Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase

Journal of General Virology

Volumn 89, Issue 3, 2008, Pages 636-641

  Radichev, Ilian ^a   Shiryaev, Sergey A ^a   Aleshin, Alexander E ^a   Ratnikov, Boris I ^a   Smith, Jeffrey W ^a   Liddington, Robert C ^a   Strongin, Alex Y ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; HYBRID PROTEIN; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 2B NONSTRUCTURAL PROTEIN 3 PROTEINASE FUSION PROTEIN; PROTEINASE; VIRUS PROTEIN; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; ENZYME ACTIVATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; STRUCTURAL HOMOLOGY; WEST NILE FLAVIVIRUS; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CRYSTALLIZATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

FLAVIVIRUS; WEST NILE VIRUS;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; CRYSTALLIZATION; GENE EXPRESSION REGULATION, VIRAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RNA HELICASES; SEQUENCE ALIGNMENT; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE VIRUS;

EID: 42449111776     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83359-0     Document Type: Article

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