Death and inflammation following somatic cell transplantation

Seminars in Immunopathology

Volumn 33, Issue 6, 2011, Pages 535-550

  Copland, Ian B ^a,b   Galipeau, Jacques ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Anoikis necrosis; Apoptosis; Mesenchymal stem cell; Programmed cell death; Somatic cell; Transplantation

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CADHERIN; CASPASE 10; CASPASE 2; CASPASE 8; CASPASE 9; CD146 ANTIGEN; CELL PROTEIN; FAS ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 3; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NERVE CELL ADHESION MOLECULE; PROTEIN BCL 2; PROTEIN BCL S1; PROTEIN MCL 1; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANOIKIS; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL ADHESION; CELL DEATH; CELL HOMING; CELL KILLING; CELL MEDIATED CYTOTOXICITY; CELL SURVIVAL; CLINICAL EFFECTIVENESS; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOGENICITY; INFLAMMATION; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SOMATIC CELL THERAPY; STROMA CELL; THERAPY EFFECT; UPREGULATION;

ANIMALS; CELL DEATH; CYTOTOXICITY, IMMUNOLOGIC; GRANZYMES; HUMANS; INFLAMMATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; PERFORIN; T-LYMPHOCYTES;

EID: 81855182158     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-011-0274-8     Document Type: Review

References (155)

1. Axis Research Mind (2010) Stem cells market and technologies
2. SM Devine, et al. 2003 Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates Blood 101 8 2999 3001 12480709 1:CAS:528:DC%2BD3sXjtFCqtr0%3D 10.1182/blood-2002-06-1830 (Pubitemid 36857986)
3. JP Chute 2006 Stem cell homing Curr Opin Hematol 13 6 399 406 17053451 10.1097/01.moh.0000245698.62511.3d (Pubitemid 44607440)
4. C Golias, et al. 2007 Review. Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease In Vivo 21 5 757 769 18019409 1:CAS:528:DC%2BD2sXhtlaru7fJ
5. C Weber 2003 Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules J Mol Med 81 1 4 19 12545245 1:CAS:528:DC%2BD3sXmtVWitw%3D%3D (Pubitemid 36207879)
6. JM Karp GS Leng Teo 2009 Mesenchymal stem cell homing: the devil is in the details Cell Stem Cell 4 3 206 216 19265660 1:CAS:528:DC%2BD1MXjvVSqsLo%3D 10.1016/j.stem.2009.02.001
7. NF Huang, et al. 2010 Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion Arterioscler Thromb Vasc Biol 30 5 984 991 20167654 1:CAS:528:DC%2BC3cXkslKqsrc%3D 10.1161/ATVBAHA.110.202796
8. W Freas, et al. 1989 Contractile properties of isolated vascular smooth muscle after photoradiation Am J Physiol 256 3 Pt 2 H655 H664 2522280 1:STN:280:DyaL1M7msVGnsA%3D%3D
9. W Hudson, et al. 2007 Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation J Surg Res 142 2 263 267 17719065 10.1016/j.jss.2007.03.021 (Pubitemid 47418824)
10. FDA (2010) Guidance for industry: cellular therapy for cardiac disease. http://www.fda.gov/downloads/BiologicsBloodVaccines/ GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ UCM164345.pdf, pp 1-28
11. AJ Friedenstein, et al. 1974 Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method Exp Hematol 2 2 83 92 4455512 1:STN:280:DyaE2M7jtFWktQ%3D%3D
12. MF Pittenger, et al. 1999 Multilineage potential of adult human mesenchymal stem cells Science 284 5411 143 147 10102814 1:CAS:528: DyaK1MXitlCnu7o%3D 10.1126/science.284.5411.143 (Pubitemid 29282067)
13. AI Caplan 2009 Why are MSCs therapeutic? New data: new insight J Pathol 217 2 318 324 19023885 1:STN:280:DC%2BD1M%2FgsVChtA%3D%3D 10.1002/path.2469
14. M Crisan, et al. 2008 A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 3 3 301 313 18786417 1:CAS:528: DC%2BD1cXhtF2jtr%2FO 10.1016/j.stem.2008.07.003
15. T Kinnaird, et al. 2004 Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms Circ Res 94 5 678 685 14739163 1:CAS:528:DC%2BD2cXitVGksr4%3D 10.1161/01.RES.0000118601.37875.AC (Pubitemid 38387752)
16. Y Shi, et al. 2010 Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair Cell Res 20 5 510 518 20368733 1:CAS:528:DC%2BC3cXlsFSqurY%3D 10.1038/cr.2010.44
17. G Chamberlain, et al. 2007 Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Stem Cells 25 11 2739 2749 17656645 1:CAS:528:DC%2BD2sXhtl2gsLjN 10.1634/stemcells.2007-0197 (Pubitemid 350127858)
18. EM Horwitz, et al. 1999 Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Nat Med 5 3 309 313 10086387 1:CAS:528:DyaK1MXhsVSltLk%3D 10.1038/6529 (Pubitemid 29124367)
19. N Awaya, et al. 2002 Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation Exp Hematol 30 8 937 942 12160845 10.1016/S0301-472X(02)00821-4 (Pubitemid 34838895)
20. CA Pettigrew TG Cotter 2009 Deregulation of cell death (apoptosis): implications for tumor development Discov Med 8 41 61 63 19788869
21. W Fiers, et al. 1999 More than one way to die: apoptosis, necrosis and reactive oxygen damage Oncogene 18 54 7719 7730 10618712 1:CAS:528: DC%2BD3cXlt1WgsA%3D%3D 10.1038/sj.onc.1203249 (Pubitemid 30052757)
22. JF Kerr AH Wyllie AR Currie 1972 Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26 4 239 257 4561027 1:STN:280:DyaE3s%2FgsFSksw%3D%3D 10.1038/bjc.1972.33
23. L Galluzzi, et al. 2007 Cell death modalities: classification and pathophysiological implications Cell Death Differ 14 7 1237 1243 17431418 1:CAS:528:DC%2BD2sXms1Sqsrk%3D 10.1038/sj.cdd.4402148 (Pubitemid 46969863)
24. FH Igney PH Krammer 2002 Death and anti-death: tumour resistance to apoptosis Nat Rev Cancer 2 4 277 288 12001989 1:CAS:528:DC%2BD38XivFGqt7s%3D 10.1038/nrc776 (Pubitemid 37328781)
25. EA Atkinson RC Bleackley 1995 Mechanisms of lysis by cytotoxic T cells Crit Rev Immunol 15 3-4 359 384 8834456 1:CAS:528:DyaK28Xhs1ygsrk%3D (Pubitemid 26259136)
26. J Grossmann 2002 Molecular mechanisms of "detachment-induced apoptosis-Anoikis" Apoptosis 7 3 247 260 11997669 1:CAS:528: DC%2BD38XmsVaitb4%3D 10.1023/A:1015312119693 (Pubitemid 34633465)
27. JM Vicencio, et al. 2008 Senescence, apoptosis or autophagy? When a damaged cell must decide its path-a mini-review Gerontology 54 2 92 99 18451641 10.1159/000129697 (Pubitemid 351667821)
28. JF Fullard A Kale NE Baker 2009 Clearance of apoptotic corpses Apoptosis 14 8 1029 1037 19291407 10.1007/s10495-009-0335-9
29. SM Frisch H Francis 1994 Disruption of epithelial cell-matrix interactions induces apoptosis J Cell Biol 124 4 619 626 8106557 1:CAS:528:DyaK2cXhtlSrsLo%3D 10.1083/jcb.124.4.619 (Pubitemid 24064472)
30. JE Meredith Jr B Fazeli MA Schwartz 1993 The extracellular matrix as a cell survival factor Mol Biol Cell 4 9 953 961 8257797 1:CAS:528: DyaK2cXhtlSrsbo%3D (Pubitemid 23309430)
31. I Zvibel F Smets H Soriano 2002 Anoikis: roadblock to cell transplantation? Cell Transplant 11 7 621 630 12518889 (Pubitemid 36026440)
32. B Guerette, et al. 1997 Prevention by anti-LFA-1 of acute myoblast death following transplantation J Immunol 159 5 2522 2531 9278346 1:CAS:528: DyaK2sXlslKhsLk%3D (Pubitemid 127681048)
33. H Song, et al. 2010 Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex Stem Cells 28 3 555 563 20073042 1:CAS:528: DC%2BC3cXlvVGltbk%3D
34. ML Matter E Ruoslahti 2001 A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription J Biol Chem 276 30 27757 27763 11333270 1:CAS:528:DC%2BD3MXls1Sktbo%3D 10.1074/jbc.M102014200
35. DG Stupack, et al. 2001 Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins J Cell Biol 155 3 459 470 11684710 1:CAS:528:DC%2BD3MXotVSrtro%3D 10.1083/jcb.200106070 (Pubitemid 34289336)
36. AA Mailleux, et al. 2007 BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms Dev Cell 12 2 221 234 17276340 1:CAS:528:DC%2BD2sXhvVKqu7c%3D 10.1016/j.devcel.2006. 12.003 (Pubitemid 46172902)
37. JM Fox, et al. 2007 Recent advances into the understanding of mesenchymal stem cell trafficking Br J Haematol 137 6 491 502 17539772 1:CAS:528: DC%2BD2sXot1KqsL4%3D 10.1111/j.1365-2141.2007.06610.x (Pubitemid 46817339)
38. Y Jung, et al. 2005 Cell-to-cell contact is critical for the survival of hematopoietic progenitor cells on osteoblasts Cytokine 32 3-4 155 162 16256361 1:CAS:528:DC%2BD2MXht1GnsL7P 10.1016/j.cyto.2005.09.001 (Pubitemid 41681789)
39. S Halfon, et al. 2010 Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging Stem Cells Dev 20 53 66 20528146 10.1089/scd.2010.0040 1:CAS:528:DC%2BC3MXhtVahtw%3D%3D
40. DS Harburger DA Calderwood 2009 Integrin signalling at a glance J Cell Sci 122 Pt 2 159 163 19118207 1:CAS:528:DC%2BD1MXit1GqtLw%3D 10.1242/jcs.018093
41. P Chiarugi E Giannoni 2008 Anoikis: a necessary death program for anchorage-dependent cells Biochem Pharmacol 76 11 1352 1364 18708031 1:CAS:528:DC%2BD1cXhtl2qtLbN 10.1016/j.bcp.2008.07.023
42. FG Giancotti 2000 Complexity and specificity of integrin signalling Nat Cell Biol 2 1 E13 E14 10620816 1:CAS:528:DC%2BD3cXhsVKisrY%3D 10.1038/71397
43. D Docheva, et al. 2007 Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system J Cell Mol Med 11 1 21 38 17367499 1:CAS:528:DC%2BD2sXlvFClsbY%3D 10.1111/j.1582-4934.2007.00001.x (Pubitemid 46439623)
44. JA Semon, et al. 2010 Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels Cell Tissue Res 341 1 147 158 20563599 1:CAS:528:DC%2BC3cXotlygt7w%3D 10.1007/s00441-010-0994-4
45. JE Ip, et al. 2007 Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment Mol Biol Cell 18 8 2873 2882 17507648 1:CAS:528:DC%2BD2sXovFalurs%3D 10.1091/mbc.E07-02-0166 (Pubitemid 47235295)
46. S Kumar S Ponnazhagan 2007 Bone homing of mesenchymal stem cells by ectopic alpha 4 integrin expression FASEB J 21 14 3917 3927 17622670 1:CAS:528:DC%2BD2sXhsVahtbrP 10.1096/fj.07-8275com (Pubitemid 350232349)
47. BD Angst C Marcozzi AI Magee 2001 The cadherin superfamily: diversity in form and function J Cell Sci 114 Pt 4 629 641 11171368 1:CAS:528: DC%2BD3MXitFWltr8%3D (Pubitemid 32237135)
48. G Christofori H Semb 1999 The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene Trends Biochem Sci 24 2 73 76 10098402 1:CAS:528:DyaK1MXltFCgsr8%3D 10.1016/S0968-0004(98)01343-7 (Pubitemid 29346577)
49. E Bergin, et al. 2000 Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism Am J Physiol Ren Physiol 278 5 F758 F768 1:CAS:528:DC%2BD3cXjvFahtbg%3D
50. VH Lugo-Martinez, et al. 2009 Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions Am J Physiol Gastrointest Liver Physiol 296 2 G235 G244 19056766 1:CAS:528:DC%2BD1MXitVaqt70%3D 10.1152/ajpgi.90313.2008
51. H Obara R Harasawa 2010 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis J Vet Med Sci 72 7 869 874 20179380 1:CAS:528:DC%2BC3cXhtVyktb7I 10.1292/jvms.09-0573
52. K Hosokawa, et al. 2010 Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells Blood 116 4 554 563 20427705 1:CAS:528:DC%2BC3cXhtVClu7rL 10.1182/blood-2009-05-224857
53. Z Karabekian, et al. 2009 Effects of N-cadherin overexpression on the adhesion properties of embryonic stem cells Cell Adh Migr 3 3 305 310 19377287 10.4161/cam.3.3.8399
54. F Wein, et al. 2010 N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells Stem Cell Res 4 2 129 139 20116358 1:CAS:528:DC%2BC3cXnvFWgsro%3D 10.1016/j.scr.2009.12.004
55. I Kim OH Yilmaz SJ Morrison 2005 CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells Blood 106 3 903 905 15831702 1:CAS:528:DC%2BD2MXntVSnurg%3D 10.1182/blood-2004-12-4960 (Pubitemid 41076431)
56. I Kii, et al. 2004 Cell-cell interaction mediated by cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage J Bone Miner Res 19 11 1840 1849 15476585 1:CAS:528:DC%2BD2cXhtVSltLfP 10.1359/JBMR.040812 (Pubitemid 41103436)
57. JB Michel 2003 Anoikis in the cardiovascular system: known and unknown extracellular mediators Arterioscler Thromb Vasc Biol 23 12 2146 2154 14551156 1:CAS:528:DC%2BD3sXpsVGhtL4%3D 10.1161/01.ATV.0000099882.52647.E4 (Pubitemid 37532313)
58. G Klein, et al. 1995 Perlecan in human bone marrow: a growth-factor-presenting, but anti-adhesive, extracellular matrix component for hematopoietic cells Matrix Biol 14 6 457 465 7795884 1:CAS:528: DyaK2MXjvFektLw%3D 10.1016/0945-053X(95)90003-9
59. S Asakura, et al. 1992 Inhibition of cell adhesion by high molecular weight kininogen J Cell Biol 116 2 465 476 1370494 1:CAS:528: DyaK38Xlt1egsQ%3D%3D 10.1083/jcb.116.2.465
60. Copland IB et al (2008) Improved autograft survival of MSCs by PAI-1 inhibition. Stem Cells Feb;27(2):467-77
61. E Migliaccio, et al. 1997 Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway EMBO J 16 4 706 716 9049300 1:CAS:528:DyaK2sXhs1Kht78%3D 10.1093/emboj/16.4.706 (Pubitemid 27089518)
62. A Natalicchio, et al. 2004 Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts J Biol Chem 279 42 43900 43909 15262993 1:CAS:528:DC%2BD2cXot1ygt7o%3D 10.1074/jbc.M403936200 (Pubitemid 39390698)
63. RA Gottlieb RM Mentzer 2010 Autophagy during cardiac stress: joys and frustrations of autophagy Annu Rev Physiol 72 45 59 20148666 1:CAS:528:DC%2BC3cXktFKktro%3D 10.1146/annurev-physiol-021909-135757
64. LA Mylotte, et al. 2008 Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment Stem Cells 26 5 1325 1336 18308942 1:CAS:528:DC%2BD1cXnsFCgtbg%3D 10.1634/stemcells.2007-1072
65. G Kroemer B Levine 2008 Autophagic cell death: the story of a misnomer Nat Rev Mol Cell Biol 9 12 1004 1010 18971948 1:CAS:528:DC%2BD1cXhsVWhurjO 10.1038/nrm2529
66. S Challa FK Chan 2010 Going up in flames: necrotic cell injury and inflammatory diseases Cell Mol Life Sci 67 19 3241 3253 20532807 1:CAS:528:DC%2BC3cXhtFWiurjO 10.1007/s00018-010-0413-8
67. DE Christofferson J Yuan 2010 Necroptosis as an alternative form of programmed cell death Curr Opin Cell Biol 22 2 263 268 20045303 1:CAS:528:DC%2BC3cXks1Sru7c%3D 10.1016/j.ceb.2009.12.003
68. M Leist M Jaattela 2001 Four deaths and a funeral: from caspases to alternative mechanisms Nat Rev Mol Cell Biol 2 8 589 598 11483992 1:CAS:528:DC%2BD3MXlvVOqs78%3D 10.1038/35085008 (Pubitemid 33674010)
69. ME Bianchi 2007 DAMPs, PAMPs and alarmins: all we need to know about danger J Leukoc Biol 81 1 1 5 17032697 1:CAS:528:DC%2BD2sXktVaisg%3D%3D 10.1189/jlb.0306164 (Pubitemid 46028489)
70. M Li, et al. 2001 An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells J Immunol 166 12 7128 7135 11390458 1:CAS:528: DC%2BD3MXksVOntLY%3D (Pubitemid 32525583)
71. K Ohashi, et al. 2000 Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex J Immunol 164 2 558 561 10623794 1:CAS:528:DC%2BD3cXlt1ChtA%3D%3D (Pubitemid 30043672)
72. JJ Oppenheim D Yang 2005 Alarmins: chemotactic activators of immune responses Curr Opin Immunol 17 4 359 365 15955682 1:CAS:528:DC%2BD2MXlvVWls78%3D 10.1016/j.coi.2005.06.002 (Pubitemid 40848537)
73. M Yu, et al. 2006 HMGB1 signals through toll-like receptor (TLR) 4 and TLR2 Shock 26 2 174 179 16878026 1:CAS:528:DC%2BD28Xot1amtrg%3D 10.1097/01.shk.0000225404.51320.82 (Pubitemid 44162504)
74. KB Elkon 2007 IL-1alpha responds to necrotic cell death Nat Med 13 7 778 780 17618263 1:CAS:528:DC%2BD2sXnsFWmsb0%3D 10.1038/nm0707-778 (Pubitemid 47038177)
75. T Eigenbrod, et al. 2008 Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells J Immunol 181 12 8194 8198 19050234 1:CAS:528:DC%2BD1cXhsVCksbbN
76. H Yang, et al. 2010 Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation Proc Natl Acad Sci USA 107 28 12611 12616 20616036 1:CAS:528:DC%2BC3cXpt1ehsr4%3D 10.1073/pnas.1006542107
77. SY Lim, et al. 2006 The effects of mesenchymal stem cells transduced with Akt in a porcine myocardial infarction model Cardiovasc Res 70 3 530 542 16563361 1:CAS:528:DC%2BD28Xks1Wlu78%3D 10.1016/j.cardiores.2006.02.016 (Pubitemid 43732376)
78. W Li, et al. 2007 Bcl-2 engineered MSCs inhibited apoptosis and improved heart function Stem Cells 25 8 2118 2127 17478584 1:CAS:528:DC%2BD2sXhtVSqsbfF 10.1634/stemcells.2006-0771 (Pubitemid 47258191)
79. YL Tang, et al. 2005 Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector J Am Coll Cardiol 46 7 1339 1350 16198853 1:CAS:528:DC%2BD2MXhtlarsr%2FI 10.1016/j.jacc.2005.05.079 (Pubitemid 41615559)
80. SW Song, et al. 2009 Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium Stem Cells 27 6 1358 1365 19489098 1:CAS:528:DC%2BD1MXovFarur8%3D 10.1002/stem.47
81. XB Liu, et al. 2008 Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway Acta Pharmacol Sin 29 7 815 822 18565279 10.1111/j.1745-7254.2008.00811. x 1:CAS:528:DC%2BD1cXovVSms7w%3D
82. M Bouchentouf, et al. 2007 Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways Am J Transplant 7 6 1491 1505 17511679 1:CAS:528:DC%2BD2sXntVSns7c%3D 10.1111/j.1600-6143.2007.01830.x (Pubitemid 46776268)
83. SS Akimov, et al. 2000 Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin J Cell Biol 148 4 825 838 10684262 1:CAS:528:DC%2BD3cXhsVOqsLg%3D 10.1083/jcb.148.4.825
84. H Song, et al. 2007 Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells Stem Cells 25 6 1431 1438 17347495 1:CAS:528:DC%2BD2sXntlWrtrs%3D 10.1634/stemcells.2006-0467 (Pubitemid 47106010)
85. K Warstat, et al. 2010 TGF-beta enhances the integrin alpha2beta1-mediated attachment of mesenchymal stem cells to type I collagen Stem Cells Dev 19 5 645 656 19827952 1:CAS:528:DC%2BC3cXmsVSmurc%3D 10.1089/scd.2009.0208
86. R Sackstein, et al. 2008 Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone Nat Med 14 2 181 187 18193058 1:CAS:528:DC%2BD1cXhs1Khsb8%3D 10.1038/nm1703 (Pubitemid 351214550)
87. RJ Lee, et al. 2007 Antibody targeting of stem cells to infarcted myocardium Stem Cells 25 3 712 717 17138964 1:CAS:528:DC%2BD2sXktlehu7k%3D 10.1634/stemcells.2005-0602 (Pubitemid 46357399)
88. TC Zhao, et al. 2008 Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction J Appl Physiol 104 6 1793 1800 18292296 10.1152/japplphysiol.01109.2007
89. RN Wang L Rosenberg 1999 Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship J Endocrinol 163 2 181 190 10556766 1:CAS:528:DyaK1MXns12isbw%3D 10.1677/joe.0.1630181
90. DA Taylor 2009 From stem cells and cadaveric matrix to engineered organs Curr Opin Biotechnol 20 5 598 605 19914057 1:CAS:528:DC%2BD1MXhsVKht7vK 10.1016/j.copbio.2009.10.016
91. DL Coutu, et al. 2011 Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B Biomaterials 32 1 295 305 20864158 1:CAS:528:DC%2BC3cXhsVWhu7vJ 10.1016/j.biomaterials.2010.08.094
92. Y Miyahara, et al. 2006 Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction Nat Med 12 4 459 465 16582917 1:CAS:528:DC%2BD28XjtFKjtbs%3D 10.1038/nm1391
93. DL Coutu AM Yousefi J Galipeau 2009 Three-dimensional porous scaffolds at the crossroads of tissue engineering and cell-based gene therapy J Cell Biochem 108 3 537 546 19681040 1:CAS:528:DC%2BD1MXhtFyntLbE 10.1002/jcb.22296
94. AJ Engler, et al. 2006 Matrix elasticity directs stem cell lineage specification Cell 126 4 677 689 16923388 1:CAS:528:DC%2BD28Xpt1aktbg%3D 10.1016/j.cell.2006.06.044 (Pubitemid 44233625)
95. R McBeath, et al. 2004 Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment Dev Cell 6 4 483 495 15068789 1:CAS:528:DC%2BD2cXjsFeqsbk%3D 10.1016/S1534-5807(04)00075-9 (Pubitemid 38456178)
96. I Rosova, et al. 2008 Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells Stem Cells 26 8 2173 2182 18511601 1:CAS:528:DC%2BD1cXhtVKmt7vJ 10.1634/stemcells. 2007-1104
97. JA Wang, et al. 2008 Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells Acta Pharmacol Sin 29 1 74 82 18158868 10.1111/j.1745-7254.2008.00716.x 1:CAS:528: DC%2BD1cXovVKgtg%3D%3D
98. L Leroux, et al. 2010 Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathway Mol Ther 18 8 1545 1552 20551912 1:CAS:528: DC%2BC3cXntlOhsbw%3D 10.1038/mt.2010.108
99. JG Rasmussen, et al. 2010 Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells Cytotherapy 13 318 328 20795759 10.3109/14653249.2010.506505 1:CAS:528:DC%2BC3MXhvFChtrY%3D
100. SC Hung, et al. 2007 Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo PLoS ONE 2 5 e416 17476338 10.1371/journal.pone.0000416 1:CAS:528:DC%2BD2sXmvFyksbo%3D
101. H Liu, et al. 2010 Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs Biochem Biophys Res Commun 401 4 509 515 20869949 1:CAS:528:DC%2BC3cXhtlKht7nK 10.1016/j.bbrc.2010.09.076
102. HW Kim, et al. 2009 Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2 J Biol Chem 284 48 33161 33168 19721136 10.1074/jbc.M109.020925 1:CAS:528: DC%2BD1MXhsVCjtLbF
103. PR Crisostomo, et al. 2008 Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism Am J Physiol Cell Physiol 294 3 C675 C682 18234850 1:CAS:528:DC%2BD1cXjsFCjtbk%3D 10.1152/ajpcell.00437.2007 (Pubitemid 351468685)
104. D Zhang, et al. 2010 Zinc supplementation results in improved therapeutic potential of bone marrow-derived mesenchymal stromal cells in a mouse ischemic limb model Cytotherapy 13 156 164 20839997 10.3109/14653249.2010.512633 1:CAS:528:DC%2BC3MXmtVCmtA%3D%3D
105. Y Suzuki, et al. 2010 Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas Am J Physiol Heart Circ Physiol 299 4 H1077 H1082 20656888 1:CAS:528: DC%2BC3cXhtlKltbvL 10.1152/ajpheart.00212.2010
106. J Chen, et al. 2008 Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis Stem Cells 26 1 135 145 17932426 1:CAS:528:DC%2BD1cXhvVCktLs%3D 10.1634/stemcells.2007-0098
107. L Danielyan, et al. 2009 Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin Cell Death Differ 16 12 1599 1614 19609278 1:CAS:528:DC%2BD1MXhsVWlsrzJ 10.1038/cdd.2009.95
108. X Hou, et al. 2010 Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia Mol Biol Rep 37 3 1467 1475 19434514 1:CAS:528: DC%2BC3cXhtlWqu7o%3D 10.1007/s11033-009-9541-3
109. D Zhang, et al. 2007 Erythropoietin enhances the angiogenic potency of autologous bone marrow stromal cells in a rat model of myocardial infarction Cardiology 108 4 228 236 17106196 1:CAS:528:DC%2BD2sXht12ktLjM 10.1159/000096803 (Pubitemid 350126464)
110. T Kucic, et al. 2008 Mesenchymal stromal cells genetically engineered to overexpress IGF-I enhance cell-based gene therapy of renal failure-induced anemia Am J Physiol Ren Physiol 295 2 F488 F496 1:CAS:528:DC%2BD1cXhtVaktL%2FE 10.1152/ajprenal.00044.2008
111. S Aggarwal MF Pittenger 2005 Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 4 1815 1822 15494428 1:CAS:528:DC%2BD2MXhsVGjt7Y%3D 10.1182/blood-2004-04-1559 (Pubitemid 40223708)
112. WE Fibbe AJ Nauta H Roelofs 2007 Modulation of immune responses by mesenchymal stem cells Ann NY Acad Sci 1106 272 278 17442776 1:CAS:528:DC%2BD2sXpt1yku7o%3D 10.1196/annals.1392.025 (Pubitemid 47443061)
113. AJ Nauta WE Fibbe 2007 Immunomodulatory properties of mesenchymal stromal cells Blood 110 10 3499 3506 17664353 1:CAS:528:DC%2BD2sXhtlarurzE 10.1182/blood-2007-02-069716 (Pubitemid 350159613)
114. NG Singer AI Caplan 2010 Mesenchymal stem cells: mechanisms of inflammation Annu Rev Pathol 6 457 478 10.1146/annurev-pathol-011110-130230 1:CAS:528:DC%2BC3MXjtVWrs7g%3D
115. D Gur-Wahnon, et al. 2007 Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling Exp Hematol 35 3 426 433 17309823 1:CAS:528:DC%2BD2sXit12nu70%3D 10.1016/j.exphem.2006.11.001
116. K Le Blanc, et al. 2008 Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study Lancet 371 9624 1579 1586 18468541 10.1016/S0140-6736(08)60690-X 1:CAS:528:DC%2BD1cXlslWhsbk%3D (Pubitemid 351626841)
117. K Le Blanc, et al. 2004 Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 9419 1439 1441 15121408 10.1016/S0140-6736(04)16104-7 (Pubitemid 38586721)
118. O Garcia-Bosch E Ricart J Panes 2010 Review article: stem cell therapies for inflammatory bowel disease-efficacy and safety Aliment Pharmacol Ther 32 8 939 952 20804451 1:CAS:528:DC%2BC3cXhtlCrur%2FO 10.1111/j.1365-2036.2010.04439.x
119. SH Mei, et al. 2010 Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis Am J Respir Crit Care Med 182 8 1047 1057 20558630 1:CAS:528:DC%2BC3cXhsVOjurfF 10.1164/rccm.201001-0010OC
120. M Rafei, et al. 2009 Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner J Immunol 182 10 5994 6002 19414750 1:CAS:528:DC%2BD1MXltlynsLo%3D 10.4049/jimmunol.0803962
121. F Mao, et al. 2010 Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis Inflamm Res 59 3 219 225 19763787 1:CAS:528:DC%2BC3cXhs1ejsbY%3D 10.1007/s00011-009-0090-y
122. PJ Psaltis, et al. 2008 Concise review: mesenchymal stromal cells: potential for cardiovascular repair Stem Cells 26 9 2201 2210 18599808 10.1634/stemcells.2008-0428
123. R Romieu-Mourez, et al. 2009 Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype J Immunol 182 12 7963 7973 19494321 1:CAS:528:DC%2BD1MXmslCntLs%3D 10.4049/jimmunol.0803864
124. RS Waterman, et al. 2010 A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype PLoS ONE 5 4 e10088 20436665 10.1371/journal.pone.0010088 1:CAS:528: DC%2BC3cXlsl2nsLw%3D
125. MR Elliott, et al. 2009 Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance Nature 461 7261 282 286 19741708 1:CAS:528:DC%2BD1MXhtFSnt7fM 10.1038/nature08296
126. K Lauber, et al. 2003 Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal Cell 113 6 717 730 12809603 1:CAS:528:DC%2BD3sXkvVekt7k%3D 10.1016/S0092-8674(03)00422-7 (Pubitemid 36724936)
127. J Savill V Fadok 2000 Corpse clearance defines the meaning of cell death Nature 407 6805 784 788 11048729 1:CAS:528:DC%2BD3cXnsFWrsbw%3D 10.1038/35037722
128. OV Vieira RJ Botelho S Grinstein 2002 Phagosome maturation: aging gracefully Biochem J 366 Pt 3 689 704 12061891 1:CAS:528:DC%2BD38XntVymtbo%3D
129. RE Voll, et al. 1997 Immunosuppressive effects of apoptotic cells Nature 390 6658 350 351 9389474 1:CAS:528:DyaK2sXnslSit74%3D 10.1038/37022 (Pubitemid 28027305)
130. VA Fadok, et al. 1998 Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF J Clin Invest 101 4 890 898 9466984 1:CAS:528:DyaK1cXht1Wrt70%3D 10.1172/JCI1112 (Pubitemid 28096086)
131. ML Huynh VA Fadok PM Henson 2002 Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation J Clin Invest 109 1 41 50 11781349 1:CAS:528:DC%2BD38Xjtlaktw%3D%3D (Pubitemid 34052540)
132. KH Grinnemo, et al. 2008 Immunogenicity of human embryonic stem cells Cell Tissue Res 331 1 67 78 17846795 10.1007/s00441-007-0486-3 (Pubitemid 350265494)
133. N Ito T Hirota 1992 Histochemical and cytochemical localization of blood group antigens Prog Histochem Cytochem 25 2 1 85 1488510 1:STN:280: DyaK3s7ktFOhtw%3D%3D
134. JA Bradley EM Bolton RA Pedersen 2002 Stem cell medicine encounters the immune system Nat Rev Immunol 2 11 859 871 12415309 1:CAS:528: DC%2BD38Xotlers7o%3D 10.1038/nri934 (Pubitemid 37328708)
135. M Francois, et al. 2009 Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties Blood 114 13 2632 2638 19654411 1:CAS:528:DC%2BD1MXht1eit7vP
136. M Dierselhuis E Goulmy 2009 The relevance of minor histocompatibility antigens in solid organ transplantation Curr Opin Organ Transplant 14 4 419 425 19444105 10.1097/MOT.0b013e32832d399c
137. EH Javazon KJ Beggs AW Flake 2004 Mesenchymal stem cells: paradoxes of passaging Exp Hematol 32 5 414 425 15145209 1:CAS:528:DC%2BD2cXktVCqtrg%3D 10.1016/j.exphem.2004.02.004 (Pubitemid 38624325)
138. R Atoui D Shum-Tim RC Chiu 2008 Myocardial regenerative therapy: immunologic basis for the potential "universal donor cells" Ann Thorac Surg 86 1 327 334 18573459 10.1016/j.athoracsur.2008.03.038
139. N Eliopoulos, et al. 2005 Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice Blood 106 13 4057 4065 16118325 1:CAS:528:DC%2BD2MXhtlaltrzP 10.1182/blood-2005-03-1004 (Pubitemid 41775910)
140. AJ Poncelet, et al. 2007 Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo Transplantation 83 6 783 790 17414713 10.1097/01.tp.0000258649.23081.a3 (Pubitemid 46569198)
141. J Stagg, et al. 2006 Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell Blood 107 6 2570 2577 16293599 1:CAS:528:DC%2BD28XisFOisrw%3D 10.1182/blood-2005-07-2793 (Pubitemid 43348704)
142. R Romieu-Mourez, et al. 2007 Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density J Immunol 179 3 1549 1558 17641021 1:CAS:528:DC%2BD2sXnvVynt7Y%3D
143. T Brunner, et al. 2003 Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology Semin Immunol 15 3 167 176 14563115 1:CAS:528:DC%2BD3sXmsl2rtLc%3D 10.1016/S1044-5323(03)00035-6 (Pubitemid 38155823)
144. J Pardo, et al. 2004 Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis J Cell Biol 167 3 457 468 15534000 1:CAS:528:DC%2BD2cXpvVCnsro%3D 10.1083/jcb.200406115 (Pubitemid 39489054)
145. D Martinvalet P Zhu J Lieberman 2005 Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis Immunity 22 3 355 370 15780992 1:CAS:528:DC%2BD2MXjt1Ohsbc%3D 10.1016/j.immuni.2005.02.004 (Pubitemid 40387477)
146. A Mackensen, et al. 2000 Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells Cancer Immunol Immunother 49 3 152 156 10881694 1:CAS:528:DC%2BD3cXltFWmsLw%3D 10.1007/s002620050614
147. TA Selvaggi RE Walker TA Fleisher 1997 Development of antibodies to fetal calf serum with Arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions Blood 89 3 776 779 9028307 1:CAS:528:DyaK2sXptVGmug%3D%3D (Pubitemid 27121269)
148. JL Spees, et al. 2004 Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy Mol Ther 9 5 747 756 15120336 1:CAS:528:DC%2BD2cXjs1alt7s%3D 10.1016/j.ymthe.2004.02.012 (Pubitemid 38660428)
149. RE Shrimpton, et al. 2009 CD205 (DEC-205): a recognition receptor for apoptotic and necrotic self Mol Immunol 46 6 1229 1239 19135256 1:CAS:528:DC%2BD1MXislKhsbs%3D 10.1016/j.molimm.2008.11.016
150. SA Kuznetsov MH Mankani PG Robey 2000 Effect of serum on human bone marrow stromal cells: ex vivo expansion and in vivo bone formation Transplantation 70 12 1780 1787 11152111 1:STN:280:DC%2BD3M%2FptlOhug%3D%3D 10.1097/00007890-200012270-00018 (Pubitemid 32064834)
151. K Tarte, et al. 2010 Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation Blood 115 8 1549 1553 20032501 1:CAS:528:DC%2BC3cXjtV2gt7c%3D 10.1182/blood-2009-05-219907
152. K Bieback, et al. 2009 Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow Stem Cells 27 9 2331 2341 19544413 1:CAS:528:DC%2BD1MXhtlGnsbrP 10.1002/stem.139
153. K Schallmoser, et al. 2007 Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells Transfusion 47 8 1436 1446 17655588 1:CAS:528:DC%2BD2sXhtVWgurjF 10.1111/j.1537-2995.2007.01220.x (Pubitemid 47101060)
154. C Lange, et al. 2007 Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine J Cell Physiol 213 1 18 26 17458897 1:CAS:528:DC%2BD2sXhtVehtLrE 10.1002/jcp.21081 (Pubitemid 47378788)
155. ME Bernardo, et al. 2007 Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute J Cell Physiol 211 1 121 130 17187344 1:CAS:528:DC%2BD2sXis12jtLw%3D 10.1002/jcp.20911 (Pubitemid 46363901)