan, Ming Huan ^b  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

Author keywords

Ca2+; Honokiol; Magnolol; Rat uterus; Smooth muscle

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL; CALCIUM ION; CARBACHOL; HONOKIOL; MAGNOLOL; OXYTOCIN; POTASSIUM ION; PROSTAGLANDIN F2 ALPHA;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; FEMALE; HIGHER PLANT; MAGNOLIA OFFICINALIS; MYOMETRIUM; NONHUMAN; RAT; UTERUS CONTRACTILITY; UTERUS RELAXATION;

ANIMALS; BIPHENYL COMPOUNDS; CALCIUM; CARBACHOL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DINOPROST; FEMALE; FLUORESCENT DYES; FURA-2; LIGNANS; MUSCARINIC AGONISTS; MYOMETRIUM; OXYTOCICS; OXYTOCIN; POTASSIUM CHLORIDE; RATS; UTERINE CONTRACTION; UTERUS;

EID: 0242392013     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0802-8     Document Type: Article

References (27)

1. Akerlund M (1979) Pathophysiology of dysmenorrhea. Acta Obstet Gynecol Scand Suppl 87:27-32
2. + channels as modulators of human myometrial contractile activity. Am J Physiol 265:C976-985
3. Caughey AB, Parer JT (2001) Tocolysis with beta-adrenergic receptor agonists. Semin Perinatol 25:248-255
4. Chan P, Cheng JT, Tsao CW, Niu CS, Hong CY (1996) The in vitro antioxidant activity of trilinolein and other lipid-related natural substances as measured by enhanced chemiluminescence. Life Sci 59:2067-2073
5. Chen QS (1986) Pharmacology and applications of Chinese materia media. In: Chang HM, But PPH (eds) World Scientific, Singapore, vol 2, pp 878-880
6. Foster RW, Small RC, Weston AH (1983) The spasmogenic action of potassium chloride in guinea-pig trachealis. Br J Pharmacol 80:553-559
7. Fuchs AR (1995) Plasma membrane receptors regulating myometrial contractility and their hormonal modulation. Semin Perinatol 19:15-30
8. Fujita M, Itokawa H, Sashida Y (1973) Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and honokiol in M. obovata and other allied plants. Yakugaku Zasshi 93:429-434
9. Hamasaki Y, Kobayashi I, Zaitu M, Tsuji K, Kita M, Hayasaki R, Muro E, Yamamoto S, Matsuo M, Ichimaru T, Miyazaki S (1999) Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. Planta Med 65:222-226
10. Haraguchi H, Ishikawa H, Shirataki N, Fukuda A (1997) Antiperoxidative activity of neolignans from Magnolia obovata. J Pharm Pharmacol 49:209-212
11. Ivorra MD, Chulia S, Noguera MA, D'Ocon MP (1994) Intervention of two voltage-dependent calcium-entry pathways in the contractile response to acetylcholine and KCl in rat uterus. Pharmacology 49:33-41
12. Kawarabayashi T, Shojo H, Tsukamoto T (1997) Effects of oxytocin, prostaglandin F2 alpha and prostaglandin E2 on intracellular free calcium concentrations of longitudinal muscle cells isolated from term pregnant rat myometrium. Gynecol Obstet Invest 43:145-149
13. Kimura M, Kimura I, Maekawa M (1978) The mode of action of contractile effects induced by external calcium and its related bivalent cations in the KCl-depolarized rat uterus. Jpn J Pharmacol 28:681-692
14. Ko CH, Chen HH, Lin YR, Chan MH (2003) Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. Planta Med 69:532-536
15. Kuribara H, Kishi E, Hattori N, Okada M, Maruyama Y (2000) The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 52:1425-1429
16. Ruttner Z, Ivanics T, Slaaf DW, Reneman RS, Toth A, Ligeti L (2002) In vivo monitoring of intracellular free calcium changes during uterine activation by prostaglandin f(2alpha) and oxytocin. J Soc Gynecol Investig 9:294-298
17. Tachikawa E, Takahashi M, Kashimoto T (2000) Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 60:433-440
18. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP, Hsu HY (1988) Two antiplatelet agents from Magnolia officinalis. Thromb Res 50:757-765
19. 2+-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta. Life Sci 47:1153-1161
20. Tsai TH, Lee TF, Chen CF, Wang LC (1995) Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices. Neurosci Lett 186:49-52
21. Tsatsaris V, Papatsonis D, Goffinet F, Dekker G, Carbonne B (2001) Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. Obstet Gynecol 97:840-847
22. Ulmsten U, Andersson KE, Wingerup L (1980) Treatment of premature labor with the calcium antagonist nifedipine. Arch Gynecol 229:1-5
23. Wang JP, Hsu MF, Raung SL, Chen CC, Kuo JS, Teng CM (1992) Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol 346:707-712
24. Wang JP, Hsu MF, Raung SL, Chang LC, Tsao LT, Lin PL, Chen CC (1999) Inhibition by magnolol of formylmethionyl-leucylphenyl alanine-induced respiratory burst in rat neutrophils. J Pharm Pharmacol 51:285-294
25. Word RA (1995) Myosin phosphorylation and the control of myomerrial contraction/relaxation. Semin Perinatol 19:3-14
26. Wu SN, Chen CC, Li HF, Lo YK, Chen SA, Chiang HT (2002) Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol. Thorax 57:67-74
27. Yamahara J, Miki S, Matsuda H, Fujimura H (1986) Screening test for calcium antagonists in natural products. The active principles of Magnolia obovata. Yakugaku Zasshi 106:888-893