Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development

Breast Cancer Research

Volumn 2, Issue 2, 2000, Pages 86-90

  Bromberg, J ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Apoptosis; Breast development; Cancer; Involution; Signal transducers and activators of transcription (STATs)

Indexed keywords

ALPHA INTERFERON; CYTOKINE; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; GROWTH HORMONE; INSULIN; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 9; LEPTIN; PLATELET DERIVED GROWTH FACTOR; PROLACTIN; STAT PROTEIN; THROMBOPOETIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN;

APOPTOSIS; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; GROWTH REGULATION; HUMAN; INVOLUTION; MOUSE; NONHUMAN; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

APOPTOSIS; BREAST; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FEMALE; HUMANS; MILK PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0034469444     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr38     Document Type: Review

References (67)

1. STATs and gene regulation
2. How cells respond to interferons
3. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
4. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends on a protein tyrosine phosphatase
5. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1
6. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
7. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
8. Essential role of Stat6 in IL-4 signalling
9. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
10. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
11. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
12. Demonstration of an interferon gamma-dependent tumor surveillance system in immuno-competent mice
13. Transcriptionally active Stat1 is required for the antiproliferative effects of both IFN-α and IFN-γ
14. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
15. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
16. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
17. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
18. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) induction
19. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
20. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
21. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
22. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL is required for leukomogenesis
23. Multiple hormone interactions in the developmental biology of the mammary gland
24. Local effects of EGF, alpha-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo
25. Stat5a is mandatory for adult mammary gland development and lactogenesis
26. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation
27. Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression
28. Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis
29. ErbB receptor-induced activation of stat transcription factors is mediated by src tyrosine kinases
30. Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family
31. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
32. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
33. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
34. Stat3 activation is required for cellular transformation by v-src
35. Stat3 as an Oncogene
36. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
37. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
38. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
39. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
40. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6
41. Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells
42. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
43. Inducible gene targeting in mice
44. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific Stat3-deficient mice
45. Keratinocyte-specific ablation of stat3 exhibits impaired skin remodelling, but does not affect skin morphogenesis
46. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of STAT3
47. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line
48. A centrol role of Stat3 in IL6 induced regulation of growth and differentiation in M1 leukemia cells
49. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
50. STAT3 is required for the gp130-mediated full activation of the c-myc gene
51. The Myc oncoprotein: A critical evaluation of transactivation and target gene regulation
52. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
53. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
54. Structure and function of a new STAT-induced STAT inhibitor
55. Specific inhibition of Stat3 signal transduction by PIAS3
56. Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
57. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
58. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions
59. Refining the origins of breast cancer
60. Cyclin D1 and associated proteins in mammary ductal carcinoma in situ and atypical ductal hyperplasia
61. Cyclin D1 protein is overexpressed in hyperplasia and intraductal carcinoma of the breast
62. C-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer
63. Epidermal growth factor-dependent cell cycle progression is altered in mammary epithelial cells that overexpress c-myc
64. Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: Correlation with poor prognosis
65. Bcl-2 protein expression is associated with a prognostically favourable phenotype in breast cancer irrespective of p53 immunostaining
66. Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis
67. Apoptosis during breast carcinoma progression