Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7582-7589

  Kim, Jihoon ^a,b   Lee, Yu Jin ^a,b   Shin, Dae Seop ^a,b   Jeon, Sun Hee ^a   Son, Kwang Hee ^a,b   Han, Dong Cho ^a,b   Jung, Seung Nam ^a   Oh, Tae Kwang ^a,b   Kwon, Byoung Mog ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

Antitumor; Apoptosis; Breast cancer; Cosmomycin; Signal transducer and activator of transcription 3 (STAT3)

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; COSMOMYCIN C; CYCLIN D1; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; PROTEIN MCL 1; STAT3 PROTEIN; SURVIVIN; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

APOPTOSIS; ARTICLE; BCL XL GENE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIN D1 GENE; CYTOPLASM; DOWN REGULATION; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; DUAL LUCIFERASE ASSAY; ENZYMATIC ASSAY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MCL 1 GENE; METABOLOME; MOLECULAR LIBRARY; MYCELIUM; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STREPTOMYCES; SURVIVIN GENE; VEGF GENE;

ANTHRACYCLINES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; FEMALE; HUMANS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOMYCES;

STREPTOMYCES SP.;

EID: 82255183028     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.025     Document Type: Article

References (31)

1. J.F. Bromberg, M.H. Wrzeszczynska, G. Devgan, Y. Zhao, R.G. Pestell, C. Albanese, and J.E. Darnell Jr. Cell 98 1999 295
2. H. Yu, D. Pardoll, and R. Jove Nat. Rev. Cancer 9 2009 798
3. T.S. Migone, J.X. Lin, A. Cereseto, J.C. Mulloy, J.J. O'Shea, G. Franchini, and W.J. Leonard Science 269 1995 79
4. J.E. Darnell Jr. Science 277 1997 1630
5. A.R. Simon, H.G. Vikis, S. Stewart, B.L. Fanburg, B.H. Cochran, and K.L. Guan Science 290 2000 144
6. M. Berishaj, S.P. Gao, S. Ahmed, K. Leslie, H. Al-Ahmadie, W.L. Gerald, W. Bornmann, and J.F. Bromberg Breast Cancer Res. 9 2007 R32
7. K. Abe, M. Hirai, K. Mizuno, N. Higashi, T. Sekimoto, T. Miki, T. Hirano, and K. Nakajima Oncogene 20 2001 3464
8. P.J. Real, A. Sierra, A. De Juan, J.C. Segovia, J.M. Lopez-Vega, and J.L. Fernandez-Luna Oncogene 21 2002 7611
9. B.B. Aggarwal, G. Sethi, K.S. Ahn, S.K. Sandur, M.K. Pandey, A.B. Kunnumakkara, B. Sung, and H. Ichikawa Ann. N.Y. Acad. Sci. 1091 2006 151
10. G. Niu, K.L. Wright, M. Huang, L. Song, E. Haura, J. Turkson, S. Zhang, T. Wang, D. Sinibaldi, D. Coppola, R. Heller, L.M. Ellis, J. Karras, J.F. Bromberg, D. Pardoll, R. Jove, and H. Yu Oncogene 21 2002 2000
11. J.F. Bromberg Breast Cancer Res. 2 2000 86
12. R. Garcia, C.L. Yu, A. Hudnall, R. Catlett, K.L. Nelson, T. Smithgall, D.J. Fujita, S.P. Ethier, and R. Jove Cell Growth Differ. 8 1997 1267
13. H. Song, R. Wang, S. Wang, and J. Lin Proc. Natl. Acad. Sci. U.S.A. 102 2005 4700
14. S. Haftchenary, M. Avadisian, and P.T. Gunning Anti-Cancer Drugs 22 2011 115
15. D.S. Shin, H.N. Kim, K.D. Shin, Y.J. Yoon, S.J. Kim, D.C. Han, and B.M. Kwon Cancer Res. 69 2009 193
16. K. Lee, D.Z. Qian, S. Rey, H. Wei, J.O. Liu, and G.L. Semenza Proc. Natl. Acad. Sci. U.S.A. 106 2009 2353
17. G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni Pharmacol. Rev. 56 2004 185
18. P.J. Grohar, G.M. Woldemichael, L.B. Griffin, A. Mendoza, Q.R. Chen, C. Yeung, D.G. Currier, S. Davis, C. Khanna, J. Khan, J.B. McMahon, and L.J. Helman J. Natl. Cancer Inst. 103 2011 962
19. A. Cipollone, M. Berettoni, M. Bigioni, M. Binaschi, C. Cermele, E. Monteagudo, L. Olivieri, D. Palomba, F. Animati, C. Goso, and C.A. Maggi Bioorg. Med. Chem. 10 2002 1459
20. A. Shimosaka, Y. Hayakawa, M. Nakagawa, K. Furihata, H. Seto, and N. Otake J. Antibiot. 40 1987 116
21. M. Li, and Y.L. Chen J. Antibiot. 39 1986 430
22. H. Carvalho, L.M. Garrido, R.L. Furlan, G. Padilla, M. Agnoletto, T. Guecheva, J.A. Henriques, J. Saffi, and C.F. Menck Cancer Chemother. Pharmacol. 65 2010 989
23. R.L. Furlan, S.J. Watt, L.M. Garrido, G.P. Amarante-Mendes, M. Nur-e-alam, J. Rohr, A. Brana, C. Mendez, J.A. Salas, M.M. Sheil, J.L. Beck, and G. Padilla J. Antibiot. 57 2004 647
24. C. Kelso, V. Tillott, J.D. Rojas, R.L.A. Furlan, G. Padill, and J.L. Beck Arch. Biochem. Biophys. 477 2008 348
25. H. Yu, D. Pardoll, and R. Jove Nature Rev. Cancer 9 2009 798
26. R. Buettner, L.B. Mora, and R. Jove Clin. Cancer Res. 2 2002 945
27. R.J. Leeman, V.W. Lui, and J.R. Grandis Expert Opin. Biol. Ther. 6 2006 231
28. J. Ma, T. Zhang, V. Novotny-Diermayr, A.L. Tan, and X. Cao J. Biol. Chem. 278 2003 29252
29. D.A. Frank Cancer Lett. 251 2007 199
30. T. Gritsko, A. Williams, J. Turkson, S. Kaneko, T. Bowman, M. Huang, S. Nam, I. Eweis, N. Diaz, D. Sullivan, S. Yoder, S. Enkemann, S. Eschrich, J.H. Lee, C.A. Beam, J. Cheng, S. Minton, C.A. Muro-Cacho, and R. Jove Clin. Cancer Res. 12 2006 11
31. H. Matsushime, M.F. Roussel, R.A. Ashmun, and C.J. Sherr Cell 65 1991 701