메뉴 건너뛰기




Volumn 2012, Issue , 2012, Pages

The role of BCL2 family of apoptosis regulator proteins in acute and chronic leukemias

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ASPARAGINASE; BH3 PROTEIN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; FLUDARABINE; NAVITOCLAX; OBLIMERSEN; PROTEIN BCL 2; PROTEIN MCL 1; RITUXIMAB; VINCRISTINE;

EID: 81555221746     PISSN: 16879104     EISSN: 16879112     Source Type: Journal    
DOI: 10.1155/2012/524308     Document Type: Review
Times cited : (211)

References (138)
  • 1
    • 0141884305 scopus 로고    scopus 로고
    • Diversity in the mechanisms of neuronal cell death
    • DOI 10.1016/S0896-6273(03)00601-9
    • Yuan J., Lipinski M., Degterev A., Diversity in the mechanisms of neuronal cell death Neuron 2003 40 2 401 413 (Pubitemid 37244104)
    • (2003) Neuron , vol.40 , Issue.2 , pp. 401-413
    • Yuan, J.1    Lipinski, M.2    Degterev, A.3
  • 3
    • 77956095537 scopus 로고    scopus 로고
    • Mitochondria and cell death: Outer membrane permeabilization and beyond
    • Tait S. W. G., Green D. R., Mitochondria and cell death: outer membrane permeabilization and beyond Nature Reviews Molecular Cell Biology 2010 11 9 621 632
    • (2010) Nature Reviews Molecular Cell Biology , vol.11 , Issue.9 , pp. 621-632
    • Tait, S.W.G.1    Green, D.R.2
  • 4
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D. R., Reed J. C., Mitochondria and apoptosis Science 1998 281 5381 1309 1312 (Pubitemid 28406816)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 5
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Tsujimoto Y., Gorham J., Cossman J., The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining Science 1985 229 4720 1390 1393 (Pubitemid 16222379)
    • (1985) Science , vol.229 , Issue.4720 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3
  • 6
    • 0036716281 scopus 로고    scopus 로고
    • The BCL2 family: Regulators of the cellular life-or-death switch
    • DOI 10.1038/nrc883
    • Cory S., Adams J. M., The BCL2 family: regulators of the cellular life-or-death switch Nature Reviews Cancer 2002 2 9 647 656 (Pubitemid 37328916)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.9 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 7
    • 33847185843 scopus 로고    scopus 로고
    • Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells
    • Pickering B. M., De Mel S., Lee M., Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells Oncogene 2007 26 8 1166 1177
    • (2007) Oncogene , vol.26 , Issue.8 , pp. 1166-1177
    • Pickering, B.M.1    De Mel, S.2    Lee, M.3
  • 8
    • 0034630161 scopus 로고    scopus 로고
    • The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems
    • DOI 10.1006/excr.2000.4840
    • Walczak H., Krammer P. H., The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems Experimental Cell Research 2000 256 1 58 66 (Pubitemid 30211167)
    • (2000) Experimental Cell Research , vol.256 , Issue.1 , pp. 58-66
    • Walczak, H.1    Krammer, P.H.2
  • 9
    • 33644928489 scopus 로고    scopus 로고
    • BCL2 family of apoptosis-related genes: Functions and clinical implications in cancer
    • DOI 10.1080/10408360500295626, PII H5662935274495
    • Thomadaki H., Scorilas A., BCL2 family of apoptosis-related genes: functions and clinical implications in cancer Critical Reviews in Clinical Laboratory Sciences 2006 43 1 1 67 (Pubitemid 43379211)
    • (2006) Critical Reviews in Clinical Laboratory Sciences , vol.43 , Issue.1 , pp. 1-67
    • Thomadaki, H.1    Scorilas, A.2
  • 10
    • 0035280247 scopus 로고    scopus 로고
    • Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family
    • DOI 10.1006/geno.2000.6455
    • Scorilas A., Kyriakopoulou L., Yousef G. M., Ashworth L. K., Kwamie A., Diamandis E. P., Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family Genomics 2001 72 2 217 221 (Pubitemid 32242963)
    • (2001) Genomics , vol.72 , Issue.2 , pp. 217-221
    • Scorilas, A.1    Kyriakopoulou, L.2    Yousef, G.M.3    Ashworth, L.K.4    Kwamie, A.5    Diamandis, E.P.6
  • 13
    • 33845631216 scopus 로고    scopus 로고
    • Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer
    • DOI 10.1016/j.canlet.2006.03.016, PII S0304383506001741
    • Thomadaki H., Talieri M., Scorilas A., Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer Cancer Letters 2007 247 1-2 48 55 (Pubitemid 44959407)
    • (2007) Cancer Letters , vol.247 , Issue.1-2 , pp. 48-55
    • Thomadaki, H.1    Talieri, M.2    Scorilas, A.3
  • 14
    • 33746880352 scopus 로고    scopus 로고
    • Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS
    • DOI 10.1515/BC.2006.133, PII BCHM38781081
    • Thomadaki H., Talieri M., Scorilas A., Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS Biological Chemistry 2006 387 8 1081 1086 (Pubitemid 44200502)
    • (2006) Biological Chemistry , vol.387 , Issue.8 , pp. 1081-1086
    • Thomadaki, H.1    Talieri, M.2    Scorilas, A.3
  • 15
    • 0033842069 scopus 로고    scopus 로고
    • TNF- expression and apoptosis-regulating proteins in oral lichen planus: A comparative immunohistochemical evaluation
    • DOI 10.1034/j.1600-0714.2000.290802.x
    • Sklavounou A., Chrysomali E., Scorilas A., Karameris A., TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation Journal of Oral Pathology and Medicine 2000 29 8 370 375 (Pubitemid 30648009)
    • (2000) Journal of Oral Pathology and Medicine , vol.29 , Issue.8 , pp. 370-375
    • Sklavounou, A.1    Chrysomali, E.2    Scorilas, A.3    Karameris, A.4
  • 17
    • 33745957572 scopus 로고    scopus 로고
    • Proapoptotic multidomain Bcl-2/Bax-family proteins: Mechanisms, physiological roles, and therapeutic opportunities
    • DOI 10.1038/sj.cdd.4401975, PII 4401975
    • Reed J. C., Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities Cell Death and Differentiation 2006 13 8 1378 1386 (Pubitemid 44057473)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1378-1386
    • Reed, J.C.1
  • 18
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams J. M., Cory S., The Bcl-2 protein family: arbiters of cell survival Science 1998 281 5381 1322 1326 (Pubitemid 28406819)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 19
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle R. J., Strasser A., The BCL-2 protein family: opposing activities that mediate cell death Nature Reviews Molecular Cell Biology 2008 9 1 47 59
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.1 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 20
    • 14144251559 scopus 로고    scopus 로고
    • Apoptosis mechanisms: Implications for cancer drug discovery
    • Reed J. C., Apoptosis mechanisms: implications for cancer drug discovery Oncology 2004 18 13 supplement 10 11 20
    • (2004) Oncology , vol.18 , Issue.13 SUPPL. 10 , pp. 11-20
    • Reed, J.C.1
  • 21
    • 0026493580 scopus 로고
    • Bcl-2: An antidote to programmed cell death
    • Korsmeyer S. J., Bcl-2: an antidote to programmed cell death Cancer Surveys 1992 15 105 118
    • (1992) Cancer Surveys , vol.15 , pp. 105-118
    • Korsmeyer, S.J.1
  • 22
    • 29844450350 scopus 로고    scopus 로고
    • Synthesis and secondary structure in membranes of the Bcl-2 anti-apoptotic domain BH4
    • DOI 10.1002/psc.686
    • Khemtemourian L., Sani M. A., Bathany K., Grobner G., Dufourc E. J., Synthesis and secondary structure in membranes of the Bcl-2 anti-apoptotic domain BH4 Journal of Peptide Science 2006 12 1 58 64 (Pubitemid 43033699)
    • (2006) Journal of Peptide Science , vol.12 , Issue.1 , pp. 58-64
    • Khemtemourian, L.1    Sani, M.-A.2    Bathany, K.3    Grobner, G.4    Dufourc, E.J.5
  • 23
    • 0030862687 scopus 로고    scopus 로고
    • The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis
    • Simonen M., Keller H., Heim J., The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis European Journal of Biochemistry 1997 249 1 85 91 (Pubitemid 27432599)
    • (1997) European Journal of Biochemistry , vol.249 , Issue.1 , pp. 85-91
    • Simonen, M.1    Keller, H.2    Heim, J.3
  • 24
    • 0034026759 scopus 로고    scopus 로고
    • Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins
    • DOI 10.1128/JVI.74.11.5024-5031.2000
    • Bellows D. S., Chau B. N., Percy L., Lazebnik Y., Burns W. H., Hardwick J. M., Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins Journal of Virology 2000 74 11 5024 5031 (Pubitemid 30313841)
    • (2000) Journal of Virology , vol.74 , Issue.11 , pp. 5024-5031
    • Bellows, D.S.1    Chau, B.N.2    Percy, L.3    Lazebnik, Y.4    Burns, W.H.5    Hardwick, J.M.6
  • 25
    • 33645337639 scopus 로고    scopus 로고
    • Mcl-1: A highly regulated cell death and survival controller
    • Yang-Yen H. F., Mcl-1: a highly regulated cell death and survival controller Journal of Biomedical Science 2006 13 2 201 204
    • (2006) Journal of Biomedical Science , vol.13 , Issue.2 , pp. 201-204
    • Yang-Yen, H.F.1
  • 27
    • 67349136004 scopus 로고    scopus 로고
    • Mcl-1 is a potential therapeutic target in multiple types of cancer
    • Akgul C., Mcl-1 is a potential therapeutic target in multiple types of cancer Cellular and Molecular Life Sciences 2009 66 8 1326 1336
    • (2009) Cellular and Molecular Life Sciences , vol.66 , Issue.8 , pp. 1326-1336
    • Akgul, C.1
  • 28
    • 77953712167 scopus 로고    scopus 로고
    • Mitochondrial signaling in cell death via the Bcl-2 family
    • Leibowitz B., Yu J., Mitochondrial signaling in cell death via the Bcl-2 family Cancer Biology and Therapy 2010 9 6 417 422
    • (2010) Cancer Biology and Therapy , vol.9 , Issue.6 , pp. 417-422
    • Leibowitz, B.1    Yu, J.2
  • 30
    • 33745953139 scopus 로고    scopus 로고
    • BCL-2 in the crosshairs: Tipping the balance of life and death
    • DOI 10.1038/sj.cdd.4401992, PII 4401992
    • Walensky L. D., BCL-2 in the crosshairs: tipping the balance of life and death Cell Death and Differentiation 2006 13 8 1339 1350 (Pubitemid 44057469)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1339-1350
    • Walensky, L.D.1
  • 31
    • 14744281338 scopus 로고    scopus 로고
    • L specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum
    • DOI 10.1083/jcb.200408169
    • Klee M., Pimentel-Muinos F. X., Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum Journal of Cell Biology 2005 168 5 723 734 (Pubitemid 40328157)
    • (2005) Journal of Cell Biology , vol.168 , Issue.5 , pp. 723-734
    • Klee, M.1    Pimentel-Muinos, F.X.2
  • 32
    • 0842278331 scopus 로고    scopus 로고
    • Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
    • DOI 10.1126/science.1092734
    • Chipuk J. E., Kuwana T., Bouchier-Hayes L., Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 2004 303 5660 1010 1014 (Pubitemid 38209704)
    • (2004) Science , vol.303 , Issue.5660 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6    Green, D.R.7
  • 34
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • DOI 10.1016/S0092-8674(00)81382-3
    • Zha J., Harada H., Yang E., Jockel J., Korsmeyer S. J., Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell 1996 87 4 619 628 (Pubitemid 26386936)
    • (1996) Cell , vol.87 , Issue.4 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 36
    • 33745954330 scopus 로고    scopus 로고
    • BCL2 family in DNA damage and cell cycle control
    • DOI 10.1038/sj.cdd.4401987, PII 4401987
    • Zinkel S., Gross A., Yang E., BCL2 family in DNA damage and cell cycle control Cell Death and Differentiation 2006 13 8 1351 1359 (Pubitemid 44057470)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1351-1359
    • Zinkel, S.1    Gross, A.2    Yang, E.3
  • 39
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X., Budihardjo I., Zou H., Slaughter C., Wang X., Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cell 1998 94 4 481 490 (Pubitemid 28391864)
    • (1998) Cell , vol.94 , Issue.4 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 40
    • 3142581992 scopus 로고    scopus 로고
    • Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens
    • DOI 10.1074/jbc.M400268200
    • Werner A. B., Tait S. W. G., De Vries E., Eldering E., Borst J., Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens Journal of Biological Chemistry 2004 279 27 28771 28780 (Pubitemid 38900162)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.27 , pp. 28771-28780
    • Werner, A.B.1    Tait, S.W.G.2    De Vries, E.3    Eldering, E.4    Borst, J.5
  • 41
    • 13944277343 scopus 로고    scopus 로고
    • BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    • DOI 10.1016/j.molcel.2005.02.003
    • Kuwana T., Bouchier-Hayes L., Chipuk J. E., BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly Molecular Cell 2005 17 4 525 535 (Pubitemid 40269117)
    • (2005) Molecular Cell , vol.17 , Issue.4 , pp. 525-535
    • Kuwana, T.1    Bouchier-Hayes, L.2    Chipuk, J.E.3    Bonzon, C.4    Sullivan, B.A.5    Green, D.R.6    Newmeyer, D.D.7
  • 45
    • 2542535233 scopus 로고    scopus 로고
    • Assessment of Bcl-2 expression ass modulator of Fas mediated apoptosis in acute leukemia
    • Aref S., Salama O., Al-Tonbary Y., Mansour A., Assessment of bcl-2 expression ass modulator of Fas mediated apoptosis in acute leukemia Hematology 2004 9 2 113 121 (Pubitemid 38697025)
    • (2004) Hematology , vol.9 , Issue.2 , pp. 113-121
    • Aref, S.1    Salama, O.2    Al-Tonbary, Y.3    Mansour, A.4
  • 46
    • 0036833979 scopus 로고    scopus 로고
    • Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia
    • Sahu G. R., Das B. R., Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia Oncology Reports 2002 9 6 1391 1398
    • (2002) Oncology Reports , vol.9 , Issue.6 , pp. 1391-1398
    • Sahu, G.R.1    Das, B.R.2
  • 48
    • 0033560819 scopus 로고    scopus 로고
    • Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia
    • Hogarth L. A., Hall A. G., Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia Blood 1999 93 8 2671 2678 (Pubitemid 29181200)
    • (1999) Blood , vol.93 , Issue.8 , pp. 2671-2678
    • Hogarth, L.A.1    Hall, A.G.2
  • 51
    • 77957957189 scopus 로고    scopus 로고
    • T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation
    • Feng H., Stachura D. L., White R. M., T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation Cancer Cell 2010 18 4 353 366
    • (2010) Cancer Cell , vol.18 , Issue.4 , pp. 353-366
    • Feng, H.1    Stachura, D.L.2    White, R.M.3
  • 52
    • 0033832590 scopus 로고    scopus 로고
    • Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
    • Prokop A., Wieder T., Sturm I., Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo Leukemia 2000 14 9 1606 1613
    • (2000) Leukemia , vol.14 , Issue.9 , pp. 1606-1613
    • Prokop, A.1    Wieder, T.2    Sturm, I.3
  • 55
    • 77953250077 scopus 로고    scopus 로고
    • Low mRNA expression of the apoptosis-related genes CASP3, CASP8, and FAS is associated with low induction treatment response in childhood acute lymphoblastic leukemia (ALL)
    • Mata J. F., Silveira V. S., Mateo E. C., Low mRNA expression of the apoptosis-related genes CASP3, CASP8, and FAS is associated with low induction treatment response in childhood acute lymphoblastic leukemia (ALL) Pediatric Blood and Cancer 2010 55 1 100 107
    • (2010) Pediatric Blood and Cancer , vol.55 , Issue.1 , pp. 100-107
    • Mata, J.F.1    Silveira, V.S.2    Mateo, E.C.3
  • 56
    • 21844470230 scopus 로고    scopus 로고
    • Flow cytometric immunophenotyping including Bcl-2 detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non-Hodgkin's lymphoma
    • DOI 10.1002/cyto.b.20043
    • Laane E., Tani E., Bjorklund E., Flow cytometric immunophenotyping including Bcl-2 detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non-Hodgkin's lymphoma Cytometry Part B 2005 64 1 34 42 (Pubitemid 40960410)
    • (2005) Cytometry Part B - Clinical Cytometry , vol.64 , Issue.1 , pp. 34-42
    • Laane, E.1    Tani, E.2    Bjorklund, E.3    Elmberger, G.4    Everaus, H.5    Skoog, L.6    Porwit-MacDonald, A.7
  • 57
    • 67349150662 scopus 로고    scopus 로고
    • Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells
    • Ploner C., Rainer J., Lobenwein S., Geley S., Kofler R., Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells Apoptosis 2009 14 6 821 828
    • (2009) Apoptosis , vol.14 , Issue.6 , pp. 821-828
    • Ploner, C.1    Rainer, J.2    Lobenwein, S.3    Geley, S.4    Kofler, R.5
  • 61
    • 0035889912 scopus 로고    scopus 로고
    • Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-b, c-Myc, and pRb pathways
    • Buggins A. G. S., Milojkovic D., Arno M. J., Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways Journal of Immunology 2001 167 10 6021 6030 (Pubitemid 33062801)
    • (2001) Journal of Immunology , vol.167 , Issue.10 , pp. 6021-6030
    • Buggins, A.G.S.1    Milojkovic, D.2    Arno, M.J.3    Lea, N.C.4    Mufti, G.J.5    Thomas, N.S.B.6    Hirst, W.J.R.7
  • 63
    • 0032734301 scopus 로고    scopus 로고
    • Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics
    • Wuchter C., Karawajew L., Ruppert V., Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics Leukemia 1999 13 12 1943 1953
    • (1999) Leukemia , vol.13 , Issue.12 , pp. 1943-1953
    • Wuchter, C.1    Karawajew, L.2    Ruppert, V.3
  • 67
    • 0031889769 scopus 로고    scopus 로고
    • High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia
    • DOI 10.1023/A:1008255511404
    • Karakas T., Maurer U., Weidmann E., Miething C. C., Hoelzer D., Bergmann L., High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia Annals of Oncology 1998 9 2 159 165 (Pubitemid 28123617)
    • (1998) Annals of Oncology , vol.9 , Issue.2 , pp. 159-165
    • Karakas, T.1    Maurer, U.2    Weidmann, E.3    Miething, C.C.4    Hoelzer, D.5    Bergmann, L.6
  • 70
    • 0036890357 scopus 로고    scopus 로고
    • The study for loss of bcl-xs expression as a prognostic factor in acute myeloid leukemia
    • DOI 10.1016/S0145-2126(02)00061-9, PII S0145212602000619
    • Yamaguchi H., Inokuchi K., Dan K., The study for loss of bcl-xs expression as a prognostic factor in acute myeloid leukemia Leukemia Research 2002 26 12 1119 1123 (Pubitemid 35346407)
    • (2002) Leukemia Research , vol.26 , Issue.12 , pp. 1119-1123
    • Yamaguchi, H.1    Inokuchi, K.2    Dan, K.3
  • 72
    • 0032820867 scopus 로고    scopus 로고
    • Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): Results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)
    • Rochlitz C., Lohri A., Bacchi M., Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK) Leukemia 1999 13 9 1352 1358 (Pubitemid 29429761)
    • (1999) Leukemia , vol.13 , Issue.9 , pp. 1352-1358
    • Rochlitz, C.1    Lohri, A.2    Bacchi, M.3    Schmidt, M.4    Nagel, S.5    Fopp, M.6    Fey, M.F.7    Herrmann, R.8    Neubauer, A.9
  • 73
    • 0025637786 scopus 로고
    • Interleukin-1 is one factor which regulates autocrine production of GM-CSF by the blast cells of acute myeloblastic leukaemia
    • Bradbury D., Rogers S., Kozlowski R., Bowen G., Reilly I. A. G., Russell N. H., Interleukin-1 is one factor which regulates autocrine production of GM-CSF by the blast cells of acute myeloblastic leukaemia British Journal of Haematology 1990 76 4 488 493
    • (1990) British Journal of Haematology , vol.76 , Issue.4 , pp. 488-493
    • Bradbury, D.1    Rogers, S.2    Kozlowski, R.3    Bowen, G.4    Reilly, I.A.G.5    Russell, N.H.6
  • 74
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signalling lipid
    • DOI 10.1038/nrm1103
    • Spiegel S., Milstien S., Sphingosine-1-phosphate: an enigmatic signalling lipid Nature Reviews Molecular Cell Biology 2003 4 5 397 407 (Pubitemid 36565571)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.5 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 75
    • 6344253247 scopus 로고    scopus 로고
    • Interleukin-1 maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways
    • DOI 10.1038/sj.leu.2403457
    • Turzanski J., Grundy M., Russell N. H., Pallis M., Interleukin-1beta maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways Leukemia 2004 18 10 1662 1670 (Pubitemid 39386345)
    • (2004) Leukemia , vol.18 , Issue.10 , pp. 1662-1670
    • Turzanski, J.1    Grundy, M.2    Russell, N.H.3    Pallis, M.4
  • 76
    • 0033972153 scopus 로고    scopus 로고
    • Interferon- has dual potentials in inhibiting or promoting cell proliferation
    • DOI 10.1074/jbc.275.2.867
    • Asao H., Fu X. Y., Interferon-gamma has dual potentials in inhibiting or promoting cell proliferation Journal of Biological Chemistry 2000 275 2 867 874 (Pubitemid 30051128)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 867-874
    • Asao, H.1    Fu, X.-Y.2
  • 77
    • 0037818425 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia
    • DOI 10.1182/blood-2002-06-1890
    • Faderl S., Harris D., Van Q., Kantarjian H. M., Talpaz M., Estrov Z., Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia Blood 2003 102 2 630 637 (Pubitemid 36841985)
    • (2003) Blood , vol.102 , Issue.2 , pp. 630-637
    • Faderl, S.1    Harris, D.2    Van, Q.3    Kantarjian, H.M.4    Talpaz, M.5    Estrov, Z.6
  • 79
    • 0034574224 scopus 로고    scopus 로고
    • Cytogenetic abnormalities in chronic lymphocytic leukemia
    • Karnolsky I. N., Cytogenetic abnormalities in chronic lymphocytic leukemia Folia Medica 2000 42 3 5 10
    • (2000) Folia Medica , vol.42 , Issue.3 , pp. 5-10
    • Karnolsky, I.N.1
  • 82
    • 33846004731 scopus 로고    scopus 로고
    • Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    • DOI 10.1182/blood-2006-03-007567
    • Nuckel H., Frey U. H., Bau M., Association of a novel regulatory polymorphism (-938 C A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia Blood 2007 109 1 290 297 (Pubitemid 46053069)
    • (2007) Blood , vol.109 , Issue.1 , pp. 290-297
    • Nuckel, H.1    Frey, U.H.2    Bau, M.3    Sellmann, L.4    Stanelle, J.5    Durig, J.6    Jockel, K.-H.7    Duhrsen, U.8    Siffert, W.9
  • 83
    • 38349186923 scopus 로고    scopus 로고
    • BCL2 expression in chronic lymphocytic leukemia: Lack of association with the BCL2 938 C A promoter single nucleotide polymorphism
    • Majid A., Tsoulakis O., Walewska R., BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938 C A promoter single nucleotide polymorphism Blood 2008 111 2 874 877
    • (2008) Blood , vol.111 , Issue.2 , pp. 874-877
    • Majid, A.1    Tsoulakis, O.2    Walewska, R.3
  • 84
    • 0031929376 scopus 로고    scopus 로고
    • Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance
    • Pepper C., Hoy T., Bentley P., Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance Leukemia and Lymphoma 1998 28 3-4 355 361 (Pubitemid 28105041)
    • (1998) Leukemia and Lymphoma , vol.28 , Issue.3-4 , pp. 355-361
    • Pepper, C.1    Hoy, T.2    Bentley, P.3
  • 85
    • 33644972037 scopus 로고    scopus 로고
    • The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia
    • Skogsberg S., Tobin G., Krober A., The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia Leukemia 2006 20 1 77 81
    • (2006) Leukemia , vol.20 , Issue.1 , pp. 77-81
    • Skogsberg, S.1    Tobin, G.2    Krober, A.3
  • 86
    • 2442454735 scopus 로고    scopus 로고
    • Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia
    • Moshynska O., Sankaran K., Pahwa P., Saxena A., Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia Journal of the National Cancer Institute 2004 96 9 673 682 (Pubitemid 38660230)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.9 , pp. 673-682
    • Moshynska, O.1    Sankaran, K.2    Pahwa, P.3    Saxena, A.4
  • 87
    • 16444375702 scopus 로고    scopus 로고
    • Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia
    • DOI 10.1111/j.1365-2567.2005.02117.x
    • Packham G., Stevenson F. K., Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia Immunology 2005 114 4 441 449 (Pubitemid 40478137)
    • (2005) Immunology , vol.114 , Issue.4 , pp. 441-449
    • Packham, G.1    Stevenson, F.K.2
  • 89
    • 0029871942 scopus 로고    scopus 로고
    • Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
    • Robertson L. E., Plunkett W., McConnell K., Keating M. J., McDonnell T. J., Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome Leukemia 1996 10 3 456 459 (Pubitemid 26128784)
    • (1996) Leukemia , vol.10 , Issue.3 , pp. 456-459
    • Robertson, L.E.1    Plunkett, W.2    McConnell, K.3    Keating, M.J.4    McDonnell, T.J.5
  • 90
    • 0032412347 scopus 로고    scopus 로고
    • Increased bcl-2/bax ratio in B-cell chronic lymphocytic leukemia is associated with a progressive pattern of disease
    • Molica S., Dattilo A., Giulino C., Levato D., Levato L., Increased bcl-2/bax ratio in B-cell chronic lymphocytic leukemia is associated with a progressive pattern of disease Haematologica 1998 83 12 1122 1124 (Pubitemid 29065932)
    • (1998) Haematologica , vol.83 , Issue.12 , pp. 1122-1124
    • Molica, S.1    Dattilo, A.2    Giulino, C.3    Levato, D.4    Levato, L.5
  • 91
    • 0029970093 scopus 로고    scopus 로고
    • Mcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression
    • DOI 10.1002/(SICI)1097-0215(19960422)69:2<114::AID-IJC8>3.0.CO;2-3
    • Aguilar-Santelises M., Rottenberg M. E., Lewin N., Mellstedt H., Jondal M., bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression International Journal of Cancer 1996 69 2 114 119 (Pubitemid 26167166)
    • (1996) International Journal of Cancer , vol.69 , Issue.2 , pp. 114-119
    • Aguilar-Santelises, M.1    Rottenberg, M.E.2    Lewin, N.3    Mellstedt, H.4    Jondal, M.5
  • 92
    • 0031466593 scopus 로고    scopus 로고
    • - B-cell lymphoid chronic leukemias
    • Molica S., Mannella A., Crispino G., Dattilo A., Levato D., Comparative flow cytometric evaluation of bcl-2 oncoprotein in CD5+ and CD5- B-cell lymphoid chronic leukemias Haematologica 1997 82 5 555 559 (Pubitemid 28023248)
    • (1997) Haematologica , vol.82 , Issue.5 , pp. 555-559
    • Molica, S.1    Mannella, A.2    Crispino, G.3    Dattilo, A.4    Levato, D.5
  • 94
    • 33644810416 scopus 로고    scopus 로고
    • Fludarabine induces apoptosis in chronic lymphocytic leukemia - The role of P53, Bcl-2, Bax, Mcl-1 and Bag-1 proteins
    • DOI 10.1590/S0100-879X2006000300003
    • Faria J. R., Yamamoto M., Faria R. M. D., Kerbauy J., Oliveira J. S. R., Fludarabine induces apoptosis in chronic lymphocytic leukemiathe role of P53, Bcl-2, Bax, Mcl-1 and Bag-1 proteins Brazilian Journal of Medical and Biological Research 2006 39 3 327 333 (Pubitemid 43349467)
    • (2006) Brazilian Journal of Medical and Biological Research , vol.39 , Issue.3 , pp. 327-333
    • Faria, J.R.1    Yamamoto, M.2    Faria, R.M.D.3    Kerbauy, J.4    Oliveira, J.S.R.5
  • 95
    • 11944251279 scopus 로고    scopus 로고
    • High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia
    • DOI 10.1002/ijc.20614
    • Morales A. A., Olsson A., Celsing F., Osterborg A., Jondal M., Osorio L. M., High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia International Journal of Cancer 2005 113 5 730 737 (Pubitemid 40101253)
    • (2005) International Journal of Cancer , vol.113 , Issue.5 , pp. 730-737
    • Morales, A.A.1    Olsson, A.2    Celsing, F.3    Osterborg, A.4    Jondal, M.5    Osorio, L.M.6
  • 97
    • 0347416908 scopus 로고    scopus 로고
    • Mcl-1 and Bcl-2/Bax Ratio Are Associated with Treatment Response but Not with Rai Stage in B-Cell Chronic Lymphocytic Leukemia
    • DOI 10.1002/ajh.10453
    • Saxena A., Viswanathan S., Moshynska O., Tandon P., Sankaran K., Sheridan D. P., Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia American Journal of Hematology 2004 75 1 22 33 (Pubitemid 38040164)
    • (2004) American Journal of Hematology , vol.75 , Issue.1 , pp. 22-33
    • Saxena, A.1    Viswanathan, S.2    Moshynska, O.3    Tandon, P.4    Sankaran, K.5    Sheridan, D.P.6
  • 98
    • 0036971988 scopus 로고    scopus 로고
    • Immunocytochemical detection of bcl-2 and p53 proteins in B-chronic lymphocytic leukemia patients
    • Klobusicka M., Kusenda J., Babusikova O., Immunocytochemical detection of bcl-2 and p53 proteins in B-chronic lymphocytic leukemia patients Neoplasma 2002 49 6 387 393 (Pubitemid 36139239)
    • (2002) Neoplasma , vol.49 , Issue.6 , pp. 387-393
    • Klobusicka, M.1    Kusenda, J.2    Babusikova, O.3
  • 99
    • 0033970414 scopus 로고    scopus 로고
    • Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and p53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): Relation to disease status
    • Lazaridou A., Miraxtsi C., Korantzis J., Eleftheriadis N., Christakis J. I., Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and p53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): relation to disease status Leukemia and Lymphoma 2000 36 5-6 503 512 (Pubitemid 30103175)
    • (2000) Leukemia and Lymphoma , vol.36 , Issue.5-6 , pp. 503-512
    • Lazaridou, A.1    Miraxtsi, C.2    Korantzis, J.3    Eleftheriadis, N.4    Christakis, J.I.5
  • 100
    • 0032438671 scopus 로고    scopus 로고
    • Elevated plasma levels of interleukin-1 receptor antagonist are associated with decreased cellular BCL-2 oncoprotein expression in B-chronic lymphocytic leukemia
    • Duensing S., Nasarek A., Grosse J., Ganser A., Atzpodien J., Elevated plasma levels of interleukin-1 receptor antagonist are associated with decreased cellular BCL-2 oncoprotein expression in B-chronic lymphocytic leukemia Cancer Biotherapy and Radiopharmaceuticals 1998 13 5 383 385 (Pubitemid 29011311)
    • (1998) Cancer Biotherapy and Radiopharmaceuticals , vol.13 , Issue.5 , pp. 383-385
    • Duensing, S.1    Nasarek, A.2    Grosse, J.3    Ganser, A.4    Atzpodien, J.5
  • 101
    • 0034651739 scopus 로고    scopus 로고
    • Modulation of NF-B activity and apoptosis in chronic lymphocytic leukemia B cells
    • Furman R. R., Asgary Z., Mascarenhas J. O., Liou H. C., Schattner E. J., Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells Journal of Immunology 2000 164 4 2200 2206 (Pubitemid 30108780)
    • (2000) Journal of Immunology , vol.164 , Issue.4 , pp. 2200-2206
    • Furman, R.R.1    Asgary, Z.2    Mascarenhas, J.O.3    Liou, H.-C.4    Schattner, E.J.5
  • 103
    • 73949119120 scopus 로고    scopus 로고
    • Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of Akt inhibition
    • Zhuang J., Hawkins S. F., Glenn M. A., Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition Haematologica 2010 95 1 110 118
    • (2010) Haematologica , vol.95 , Issue.1 , pp. 110-118
    • Zhuang, J.1    Hawkins, S.F.2    Glenn, M.A.3
  • 105
    • 0030986407 scopus 로고    scopus 로고
    • Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase
    • DOI 10.1016/S0145-2126(97)00006-4, PII S0145212697000064
    • Handa H., Hegde U. P., Kotelnikov V. M., Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase Leukemia Research 1997 21 6 479 489 (Pubitemid 27384902)
    • (1997) Leukemia Research , vol.21 , Issue.6 , pp. 479-489
    • Handa, H.1    Hegde, U.P.2    Kotelnikov, V.M.3    Mundle, S.D.4    Dong, L.-M.5    Burke, P.6    Rose, S.7    Gaskin, F.8    Raza, A.9    Preisler, H.D.10
  • 106
    • 0023819693 scopus 로고
    • Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1
    • Freytag S. O., Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1 Molecular and Cellular Biology 1988 8 4 1614 1624
    • (1988) Molecular and Cellular Biology , vol.8 , Issue.4 , pp. 1614-1624
    • Freytag, S.O.1
  • 107
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K., Halpern J., Hoeve J. T., Rao X., Sawyers C. L., Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia Oncogene 1996 13 2 247 254 (Pubitemid 26334856)
    • (1996) Oncogene , vol.13 , Issue.2 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 108
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • DOI 10.1126/science.277.5332.1630
    • Darnell J. E. Jr., STATs and gene regulation Science 1997 277 5332 1630 1635 (Pubitemid 27446219)
    • (1997) Science , vol.277 , Issue.5332 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 109
    • 0033959620 scopus 로고    scopus 로고
    • The survival function of the Bcr-Abl oncogene is mediated by bad- dependent and -independent pathways: Roles for phosphatidylinositol 3-kinase and Raf
    • DOI 10.1128/MCB.20.4.1179-1186.2000
    • Neshat M. S., Raitano A. B., Wang H. G., Reed J. C., Sawyers C. L., The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf Molecular and Cellular Biology 2000 20 4 1179 1186 (Pubitemid 30069238)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.4 , pp. 1179-1186
    • Neshat, M.S.1    Raitano, A.B.2    Wang, H.-G.3    Reed, J.C.4    Sawyers, C.L.5
  • 110
    • 0036739778 scopus 로고    scopus 로고
    • High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion
    • Keeshan K., Cotter T. G., McKenna S. L., High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion Leukemia 2002 16 9 1725 1734
    • (2002) Leukemia , vol.16 , Issue.9 , pp. 1725-1734
    • Keeshan, K.1    Cotter, T.G.2    McKenna, S.L.3
  • 113
    • 20144388297 scopus 로고    scopus 로고
    • Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): Evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
    • Aichberger K. J., Mayerhofer M., Krauth M. T., Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides Blood 2005 105 8 3303 3311
    • (2005) Blood , vol.105 , Issue.8 , pp. 3303-3311
    • Aichberger, K.J.1    Mayerhofer, M.2    Krauth, M.T.3
  • 114
    • 32944475363 scopus 로고    scopus 로고
    • Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia
    • DOI 10.1200/JCO.2005.02.4364
    • O'Brien S. M., Cunningham C. C., Golenkov A. K., Turkina A. G., Novick S. C., Rai K. R., Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia Journal of Clinical Oncology 2005 23 30 7697 7702 (Pubitemid 46291834)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.30 , pp. 7697-7702
    • O'Brien, S.M.1    Cunningham, C.C.2    Golenkov, A.K.3    Turkina, A.G.4    Novick, S.C.5    Rai, K.R.6
  • 115
    • 0037265811 scopus 로고    scopus 로고
    • Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein
    • DOI 10.1038/sj.leu.2402768
    • van de Donk N. W. C., Kamphuis M. M. J., van Dijk M., Borst H. P. E., Bloem A. C., Lokhorst H. M., Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein Leukemia 2003 17 1 211 219 (Pubitemid 36175908)
    • (2003) Leukemia , vol.17 , Issue.1 , pp. 211-219
    • Van De Donk, N.W.C.J.1    Kamphuis, M.M.J.2    Van Dijk, M.3    Borst, H.P.E.4    Bloem, A.C.5    Lokhorst, H.M.6
  • 116
    • 0029366403 scopus 로고
    • Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL
    • Smith M. R., Abubakr Y., Mohammad R., Xie T., Hamdan M., al-Katib A., Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL Cancer Gene Therapy 1995 2 3 207 212
    • (1995) Cancer Gene Therapy , vol.2 , Issue.3 , pp. 207-212
    • Smith, M.R.1    Abubakr, Y.2    Mohammad, R.3    Xie, T.4    Hamdan, M.5    Al-Katib, A.6
  • 118
    • 15244355253 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy in B-cell malignancies
    • DOI 10.1016/j.blre.2004.11.002
    • Chanan-Khan A., Bcl-2 antisense therapy in B-cell malignancies Blood Reviews 2005 19 4 213 221 (Pubitemid 40387412)
    • (2005) Blood Reviews , vol.19 , Issue.4 , pp. 213-221
    • Chanan-Khan, A.1
  • 119
    • 20644469046 scopus 로고    scopus 로고
    • Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: Pharmacokinetics, pharmacodynamics, and clinical activity
    • Marcucci G., Stock W., Dai G., Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity Journal of Clinical Oncology 2005 23 15 3404 3411
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.15 , pp. 3404-3411
    • Marcucci, G.1    Stock, W.2    Dai, G.3
  • 121
    • 0036716596 scopus 로고    scopus 로고
    • New drugs in acute myeloid leukemia
    • Giles F. J., New drugs in acute myeloid leukemia Current Oncology Reports 2002 4 5 369 374
    • (2002) Current Oncology Reports , vol.4 , Issue.5 , pp. 369-374
    • Giles, F.J.1
  • 122
    • 33751503189 scopus 로고    scopus 로고
    • Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells
    • DOI 10.1515/BC.2006.203, PII BCHM387121629
    • Floros K. V., Talieri M., Scorilas A., Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells Biological Chemistry 2006 387 12 1629 1633 (Pubitemid 44837589)
    • (2006) Biological Chemistry , vol.387 , Issue.12 , pp. 1629-1633
    • Floros, K.V.1    Talieri, M.2    Scorilas, A.3
  • 123
    • 33947615372 scopus 로고    scopus 로고
    • Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide
    • DOI 10.1196/annals.1378.009, Signal Transduction Pathways, Part A: Apoptotic and Extracellular Signalling
    • Floros K. V., Thomadaki H., Florou D., Talieri M., Scorilas A., Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide Annals of the New York Academy of Sciences 2006 1090 89 97 (Pubitemid 47092111)
    • (2006) Annals of the New York Academy of Sciences , vol.1090 , pp. 89-97
    • Floros, K.V.1    Thomadaki, H.2    Florou, D.3    Talieri, M.4    Scorilas, A.5
  • 124
    • 10044239114 scopus 로고    scopus 로고
    • MRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin
    • DOI 10.1515/BC.2004.143
    • Floros K. V., Thomadaki H., Katsaros N., Taileri M., Scorilas A., mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin Biological Chemistry 2004 385 11 1099 1103 (Pubitemid 39600320)
    • (2004) Biological Chemistry , vol.385 , Issue.11 , pp. 1099-1103
    • Floros, K.V.1    Thomadaki, H.2    Katsaros, N.3    Taileri, M.4    Scorilas, A.5
  • 125
    • 1342347887 scopus 로고    scopus 로고
    • Cisplatin-Induced Apoptosis in HL-60 Human Promyelocytic Leukemia Cells: Differential Expression of BCL2 and Novel Apoptosis-Related Gene BCL2L12
    • DOI 10.1196/annals.1299.025
    • Floros K. V., Thomadaki H., Lallas G., Katsaros N., Talieri M., Scorilas A., Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12 Annals of the New York Academy of Sciences 2003 1010 153 158 (Pubitemid 38264966)
    • (2003) Annals of the New York Academy of Sciences , vol.1010 , pp. 153-158
    • Floros, K.V.1    Thomadaki, H.2    Lallas, G.3    Katsaros, N.4    Talieri, M.5    Scorilas, A.6
  • 126
    • 33947683157 scopus 로고    scopus 로고
    • Enhanced antileukemic activity of the novel complex 2,5-dihydroxybenzoate molybdenum(VI) against 2,5-dihydroxybenzoate, polyoxometalate of Mo(VI), and tetraphenylphosphonium in the human HL-60 and K562 leukemic cell lines
    • DOI 10.1021/jm0610797
    • Thomadaki H., Karaliota A., Litos C., Scorilas A., Enhanced antileukemic activity of the novel complex 2,5-dihydroxybenzoate molybdenum(VI) against 2,5-dihydroxybenzoate, polyoxometalate of Mo(VI), and tetraphenylphosphonium in the human HL-60 and K562 leukemic cell lines Journal of Medicinal Chemistry 2007 50 6 1316 1321 (Pubitemid 46496330)
    • (2007) Journal of Medicinal Chemistry , vol.50 , Issue.6 , pp. 1316-1321
    • Thomadaki, H.1    Karaliota, A.2    Litos, C.3    Scorilas, A.4
  • 127
    • 46849086736 scopus 로고    scopus 로고
    • 2, compared to L-carnitine or copper chloride dihydrate, in human leukemic cell lines
    • DOI 10.1021/jm701473x
    • Thomadaki H., Karaliota A., Litos C., Scorilas A., Enhanced concentration-dependent cytotoxic effect of the dinuclear copper(II) complex of L-carnitine [Cu2(L-carnitine) 2Cl2(H2O)2]Cl2, compared to L-carnitine or copper chloride dihydrate, in human leukemic cell lines Journal of Medicinal Chemistry 2008 51 13 3713 3719 (Pubitemid 351956503)
    • (2008) Journal of Medicinal Chemistry , vol.51 , Issue.13 , pp. 3713-3719
    • Thomadaki, H.1    Karaliota, A.2    Litos, C.3    Scorilas, A.4
  • 128
    • 69149085106 scopus 로고    scopus 로고
    • Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12
    • Thomadaki H., Floros K. V., Scorilas A., Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12 Annals of the New York Academy of Sciences 2009 1171 276 283
    • (2009) Annals of the New York Academy of Sciences , vol.1171 , pp. 276-283
    • Thomadaki, H.1    Floros, K.V.2    Scorilas, A.3
  • 129
    • 44849112219 scopus 로고    scopus 로고
    • ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
    • Tse C., Shoemaker A. R., Adickes J., ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor Cancer Research 2008 68 9 3421 3428
    • (2008) Cancer Research , vol.68 , Issue.9 , pp. 3421-3428
    • Tse, C.1    Shoemaker, A.R.2    Adickes, J.3
  • 130
    • 34548814971 scopus 로고    scopus 로고
    • Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    • DOI 10.1182/blood-2007-03-080325
    • Kang M. H., Kang H. K., Szymanska B., Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo Blood 2007 110 6 2057 2066 (Pubitemid 47443923)
    • (2007) Blood , vol.110 , Issue.6 , pp. 2057-2066
    • Kang, M.H.1    Kang, H.K.2    Szymanska, B.3    Wilczynska-Kalak, U.4    Sheard, M.A.5    Harned, T.M.6    Lock, R.B.7    Reynolds, C.P.8
  • 131
    • 43149117910 scopus 로고    scopus 로고
    • Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation
    • Kang M. H., Wan Z., Kang Y. H., Sposto R., Reynolds C. P., Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation Journal of the National Cancer Institute 2008 100 8 580 595
    • (2008) Journal of the National Cancer Institute , vol.100 , Issue.8 , pp. 580-595
    • Kang, M.H.1    Wan, Z.2    Kang, Y.H.3    Sposto, R.4    Reynolds, C.P.5
  • 132
    • 41349123507 scopus 로고    scopus 로고
    • BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia
    • DOI 10.1182/blood-2007-06-098012
    • Del Gaizo Moore V., Schlis K. D., Sallan S. E., Armstrong S. A., Letai A., BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia Blood 2008 111 4 2300 2309 (Pubitemid 351451437)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2300-2309
    • Del Gaizo Moore, V.1    Schlis, K.D.2    Sallan, S.E.3    Armstrong, S.A.4    Letai, A.5
  • 134
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M., Butterworth M., Majid A., Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia Blood 2009 113 18 4403 4413
    • (2009) Blood , vol.113 , Issue.18 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Majid, A.3
  • 136
    • 77955748052 scopus 로고    scopus 로고
    • Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood
    • Vogler M., Furdas S. D., Jung M., Kuwana T., Dyer M. J. S., Cohen G. M., Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood Clinical Cancer Research 2010 16 16 4217 4225
    • (2010) Clinical Cancer Research , vol.16 , Issue.16 , pp. 4217-4225
    • Vogler, M.1    Furdas, S.D.2    Jung, M.3    Kuwana, T.4    Dyer, M.J.S.5    Cohen, G.M.6
  • 137
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
    • DOI 10.1172/JCI28281
    • Del Gaizo Moore V., Brown J. R., Certo M., Love T. M., Novina C. D., Letai A., Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 Journal of Clinical Investigation 2007 117 1 112 121 (Pubitemid 46048458)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 112-121
    • Moore, V.D.G.1    Brown, J.R.2    Certo, M.3    Love, T.M.4    Novina, C.D.5    Letai, A.6
  • 138
    • 70450265383 scopus 로고    scopus 로고
    • The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia
    • Mason K. D., Khaw S. L., Rayeroux K. C., The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia Leukemia 2009 23 11 2034 2041
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2034-2041
    • Mason, K.D.1    Khaw, S.L.2    Rayeroux, K.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.