Design, synthesis and antitumor cytotoxicity of novel bis-benzimidazoles

Anti-Cancer Drug Design

Volumn 15, Issue 4, 2000, Pages 265-275

  Singh, A K ^a   Lown, J W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anticancer; Bioreduction; Bisbenzimidazoles; Cytotoxic specificity; DNA binding

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (ACETOXYMETHYL) 1' METHYL 4',7' DIMETHOXY 5' BENZIMIDAZOLYL]IMIDAZO[4,5 B]PYRIDINE; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (ACETOXYMETHYL) 4',7' DIMETHOXY 5' BENZIMIDAZOLYL]IMIDAZO[4,5 B]PYRIDINE; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (CHLOROMETHYL) 1' METHYL 4',7' DIMETHOXY 5' BENZIMIDAZOLYL]IMIDAZO[4,5 B]PYRIDINE; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (CHLOROMETHYL) 1' METHYL 4',7' DIOXO,6' HYDROXY 5 BENZIMIDAZOLYL] IMIDAZO[4,5 B]PYRIDINE; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (METHOXYMETHYL) 1'METHYL 4',7' DIMETHOXY 5' BENZIMIDAZOLYL] IMIDAZO[4,5 B]PYRIDINE; 5 (4 METHYL 1 PIPERAZINYL) 2 [2' (METHOXYMETHYL) 4',7' DIMETHOXY 5' BENZIMIDAZOLYL]IMIDAZO[4,5 B]PYRIDINE; BENZIMIDAZOLE DERIVATIVE; CYCLOPROPAMITOSENE; MITOMYCIN C; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CYTOTOXICITY; DNA BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; KIDNEY CANCER; MELANOMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS, ALKYLATING; BENZIMIDAZOLES; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GROWTH INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

IVA;

EID: 0034489297     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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