Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor

Toxicology and Applied Pharmacology

Volumn 257, Issue 2, 2011, Pages 165-173

  Choi, Sunga ^a   Lim, Mi Hee ^b   Kim, Ki Mo ^c   Jeon, Byeong Hwa ^a   Song, Won O ^d   Kim, Tae Woong ^b  

^a Chungnam National University   (South Korea)

^b Kangwon National University   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^d Michigan State University   (United States)

Author keywords

Apoptosis; Autophagy; Cordycepin; Estrogen Receptor

Indexed keywords

CASPASE 3; CASPASE 9; CORDYCEPIN; CYTOCHROME C; ESTROGEN RECEPTOR; PROTEIN BAX;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORDYCEPS; DNA DEGRADATION; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; NICK END LABELING;

APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL LINE, TUMOR; DEOXYADENOSINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; RECEPTORS, ESTROGEN;

CORDYCEPS;

EID: 81855185492     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.08.030     Document Type: Article

References (43)

1. Ahn S.H. Clinical Characteristics of Breast Cancer Patients in Korea in Year 2000. J. Korean Breast Cancer Soc. 2002, 5:217-224.
2. Amaravadi R.K., Yu D., Lum J.J., Bui T., Christophorou M.A., Evan G.I., Thomas-Tikhonenko A., Thompson C.B. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 2007, 117:326-336.
3. Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J. Nutr. 2004, 134:1134-1138.
4. Bilir A., Altinoz M.A., Erkan M., Ozmen V., Aydiner A. Autophagy and nuclear changes in FM3A breast tumor cells after epirubicin, medroxyprogesterone and tamoxifen treatment in vitro. Pathobiology 2001, 69:120-126.
5. Bommareddy A., Hahm E.R., Xiao D., Powolny A.A., Fisher A.L., Jiang Y., Singh S.V. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res. 2009, 69:3704-3712.
6. Bowen I.D., Mullarkey K., Morgan S.M. Programmed cell death during metamorphosis in the blow-fly Calliphora vomitoria. Micrisc. Res. Tech. 1996, 34:202-217.
7. Chang W., Lim S., Song H., Song B.W., Kim H.J., Cha M.J., Sung J.M., Kim T., Hwang K.C. Cordycepin inhibits vascular smooth muscle cell proliferation. Eur. J. Pharmacol. 2008, 597:64-69.
8. Cho M.A., Lee D.S., Kim M.J., Sung J.M., Ham S.S. Antimutagenicity and Cytotoxicity of Cordycepin Isolated from Cordyceps militaris. Food Sci. Biotechnol. 2003, 12:472-475.
9. Cho H.J., Cho J.Y., Rhee M.H., Kim H.S., Lee H.S., Park H.J. Inhibitory effects of cordycepin (3'-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin. J. Microbiol. Biotechnol. 2007, 17:1134-1138.
10. Choi S., Singh S.V. Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable derived cancer chemopreventive agent. Cancer Res. 2005, 65:2035-2043.
11. Choi S., Kim T.W., Singh S.V. Ginsenoside Rh2-mediated G1 Phase Cell Cycle Arrest in Human Breast Cancer Cells Is Caused by p15Ink4B and p27Kip1-dependent Inhibition of Cyclindependent Kinases. Pharm. Res. 2009, 26:2280-2288.
12. Codogno P., Meijer A.J. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 2005, 12:1509-1518.
13. DeSantis C., Jemal A., Ward E., Thun M.J. Temporal trends in breast cancer mortality by state and race. Cancer Causes Control 2008, 19:537-545.
14. Fuqua S.A., Schiff R., Parra I., Moore J.T., Mohsin S.K., Osborne C.K., Clark G.M., Allred D.C. Estrogen receptor β protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res. 2003, 63:2434-2439.
15. Huang S., Houghton P.J. Targeting m-TOR signaling for cancer therapy. Curr. Opin. Pharmacol. 2003, 3:371-377.
16. Iwamaru A., Kondo Y., Iwado E., Aoki H., Fujiwara K., Yokoyama T., Mills G.B., Kondo S. Silencing mammalian target of rapamycin signaling bysmall interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007, 26:1840-1851.
17. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., Thun M.J. Cancer statistics. CA Cancer J. Clin. 2008, 58:71-96.
18. Jen C.Y., Lin C.Y., Leu S.F., Huang B.M. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway. Evid. Based Complement. Altern. Med. 2009, [Epub ahead of print. 10.1093/ecam/nen084.
19. Jia L., Dourmashkin R.R., Allen P.D., Gray A.B., Newland A.C., Kelsey S.M. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br. J. Haematol. 1997, 98:673-685.
20. Kanzawa T., Kondo Y., Ito H., Kondo S., Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003, 63:2103-2108.
21. Kanzawa T., Germano I.M., Komata T., Ito H., Kondo Y., Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 2004, 11:448-457.
22. Katzenellenbogen B.S., Montano M.M., Ediger T.R., Sun J., Ekena K., Lazennec G., Martini P.G., McInerney E.M., Delage-Mourroux R., Weis K., Katzenellenbogen J.A. Estrogen receptors: selective ligands, partners, and distinctive pharmacology. Recent Prog. Horm. Res. 2005, 55:163-193.
23. Kuo P.L., Hsu Y.L., Cho C.Y. Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol. Cancer Ther. 2006, 5:3209-3221.
24. Lee E.J., Kim W.J., Moon S.K. Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells. Phytother. Res. 2010, 24:1755-1761.
25. Lockshin R.A., Zakeri Z. Apoptosis, autophagy, and more. Int. J. Biochem. Cell Biol. 2004, 36:2405-2419.
26. Munafó D.B., Colombo M.I. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 2001, 114:3619-3629.
27. Myzak M.C., Hardin K., Wang R., Dashwood R.H., Ho E. Sulforaphane inhibits histone deacetylase activity in BPH-1, LNCaP and PC-3 prostate epithelial cells. Carcinogenesis 2006, 27:811-819.
28. Nakamura K., Konoha K., Yoshikawa N., Yamaguchi Y., Kagota S., Shinozuka K., Kunitomo M. Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo 2005, 19:137-141.
29. Nilsson S., Mäkelä S., Treuter E., Tujague M., Thomsen J., Andersson G., Enmark E., Pettersson K., Warner M., Gustafsson J.A. Mechanisms of estrogen action. Physiol. Rev. 2001, 81:1535-1565.
30. Okoh V., Deoraj A., Roy D. Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. Biochim. Biophys. Acta 2011, 1815:115-133.
31. Paruthiyil S., Parmar H., Kerekatte V., Cunha G.R., Firestone G.L., Leitman D.C. Estrogen Receptor β Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest. Cancer Res. 2004, 64:423-428.
32. Shi P., Huang Z., Tan X., Chen G. Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells. Meth. Find. Exp. Clin. Pharmacol. 2008, 30:347-353.
33. Shin S., Lee S., Kwon J., Moon S., Lee S., Lee C.K., Cho K., Ha N.J., Kim K. Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages. Immune Netw. 2009, 9(3):98-105.
34. Singh A.V., Xiao D., Lew K.L., Dhir R., Singh S.V. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 2004, 25:83-90.
35. Singh S.V., Herman-Antosiewicz A., Singh A.V., Lew K.L., Srivastava S.K., Kamath R., Brown K.D., Zhang L., Baskaran R. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2 mediated phosphorylation of Cdc25C. J. Biol. Chem. 2004, 279:25813-25822.
36. Sommer S., Fuqua S.A. Estrogen receptor and breast cancer. Semin. Cancer Biol. 2001, 11:339-352.
37. Speirs V., Parkes A.T., Kerin M.J., Walton D.S., Carleton P.J., Fox J.N., Atkin S.L. Coexpression of estrogen receptor α and β: poor prognostic factors in human breast cancer?. Cancer Res. 1999, 59:525-528.
38. Thomadaki H., Scorilas A., Tsiapalis C.M., Havredaki M. The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner. Cancer Chemother. Pharmacol. 2008, 61:251-265.
39. Wong Y.Y., Moon A., Duffin R., Barthet-Barateig A., Meijer H.A., Clemens M.J., de Moor C.H. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J. Biol. Chem. 2010, 285(4):2610-2621.
40. Wu W.C., Hsiao J.R., Lian Y.Y., Lin C.Y., Huang B.M. The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line. Cancer Chemother. Pharmacol. 2007, 60:103-111.
41. Xue L., Fletcher G.C., Tolkovsky A.M. Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol. Cell. Neurosci. 1999, 14:180-198.
42. Yorimitsu T., Klionsky D.J. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005, 12:1542-1552.
43. Zhang S.M., Hunter D.J., Rosner B.A., Giovannucci E.L., Colditz G.A., Speizer F.E., Willett W.C. Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women. Cancer Epidemiol. Biomarkers Prev. 2000, 9:477-485.