Estrogen receptor β protein in human breast cancer: Correlation with clinical tumor parameters

Cancer Research

Volumn 63, Issue 10, 2003, Pages 2434-2439

  Fuqua, Suzanne A W ^a   Schiff, Rachel ^a   Parra, Irma ^a   Moore, John T ^b   Mohsin, Syed K ^a   Osborne, C Kent ^a   Clark, Gary M ^a   Allred, D Craig ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR BETA; MONOCLONAL ANTIBODY; PROGESTERONE;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GRADING; CELL CYCLE S PHASE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIPLOIDY; DISEASE MARKER; FEMALE; FLOW CYTOMETRY; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; PROGNOSIS; RECEPTORS, ESTROGEN;

EID: 0037506015     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J-M., Argos, P., and Chambon, P. Human oestrogen receptor cDNA; sequence, expression and homology to v-erbA. Nature (Lond.), 320: 134-139, 1986.
2. Kuiper, G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustafsson, J. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology, 138: 863-870, 1997.
3. Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomized trials involving 31000 recurrences and 24000 deaths among 75000 women. Lancet. 339: 1-15, 71-85, 1992.
4. Elledge, R. M., and Fuqua, S. A. W. Estrogen and progesterone receptors. In: J. R. Harris, M. E. Lippman, M. Morrow, and C. K. Osborne (eds.), Diseases of the Breast, Vol. 2, pp. 471-488. Philadelphia: Lippincott, Williams & Wilkins, 2000.
5. Fuqua, S. A., Schiff, R., Parra, I., Friedrichs, W. E., Su, J. L., McKee, D. D., Slentz-Kesler, K., Moore, L. B., Willson, T. M., and Moore, J. T. Expression of wild-type estrogen receptor β and variant isoforms in human breast cancer. Cancer Res., 59: 5425-5428, 1999.
6. Hall, J. M., and McDonnell, D. P. The estrogen receptor β-isoform (ER β) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology, 140: 5566-5578, 1999.
7. Speirs, V., Parkes, A., Kerin, M., Walton, D., Carleton, P., Fox, J., and Atkin, S. Coexpression of estrogen receptor α and β: poor prognostic factors in human breast cancer? Cancer Res., 59: 525-528, 1999.
8. Jarvinen, T., Pelto-Huikko, M., Holli, K., and Isola, J. Estrogen receptor β is coexpressed with ERα and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am. J. Pathol., 156: 29-35, 2000.
9. Moore, J., McKee, D., Slentz-Kesler, K., Moore, L., Jones, S., Horne, E., Su, J-L., Kliewer, S., Lehmann, J., and Willson, T. Cloning and characterization of human estrogen receptor β isoforms. Biochem. Biophys. Res. Commun., 247: 75-78, 1998.
10. McGuire, W. L., Carbone, P. P., and Vollmer, E. P. (eds.) Estrogen Receptors in Human Breast Cancer. New York: Raven Press, 1975.
11. Wenger, C. R., Beardslee, S., Owens, M. A., Pounds, G., Oldaker, T., Vendely, P., Pandian, M. R., Harrington, D., Clark, G. M., and McGuire, W. L. DNA ploidy, S-phase, and steroid receptors in more than 127,000 breast cancer patients. Breast Cancer Res. Treat., 28: 9-20, 1993.
12. Brown, R. W., Allred, D. C., Clark, G. M., Osborne, C. K., and Hilsenbeck, S. G. Prognostic value of Ki67 compared to S phase fraction in axillary node-negative breast cancer. Clin. Cancer Res., 2: 585-592, 1996.
13. Elston, C. E., and Ellis, I. O. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology, 19: 403-410, 1991.
14. Patey, D. H., and Scarff, R. W. The position of histology in the prognosis of carcinoma of the breast. Lancet, 1: 801-804, 1928.
15. Mosselman, S., Polman, J., and Dijkema, R. ER β: identification and characterization of a novel human estrogen receptor. FEBS Lett., 392: 49-53, 1996.
16. Fuqua, S. A. W., Allred, D. C., Elledge, R. M., Krieg, S. L., Benedix, M. G., Nawaz, Z., O'Malley, B. W., Greene, G. L., and McGuire, W. L. The ER-positive/PgR-negative breast cancer phenotype is not associated with mutations within the DNA binding domain. Breast Cancer Res. Treat., 26: 191-202, 1993.
17. Fuqua, S., and Wolf, D. Molecular aspects of estrogen receptor variants in breast cancer. Breast Cancer Res. Treat., 35: 233-241, 1995.
18. Allred, D. C., Clark, G. M., Tandon, A. K., and McGuire, W. L. Immunohistochemistry on histological sections from small (50 mg) samples of pulverized breast cancer. J. Histotechnol., 16: 117-120, 1993.
19. Harvey, J. M. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J. Clin. Oncol., 17: 1474-1481, 1999.
20. Dotzlaw, H., Leygue, E., Watson, P., and Murphy, L. Estrogen receptor-β RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins. Cancer Res., 59: 529-532, 1999.
21. Clark, G. M. Prognostic and predictive factors. In: J. R. Harris, M. E. Lippman, M. Morrow, and C. K. Osborne (eds.), Diseases of the Breast, Vol. 2. Philadelphia: Lippincott, Williams & Wilkins, 2000.
22. ASCO Expert Panel. 1997 Update of recommendations for the use of tumor markers in breast and colorectal cancer. J. Clin. Oncol. 16: 793-795, 1998.
23. Pavao, M., and Traish, A. M. Estrogen receptor antibodies: specificity and utility in detection, localization and analyses of estrogen receptor α and β. Steroids, 66: 1-16, 2001.
24. Chio, I., Ko, C., Park-Sarge, O-K., Nie, R., Hess, R. A., Graves, C. and Katzenellenbogen, B. S. Human estrogen receptor β-specific antibodies: characterization and use in studies of estrogen receptor β protein expression in reproductive tissues. Mol. Cell. Endocrinol., 181: 139-150, 2001.
25. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., and Muramatsu, M. The complete primary structure of human estrogen receptor β (hER β) and its heterodimerization with ER α in vivo and in vitro. Biochem. Biophys. Res. Commun., 243: 122-126, 1998.
26. Pettersson, K., Grandien, K., Kuiper, G., and Gustafsson, J-A. Mouse estrogen receptor β forms estrogen response element-binding heterodimers with estrogen receptor α. Mol. Endocrinol., 11: 1486-1496, 1997.
27. Krege, J. H., Hodgin, J. B., Couse, J. F., Enmark, E., Warner, M., Mahler, J. F., Sar, M., Korach, K. S., Gustafsson, J. A., and Smithies, O. Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc. Natl. Acad. Sci. USA, 95: 15677-15682, 1998.
28. Saji, S., Jensen, E. V., Nilsson, S., Rylander, T., Warner, M., and Gustafsson, J-A. Estrogen receptor α and β in the rodent mammary gland. Proc. Natl. Acad. Sci. USA, 97: 337-342, 2000.
29. Speirs, V., Malone, C., Walton, D. S., Kerin, M. J., and Atkin, S. L. Increased expression of estrogen receptor β mRNA in tamoxifen-resistant breast cancer patients. Cancer Res., 59: 5421-5424, 1999.