Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 27900-27910

  Mistafa, Oras ^a   Ghalali, Aram ^a   Kadekar, Sandeep ^a   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; COORDINATION REACTIONS; ENZYME ACTIVITY; NUCLEIC ACIDS; PHOSPHORYLATION; PROTEINS;

A549 CELLS; CALCINEURIN; CANCER DEVELOPMENT; CELL CYCLE; CHEMICAL INHIBITION; COMPLEX FORMATIONS; CYCLIND1; DOWNSTREAM TARGET; EXTRACELLULAR ATP; FK506-BINDING PROTEINS; IMMUNOCYTOLOGY; IMMUNOPHILINS; IMMUNOPRECIPITATIONS; LEUCINE-RICH REPEATS; NUCLEAR MEMBRANES; OKADAIC ACID; ONCOPROTEINS; PLECKSTRIN HOMOLOGY DOMAINS; PROLIFERATING CELL NUCLEAR ANTIGENS; PROSTATE CANCER CELLS; PROTEIN PHOSPHATASE 2A; PURINERGIC RECEPTORS; SIGNALING PATHWAYS; STATINS;

PHOSPHATASES;

ADENOSINE TRIPHOSPHATE; ATORVASTATIN; CALCINEURIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; FK 506 BINDING PROTEIN; OKADAIC ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PLECKSTRIN HOMOLOGY DOMAIN LEUCINE RICH REPEAT PHOSPHATASE; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EGTAZIC ACID; ENZYME INHIBITOR; HEPTANOIC ACID DERIVATIVE; P2RX7 PROTEIN, HUMAN; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2; PURINERGIC P2 RECEPTOR; PYRROLE DERIVATIVE; TACROLIMUS BINDING PROTEIN 5;

ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; DOSE RESPONSE; DRUG EFFECTS; KINETICS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE; UBIQUITINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCINEURIN; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENZYME ACTIVATION; ENZYME INHIBITORS; HEPTANOIC ACIDS; HUMANS; KINETICS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRROLES; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; TACROLIMUS BINDING PROTEINS; UBIQUITINATION;

EID: 77956236967     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.117093     Document Type: Article

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