Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 32, 2004, Pages 11791-11796

  Bertini, Riccardo ^a   Allegretti, Marcello ^a   Bizzarri, Cinzia ^a   Moriconi, Alessio ^a   Locati, Massimo ^b   Zampella, Giuseppe ^c   Cervellera, Maria N ^a   Di Cioccio, Vito ^a   Cesta, Maria C ^a   Galliera, Emanuela ^b   Martinez, Fernando O ^b   Di Bitondo, Rosa ^a   Troiani, Giulia ^a   Sabbatini, Vilma ^a   D'Anniballe, Gaetano ^a   Anacardio, Roberto ^a   Cutrin, Juan C ^d   Cavalieri, Barbara ^d   Mainiero, Fabrizio ^e   Strippoli, Raffaele ^e   Villa, Pia ^f,g   Di Girolamo, Maria ^f   Martin, Franck ^a   Gentile, Marco ^a   Santoni, Angela ^e   Corda, Daniela ^f   Poli, Giuseppe ^d   Mantovani, Alberto ^b,f   Ghezzi, Pietro ^f   Colotta, Francesco ^a   more..

^a Chemistry Section   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^g CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; MESYLIC ACID DERIVATIVE; REPERTAXIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; HUMANS; INFLAMMATION; LIVER DISEASES; MODELS, MOLECULAR; PROTEIN CONFORMATION; RATS; RECEPTORS, INTERLEUKIN-8A; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

ANIMALIA;

EID: 4143050328     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0402090101     Document Type: Article

References (31)

1. Mantovani, A. (1999) Immunol. Today 20, 254-257.
2. Rollins, B. J. (1997) Blood 90, 909-928.
3. Gerard, C. & Rollins, B. J. (2001) Nat. Immunol. 2, 108-115.
4. Howard, O. M., Oppenheim, J. J. & Wang, J. M. (1999) J. Clin. Immunol. 19, 280-292.
5. Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J. & Power, C. A. (2000) Pharmacol. Rev. 52, 145-176.
6. Proudfoot, A. E. (2002) Nat. Rev. Immunol. 2, 106-115.
7. Horuk, R. & Ng, H. P. (2000) Med. Res. Rev. 20, 155-168.
8. White, J. R., Lee, J. M., Dede, K., Imburgia, C. S., Jurewicz, A. J., Chan, G., Fornwald, J. A., Dhanak, D., Christmann, L. T., Darcy, M. G., et al. (2000) J. Biol. Chem. 275, 36626-36631.
9. Bizzarri, C., Allegretti, M., Di Bitondo, R., Cervellera, M. N., Colotta, F. & Bertini, R. (2003) Curr. Med. Chem. 2, 67-79.
10. Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O. & Gray, P. W. (1998) J. Biol. Chem. 273, 1764-1768.
11. Bizzarri, C., Pagliei, S., Brandolini, L., Mascagni, P., Caselli, G., Transidico, P., Sozzani, S. & Bertini, R. (2001) Biochem. Pharmacol. 61, 1429-1437.
12. Munson, P. J. & Rodbard, D. (1980) Anal. Biochem. 107, 220-239.
13. Locati, M., Deuschle, U., Massardi, M. L., Martinez, F. O., Sironi, M., Sozzani, S., Bartfai, T. & Mantovani, A. (2002) J. Immunol. 168, 3557-3562.
14. Villa, P., Meazza, C., Sironi, M., Bianchi, M., Ulrich, P., Bothkina, G., Tracey, K. J. & Ghezzi, P. (1997) J. Endotoxin Res. 4, 197-204.
15. Cutrin, J. C., Boveris, A., Zingaro, B., Corvetti, G. & Poli, G. (2000) Hepatology 31, 622-632.
16. Cavalieri, B., Perrelli, M. G., Aragno, M., Mastrocola, R., Corvetti, G., Durazzo, M., Poli, G. & Cutrin, J. C. (2002) Liver Transplant. 8, 990-999.
17. Moloney, W. C., McPherson, K. & Fliegelman, L. (1960) J. Histochem. Cytochem. 8, 200-207.
18. Selinsky, B. S., Gupta, K., Sharkey, C. T. & Loll, P. J. (2001) Biochemistry 40, 5172-5180.
19. Hammond, M. E., Lapointe, G. R., Feucht, P. H., Hilt, S., Gallegos, C. A., Gordon, C. A., Giedlin, M. A., Mullenbach, G. & Tekamp-Olson, P. (1995) J. Immunol. 155, 1428-1433.
20. Christopoulos, A. & Kenakin, T. (2002) Pharmacol. Rev. 54, 323-374.
21. Sabroe, I., Peck, M. J., Van Keulen, B. J., Jorritsma, A., Simmons, G., Clapham, P. R., Williams, T. J. & Pease, J. E. (2000) J. Biol. Chem. 275, 25985-25992.
22. Chuang, V. T., Kuniyasu, A., Nakayama, H., Matsushita, Y., Hirono, S. & Otagiri, M. (1999) Biochim. Biophys. Acta. 1434, 18-30.
23. Meng, E. C. & Bourne, H. R. (2001) Trends Pharmacol. Sci. 22, 587-593.
24. Podolin, P. L., Bolognese, B. J., Foley, J. J., Schmidt, D. B., Buckley, P. T., Widdowson, K. L., Jin, Q., White, J. R., Lee, J. M., Goodman, R. B., et al. (2002) J. Immunol. 169, 6435-6444.
25. White, J. R., Lee, J. M., Young, P. R., Hertzberg, R. P., Jurewicz, A. J., Chaikin, M. A., Widdowson, K., Foley, J. J., Martin, L. D., Griswold, D. E. & Sarau, H. M. (1998) J. Biol. Chem. 273, 10095-10098.
26. Dragic, T., Trkola, A., Thompson, D. A., Cormier, E. G., Kajumo, F. A., Maxwell, E., Lin, S. W., Ying, W., Smith, S. O., Sakmar, T. P. & Moore, J. P. (2000) Proc. Natl. Acad. Sci. USA 97, 5639-5644.
27. Tarasova, N. I., Rice, W. G. & Michejda, C. J. (1999) J. Biol. Chem. 274, 34911-34915.
28. Shoskes, A. D., Shahed, A. R. & Kim, S. (2001) Renal Vasc. Dis. Transplant. 28, 721-732.
29. Ojo, A. O., Wolfe, R. A., Held, P. J., Port, F. K. & Schmouder, R. L. (1997) Transplantation 63, 968-974.
30. Ploeg, R. J., van Bockel, J. H., Langendijk, P. T., Groenewegen, M., van der Woude, F. J., Persijn, G. G., Thorogood, J. & Hermans, J. (1992) Lancet 340, 129-137.
31. Tilney, N. L., Paz, D., Ames, J., Gasser, M., Laskowski, I. & Hancock, W. W. (2001) Transplant. Proc. 33, 843-844.