-
1
-
-
0017136711
-
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)
-
Sporn, M. B., Dunlop, N. M., Newton, D. L. & Smith, J. M. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed. Proc. 35, 1332-1338 (1976).
-
(1976)
Fed. Proc.
, vol.35
, pp. 1332-1338
-
-
Sporn, M.B.1
Dunlop, N.M.2
Newton, D.L.3
Smith, J.M.4
-
2
-
-
79959403574
-
Exemestane for breast-cancer prevention in postmenopausal women
-
Goss, P. E. et al. Exemestane for breast-cancer prevention in postmenopausal women. N. Engl. J. Med. 364, 2381-2391 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2381-2391
-
-
Goss, P.E.1
-
3
-
-
77349090257
-
Lasofoxifene in postmenopausal women with osteoporosis
-
Cummings, S. R. et al. Lasofoxifene in postmenopausal women with osteoporosis. N. Engl. J. Med. 362, 686-696 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 686-696
-
-
Cummings, S.R.1
-
4
-
-
77953529620
-
Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: Preventing breast cancer
-
Vogel, V. G. et al. Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: preventing breast cancer. Cancer Prev. Res. (Phila) 3, 696-706 (2010).
-
(2010)
Cancer Prev. Res. (Phila)
, vol.3
, pp. 696-706
-
-
Vogel, V.G.1
-
5
-
-
67650496219
-
Cancer prevention: From 1727 to milestones of the past 100 years
-
Lippman, S. M. & Hawk, E. T. Cancer prevention: from 1727 to milestones of the past 100 years. Cancer Res. 69, 5269-5284 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 5269-5284
-
-
Lippman, S.M.1
Hawk, E.T.2
-
6
-
-
77950498003
-
Effect of dutasteride on the risk of prostate cancer
-
Andriole, G. L. et al. Effect of dutasteride on the risk of prostate cancer. N. Engl. J. Med. 362, 1192-1202 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1192-1202
-
-
Andriole, G.L.1
-
7
-
-
0037812658
-
The influence of finasteride on the development of prostate cancer
-
Thompson, I. M. et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 349, 215-224 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 215-224
-
-
Thompson, I.M.1
-
8
-
-
33748196958
-
Celecoxib for the prevention of sporadic colorectal adenomas
-
Bertagnolli, M. M. et al. Celecoxib for the prevention of sporadic colorectal adenomas. N. Engl. J. Med. 355, 873-884 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 873-884
-
-
Bertagnolli, M.M.1
-
9
-
-
79957830986
-
C-reactive protein and risk of colorectal adenoma according to celecoxib treatment
-
Chan, A. T. et al. C-reactive protein and risk of colorectal adenoma according to celecoxib treatment. Cancer Prev. Res. (Phila) 4, 1172-1180 (2011).
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 1172-1180
-
-
Chan, A.T.1
-
10
-
-
76149136014
-
Prevalence of tamoxifen use for breast cancer chemoprevention among. US women
-
Waters, E. A., Cronin, K. A., Graubard, B. I., Han, P. K. & Freedman, A. N. Prevalence of tamoxifen use for breast cancer chemoprevention among, US women. Cancer Epidemiol. Biomarkers Prev. 19, 443-446 (2010).
-
(2010)
Cancer Epidemiol. Biomarkers Prev.
, vol.19
, pp. 443-446
-
-
Waters, E.A.1
Cronin, K.A.2
Graubard, B.I.3
Han, P.K.4
Freedman, A.N.5
-
11
-
-
79959199141
-
Benefit/Risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older
-
Freedman, A. N. et al. Benefit/Risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older. J. Clin. Oncol. 29, 2327-2333 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2327-2333
-
-
Freedman, A.N.1
-
12
-
-
79960210525
-
The risks and benefits of 5a-reductase inhibitors for prostate-cancer prevention
-
Theoret, M. R. et al. The risks and benefits of 5a-reductase inhibitors for prostate-cancer prevention. N. Engl. J. Med. 365, 97-99 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 97-99
-
-
Theoret, M.R.1
-
13
-
-
79955466351
-
Regulatory approval of cancer risk-reducing (chemopreventive). Drugs: Moving what we have learned into the clinic
-
Meyskens, F. L. Jr et al. Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic. Cancer Prev. Res. (Phila) 4, 311-323 (2011).
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 311-323
-
-
Meyskens Jr., F.L.1
-
14
-
-
77958028795
-
Intermittent androgen suppression for prostate cancer
-
Buchan, N. C. & Goldenberg, S. L. Intermittent androgen suppression for prostate cancer. Nature Rev. Urol. 7, 552-560 (2010).
-
(2010)
Nature Rev. Urol.
, vol.7
, pp. 552-560
-
-
Buchan, N.C.1
Goldenberg, S.L.2
-
15
-
-
0033041892
-
Determination of an optimal dosing regimen for aspirin chemoprevention of 1, 2-dimethylhydrazine-induced colon tumours in rats
-
Barnes, C. J. & Lee, M. Determination of an optimal dosing regimen for aspirin chemoprevention of 1, 2-dimethylhydrazine-induced colon tumours in rats. Br. J. Cancer 79, 1646-1650 (1999).
-
(1999)
Br. J. Cancer
, vol.79
, pp. 1646-1650
-
-
Barnes, C.J.1
Lee, M.2
-
16
-
-
0029048396
-
Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
-
Primiano, T. et al. Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res. 55, 4319-4324 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4319-4324
-
-
Primiano, T.1
-
17
-
-
2442688166
-
The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer
-
Rendi, M. H. et al. The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. Cancer Res. 64, 3566-3571 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 3566-3571
-
-
Rendi, M.H.1
-
18
-
-
67650096861
-
Continuous finasteride therapy for benign prostate hypertrophy upgrades both neuroendorcine differentiation and aggressive prostate cancer
-
Tarle, M., Spajic, B., Kraljic, I. & Kusic, Z. Continuous finasteride therapy for benign prostate hypertrophy upgrades both neuroendorcine differentiation and aggressive prostate cancer. Anticancer Res. 29, 1797-1801 (2009).
-
(2009)
Anticancer Res.
, vol.29
, pp. 1797-1801
-
-
Tarle, M.1
Spajic, B.2
Kraljic, I.3
Kusic, Z.4
-
19
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
20
-
-
2442561553
-
Apoptosis as a novel target for cancer chemoprevention
-
Sun, S. Y., Hail, N. Jr & Lotan, R. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer Inst. 96, 662-672 (2004).
-
(2004)
J. Natl. Cancer Inst.
, vol.96
, pp. 662-672
-
-
Sun, S.Y.1
Hail Jr., N.2
Lotan, R.3
-
21
-
-
62349119760
-
High-dose fenretinide in oral leukoplakia
-
William, W. N. Jr et al. High-dose fenretinide in oral leukoplakia. Cancer Prev. Res. (Phila) 2, 22-26 (2009).
-
(2009)
Cancer Prev. Res. (Phila)
, vol.2
, pp. 22-26
-
-
William Jr., W.N.1
-
22
-
-
78650569570
-
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
-
Qiu, W. et al. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc. Natl Acad. Sci. USA 107, 20027-20032 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 20027-20032
-
-
Qiu, W.1
-
23
-
-
55549132996
-
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
-
Meyskens, F. L. Jr. et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev. Res. (Phila) 1, 32-38 (2008).
-
(2008)
Cancer Prev. Res. (Phila)
, vol.1
, pp. 32-38
-
-
Meyskens Jr., F.L.1
-
24
-
-
0036310589
-
Rectal epithelial apoptosis does not predict response to sulindac treatment or polyp development in presymptomatic familial adenomatous polyposis patients
-
Keller, J. J., Offerhaus, G. J., Hylind, L. M. & Giardiello, F. M. Rectal epithelial apoptosis does not predict response to sulindac treatment or polyp development in presymptomatic familial adenomatous polyposis patients. Cancer Epidemiol. Biomarkers Prev. 11, 670-671 (2002).
-
(2002)
Cancer Epidemiol. Biomarkers Prev.
, vol.11
, pp. 670-671
-
-
Keller, J.J.1
Offerhaus, G.J.2
Hylind, L.M.3
Giardiello, F.M.4
-
25
-
-
79955831572
-
Back to the future: Mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach
-
Meyskens, F. L. Jr & Gerner, E. W. Back to the future: mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach. Cancer Prev. Res. (Phila) 4, 628-632 (2011).
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 628-632
-
-
Meyskens Jr., F.L.1
Gerner, E.W.2
-
26
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
27
-
-
28844507883
-
Mutant KRAS in the initiation of pancreatic cancer
-
Deramaudt, T. & Rustgi, A. K. Mutant KRAS in the initiation of pancreatic cancer. Biochim. Biophys. Acta 1756, 97-101 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, pp. 97-101
-
-
Deramaudt, T.1
Rustgi, A.K.2
-
28
-
-
52649131951
-
Lung cancer
-
Herbst, R. S., Heymach, J. V. & Lippman, S. M. Lung cancer. N. Engl. J. Med. 359, 1367-1380 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1367-1380
-
-
Herbst, R.S.1
Heymach, J.V.2
Lippman, S.M.3
-
29
-
-
77954706620
-
Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer
-
Taoudi Benchekroun, M. et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev. Res. (Phila) 3, 800-809 (2010).
-
(2010)
Cancer Prev. Res. (Phila)
, vol.3
, pp. 800-809
-
-
Taoudi Benchekroun, M.1
-
30
-
-
61449259809
-
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
-
Tang, X. et al. Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas. Cancer Prev. Res. (Phila) 1, 192-200 (2008).
-
(2008)
Cancer Prev. Res. (Phila)
, vol.1
, pp. 192-200
-
-
Tang, X.1
-
31
-
-
34347363140
-
Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas
-
Sakamoto, H. et al. Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas. J. Pathol. 212, 287-294 (2007).
-
(2007)
J. Pathol.
, vol.212
, pp. 287-294
-
-
Sakamoto, H.1
-
32
-
-
80051534901
-
Targeting the HER/EGFR/ErbB family to prevent breast cancer
-
Howe, L. R. & Brown, P. H. Targeting the HER/EGFR/ErbB family to prevent breast cancer. Cancer Prev. Res. (Phila). 4, 1149-1157 (2011).
-
(2011)
Cancer Prev. Res. (Phila).
, vol.4
, pp. 1149-1157
-
-
Howe, L.R.1
Brown, P.H.2
-
33
-
-
84872625067
-
Genetics of Natural Populations. Xiii. Recombination and variability in populations of Drosophila melanogaster
-
Dobzhansky, T. Genetics of Natural Populations. Xiii. Recombination and variability in populations of Drosophila melanogaster. Genetics 31, 269-290 (1946).
-
(1946)
Genetics
, vol.31
, pp. 269-290
-
-
Dobzhansky, T.1
-
34
-
-
0014285011
-
Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanogaster
-
Lucchesi, J. C. Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanogaster. Genetics 59, 37-44 (1968).
-
(1968)
Genetics
, vol.59
, pp. 37-44
-
-
Lucchesi, J.C.1
-
35
-
-
0027515605
-
Synthetic enhancement in gene interaction: A genetic tool come of age
-
Guarente, L. Synthetic enhancement in gene interaction: a genetic tool come of age. Trends Genet. 9, 362-366 (1993).
-
(1993)
Trends Genet.
, vol.9
, pp. 362-366
-
-
Guarente, L.1
-
36
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin, W. G. Jr. The concept of synthetic lethality in the context of anticancer therapy. Nature Rev. Cancer 5, 689-698 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 689-698
-
-
Kaelin Jr., W.G.1
-
37
-
-
70349912096
-
Exploiting synthetic lethal interactions for targeted cancer therapy
-
Reinhardt, H. C., Jiang, H., Hemann, M. T. & Yaffe, M. B. Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle 8, 3112-3119 (2009).
-
(2009)
Cell Cycle 8
, pp. 3112-3119
-
-
Reinhardt, H.C.1
Jiang, H.2
Hemann, M.T.3
Yaffe, M.B.4
-
38
-
-
77951134107
-
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
-
Zhang, L. et al. Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464, 1058-1061 (2010).
-
(2010)
Nature
, vol.464
, pp. 1058-1061
-
-
Zhang, L.1
-
39
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
Pitti, R. M. et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12687-12690
-
-
Pitti, R.M.1
-
40
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley, S. R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682 (1995).
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
-
41
-
-
3342894130
-
Targeting death receptors in cancer with Apo2L/TRAIL
-
Kelley, S. K. & Ashkenazi, A. Targeting death receptors in cancer with Apo2L/TRAIL. Curr. Opin. Pharmacol. 4, 333-339 (2004).
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 333-339
-
-
Kelley, S.K.1
Ashkenazi, A.2
-
42
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick, M. R. et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12, 599-609 (2000).
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
-
43
-
-
0034037333
-
Apoptosis induced by death receptors
-
Schneider, P. & Tschopp, J. Apoptosis induced by death receptors. Pharm. Acta. Helv. 74, 281-286 (2000).
-
(2000)
Pharm. Acta. Helv.
, vol.74
, pp. 281-286
-
-
Schneider, P.1
Tschopp, J.2
-
44
-
-
34447094000
-
TRAIL signalling: Decisions between life and death
-
Falschlehner, C., Emmerich, C. H., Gerlach, B. & Walczak, H. TRAIL signalling: decisions between life and death. Int. J. Biochem. Cell Biol. 39, 1462-1475 (2007).
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 1462-1475
-
-
Falschlehner, C.1
Emmerich, C.H.2
Gerlach, B.3
Walczak, H.4
-
45
-
-
34547819299
-
The promise of TRAIL-potential and risks of a novel anticancer therapy
-
Koschny, R., Walczak, H. & Ganten, T. M. The promise of TRAIL-potential and risks of a novel anticancer therapy. J. Mol. Med. 85, 923-935 (2007).
-
(2007)
J. Mol. Med.
, vol.85
, pp. 923-935
-
-
Koschny, R.1
Walczak, H.2
Ganten, T.M.3
-
46
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi, A. et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162 (1999).
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
-
47
-
-
0034812659
-
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
-
Kelley, S. K. et al. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther. 299, 31-38 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 31-38
-
-
Kelley, S.K.1
-
48
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence, D. et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nature Med. 7, 383-385 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
-
49
-
-
77956414973
-
Phase i dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
-
Herbst, R. S. et al. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J. Clin. Oncol. 28, 2839-2846 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2839-2846
-
-
Herbst, R.S.1
-
50
-
-
76749110412
-
A phase i safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies
-
Camidge, D. R. et al. A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies. Clin. Cancer Res. 16, 1256-1263 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1256-1263
-
-
Camidge, D.R.1
-
51
-
-
34248187996
-
Phase i pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
Tolcher, A. W. et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J. Clin. Oncol. 25, 1390-1395 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1390-1395
-
-
Tolcher, A.W.1
-
52
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/TRAIL
-
Gonzalvez, F. & Ashkenazi, A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29, 4752-4765 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.1
Ashkenazi, A.2
-
53
-
-
84876085177
-
Targeting c-FLIP in cancer
-
9 Nov 2010 doi:10.1016/j.canlet.2010.10.009
-
Shirley, S. & Micheau, O. Targeting c-FLIP in cancer. Cancer Lett. 9 Nov 2010 (doi:10.1016/j.canlet.2010.10.009).
-
Cancer Lett.
-
-
Shirley, S.1
Micheau, O.2
-
54
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner, K. W. et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nature Med. 13, 1070-1077 (2007).
-
(2007)
Nature Med.
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
-
55
-
-
20444490754
-
Getting at MYC through RAS
-
Bachireddy, P., Bendapudi, P. K. & Felsher, D. W. Getting at MYC through RAS. Clin. Cancer Res. 11, 4278-4281 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 4278-4281
-
-
Bachireddy, P.1
Bendapudi, P.K.2
Felsher, D.W.3
-
56
-
-
79955872479
-
Lung cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo
-
Huang, S., Ren, X., Wang, L., Zhang, L. & Wu, X. Lung cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo. Cancer Prev. Res. (Phila) 4, 666-673 (2011).
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 666-673
-
-
Huang, S.1
Ren, X.2
Wang, L.3
Zhang, L.4
Wu, X.5
-
57
-
-
66149091940
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
-
58
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
Scholl, C. et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-834 (2009).
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
-
59
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917 (2005).
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
-
60
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
-
61
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
-
62
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh, M. W. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 376, 245-251 (2010).
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
-
63
-
-
77955019962
-
Can we define tumours that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer
-
Gelmon, K. A. et al. Can we define tumours that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. J. Clin. Oncol. Abstr. 28, 3002 (2010).
-
(2010)
J. Clin. Oncol. Abstr.
, vol.28
, pp. 3002
-
-
Gelmon, K.A.1
-
64
-
-
34347273049
-
Prostate cancer progression and survival in BRCA2 mutation carriers
-
Tryggvadottir, L. et al. Prostate cancer progression and survival in BRCA2 mutation carriers. J. Natl. Cancer Inst. 99, 929-935 (2007).
-
(2007)
J. Natl. Cancer Inst.
, vol.99
, pp. 929-935
-
-
Tryggvadottir, L.1
-
65
-
-
79952409338
-
Targeting the missing links for cancer therapy
-
Polyak, K. & Garber, J. Targeting the missing links for cancer therapy. Nature Med. 17, 283-284 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 283-284
-
-
Polyak, K.1
Garber, J.2
-
66
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg, S. et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl Acad. Sci. USA 105, 17079-17084 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
-
67
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
Ashkenazi, A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nature Rev. Cancer 2, 420-430 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
69
-
-
49649108897
-
Prevention of breast cancer using SERMs
-
Powles, T. J. Prevention of breast cancer using SERMs. Adv. Exp. Med. Biol. 630, 232-236 (2008).
-
(2008)
Adv. Exp. Med. Biol.
, vol.630
, pp. 232-236
-
-
Powles, T.J.1
-
70
-
-
0025817880
-
Identification of FAP locus genes from chromosome 5q21
-
Kinzler, K. W. et al. Identification of FAP locus genes from chromosome 5q21. Science 253, 661-665 (1991).
-
(1991)
Science
, vol.253
, pp. 661-665
-
-
Kinzler, K.W.1
-
71
-
-
0028350369
-
Familial adenomatous polyposis (FAP): Frequency, penetrance, and mutation rate
-
Bisgaard, M. L., Fenger, K., Bulow, S., Niebuhr, E. & Mohr, J. Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. Hum. Mutat. 3, 121-125 (1994).
-
(1994)
Hum. Mutat.
, vol.3
, pp. 121-125
-
-
Bisgaard, M.L.1
Fenger, K.2
Bulow, S.3
Niebuhr, E.4
Mohr, J.5
-
72
-
-
46449094710
-
Chemoprevention with special reference to inherited colorectal cancer
-
Lynch, P. M. Chemoprevention with special reference to inherited colorectal cancer. Fam. Cancer 7, 59-64 (2008).
-
(2008)
Fam. Cancer
, vol.7
, pp. 59-64
-
-
Lynch, P.M.1
-
73
-
-
33749021639
-
The current status of chemoprevention in FAP
-
Wallace, M. H. & Lynch, P. M. The current status of chemoprevention in FAP. Fam. Cancer 5, 289-296 (2006).
-
(2006)
Fam. Cancer
, vol.5
, pp. 289-296
-
-
Wallace, M.H.1
Lynch, P.M.2
-
74
-
-
0025015168
-
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
-
Moser, A. R., Pitot, H. C. & Dove, W. F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324 (1990).
-
(1990)
Science
, vol.247
, pp. 322-324
-
-
Moser, A.R.1
Pitot, H.C.2
Dove, W.F.3
-
75
-
-
0026562404
-
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
-
Su, L. K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 668-670 (1992).
-
(1992)
Science
, vol.256
, pp. 668-670
-
-
Su, L.K.1
-
76
-
-
0031568788
-
A mouse model of human familial adenomatous polyposis
-
Yang, K. et al. A mouse model of human familial adenomatous polyposis. J. Exp. Zool. 277, 245-254 (1997).
-
(1997)
J. Exp. Zool.
, vol.277
, pp. 245-254
-
-
Yang, K.1
-
77
-
-
0028567875
-
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
-
Fodde, R. et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl Acad. Sci. USA 91, 8969-8973 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 8969-8973
-
-
Fodde, R.1
-
78
-
-
3242772301
-
Colon cancer: Genomics and apoptotic events
-
Rupnarain, C., Dlamini, Z., Naicker, S. & Bhoola, K. Colon cancer: genomics and apoptotic events. Biol. Chem. 385, 449-464 (2004).
-
(2004)
Biol. Chem.
, vol.385
, pp. 449-464
-
-
Rupnarain, C.1
Dlamini, Z.2
Naicker, S.3
Bhoola, K.4
-
79
-
-
79955592811
-
Harnessing synthetic lethal interactions in anticancer drug discovery
-
Chan, D. A. & Giaccia, A. J. Harnessing synthetic lethal interactions in anticancer drug discovery. Nature Rev. Drug Discov. 10, 351-364 (2011).
-
(2011)
Nature Rev. Drug Discov.
, vol.10
, pp. 351-364
-
-
Chan, D.A.1
Giaccia, A.J.2
|