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Volumn 11, Issue 12, 2011, Pages 879-885

An intermittent approach for cancer chemoprevention

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; DROZITUMAB; EFLORNITHINE; MAPATUMUMAB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; OLAPARIB; RETINOL ACETATE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SULINDAC; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 81855207248     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3167     Document Type: Review
Times cited : (44)

References (79)
  • 1
    • 0017136711 scopus 로고
    • Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)
    • Sporn, M. B., Dunlop, N. M., Newton, D. L. & Smith, J. M. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed. Proc. 35, 1332-1338 (1976).
    • (1976) Fed. Proc. , vol.35 , pp. 1332-1338
    • Sporn, M.B.1    Dunlop, N.M.2    Newton, D.L.3    Smith, J.M.4
  • 2
    • 79959403574 scopus 로고    scopus 로고
    • Exemestane for breast-cancer prevention in postmenopausal women
    • Goss, P. E. et al. Exemestane for breast-cancer prevention in postmenopausal women. N. Engl. J. Med. 364, 2381-2391 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2381-2391
    • Goss, P.E.1
  • 3
    • 77349090257 scopus 로고    scopus 로고
    • Lasofoxifene in postmenopausal women with osteoporosis
    • Cummings, S. R. et al. Lasofoxifene in postmenopausal women with osteoporosis. N. Engl. J. Med. 362, 686-696 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 686-696
    • Cummings, S.R.1
  • 4
    • 77953529620 scopus 로고    scopus 로고
    • Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: Preventing breast cancer
    • Vogel, V. G. et al. Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: preventing breast cancer. Cancer Prev. Res. (Phila) 3, 696-706 (2010).
    • (2010) Cancer Prev. Res. (Phila) , vol.3 , pp. 696-706
    • Vogel, V.G.1
  • 5
    • 67650496219 scopus 로고    scopus 로고
    • Cancer prevention: From 1727 to milestones of the past 100 years
    • Lippman, S. M. & Hawk, E. T. Cancer prevention: from 1727 to milestones of the past 100 years. Cancer Res. 69, 5269-5284 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5269-5284
    • Lippman, S.M.1    Hawk, E.T.2
  • 6
    • 77950498003 scopus 로고    scopus 로고
    • Effect of dutasteride on the risk of prostate cancer
    • Andriole, G. L. et al. Effect of dutasteride on the risk of prostate cancer. N. Engl. J. Med. 362, 1192-1202 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1192-1202
    • Andriole, G.L.1
  • 7
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson, I. M. et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 349, 215-224 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 215-224
    • Thompson, I.M.1
  • 8
    • 33748196958 scopus 로고    scopus 로고
    • Celecoxib for the prevention of sporadic colorectal adenomas
    • Bertagnolli, M. M. et al. Celecoxib for the prevention of sporadic colorectal adenomas. N. Engl. J. Med. 355, 873-884 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 873-884
    • Bertagnolli, M.M.1
  • 9
    • 79957830986 scopus 로고    scopus 로고
    • C-reactive protein and risk of colorectal adenoma according to celecoxib treatment
    • Chan, A. T. et al. C-reactive protein and risk of colorectal adenoma according to celecoxib treatment. Cancer Prev. Res. (Phila) 4, 1172-1180 (2011).
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 1172-1180
    • Chan, A.T.1
  • 11
    • 79959199141 scopus 로고    scopus 로고
    • Benefit/Risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older
    • Freedman, A. N. et al. Benefit/Risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older. J. Clin. Oncol. 29, 2327-2333 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2327-2333
    • Freedman, A.N.1
  • 12
    • 79960210525 scopus 로고    scopus 로고
    • The risks and benefits of 5a-reductase inhibitors for prostate-cancer prevention
    • Theoret, M. R. et al. The risks and benefits of 5a-reductase inhibitors for prostate-cancer prevention. N. Engl. J. Med. 365, 97-99 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 97-99
    • Theoret, M.R.1
  • 13
    • 79955466351 scopus 로고    scopus 로고
    • Regulatory approval of cancer risk-reducing (chemopreventive). Drugs: Moving what we have learned into the clinic
    • Meyskens, F. L. Jr et al. Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic. Cancer Prev. Res. (Phila) 4, 311-323 (2011).
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 311-323
    • Meyskens Jr., F.L.1
  • 14
    • 77958028795 scopus 로고    scopus 로고
    • Intermittent androgen suppression for prostate cancer
    • Buchan, N. C. & Goldenberg, S. L. Intermittent androgen suppression for prostate cancer. Nature Rev. Urol. 7, 552-560 (2010).
    • (2010) Nature Rev. Urol. , vol.7 , pp. 552-560
    • Buchan, N.C.1    Goldenberg, S.L.2
  • 15
    • 0033041892 scopus 로고    scopus 로고
    • Determination of an optimal dosing regimen for aspirin chemoprevention of 1, 2-dimethylhydrazine-induced colon tumours in rats
    • Barnes, C. J. & Lee, M. Determination of an optimal dosing regimen for aspirin chemoprevention of 1, 2-dimethylhydrazine-induced colon tumours in rats. Br. J. Cancer 79, 1646-1650 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 1646-1650
    • Barnes, C.J.1    Lee, M.2
  • 16
    • 0029048396 scopus 로고
    • Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
    • Primiano, T. et al. Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res. 55, 4319-4324 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4319-4324
    • Primiano, T.1
  • 17
    • 2442688166 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer
    • Rendi, M. H. et al. The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. Cancer Res. 64, 3566-3571 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3566-3571
    • Rendi, M.H.1
  • 18
    • 67650096861 scopus 로고    scopus 로고
    • Continuous finasteride therapy for benign prostate hypertrophy upgrades both neuroendorcine differentiation and aggressive prostate cancer
    • Tarle, M., Spajic, B., Kraljic, I. & Kusic, Z. Continuous finasteride therapy for benign prostate hypertrophy upgrades both neuroendorcine differentiation and aggressive prostate cancer. Anticancer Res. 29, 1797-1801 (2009).
    • (2009) Anticancer Res. , vol.29 , pp. 1797-1801
    • Tarle, M.1    Spajic, B.2    Kraljic, I.3    Kusic, Z.4
  • 19
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 20
    • 2442561553 scopus 로고    scopus 로고
    • Apoptosis as a novel target for cancer chemoprevention
    • Sun, S. Y., Hail, N. Jr & Lotan, R. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer Inst. 96, 662-672 (2004).
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 662-672
    • Sun, S.Y.1    Hail Jr., N.2    Lotan, R.3
  • 21
    • 62349119760 scopus 로고    scopus 로고
    • High-dose fenretinide in oral leukoplakia
    • William, W. N. Jr et al. High-dose fenretinide in oral leukoplakia. Cancer Prev. Res. (Phila) 2, 22-26 (2009).
    • (2009) Cancer Prev. Res. (Phila) , vol.2 , pp. 22-26
    • William Jr., W.N.1
  • 22
    • 78650569570 scopus 로고    scopus 로고
    • Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
    • Qiu, W. et al. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc. Natl Acad. Sci. USA 107, 20027-20032 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20027-20032
    • Qiu, W.1
  • 23
    • 55549132996 scopus 로고    scopus 로고
    • Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
    • Meyskens, F. L. Jr. et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev. Res. (Phila) 1, 32-38 (2008).
    • (2008) Cancer Prev. Res. (Phila) , vol.1 , pp. 32-38
    • Meyskens Jr., F.L.1
  • 24
    • 0036310589 scopus 로고    scopus 로고
    • Rectal epithelial apoptosis does not predict response to sulindac treatment or polyp development in presymptomatic familial adenomatous polyposis patients
    • Keller, J. J., Offerhaus, G. J., Hylind, L. M. & Giardiello, F. M. Rectal epithelial apoptosis does not predict response to sulindac treatment or polyp development in presymptomatic familial adenomatous polyposis patients. Cancer Epidemiol. Biomarkers Prev. 11, 670-671 (2002).
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , pp. 670-671
    • Keller, J.J.1    Offerhaus, G.J.2    Hylind, L.M.3    Giardiello, F.M.4
  • 25
    • 79955831572 scopus 로고    scopus 로고
    • Back to the future: Mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach
    • Meyskens, F. L. Jr & Gerner, E. W. Back to the future: mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach. Cancer Prev. Res. (Phila) 4, 628-632 (2011).
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 628-632
    • Meyskens Jr., F.L.1    Gerner, E.W.2
  • 26
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 27
    • 28844507883 scopus 로고    scopus 로고
    • Mutant KRAS in the initiation of pancreatic cancer
    • Deramaudt, T. & Rustgi, A. K. Mutant KRAS in the initiation of pancreatic cancer. Biochim. Biophys. Acta 1756, 97-101 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1756 , pp. 97-101
    • Deramaudt, T.1    Rustgi, A.K.2
  • 29
    • 77954706620 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer
    • Taoudi Benchekroun, M. et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev. Res. (Phila) 3, 800-809 (2010).
    • (2010) Cancer Prev. Res. (Phila) , vol.3 , pp. 800-809
    • Taoudi Benchekroun, M.1
  • 30
    • 61449259809 scopus 로고    scopus 로고
    • Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
    • Tang, X. et al. Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas. Cancer Prev. Res. (Phila) 1, 192-200 (2008).
    • (2008) Cancer Prev. Res. (Phila) , vol.1 , pp. 192-200
    • Tang, X.1
  • 31
    • 34347363140 scopus 로고    scopus 로고
    • Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas
    • Sakamoto, H. et al. Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas. J. Pathol. 212, 287-294 (2007).
    • (2007) J. Pathol. , vol.212 , pp. 287-294
    • Sakamoto, H.1
  • 32
    • 80051534901 scopus 로고    scopus 로고
    • Targeting the HER/EGFR/ErbB family to prevent breast cancer
    • Howe, L. R. & Brown, P. H. Targeting the HER/EGFR/ErbB family to prevent breast cancer. Cancer Prev. Res. (Phila). 4, 1149-1157 (2011).
    • (2011) Cancer Prev. Res. (Phila). , vol.4 , pp. 1149-1157
    • Howe, L.R.1    Brown, P.H.2
  • 33
    • 84872625067 scopus 로고
    • Genetics of Natural Populations. Xiii. Recombination and variability in populations of Drosophila melanogaster
    • Dobzhansky, T. Genetics of Natural Populations. Xiii. Recombination and variability in populations of Drosophila melanogaster. Genetics 31, 269-290 (1946).
    • (1946) Genetics , vol.31 , pp. 269-290
    • Dobzhansky, T.1
  • 34
    • 0014285011 scopus 로고
    • Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanogaster
    • Lucchesi, J. C. Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanogaster. Genetics 59, 37-44 (1968).
    • (1968) Genetics , vol.59 , pp. 37-44
    • Lucchesi, J.C.1
  • 35
    • 0027515605 scopus 로고
    • Synthetic enhancement in gene interaction: A genetic tool come of age
    • Guarente, L. Synthetic enhancement in gene interaction: a genetic tool come of age. Trends Genet. 9, 362-366 (1993).
    • (1993) Trends Genet. , vol.9 , pp. 362-366
    • Guarente, L.1
  • 36
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin, W. G. Jr. The concept of synthetic lethality in the context of anticancer therapy. Nature Rev. Cancer 5, 689-698 (2005).
    • (2005) Nature Rev. Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 37
    • 70349912096 scopus 로고    scopus 로고
    • Exploiting synthetic lethal interactions for targeted cancer therapy
    • Reinhardt, H. C., Jiang, H., Hemann, M. T. & Yaffe, M. B. Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle 8, 3112-3119 (2009).
    • (2009) Cell Cycle 8 , pp. 3112-3119
    • Reinhardt, H.C.1    Jiang, H.2    Hemann, M.T.3    Yaffe, M.B.4
  • 38
    • 77951134107 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
    • Zhang, L. et al. Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464, 1058-1061 (2010).
    • (2010) Nature , vol.464 , pp. 1058-1061
    • Zhang, L.1
  • 39
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • Pitti, R. M. et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 12687-12690
    • Pitti, R.M.1
  • 40
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley, S. R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682 (1995).
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1
  • 41
    • 3342894130 scopus 로고    scopus 로고
    • Targeting death receptors in cancer with Apo2L/TRAIL
    • Kelley, S. K. & Ashkenazi, A. Targeting death receptors in cancer with Apo2L/TRAIL. Curr. Opin. Pharmacol. 4, 333-339 (2004).
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 333-339
    • Kelley, S.K.1    Ashkenazi, A.2
  • 42
    • 0033667778 scopus 로고    scopus 로고
    • FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    • Sprick, M. R. et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12, 599-609 (2000).
    • (2000) Immunity , vol.12 , pp. 599-609
    • Sprick, M.R.1
  • 43
    • 0034037333 scopus 로고    scopus 로고
    • Apoptosis induced by death receptors
    • Schneider, P. & Tschopp, J. Apoptosis induced by death receptors. Pharm. Acta. Helv. 74, 281-286 (2000).
    • (2000) Pharm. Acta. Helv. , vol.74 , pp. 281-286
    • Schneider, P.1    Tschopp, J.2
  • 45
    • 34547819299 scopus 로고    scopus 로고
    • The promise of TRAIL-potential and risks of a novel anticancer therapy
    • Koschny, R., Walczak, H. & Ganten, T. M. The promise of TRAIL-potential and risks of a novel anticancer therapy. J. Mol. Med. 85, 923-935 (2007).
    • (2007) J. Mol. Med. , vol.85 , pp. 923-935
    • Koschny, R.1    Walczak, H.2    Ganten, T.M.3
  • 46
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi, A. et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 155-162
    • Ashkenazi, A.1
  • 47
    • 0034812659 scopus 로고    scopus 로고
    • Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
    • Kelley, S. K. et al. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther. 299, 31-38 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 31-38
    • Kelley, S.K.1
  • 48
    • 0035050960 scopus 로고    scopus 로고
    • Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
    • Lawrence, D. et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nature Med. 7, 383-385 (2001).
    • (2001) Nature Med. , vol.7 , pp. 383-385
    • Lawrence, D.1
  • 49
    • 77956414973 scopus 로고    scopus 로고
    • Phase i dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
    • Herbst, R. S. et al. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J. Clin. Oncol. 28, 2839-2846 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2839-2846
    • Herbst, R.S.1
  • 50
    • 76749110412 scopus 로고    scopus 로고
    • A phase i safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies
    • Camidge, D. R. et al. A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies. Clin. Cancer Res. 16, 1256-1263 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1256-1263
    • Camidge, D.R.1
  • 51
    • 34248187996 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher, A. W. et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J. Clin. Oncol. 25, 1390-1395 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1
  • 52
    • 77956170550 scopus 로고    scopus 로고
    • New insights into apoptosis signaling by Apo2L/TRAIL
    • Gonzalvez, F. & Ashkenazi, A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29, 4752-4765 (2010).
    • (2010) Oncogene , vol.29 , pp. 4752-4765
    • Gonzalvez, F.1    Ashkenazi, A.2
  • 53
    • 84876085177 scopus 로고    scopus 로고
    • Targeting c-FLIP in cancer
    • 9 Nov 2010 doi:10.1016/j.canlet.2010.10.009
    • Shirley, S. & Micheau, O. Targeting c-FLIP in cancer. Cancer Lett. 9 Nov 2010 (doi:10.1016/j.canlet.2010.10.009).
    • Cancer Lett.
    • Shirley, S.1    Micheau, O.2
  • 54
    • 34948894931 scopus 로고    scopus 로고
    • Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
    • Wagner, K. W. et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nature Med. 13, 1070-1077 (2007).
    • (2007) Nature Med. , vol.13 , pp. 1070-1077
    • Wagner, K.W.1
  • 56
    • 79955872479 scopus 로고    scopus 로고
    • Lung cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo
    • Huang, S., Ren, X., Wang, L., Zhang, L. & Wu, X. Lung cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo. Cancer Prev. Res. (Phila) 4, 666-673 (2011).
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 666-673
    • Huang, S.1    Ren, X.2    Wang, L.3    Zhang, L.4    Wu, X.5
  • 57
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.1
  • 58
    • 65849111219 scopus 로고    scopus 로고
    • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
    • Scholl, C. et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-834 (2009).
    • (2009) Cell , vol.137 , pp. 821-834
    • Scholl, C.1
  • 59
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917 (2005).
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1
  • 60
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1
  • 61
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 123-134
    • Fong, P.C.1
  • 62
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh, M. W. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 376, 245-251 (2010).
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1
  • 63
    • 77955019962 scopus 로고    scopus 로고
    • Can we define tumours that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer
    • Gelmon, K. A. et al. Can we define tumours that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. J. Clin. Oncol. Abstr. 28, 3002 (2010).
    • (2010) J. Clin. Oncol. Abstr. , vol.28 , pp. 3002
    • Gelmon, K.A.1
  • 64
    • 34347273049 scopus 로고    scopus 로고
    • Prostate cancer progression and survival in BRCA2 mutation carriers
    • Tryggvadottir, L. et al. Prostate cancer progression and survival in BRCA2 mutation carriers. J. Natl. Cancer Inst. 99, 929-935 (2007).
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 929-935
    • Tryggvadottir, L.1
  • 65
    • 79952409338 scopus 로고    scopus 로고
    • Targeting the missing links for cancer therapy
    • Polyak, K. & Garber, J. Targeting the missing links for cancer therapy. Nature Med. 17, 283-284 (2011).
    • (2011) Nature Med. , vol.17 , pp. 283-284
    • Polyak, K.1    Garber, J.2
  • 66
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg, S. et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl Acad. Sci. USA 105, 17079-17084 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17079-17084
    • Rottenberg, S.1
  • 67
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi, A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nature Rev. Cancer 2, 420-430 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 420-430
    • Ashkenazi, A.1
  • 69
    • 49649108897 scopus 로고    scopus 로고
    • Prevention of breast cancer using SERMs
    • Powles, T. J. Prevention of breast cancer using SERMs. Adv. Exp. Med. Biol. 630, 232-236 (2008).
    • (2008) Adv. Exp. Med. Biol. , vol.630 , pp. 232-236
    • Powles, T.J.1
  • 70
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler, K. W. et al. Identification of FAP locus genes from chromosome 5q21. Science 253, 661-665 (1991).
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1
  • 71
    • 0028350369 scopus 로고
    • Familial adenomatous polyposis (FAP): Frequency, penetrance, and mutation rate
    • Bisgaard, M. L., Fenger, K., Bulow, S., Niebuhr, E. & Mohr, J. Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. Hum. Mutat. 3, 121-125 (1994).
    • (1994) Hum. Mutat. , vol.3 , pp. 121-125
    • Bisgaard, M.L.1    Fenger, K.2    Bulow, S.3    Niebuhr, E.4    Mohr, J.5
  • 72
    • 46449094710 scopus 로고    scopus 로고
    • Chemoprevention with special reference to inherited colorectal cancer
    • Lynch, P. M. Chemoprevention with special reference to inherited colorectal cancer. Fam. Cancer 7, 59-64 (2008).
    • (2008) Fam. Cancer , vol.7 , pp. 59-64
    • Lynch, P.M.1
  • 73
    • 33749021639 scopus 로고    scopus 로고
    • The current status of chemoprevention in FAP
    • Wallace, M. H. & Lynch, P. M. The current status of chemoprevention in FAP. Fam. Cancer 5, 289-296 (2006).
    • (2006) Fam. Cancer , vol.5 , pp. 289-296
    • Wallace, M.H.1    Lynch, P.M.2
  • 74
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser, A. R., Pitot, H. C. & Dove, W. F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324 (1990).
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 75
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su, L. K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 668-670 (1992).
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1
  • 76
    • 0031568788 scopus 로고    scopus 로고
    • A mouse model of human familial adenomatous polyposis
    • Yang, K. et al. A mouse model of human familial adenomatous polyposis. J. Exp. Zool. 277, 245-254 (1997).
    • (1997) J. Exp. Zool. , vol.277 , pp. 245-254
    • Yang, K.1
  • 77
    • 0028567875 scopus 로고
    • A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
    • Fodde, R. et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl Acad. Sci. USA 91, 8969-8973 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 8969-8973
    • Fodde, R.1
  • 79
    • 79955592811 scopus 로고    scopus 로고
    • Harnessing synthetic lethal interactions in anticancer drug discovery
    • Chan, D. A. & Giaccia, A. J. Harnessing synthetic lethal interactions in anticancer drug discovery. Nature Rev. Drug Discov. 10, 351-364 (2011).
    • (2011) Nature Rev. Drug Discov. , vol.10 , pp. 351-364
    • Chan, D.A.1    Giaccia, A.J.2


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