Novel anthracycline oligosaccharides: Influence of chemical modifications of the carbohydrate moiety on biological activity

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 5, 2002, Pages 1459-1470

  Cipollone, A ^a   Berettoni, M ^a   Bigioni, M ^a   Binaschi, M ^a   Cermele, C ^a   Monteagudo, E ^a   Olivieri, L ^a   Palomba, D ^a   Animati, F ^a   Goso, C ^a   Maggi, C A ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 DEMETHOXY 14 HYDROXYDAUNOMYCINONE 7 O [4 O (3 AMINO 2,3,6 TRIDEOXY ALPHA LYXO HEXOPYRANOSYL) 2,6 DIDEOXY ALPHA LYXOHEXOPYRANOSIDE]; 7 [4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO ARABINOHEXOPYRANOSYL) 2,3,6 TRIDEOXY ALPHA LEVO LYXOHEXOPYRANOSYL] 4 DEMETHOXYADRIAMICINONE; 7 [4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO ARABINOHEXOPYRANOSYL) 2,6 DIDEOXY ALPHA LEVO LYXO HEXOPYRANOSYL] 4 DEMETHOXYADRIAMYCINONE; 7 [4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO LYXOHEXOPYRANOSYL) 2,3,6 TRIDEOXY ALPHA LEVO LYXO HEXOPYRANOSYL] 4 DEMETHOXYADRIAMYCINONE; 7 [4 O [4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO HEXOPYRANOSYL) 2,6 DIDEOXY ALPHA LEVO LYXOHEXOPYRANOSYL] 2,6 DIDEOXY ALPHA LEVO LYXO HEXOPYRONSYL] 4 DEMETHOXYADRIAMYCINONE; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CARBOHYDRATE; DNA; OLIGOSACCHARIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBOHYDRATE ANALYSIS; CELL LINE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG ACTIVITY; HUMAN; HUMAN CELL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIBIOTICS, ANTINEOPLASTIC; CARBOHYDRATES; CELL SURVIVAL; DNA; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OLIGOSACCHARIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 17744416365     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00411-4     Document Type: Article

References (35)