메뉴 건너뛰기




Volumn 51, Issue 13, 2008, Pages 3713-3719

Enhanced concentration-dependent cytotoxic effect of the dinuclear copper(II) complex of L-carnitine [Cu2(L-carnitine) 2Cl2(H2O)2]Cl2, compared to L-carnitine or copper chloride dihydrate, in human leukemic cell lines

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CARNITINE; CARNITINE DERIVATIVE; COPPER CARNITINE COMPLEX; COPPER CHLORIDE; COPPER COMPLEX; TRYPAN BLUE;

EID: 46849086736     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701473x     Document Type: Article
Times cited : (12)

References (73)
  • 2
    • 23944437099 scopus 로고    scopus 로고
    • Harpaz, S. L-Carnitine and its attributed functions in fish culture and nutrition. Aquaculture 2005, 249, 3-21.
    • Harpaz, S. L-Carnitine and its attributed functions in fish culture and nutrition. Aquaculture 2005, 249, 3-21.
  • 3
    • 0031769517 scopus 로고    scopus 로고
    • Biological roles of L-carnitine in perinatal metabolism
    • Arenas, J.; Rubio, J. C.; Martín, M. A.; Campos, Y. Biological roles of L-carnitine in perinatal metabolism. Early Hum. Dev. 1998, 53 Suppl, S43-50.
    • (1998) Early Hum. Dev , vol.53 , Issue.SUPPL.
    • Arenas, J.1    Rubio, J.C.2    Martín, M.A.3    Campos, Y.4
  • 4
    • 46849117872 scopus 로고    scopus 로고
    • Walter, P.; Schaffhauser, A. O. L-Carnitine, a vitamin-like substance for functional food. Proceedings of the symposium on L-carnitine, April 28 to May 1, 2000, Zermatt, Switzerland. Ann. Nutr. Metab. 2000, 44, 75-96.
    • Walter, P.; Schaffhauser, A. O. L-Carnitine, a "vitamin-like substance" for functional food. Proceedings of the symposium on L-carnitine, April 28 to May 1, 2000, Zermatt, Switzerland. Ann. Nutr. Metab. 2000, 44, 75-96.
  • 5
    • 2942707816 scopus 로고    scopus 로고
    • Supplementation of L-carnitine in athletes: Does it make sense?
    • Karlic, H.; Lohninger, A. Supplementation of L-carnitine in athletes: does it make sense? Nutrition 2004, 20, 709-715.
    • (2004) Nutrition , vol.20 , pp. 709-715
    • Karlic, H.1    Lohninger, A.2
  • 6
    • 0034802220 scopus 로고    scopus 로고
    • Minerals, trace elements and related biological variables in athletes and during physical activity
    • Speich, M.; Pineau, A.; Ballereau, F. Minerals, trace elements and related biological variables in athletes and during physical activity. Clin. Chim. Acta 2001, 312, 1-11.
    • (2001) Clin. Chim. Acta , vol.312 , pp. 1-11
    • Speich, M.1    Pineau, A.2    Ballereau, F.3
  • 7
    • 0025893278 scopus 로고
    • Carnitine in muscle, serum, and urine of nonprofessional athletes: Effects of physical exercise, training, and L-carnitine administration
    • Arenas, J.; Ricoy, J. R.; Encinas, A. R.; Pola, P.; D'Iddio, S.; Zeviani, M.; Didonato, S.; Corsi, M. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. Muscle Nerve 1991, 14, 598-604.
    • (1991) Muscle Nerve , vol.14 , pp. 598-604
    • Arenas, J.1    Ricoy, J.R.2    Encinas, A.R.3    Pola, P.4    D'Iddio, S.5    Zeviani, M.6    Didonato, S.7    Corsi, M.8
  • 8
    • 0037359748 scopus 로고    scopus 로고
    • Heart metabolic disturbances in cardiovascular diseases
    • Carvajal, K.; Moreno-Sanchez, R. Heart metabolic disturbances in cardiovascular diseases. Arch. Med. Res. 2003, 34, 89-99.
    • (2003) Arch. Med. Res , vol.34 , pp. 89-99
    • Carvajal, K.1    Moreno-Sanchez, R.2
  • 11
    • 10644280659 scopus 로고    scopus 로고
    • Carnitine in type 2 diabetes
    • Mingrone, G. Carnitine in type 2 diabetes. Ann. N.Y. Acad. Sci. 2004, 1033, 99-107.
    • (2004) Ann. N.Y. Acad. Sci , vol.1033 , pp. 99-107
    • Mingrone, G.1
  • 12
    • 0034994973 scopus 로고    scopus 로고
    • Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats
    • Dayanandan, A.; Kumar, P.; Panneerselvam, C. Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats. J. Nutr. Biochem. 2001, 12, 254-257.
    • (2001) J. Nutr. Biochem , vol.12 , pp. 254-257
    • Dayanandan, A.1    Kumar, P.2    Panneerselvam, C.3
  • 13
    • 1042266246 scopus 로고    scopus 로고
    • Down syndrome and epilepsy: A nutritional connection
    • Thiel, R. J.; Fowkes, S. W. Down syndrome and epilepsy: a nutritional connection. Med. Hypotheses 2004, 62, 35-44.
    • (2004) Med. Hypotheses , vol.62 , pp. 35-44
    • Thiel, R.J.1    Fowkes, S.W.2
  • 14
    • 0035183350 scopus 로고    scopus 로고
    • Plasma carnitine levels in children with Down syndrome
    • Seven, M.; Cengiz, M.; Tüzgen, S.; Iscan, M. Y. Plasma carnitine levels in children with Down syndrome. Am. J. Hum. Biol. 2001, 13, 721-725.
    • (2001) Am. J. Hum. Biol , vol.13 , pp. 721-725
    • Seven, M.1    Cengiz, M.2    Tüzgen, S.3    Iscan, M.Y.4
  • 15
    • 28844438030 scopus 로고    scopus 로고
    • Antioxidant effect of L-carnitine and its short chain esters: Relevance for the protection from oxidative stress related cardiovascular damage
    • Calò, L. A.; Pagnin, E.; Davis, P. A.; Semplicini, A.; Nicolai, R.; Calvani, M.; Pessina, A. C. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int. J. Cardiol. 2006, 107, 54-60.
    • (2006) Int. J. Cardiol , vol.107 , pp. 54-60
    • Calò, L.A.1    Pagnin, E.2    Davis, P.A.3    Semplicini, A.4    Nicolai, R.5    Calvani, M.6    Pessina, A.C.7
  • 16
    • 0031443202 scopus 로고    scopus 로고
    • Carnitine and its derivatives in cardiovascular disease
    • Arsenian, M. A. Carnitine and its derivatives in cardiovascular disease. Prog. Cardiovasc. Dis. 1997, 40, 265-286.
    • (1997) Prog. Cardiovasc. Dis , vol.40 , pp. 265-286
    • Arsenian, M.A.1
  • 17
    • 17044429015 scopus 로고    scopus 로고
    • Oxidative stress on mitochondrial antioxidant defense system in the aging process: Role of DL-alpha-lipoic acid and L-carnitine
    • Savitha, S.; Tamilselvan, J.; Anusuyadevi, M.; Panneerselvam, C. Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. Clin. Chim. Acta 2005, 355, 173-180.
    • (2005) Clin. Chim. Acta , vol.355 , pp. 173-180
    • Savitha, S.1    Tamilselvan, J.2    Anusuyadevi, M.3    Panneerselvam, C.4
  • 19
    • 23744493081 scopus 로고    scopus 로고
    • Bueno, R.; Alvarez de Sotomayor, M.; Perez-Guerrero, C.; Gomez-Amores, L.; Vazquez, C. M.; Herrera, M. D. L-Carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci. 2005, 77, 2082-9207.
    • Bueno, R.; Alvarez de Sotomayor, M.; Perez-Guerrero, C.; Gomez-Amores, L.; Vazquez, C. M.; Herrera, M. D. L-Carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci. 2005, 77, 2082-9207.
  • 20
    • 0036192012 scopus 로고    scopus 로고
    • Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review
    • Hurot, J. M.; Cucherat, M.; Haugh, M.; Fouque, D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. J. Am. Soc. Nephrol. 2002, 13, 708-714.
    • (2002) J. Am. Soc. Nephrol , vol.13 , pp. 708-714
    • Hurot, J.M.1    Cucherat, M.2    Haugh, M.3    Fouque, D.4
  • 21
    • 0035214728 scopus 로고    scopus 로고
    • Effects of L-carnitine supplementation on renal anemia in poor responders to erythropoietin
    • Matsumoto, Y.; Amano, I.; Hirose, S.; Tsuruta, Y.; Hara, S.; Murata, M.; Imai, T. Effects of L-carnitine supplementation on renal anemia in poor responders to erythropoietin. Blood Purif. 2001, 19, 24-32.
    • (2001) Blood Purif , vol.19 , pp. 24-32
    • Matsumoto, Y.1    Amano, I.2    Hirose, S.3    Tsuruta, Y.4    Hara, S.5    Murata, M.6    Imai, T.7
  • 22
    • 20444408453 scopus 로고    scopus 로고
    • Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis
    • Wenzel, U.; Nickel, A.; Daniel, H. Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. J. Nutr. 2005, 135, 1510-1514.
    • (2005) J. Nutr , vol.135 , pp. 1510-1514
    • Wenzel, U.1    Nickel, A.2    Daniel, H.3
  • 23
    • 33644654215 scopus 로고    scopus 로고
    • Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by microarray-bioinformatics analysis
    • Yeh, C. S.; Wang, J. Y.; Cheng, T. L.; Juan, C. H.; Wu, C. H.; Lin, S. R. Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by microarray-bioinformatics analysis. Cancer Lett. 2006, 233, 297-308.
    • (2006) Cancer Lett , vol.233 , pp. 297-308
    • Yeh, C.S.1    Wang, J.Y.2    Cheng, T.L.3    Juan, C.H.4    Wu, C.H.5    Lin, S.R.6
  • 24
    • 0033978634 scopus 로고    scopus 로고
    • Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system
    • Peluso, G.; Nicolai, R.; Reda, E.; Benatti, P.; Barbarisi, A.; Calvani, M. Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system. J. Cell. Physiol. 2000, 182, 339-350.
    • (2000) J. Cell. Physiol , vol.182 , pp. 339-350
    • Peluso, G.1    Nicolai, R.2    Reda, E.3    Benatti, P.4    Barbarisi, A.5    Calvani, M.6
  • 25
    • 0036715482 scopus 로고    scopus 로고
    • Chang, B.; Nishikawa, M.; Sato, E.; Utsumi, K.; Inoue, M. L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch. Biochem. Biophys. 2002, 405, 55-64.
    • Chang, B.; Nishikawa, M.; Sato, E.; Utsumi, K.; Inoue, M. L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch. Biochem. Biophys. 2002, 405, 55-64.
  • 26
    • 0033617701 scopus 로고    scopus 로고
    • A study on a novel superoxide dismutase mimic bis(dioxotetraamine) copper(II) complex - kinetics of catalytic dismutation of superoxide anion by pulse radiolysis and solution equilibrium
    • Feng, C. J.; Luo, Q. H.; Wang, Z. L.; Shen, M. C.; Wang, H. W.; Zhao, M. H. A study on a novel superoxide dismutase mimic bis(dioxotetraamine) copper(II) complex - kinetics of catalytic dismutation of superoxide anion by pulse radiolysis and solution equilibrium. J. Inorg. Biochem. 1999, 75, 1-6.
    • (1999) J. Inorg. Biochem , vol.75 , pp. 1-6
    • Feng, C.J.1    Luo, Q.H.2    Wang, Z.L.3    Shen, M.C.4    Wang, H.W.5    Zhao, M.H.6
  • 27
    • 0032468771 scopus 로고    scopus 로고
    • Formation of Cu or Fe thiobarbiturate complexes interfere with the determination of malondialdehyde
    • Zhou, L.; Sorenson, J. R. J. Formation of Cu or Fe thiobarbiturate complexes interfere with the determination of malondialdehyde. J. Inorg. Biochem. 1998, 72, 217-225.
    • (1998) J. Inorg. Biochem , vol.72 , pp. 217-225
    • Zhou, L.1    Sorenson, J.R.J.2
  • 28
    • 33746690455 scopus 로고    scopus 로고
    • Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin
    • Efthimiadou, E. K.; Sanakis, Y.; Raptopoulou, C. P.; Karaliota, A.; Katsaros, N.; Psomas, G. Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin. Bioorg. Med. Chem. Lett. 2006, 16, 3864-3867.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 3864-3867
    • Efthimiadou, E.K.1    Sanakis, Y.2    Raptopoulou, C.P.3    Karaliota, A.4    Katsaros, N.5    Psomas, G.6
  • 30
    • 0035062373 scopus 로고    scopus 로고
    • Synthesis and characterization of a binuclear coumarin-3-carboxylate copper(II) complex
    • Karaliota, A.; Kretsi, O.; Tzougraki, C. Synthesis and characterization of a binuclear coumarin-3-carboxylate copper(II) complex. J. Inorg. Biochem. 2001, 84, 33-37.
    • (2001) J. Inorg. Biochem , vol.84 , pp. 33-37
    • Karaliota, A.1    Kretsi, O.2    Tzougraki, C.3
  • 31
    • 1842791279 scopus 로고
    • Study of the relation between the structural data and magnetic interaction in oxo-bridged binuclear copper(II) compounds
    • Melnik, M. Study of the relation between the structural data and magnetic interaction in oxo-bridged binuclear copper(II) compounds. Coord. Chem. Rev. 1982, 42, 259-293.
    • (1982) Coord. Chem. Rev , vol.42 , pp. 259-293
    • Melnik, M.1
  • 32
    • 4243820801 scopus 로고
    • Factors affecting the magnetic properties of dimeric copper(II) complexes
    • Kato, M.; Muto, Y. Factors affecting the magnetic properties of dimeric copper(II) complexes. Coord. Chem. Rev. 1988, 92, 45-83.
    • (1988) Coord. Chem. Rev , vol.92 , pp. 45-83
    • Kato, M.1    Muto, Y.2
  • 35
    • 1542543445 scopus 로고    scopus 로고
    • GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways
    • Qi, S. N.; Yoshida, A.; Wang, Z. R.; Ueda, T. GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways. Int. J. Mol. Med. 2004, 13, 163-167.
    • (2004) Int. J. Mol. Med , vol.13 , pp. 163-167
    • Qi, S.N.1    Yoshida, A.2    Wang, Z.R.3    Ueda, T.4
  • 36
    • 0043130473 scopus 로고    scopus 로고
    • Activation of caspases-3/7 is dispensable for idarubicin-induced apoptotic DNA fragmentation in human leukemia cells
    • Qi, S. N.; Yoshida, A.; Ueda, T. Activation of caspases-3/7 is dispensable for idarubicin-induced apoptotic DNA fragmentation in human leukemia cells. Int. J. Oncol. 2003, 22, 1123-1128.
    • (2003) Int. J. Oncol , vol.22 , pp. 1123-1128
    • Qi, S.N.1    Yoshida, A.2    Ueda, T.3
  • 39
    • 0021807461 scopus 로고
    • Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells
    • Nikula, P.; Ruohola, H.; Alhonen-Hongisto, L.; Jänne, J. Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells. Biochem. J. 1985, 228, 513-516.
    • (1985) Biochem. J , vol.228 , pp. 513-516
    • Nikula, P.1    Ruohola, H.2    Alhonen-Hongisto, L.3    Jänne, J.4
  • 40
    • 34147145915 scopus 로고    scopus 로고
    • Synthesis of two dicopper(II) complexes of L-carnitine: The first structural determination of a metal complex containing L-carnitine
    • Litos, C.; Parsons, S.; Karaliota, A. Synthesis of two dicopper(II) complexes of L-carnitine: the first structural determination of a metal complex containing L-carnitine. Polyhedron 2007, 26, 1397-1403.
    • (2007) Polyhedron , vol.26 , pp. 1397-1403
    • Litos, C.1    Parsons, S.2    Karaliota, A.3
  • 41
    • 0036145235 scopus 로고    scopus 로고
    • Functional characterization of intestinal L-carnitine transport
    • Durán, J. M.; Peral, M. J.; Calonge, M. L.; Ilundáin, A. A. Functional characterization of intestinal L-carnitine transport. J. Membr. Biol. 2002, 185, 65-74.
    • (2002) J. Membr. Biol , vol.185 , pp. 65-74
    • Durán, J.M.1    Peral, M.J.2    Calonge, M.L.3    Ilundáin, A.A.4
  • 43
    • 0043023404 scopus 로고    scopus 로고
    • Anti-diabetes effect of Zn(II)/carnitine complex by oral administration
    • Yoshikawa, Y.; Ueda, E.; Sakurai, H.; Kojima, Y. Anti-diabetes effect of Zn(II)/carnitine complex by oral administration. Chem. Pharm. Bull. (Tokyo) 2003, 51, 230-231.
    • (2003) Chem. Pharm. Bull. (Tokyo) , vol.51 , pp. 230-231
    • Yoshikawa, Y.1    Ueda, E.2    Sakurai, H.3    Kojima, Y.4
  • 45
    • 0025895541 scopus 로고
    • Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart
    • Packer, L.; Valenza, M.; Serbinova, E.; Starke-Reed, P.; Frost, K.; Kagan, V. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart. Arch. Biochem. Biophys. 1991, 288, 533-537.
    • (1991) Arch. Biochem. Biophys , vol.288 , pp. 533-537
    • Packer, L.1    Valenza, M.2    Serbinova, E.3    Starke-Reed, P.4    Frost, K.5    Kagan, V.6
  • 46
    • 11944275346 scopus 로고    scopus 로고
    • Chang, B.; Nishikawa, M.; Nishiguchi, S.; Inoue, M. L-Carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int. J. Cancer. 2005, 113, 719-729.
    • Chang, B.; Nishikawa, M.; Nishiguchi, S.; Inoue, M. L-Carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int. J. Cancer. 2005, 113, 719-729.
  • 48
    • 0035062373 scopus 로고    scopus 로고
    • Synthesis and characterization of a binuclear coumarin-3-carboxylate copper(II) complex
    • Karaliota, A.; Kretsi, O.; Tzougraki, C. Synthesis and characterization of a binuclear coumarin-3-carboxylate copper(II) complex. J. Inorg. Biochem. 2001, 84, 33-37.
    • (2001) J. Inorg. Biochem , vol.84 , pp. 33-37
    • Karaliota, A.1    Kretsi, O.2    Tzougraki, C.3
  • 51
    • 0034534025 scopus 로고    scopus 로고
    • 2Cu dimers influence their electronic and magnetic properties
    • 2Cu dimers influence their electronic and magnetic properties. Polyhedron 2000, 19, 2483-2491.
    • (2000) Polyhedron , vol.19 , pp. 2483-2491
    • Rodriguez, M.1    Llobet, A.2    Corbella, M.3
  • 53
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • Cotman, C. W.; Anderson, A. J. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 1995, 10, 19-45.
    • (1995) Mol. Neurobiol , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 56
    • 33947683157 scopus 로고    scopus 로고
    • Enhanced antileukemic activity of the novel complex 2,5-dihydroxybenzoate molybdenum(VI) against 2,5-dihydroxybenzoate, polyoxometalate of Mo(VI), and tetraphenylphosphonium in the human HL-60 and K562 leukemic cell lines
    • Thomadaki, H.; Karaliota, A.; Litos, C.; Scorilas, A. Enhanced antileukemic activity of the novel complex 2,5-dihydroxybenzoate molybdenum(VI) against 2,5-dihydroxybenzoate, polyoxometalate of Mo(VI), and tetraphenylphosphonium in the human HL-60 and K562 leukemic cell lines. J. Med. Chem. 2007, 50, 1316-1321.
    • (2007) J. Med. Chem , vol.50 , pp. 1316-1321
    • Thomadaki, H.1    Karaliota, A.2    Litos, C.3    Scorilas, A.4
  • 57
    • 33845458214 scopus 로고    scopus 로고
    • Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2′-bipyridine
    • Efthimiadou, E. K.; Thomadaki, H.; Sanakis, Y.; Raptopoulou, C. P.; Katsaros, N.; Scorilas, A.; Karaliota, A.; Psomas, G. Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2′-bipyridine. J. Inorg. Biochem. 2007, 101, 64-73.
    • (2007) J. Inorg. Biochem , vol.101 , pp. 64-73
    • Efthimiadou, E.K.1    Thomadaki, H.2    Sanakis, Y.3    Raptopoulou, C.P.4    Katsaros, N.5    Scorilas, A.6    Karaliota, A.7    Psomas, G.8
  • 58
    • 1342347887 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: Differential expression of BCL2 and novel apoptosis-related gene BCL2L12
    • Floras, K. V.; Thomadaki, H.; Lallas, G.; Katsaros, N.; Talieri, M.; Scorilas, A. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Ann. N.Y. Acad. Sci. 2003, 1010, 153-158.
    • (2003) Ann. N.Y. Acad. Sci , vol.1010 , pp. 153-158
    • Floras, K.V.1    Thomadaki, H.2    Lallas, G.3    Katsaros, N.4    Talieri, M.5    Scorilas, A.6
  • 59
    • 10044239114 scopus 로고    scopus 로고
    • mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin
    • Floros, K. V.; Thomadaki, H.; Katsaros, N.; Talieri, M.; Scorilas, A. mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol. Chem. 2004, 385, 1099-1103.
    • (2004) Biol. Chem , vol.385 , pp. 1099-1103
    • Floros, K.V.1    Thomadaki, H.2    Katsaros, N.3    Talieri, M.4    Scorilas, A.5
  • 60
    • 26844509688 scopus 로고    scopus 로고
    • Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction
    • Thomadaki, H.; Tsiapalis, C. M.; Scorilas, A. Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction. Biol Chem. 2005, 386, 471-480.
    • (2005) Biol Chem , vol.386 , pp. 471-480
    • Thomadaki, H.1    Tsiapalis, C.M.2    Scorilas, A.3
  • 61
    • 46849117868 scopus 로고    scopus 로고
    • Alterations in the mRNA expression of the apoptosis-related genes BCL2, BAX, FAS, CASPASE-3 and the novel member, BCL2L12, after treatment of human leukemic cell line HL60 with the antineoplasitic agent etoposide
    • in press
    • Floras, K. V.; Thomadaki, H.; Florou, D.; Talieri, M.; Scorilas, A. Alterations in the mRNA expression of the apoptosis-related genes BCL2, BAX, FAS, CASPASE-3 and the novel member, BCL2L12, after treatment of human leukemic cell line HL60 with the antineoplasitic agent etoposide. Ann. N.Y. Acad. Sci., in press.
    • Ann. N.Y. Acad. Sci
    • Floras, K.V.1    Thomadaki, H.2    Florou, D.3    Talieri, M.4    Scorilas, A.5
  • 62
    • 33947665188 scopus 로고    scopus 로고
    • Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin and doxorubicin, at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12
    • in press
    • Thomadaki, H.; Scorilas, A Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin and doxorubicin, at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann. N.Y. Acad. Sci., in press.
    • Ann. N.Y. Acad. Sci
    • Thomadaki, H.1    Scorilas, A.2
  • 63
    • 0032877668 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in cancer
    • Reed, J. C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 1999, 17, 2941-2953.
    • (1999) J. Clin. Oncol , vol.17 , pp. 2941-2953
    • Reed, J.C.1
  • 64
    • 0033400809 scopus 로고    scopus 로고
    • Apoptosis and cancer drug targeting
    • Seller, W. R.; Fisher, D. E. Apoptosis and cancer drug targeting. J. Clin. Invest. 1999, 104, 1655-1661.
    • (1999) J. Clin. Invest , vol.104 , pp. 1655-1661
    • Seller, W.R.1    Fisher, D.E.2
  • 65
    • 0028025563 scopus 로고
    • Apoptosis
    • cancer therapy: crossing the threshold
    • Fisher, D. E. Apoptosis in cancer therapy: crossing the threshold. Cell 1994, 78, 539-542.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 66
    • 0028329172 scopus 로고    scopus 로고
    • Kerr, J. F.; Winterford, C. M.; Harmon, B. V. Apoptosis. Its significance in cancer and cancer chemotherapy. Cancer 1994, 73, 2013-2026.
    • Kerr, J. F.; Winterford, C. M.; Harmon, B. V. Apoptosis. Its significance in cancer and cancer chemotherapy. Cancer 1994, 73, 2013-2026.
  • 67
    • 0029247944 scopus 로고
    • Cell death in health and disease: The biology and regulation of apoptosis
    • Belamy, C. O.; Malcomson, R. D.; Harrison, D. J.; Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis. Semin. Cancer Biol. 1995, 6, 3-16.
    • (1995) Semin. Cancer Biol , vol.6 , pp. 3-16
    • Belamy, C.O.1    Malcomson, R.D.2    Harrison, D.J.3    Wyllie, A.H.4
  • 68
    • 0029247959 scopus 로고
    • Implications of apoptosis cell death regulation in cancer therapy
    • McDonnell, T. J.; Meyn, R. E.; Robertson, L. E. Implications of apoptosis cell death regulation in cancer therapy. Semin. Cancer Biol. 1995, 6, 3-16.
    • (1995) Semin. Cancer Biol , vol.6 , pp. 3-16
    • McDonnell, T.J.1    Meyn, R.E.2    Robertson, L.E.3
  • 69
    • 0029244997 scopus 로고
    • Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis
    • Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis. Cancer Biol. 1995, 6, 53-60.
    • (1995) Cancer Biol , vol.6 , pp. 53-60
    • Eastman, A.1
  • 70
    • 0034887884 scopus 로고    scopus 로고
    • Cell cycle-mediated drug resistances emerging concept in cancer therapy
    • Shah, A. M.; Schwartz, G. K. Cell cycle-mediated drug resistances emerging concept in cancer therapy. Clin. Cancer Res. 2001, 7, 2168-2181.
    • (2001) Clin. Cancer Res , vol.7 , pp. 2168-2181
    • Shah, A.M.1    Schwartz, G.K.2
  • 72
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.