Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties

Blood

Volumn 114, Issue 13, 2009, Pages 2632-2638

  François, Moïra ^a,b   Romieu Mourez, Raphaëlle ^a   Stock Martineau, Sophie ^a   Boivin, Marie Noëlle ^a   Bramson, Jonathan L ^c   Galipeau, Jacques ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN; PROTEASOME; TRANSFORMING GROWTH FACTOR BETA; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS PRESENTATION; FEMALE; FLOW CYTOMETRY; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNOLOGY; MESENCHYMAL STEM CELL; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SOLUBILITY;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS; BETA 2-MICROGLOBULIN; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CROSS-PRIMING; FEMALE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; SOLUBILITY; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 70350512378     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-02-207795     Document Type: Article

References (28)

1. Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA. Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev. 2005;207(1):145-157. (Pubitemid 41415014)
2. Lin ML, Zhan Y, Villadangos JA, Lew AM. The cell biology of cross-presentation and the role of dendritic cell subsets. Immunol Cell Biol. 2008;86(4):353-362. (Pubitemid 351667998)
3. Ackerman AL, Cresswell P. Cellular mechanisms governing cross-presentation of exogenous antigens. Nat Immunol. 2004;5(7):678-684. (Pubitemid 39023296)
4. Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol. 2002;20(1):621-667. (Pubitemid 34293436)
5. Khor B, Makar RS. Toward a molecular explanation for cross-presentation of antigens to the immune system. Transfus Med Rev. 2008;22(3):188-201. (Pubitemid 351842623)
6. Rock KL, Shen L. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol Rev. 2005;207(1):166-183. (Pubitemid 41415016)
7. Neijssen J, Herberts C, Drijfhout JW, et al. Cross-presentation by intercellular peptide transfer through gap junctions. Nature. 2005;434(7029):83-88. (Pubitemid 40349389)
8. Kloetzel PM. Antigen processing by the proteasome. Nat Rev Mol Cell Biol. 2001;2(3):179-187.
9. Paglia P, Chiodoni C, Rodolfo M, Colombo MP. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp Med. 1996;183(1):317-322. (Pubitemid 26028774)
10. Kovacsovics-Bankowski M, Clark K, Benacerraf B, Rock KL. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A. 1993;90(11):4942-4946. (Pubitemid 23182951)
11. Beauvillain C, Delneste Y, Scotet M, et al. Neutrophils efficiently cross-prime naive T cells in vivo. Blood. 2007;110(8):2965-2973. (Pubitemid 350006950)
12. Robson NC, Donachie AM, Mowat AM. Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells. Eur J Immunol. 2008;38(5):1238-1246.
13. Bagai R, Valujskikh A, Canaday DH, et al. Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a. J Immunol. 2005;174(12):7711-7715.
14. Chan JL, Tang KC, Patel AP, et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood. 2006;107(12):4817-4824.
15. Stagg J, Pommey S, Eliopoulos N, Galipeau J. Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood. 2006;107(6):2570-2577. (Pubitemid 43348704)
16. Eliopoulos N, Stagg J, Lejeune L, Pommey S, Galipeau J. Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice. Blood. 2005;106(13):4057-4065. (Pubitemid 41775910)
17. Romieu-Mourez R, Francois M, Boivin MN, Stagg J, Galipeau J. Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density. J Immunol. 2007;179(3):1549-1558.
18. Morandi F, Raffaghello L, Bianchi G, et al. Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens. Stem Cells. 2008;26(5):1275-1287.
19. Dick LR, Cruikshank AA, Destree AT, et al. Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J Biol Chem. 1997;272(1):182-188.
20. Strobl H, Knapp W. TGF-beta1 regulation of dendritic cells. Microbes Infect. 1999;1(15):1283-1290.
21. Delvig AA, Lee JJ, Chrzanowska-Lightowlers ZM, Robinson JH. TGF-beta1 and IFN-gamma cross-regulate antigen presentation to CD4 T cells by macrophages. J Leukoc Biol. 2002;72(1):163-166.
22. Gagnon E, Duclos S, Rondeau C, et al. Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell. 2002;110(1):119-131. (Pubitemid 34874611)
23. Houde M, Bertholet S, Gagnon E, et al. Phagosomes are competent organelles for antigen cross-presentation. Nature. 2003;425(6956):402-406. (Pubitemid 37187269)
24. Strehl B, Seifert U, Kruger E, et al. Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing. Immunol Rev. 2005;207(1):19-30. (Pubitemid 41415005)
25. Dazzi F, Ramasamy R, Glennie S, Jones SP, Roberts I. The role of mesenchymal stem cells in haemopoiesis. Blood Rev. 2006;20(3):161-171.
26. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair - current views. Stem Cells. 2007;25(11):2896-2902.
27. Rafei M, Hsieh J, Fortier S, et al. Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood. 2008;112(13):4991-4998.
28. Romieu-Mourez R, Francois M, Boivin MN, et al. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 2009;182(12):7963-7973.