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Volumn 18, Issue 35, 2011, Pages 5424-5429

The emerging role of large immunophilin FK506 binding protein 51 in cancer

Author keywords

Apoptosis; Cancer; FKBP51; NF B; Rapamycin

Indexed keywords

ANDROGEN RECEPTOR; ATORVASTATIN; CALCINEURIN; CHAPERONE; DOXORUBICIN; ESTROGEN RECEPTOR; EVEROLIMUS; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOPHILIN; INTERLEUKIN 2; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MOLECULAR SCAFFOLD; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN KINASE B; RAPAMYCIN; RIDAFOROLIMUS; STAT5 PROTEIN; TAU PROTEIN; TEMSIROLIMUS; TRANSCRIPTION FACTOR RELA; TUMOR PROMOTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 82255173727     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711798194333     Document Type: Article
Times cited : (35)

References (81)
  • 2
    • 1242292029 scopus 로고    scopus 로고
    • Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes
    • Fischer, G.; Aumüller, T. Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes. Rev Physiol Biochem Pharmacol, 2003, 148, 105-150.
    • (2003) Rev Physiol Biochem Pharmacol , vol.148 , pp. 105-150
    • Fischer, G.1    Aumüller, T.2
  • 4
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • DOI 10.1038/nrc1974, PII NRC1974
    • Sabatini, D. M. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer, 2006, 6(9), 729-734. (Pubitemid 44286004)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 6
    • 77949654801 scopus 로고    scopus 로고
    • FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A
    • Periyasamy, S.; Hinds, T. Jr.; Shemshedini, L.; Shou, W.; Sanchez, E. R. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene, 2010, 29(11), 1691-1701.
    • (2010) Oncogene , vol.29 , Issue.11 , pp. 1691-1701
    • Periyasamy, S.1    Hinds Jr., T.2    Shemshedini, L.3    Shou, W.4    Sanchez, E.R.5
  • 8
    • 23744494993 scopus 로고    scopus 로고
    • Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
    • DOI 10.1182/blood-2005-03-0929
    • Avellino, R.; Romano, S.; Parasole, R.; Bisogni, R.; Lamberti, A.; Poggi, V.; Venuta, S.; Romano, M. F. Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood, 2005, 106(4), 1400-1406. (Pubitemid 41129607)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1400-1406
    • Avellino, R.1    Romano, S.2    Parasole, R.3    Bisogni, R.4    Lamberti, A.5    Poggi, V.6    Venuta, S.7    Romano, M.F.8
  • 9
    • 9644252848 scopus 로고    scopus 로고
    • Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells
    • DOI 10.1016/j.ejca.2004.08.017, PII S095980490400704X
    • Romano, M. F.; Avellino, R.; Petrella, A.; Bisogni, R.; Romano, S.; Venuta, S. Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer, 2004, 40(18), 2829-2836. (Pubitemid 39574738)
    • (2004) European Journal of Cancer , vol.40 , Issue.18 , pp. 2829-2836
    • Romano, M.F.1    Avellino, R.2    Petrella, A.3    Bisogni, R.4    Romano, S.5    Venuta, S.6
  • 11
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T.; Hall, M. N. TOR, a central controller of cell growth. Cell, 2000, 103(2), 253-262.
    • (2000) Cell , vol.103 , Issue.2 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 12
    • 40349098670 scopus 로고    scopus 로고
    • FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-κB signaling pathway
    • DOI 10.1593/neo.07929
    • Jiang, W.; Cazacu, S.; Xiang, C.; Zenklusen, J. C.; Fine, H. A.; Berens, M.; Armstrong, B.; Brodie, C.; Mikkelsen, T. FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia, 2008, 10(3), 235-243. (Pubitemid 351337518)
    • (2008) Neoplasia , vol.10 , Issue.3 , pp. 235-243
    • Jiang, W.1    Cazacu, S.2    Xiang, C.3    Zenklusen, J.C.4    Fine, H.A.5    Berens, M.6    Armstrong, B.7    Brodie, C.8    Mikkelsen, T.9
  • 14
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • DOI 10.1101/gad.1102703
    • Hogan, P. G.; Chen, L.; Nardone, J.; Rao, A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev, 2003, 17(18), 2205-2232. (Pubitemid 37128637)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 15
    • 33845961032 scopus 로고    scopus 로고
    • Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins
    • DOI 10.1021/bi061616p
    • Weiwad, M.; Edlich, F.; Kilka, S.; Erdmann, F.; Jarczowski, F.; Dorn, M.; Moutty, M. C.; Fischer, G. Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. Biochemistry, 2006, 45(51), 15776-15784. (Pubitemid 46032498)
    • (2006) Biochemistry , vol.45 , Issue.51 , pp. 15776-15784
    • Weiwad, M.1    Edlich, F.2    Kilka, S.3    Erdmann, F.4    Jarczowski, F.5    Dorn, M.6    Moutty, M.-C.7    Fischer, G.8
  • 16
    • 0038269022 scopus 로고    scopus 로고
    • C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90
    • DOI 10.1074/jbc.M300955200
    • Cheung-Flynn, J.; Roberts, P. J.; Riggs, D. L.; Smith, D. F. C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. J Biol Chem, 2003, 278(19), 17388-17394. (Pubitemid 36799624)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.19 , pp. 17388-17394
    • Cheung-Flynn, J.1    Roberts, P.J.2    Riggs, D.L.3    Smith, D.F.4
  • 17
    • 0034463399 scopus 로고    scopus 로고
    • Molecular chaperone interactions with steroid receptors: An update
    • DOI 10.1210/me.14.7.939
    • Cheung, J.; Smith, D. F. Molecular chaperone interactions with steroid receptors: an update. Mol Endocrinol, 2000, 14(7), 939-946. (Pubitemid 32250512)
    • (2000) Molecular Endocrinology , vol.14 , Issue.7 , pp. 939-946
    • Cheung, J.1    Smith, D.F.2
  • 19
    • 0022918191 scopus 로고
    • A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors
    • DOI 10.1021/bi00366a043
    • Tai, P. K.; Maeda, Y.; Nakao, K.; Wakim, N. G.; Duhring, J. L.; Faber, L. E. A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors. Biochemistry, 1986, 5269-5275. (Pubitemid 17016541)
    • (1986) Biochemistry , vol.25 , Issue.18 , pp. 5269-5275
    • Tai Maeda, P.-K.K.Y.1    Nakao, K.2
  • 20
    • 37049025017 scopus 로고    scopus 로고
    • Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity
    • DOI 10.1021/bi701372c
    • Gallo, L. I.; Ghini, A. A.; Pilipuk, G. P.; Galigniana, M. D. Differential Recruitment of Tetratricorpeptide Repeat Domain Immunophilins to the Mineralocorticoid Receptor Influences both Heat-Shock Protein 90-Dependent Retrotransport and Hormone-Dependent Transcriptional Activity. Biochemistry, 2007, 46, 14044-14057. (Pubitemid 350250300)
    • (2007) Biochemistry , vol.46 , Issue.49 , pp. 14044-14057
    • Gallo, L.I.1    Ghini, A.A.2    Pilipuk, G.P.3    Galigniana, M.D.4
  • 21
    • 17144370286 scopus 로고    scopus 로고
    • Androgen mediated regulation and functional implications of FKBP51 expression in prostate cancer
    • DOI 10.1097/01.ju.0000155845.44729.ba
    • Febbo, P. G.; Lowenberg, M.; Thorner, A. R.; Brown, M.; Loda, M.; Golub, T. R. Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer. J Urol, 2005, 173, 1772-1777. (Pubitemid 40524830)
    • (2005) Journal of Urology , vol.173 , Issue.5 , pp. 1772-1777
    • Febbo, P.G.1    Lowenberg, M.2    Thorner, A.R.3    Brown, M.4    Loda, M.5    Golub, T.R.6
  • 23
    • 80051935829 scopus 로고    scopus 로고
    • The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 Is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
    • Gallo, L. I.; Lagadari, M.; Piwien-Pilipuk, G.; Galigniana, M. D. The 90-kDa Heat-shock Protein (Hsp90)-binding Immunophilin FKBP51 Is a Mitochondrial Protein That Translocates to the Nucleus to Protect Cells against Oxidative Stress. J Biol Chem, 2011, 286(34), 30152-30160.
    • (2011) J Biol Chem , vol.286 , Issue.34 , pp. 30152-30160
    • Gallo, L.I.1    Lagadari, M.2    Piwien-Pilipuk, G.3    Galigniana, M.D.4
  • 25
    • 0002792366 scopus 로고    scopus 로고
    • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
    • Goedert, M.; Wischik, C. M.; Crowther, R. A.; Walker, J. E.; Klug, A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA, 2000, 85(11), 4051-4055.
    • (2000) Proc Natl Acad Sci USA , vol.85 , Issue.11 , pp. 4051-4055
    • Goedert, M.1    Wischik, C.M.2    Crowther, R.A.3    Walker, J.E.4    Klug, A.5
  • 27
    • 0031945523 scopus 로고    scopus 로고
    • Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506- binding protein-like protein, has a dramatic effect on plant development
    • Vittorioso, P.; Cowling, R.; Faure, J. D.; Caboche, M.; Bellini, C. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Molecular and Cellular biology, 1998, 18(5), 3034-3043. (Pubitemid 28183472)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 3034-3043
    • Vittorioso, P.1    Cowling, R.2    Faure, J.-D.3    Caboche, M.4    Bellini, C.5
  • 28
    • 33847650121 scopus 로고    scopus 로고
    • Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages
    • DOI 10.1634/stemcells.2006-0394
    • Liu, T. M.; Martina, M.; Hutmacher, D. W.; Hui, J. H.; Lee, E. H.; Lim, B. Identification of common pathways mediating differentiation of bone marrow-and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem cells, 2007, 25(3), 750-760. (Pubitemid 46354235)
    • (2007) Stem Cells , vol.25 , Issue.3 , pp. 750-760
    • Tong, M.L.1    Martina, M.2    Hutmacher, D.W.3    Hui, J.H.P.O.4    Eng, H.L.5    Lim, B.6
  • 31
    • 0028885873 scopus 로고
    • Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
    • Yeh, W. C.; Bierer, B. E.; McKnight, S. L. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad U S A, 1995, 92(24), 11086-11890.
    • (1995) Proc Natl Acad U S A , vol.92 , Issue.24 , pp. 11086-11890
    • Yeh, W.C.1    Bierer, B.E.2    McKnight, S.L.3
  • 35
    • 20244377844 scopus 로고    scopus 로고
    • Role for the nuclear factor κB pathway in transforming growth factor-β1 production in idiopathic myelofibrosis: Possible relationship with FK506 binding protein 51 overexpression
    • Komura, E.; Tonetti, C.; Penard-Lacronique, V.; Chagraoui, H.; Lacout, C.; Lecouédic, J. P.; Rameau, P.; Debili, N.; Vainchenker, W.; Giraudier S. Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression. Cancer Res, 2005, 65(8), 3281-3289. (Pubitemid 40524612)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3281-3289
    • Komura, E.1    Tonetti, C.2    Penard-Lacronique, V.3    Chagraoui, H.4    Lacout, C.5    LeCouedic, J.P.6    Rameau, P.7    Debili, N.8    Vainchenker, W.9    Giraudier, S.10
  • 36
    • 80051673317 scopus 로고    scopus 로고
    • FKBP51 and the NF-kappaB regulatory pathway in cancer
    • Romano, S.; Mallardo, M.; Romano, M. F. FKBP51 and the NF-kappaB regulatory pathway in cancer. Curr Opin Pharmacol, 2011, 11(4), 288-293.
    • (2011) Curr Opin Pharmacol , vol.11 , Issue.4 , pp. 288-293
    • Romano, S.1    Mallardo, M.2    Romano, M.F.3
  • 38
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan, N.; Di Donato, J. A.; Rosette, C.; Helmberg, A.; Karin, M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science, 1995, 270(5234), 286-290.
    • (1995) Science , vol.270 , Issue.5234 , pp. 286-290
    • Auphan, N.1    Di Donato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 39
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
    • Ray, A.; Prefontaine, K. E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. P roc Natl Acad Sci U S A, 1994, 91(2), 752-756. (Pubitemid 24041480)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.2 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 40
    • 0028831128 scopus 로고
    • Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors
    • Scheinman, R. I.; Gualberto, A.; Jewell, CM.; Cidlowski, J. A.; Baldwin, A. S. Jr. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol, 1995, 15(2), 943-953.
    • (1995) Mol Cell Biol , vol.15 , Issue.2 , pp. 943-953
    • Scheinman, R.I.1    Gualberto, A.2    Jewell, C.M.3    Cidlowski, J.A.4    Baldwin Jr., A.S.5
  • 42
  • 43
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • DOI 10.1146/annurev.immunol.14.1.649
    • Baldwin, A. S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol, 1996, 14, 649-683. (Pubitemid 26130197)
    • (1996) Annual Review of Immunology , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 44
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and rel proteins: Evolutionarily conserved mediators of immune responses
    • DOI 10.1146/annurev.immunol.16.1.225
    • Ghosh, S.; May, M. J.; Kopp, E. B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune response. Annu Rev Immunol, 1998, 16, 225-260. (Pubitemid 28183365)
    • (1998) Annual Review of Immunology , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 45
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin, M.; Cao, X.; Greten, F. R.; Li, Z. W. NF-kappaB in cancer: from innocent bystander to major culprit, Nat Rev Cancer, 2002, 2(4), 301-310. (Pubitemid 37328783)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.4 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.-W.4
  • 46
    • 0034745420 scopus 로고    scopus 로고
    • NF-κB-inducing kinase regulates the processing of NF-κB2 p100
    • DOI 10.1016/S1097-2765(01)00187-3
    • Xiao, G.; Harhaj, E. W.; Sun, S. C. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell, 2001, 7(2), 401-409. (Pubitemid 32206507)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.-C.3
  • 47
    • 34047248402 scopus 로고    scopus 로고
    • Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB
    • Huang, W. C.; Ju, T. K.; Hung, M. C.; Chen, C. C. Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Molecular Cell, 2007, 26(1), 75-87.
    • (2007) Molecular Cell , vol.26 , Issue.1 , pp. 75-87
    • Huang, W.C.1    Ju, T.K.2    Hung, M.C.3    Chen, C.C.4
  • 52
    • 77956236967 scopus 로고    scopus 로고
    • Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases
    • Mistafa, O.; Ghalali, A.; Kadekar, S.; Högberg, J.; Stenius, U. Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem, 2010, 285(36), 27900-27910.
    • (2010) J Biol Chem , vol.285 , Issue.36 , pp. 27900-27910
    • Mistafa, O.1    Ghalali, A.2    Kadekar, S.3    Högberg, J.4    Stenius, U.5
  • 53
    • 0031575750 scopus 로고    scopus 로고
    • Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition
    • DOI 10.1006/bbrc.1997.6307
    • Baughman, G.; Wiederrecht, G. J.; Chang, F.; Martin, MM.; Bourgeois, S. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition. Biochem Biophys Res Commun, 1997, 232(2), 437-443. (Pubitemid 27216235)
    • (1997) Biochemical and Biophysical Research Communications , vol.232 , Issue.2 , pp. 437-443
    • Baughman, G.1    Wiederrecht, G.J.2    Chang, F.3    Martin, M.M.4    Bourgeois, S.5
  • 54
    • 79957461151 scopus 로고    scopus 로고
    • FKBP51 protects 661w cell culture from staurosporineinduced apoptosis
    • Daudt DR, Yorio T. FKBP51 protects 661w cell culture from staurosporineinduced apoptosis. Mol Vis. 2011, 17:1172-1181.
    • (2011) Mol Vis. , vol.17 , pp. 1172-1181
    • Daudt, D.R.1    Yorio, T.2
  • 55
    • 76749108107 scopus 로고    scopus 로고
    • FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    • Ni, L.; Yang, C. S.; Gioeli, D.; Frierson, H.; Toft, D. O.; Paschal, BM. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol, 2010, 30(5), 1243-1253.
    • (2010) Mol Cell Biol , vol.30 , Issue.5 , pp. 1243-1253
    • Ni, L.1    Yang, C.S.2    Gioeli, D.3    Frierson, H.4    Toft, D.O.5    Paschal, B.M.6
  • 56
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • Ammirante, M.; Luo, J. L.; Grivennikov, S.; Nedospasov, S.; Karin, M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature, 2010, 464(7286), 302-305.
    • (2010) Nature , vol.464 , Issue.7286 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 57
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi, J.; Chen, J.; Schreiber, S. L.; Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science, 1996, 273(5272), 239-242. (Pubitemid 26285890)
    • (1996) Science , vol.273 , Issue.5272 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 59
    • 0026759874 scopus 로고
    • Rapamycininduced inhibition of the 70-kilodalton S6 protein kinase
    • Price, D. J.; Grove, J. R.; Calvo, V.; Avruch, J.; Bierer, B. E. Rapamycininduced inhibition of the 70-kilodalton S6 protein kinase. Science, 1992, 257(5072), 973-977.
    • (1992) Science , vol.257 , Issue.5072 , pp. 973-977
    • Price, D.J.1    Grove, J.R.2    Calvo, V.3    Avruch, J.4    Bierer, B.E.5
  • 61
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • DOI 10.1101/gad.887201
    • Gingras, A. C.; Raught, B.; Sonenberg, N. Regulation of translation initiation by FRAP/mTOR. Genes Dev, 2001, 15(7), 807-826. (Pubitemid 32295062)
    • (2001) Genes and Development , vol.15 , Issue.7 , pp. 807-826
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 62
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering, B. M.; Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature, 1995, 376(6541), 599-602.
    • (1995) Nature , vol.376 , Issue.6541 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 63
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • DOI 10.1101/gad.901101
    • Gao, X.; Pan, D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev, 2001, 15(11), 1383-1392. (Pubitemid 32524645)
    • (2001) Genes and Development , vol.15 , Issue.11 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 66
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • Mita, M. M.; Mita, A.; Rowinsky, E. K. The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther, 2003, 2, S169-77.
    • (2003) Cancer Biol Ther , vol.2
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 68
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • DOI 10.1038/sj.onc.1206451, Melanoma
    • Wu, H.; Goel, V.; Haluska, F. G. PTEN signaling pathways in melanoma. Oncogene, 2003, 22(20), 3113-22. (Pubitemid 36713763)
    • (2003) Oncogene , vol.22 , Issue.20 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 69
    • 0035504081 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
    • DOI 10.1038/sj.onc.1204926
    • Catz, S. D.; Johnson, J. L. Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene, 2001, 20(50), 7342-7351. (Pubitemid 33078205)
    • (2001) Oncogene , vol.20 , Issue.50 , pp. 7342-7351
    • Catz, S.D.1    Johnson, J.L.2
  • 70
    • 0032516651 scopus 로고    scopus 로고
    • IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
    • Wu, M. X.; Ao, Z.; Prasad, K. V. S.; Wu, R.; Schlossman, S. F. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Science, 1998, 281(5379), 998-999.
    • (1998) Science , vol.281 , Issue.5379 , pp. 998-999
    • Wu, M.X.1    Ao, Z.2    Prasad, K.V.S.3    Wu, R.4    Schlossman, S.F.5
  • 71
    • 0038792322 scopus 로고    scopus 로고
    • Combined treatment of Bcl-2 antisense oligodeoxynucleotides (G3139), p-glycoprotein inhibitor (PSC833), and sterically stabilized liposomal doxorubicin suppresses growth of drug-resistant growth of drug-resistant breast cancer in severely combined immunodeficient mice
    • DOI 10.1046/j.1359-4117.2003.01075.x
    • Lopes de Menezes, D. E.; Hu, Y.; Mayer, L. D. Combined treatment of Bcl-2 antisense oligodeoxynucleotides (G3139), p-glycoprotein inhibitor (PSC833), and sterically stabilized liposomal doxorubicin suppresses growth of drug-resistant growth of drug-resistant breast cancer in severely combined immunodeficient mice. J Exp Ther Oncol, 2003, 3(2), 72-82. (Pubitemid 36702520)
    • (2003) Journal of Experimental Therapeutics and Oncology , vol.3 , Issue.2 , pp. 72-82
    • Lopes De Menezes, D.E.1    Hu, Y.2    Mayer, L.D.3
  • 74
    • 82255181334 scopus 로고    scopus 로고
    • Rapamycin controls multiple signalling pathways involved in cancer cell survival
    • Nova Publishers
    • Romano, M. F.; Romano, S.; Mallardo, M.; Bisogni, R.; Venuta, S. Rapamycin controls multiple signalling pathways involved in cancer cell survival. Cell Apoptosis Research Trends. Nova Publishers, 2007, 263-276.
    • (2007) Cell Apoptosis Research Trends , pp. 263-276
    • Romano, M.F.1    Romano, S.2    Mallardo, M.3    Bisogni, R.4    Venuta, S.5
  • 75
    • 48949098967 scopus 로고    scopus 로고
    • New insights into the mechanisms of macroautophagy in mammalian cells
    • Eskelinen, E. L. New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol, 2008, 266, 207-247.
    • (2008) Int Rev Cell Mol Biol , vol.266 , pp. 207-247
    • Eskelinen, E.L.1
  • 78
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • DOI 10.1038/nrc2419, PII NRC2419
    • Baumann, M.; Krause, M.; Hill, R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer, 2008, 8, 545-54. (Pubitemid 351881850)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 80
  • 81
    • 51649100465 scopus 로고    scopus 로고
    • Behavioral genetics of the depression/cancer correlation: A look at the Ras oncogene family and the 'cerebral diabetes paradigm
    • Brewer, J. K. Behavioral genetics of the depression/cancer correlation: a look at the Ras oncogene family and the 'cerebral diabetes paradigm. J Mol Neurosc, 2008, 35(3), 307-322.
    • (2008) J Mol Neurosc , vol.35 , Issue.3 , pp. 307-322
    • Brewer, J.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.