메뉴 건너뛰기




Volumn 49, Issue 1-2, 2011, Pages 290-296

Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis

Author keywords

Anakinra; IL 1 receptor Antagonist; Immune regulation; Rheumatoid arthritis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 21; METHOTREXATE; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

EID: 82455181862     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.08.020     Document Type: Article
Times cited : (33)

References (47)
  • 1
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 2007, 8:942-949.
    • (2007) Nat. Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 2
    • 33847667225 scopus 로고    scopus 로고
    • The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    • Afzali B., Lombardi G., Lechler R.I., Lord G.M. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 2007, 148:32-46.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 32-46
    • Afzali, B.1    Lombardi, G.2    Lechler, R.I.3    Lord, G.M.4
  • 3
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 5
    • 46749125294 scopus 로고    scopus 로고
    • Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm
    • Boissier M.C., Assier E., Falgarone G., Bessis N. Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine 2008, 75:373-375.
    • (2008) Joint Bone Spine , vol.75 , pp. 373-375
    • Boissier, M.C.1    Assier, E.2    Falgarone, G.3    Bessis, N.4
  • 7
    • 76649105764 scopus 로고    scopus 로고
    • Immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells
    • Chen G. Immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells. Arch. Immunol. Ther. Exp. (Warsz) 2010, 58:27-36.
    • (2010) Arch. Immunol. Ther. Exp. (Warsz) , vol.58 , pp. 27-36
    • Chen, G.1
  • 8
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 9
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • Chen Z., Tato C.M., Muul L., Laurence A., O'Shea J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis. Rheum. 2007, 56:2936-2946.
    • (2007) Arthritis. Rheum. , vol.56 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 11
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with Anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
    • Cohen S., Hurd E., Cush J., Schiff M., Weinblatt M.E., Moreland L.W., Kremer J., Bear M.B., Rich W.J., McCabe D. Treatment of rheumatoid arthritis with Anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis. Rheum. 2002, 46:614-624.
    • (2002) Arthritis. Rheum. , vol.46 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3    Schiff, M.4    Weinblatt, M.E.5    Moreland, L.W.6    Kremer, J.7    Bear, M.B.8    Rich, W.J.9    McCabe, D.10
  • 12
    • 0034469924 scopus 로고    scopus 로고
    • Cell fate decision: T-helper 1 and 2 subsets in immune responses
    • Dong C., Flavell R.A. Cell fate decision: T-helper 1 and 2 subsets in immune responses. Arthritis. Res. 2000, 2:179-188.
    • (2000) Arthritis. Res. , vol.2 , pp. 179-188
    • Dong, C.1    Flavell, R.A.2
  • 15
    • 37349052871 scopus 로고    scopus 로고
    • Cytokines in arthritis: the 'big numbers' move centre stage
    • Gaston J.S. Cytokines in arthritis: the 'big numbers' move centre stage. Rheumatology (Oxford) 2008, 47:8-12.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 8-12
    • Gaston, J.S.1
  • 16
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6:1123-1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 18
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai R., Sai S., Tanioka H., Nakae S., Sudo K., Okahara A., Ikuse T., Asano M., Iwakura Y. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 2000, 191:313-320.
    • (2000) J. Exp. Med. , vol.191 , pp. 313-320
    • Horai, R.1    Sai, S.2    Tanioka, H.3    Nakae, S.4    Sudo, K.5    Okahara, A.6    Ikuse, T.7    Asano, M.8    Iwakura, Y.9
  • 19
    • 0034083128 scopus 로고    scopus 로고
    • A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores
    • Jiang Y., Genant H.K., Watt I., Cobby M., Bresnihan B., Aitchison R., McCabe D. A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis. Rheum. 2000, 43:1001-1009.
    • (2000) Arthritis. Rheum. , vol.43 , pp. 1001-1009
    • Jiang, Y.1    Genant, H.K.2    Watt, I.3    Cobby, M.4    Bresnihan, B.5    Aitchison, R.6    McCabe, D.7
  • 20
    • 16644365071 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of rheumatoid arthritis
    • Kay J., Calabrese L. The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2004, 43:iii2-iii9.
    • (2004) Rheumatology (Oxford) , vol.43
    • Kay, J.1    Calabrese, L.2
  • 22
    • 75749090445 scopus 로고    scopus 로고
    • Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist
    • Lamacchia C., Palmer G., Seemayer C.A., Talabot-Ayer D., Gabay C. Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist. Arthritis. Rheum. 2010, 62:452-462.
    • (2010) Arthritis. Rheum. , vol.62 , pp. 452-462
    • Lamacchia, C.1    Palmer, G.2    Seemayer, C.A.3    Talabot-Ayer, D.4    Gabay, C.5
  • 23
    • 57049172430 scopus 로고    scopus 로고
    • Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes
    • Lee Y.R., Kweon S.H., Kwon K.B., Park J.W., Yoon T.R., Park B.H. Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. Biochem. Biophys. Res. Commun. 2009, 378:90-94.
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 90-94
    • Lee, Y.R.1    Kweon, S.H.2    Kwon, K.B.3    Park, J.W.4    Yoon, T.R.5    Park, B.H.6
  • 25
    • 38949197817 scopus 로고    scopus 로고
    • IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?
    • Lubberts E. IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?. Cytokine 2008, 41:84-91.
    • (2008) Cytokine , vol.41 , pp. 84-91
    • Lubberts, E.1
  • 27
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N., Unutmaz D., Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 2008, 9:641-649.
    • (2008) Nat. Immunol. , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 29
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986, 136:2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 30
    • 0034677174 scopus 로고    scopus 로고
    • Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
    • Nicklin M.J., Hughes D.E., Barton J.L., Ure J.M., Duff G.W. Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J. Exp. Med. 2000, 191:303-312.
    • (2000) J. Exp. Med. , vol.191 , pp. 303-312
    • Nicklin, M.J.1    Hughes, D.E.2    Barton, J.L.3    Ure, J.M.4    Duff, G.W.5
  • 32
    • 0036845130 scopus 로고    scopus 로고
    • European Group of Clinical Investigators, long-term safety and maintenance of clinical improvement following treatment with Anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial
    • Nuki G., Bresnihan B., Bear M.B., McCabe D. European Group of Clinical Investigators, long-term safety and maintenance of clinical improvement following treatment with Anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis. Rheum. 2002, 46:2838-2846.
    • (2002) Arthritis. Rheum. , vol.46 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3    McCabe, D.4
  • 35
    • 46049087498 scopus 로고    scopus 로고
    • Th17 cells and rheumatoid arthritis: from the standpoint of osteoclast differentiation
    • Sato K. Th17 cells and rheumatoid arthritis: from the standpoint of osteoclast differentiation. Allergol. Int. 2008, 57:109-114.
    • (2008) Allergol. Int. , vol.57 , pp. 109-114
    • Sato, K.1
  • 36
    • 0033765449 scopus 로고    scopus 로고
    • Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis
    • Schiff M.H. Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis. Ann. Rheum. Dis. 2000, 59:i103-i108.
    • (2000) Ann. Rheum. Dis. , vol.59
    • Schiff, M.H.1
  • 37
    • 0032199621 scopus 로고    scopus 로고
    • Update on treatment of rheumatoid arthritis
    • Schuna A.A. Update on treatment of rheumatoid arthritis. J. Am. Pharm. Assoc. (Wash.) 1998, 38:728-735.
    • (1998) J. Am. Pharm. Assoc. (Wash.) , vol.38 , pp. 728-735
    • Schuna, A.A.1
  • 40
    • 35948937642 scopus 로고    scopus 로고
    • Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy
    • Singh R., Aggarwal A., Misra R. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J. Rheumatol. 2007, 34:2285-2290.
    • (2007) J. Rheumatol. , vol.34 , pp. 2285-2290
    • Singh, R.1    Aggarwal, A.2    Misra, R.3
  • 41
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 42
    • 0031596140 scopus 로고    scopus 로고
    • Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts
    • Vincenti M.P., Coon C.I., Brinckerhoff C.E. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis. Rheum. 1998, 41:1987-1994.
    • (1998) Arthritis. Rheum. , vol.41 , pp. 1987-1994
    • Vincenti, M.P.1    Coon, C.I.2    Brinckerhoff, C.E.3
  • 43
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe E., Servant N., Zollinger R., Bogiatzi S.I., Hupé P., Barillot E., Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 2008, 9:650-657.
    • (2008) Nat. Immunol. , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupé, P.5    Barillot, E.6    Soumelis, V.7
  • 44
    • 45349102912 scopus 로고    scopus 로고
    • Suppressor activity among CD4+, CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha
    • Wang J., van Dongen H., Scherer H.U., Huizinga T.W., Toes R.E. Suppressor activity among CD4+, CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha. Arthritis. Rheum. 2008, 58:1609-1618.
    • (2008) Arthritis. Rheum. , vol.58 , pp. 1609-1618
    • Wang, J.1    van Dongen, H.2    Scherer, H.U.3    Huizinga, T.W.4    Toes, R.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.