Isoform identification, recombinant production and characterization of the allergen lipid transfer protein 1 from pear (Pyr c 3)

Gene

Volumn 491, Issue 2, 2012, Pages 173-181

  Ramazzina, Ileana ^a   Amato, Stefano ^b   Passera, Elisabetta ^a   Sforza, Stefano ^a   Mistrello, Gianni ^b   Berni, Rodolfo ^a   Folli, Claudia ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Lofarma SpA   (Italy)

Author keywords

Food allergy; Lipid transfer protein; LTP; Pear allergen; Pru p 3; Pyr c 3

Indexed keywords

COMPLEMENTARY DNA; LIPID TRANSFER PROTEIN; LIPID TRANSFER PROTEIN 1; MESSENGER RNA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC REACTION; AMINO ACID SEQUENCE; APPLE; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PEAR; PRIORITY JOURNAL; PROTEIN ANALYSIS; ROSACEAE;

ALLERGENS; ANTIGENS, PLANT; CARRIER PROTEINS; HOT TEMPERATURE; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; PROTEIN ISOFORMS; PROTEIN STABILITY; PYRUS; RECOMBINANT PROTEINS;

MALUS X DOMESTICA; PRUNUS PERSICA; PYRUS; ROSACEAE;

EID: 81455124792     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.09.034     Document Type: Article

References (47)

1. Asero R., et al. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int. Arch. Allergy Immunol. 2001, 124:67-69.
2. Asero R., et al. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002, 57:900-906.
3. Asero R., Mistrello G., Roncarolo D., Amato S. Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Ann. Allergy Asthma Immunol. 2004, 92:268-272.
4. Asero R., Mistrello G., Amato S., Roncarolo D., Martinelli A., Zaccarini M. Peach fuzz contains large amounts of lipid transfer protein: is this the cause of the high prevalence of sensitization to LTP in Mediterranean countries?. Eur. Ann. Allergy Clin. Immunol. 2006, 38:118-121.
5. Bjorksten F., Halmepuro L., Hannuksela M., Lahti A. Extraction and properties of apple allergens. Allergy 1980, 35:671-677.
6. Borges J.P., Barre A., Culerrier R., Granier C., Didier A., Rouge P. Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity. Biochem. Biophys. Res. Commun. 2008, 365:685-690.
7. Borghesan F., Mistrello G., Roncarolo D., Amato S., Plebani M., Asero R. Respiratory allergy to lipid transfer protein. Int. Arch. Allergy Immunol. 2008, 147:161-165.
8. Botton A., Begheldo M., Rasori A., Bonghi C., Tonutti P. Differential expression of two lipid transfer protein genes in reproductive organs of peach (Prunus persica L. Batsch). Plant Sci. 2002, 163:993-1000.
9. Botton A., et al. Different expression of Pp-LTP1 and accumulation of Pru p 3 in fruits of two Prunus persica L. Batsch genotypes. Plant Sci. 2006, 171:106-113.
10. Botton A., Andreotti C., Costa G., Ramina A. Peach (Prunus persica L. Batsch) allergen-encoding genes are developmentally regulated and affected by fruit load and light radiation. J. Agric. Food Chem. 2009, 57:724-734.
11. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
12. Brenna O.V., Pastorello E.A., Farioli L., Pravettoni V., Pompei C. Presence of allergenic proteins in different peach (Prunus persica) cultivars and dependence of their content on fruit ripening. J. Agric. Food Chem. 2004, 52:7997-8000.
13. Cameron K.D., Teece M.A., Smart L.B. Increased accumulation of cuticular wax and expression of lipid transfer protein in response to periodic drying events in leaves of tree tobacco. Plant Physiol. 2006, 140:176-183.
14. Carnes J., Fernandez-Caldas E., Gallego M.T., Ferrer A., Cuesta-Herranz J. Pru p 3 (LTP) content in peach extracts. Allergy 2002, 57:1071-1075.
15. Cavatorta V., et al. Unambiguous characterization and tissue localization of Pru P 3 peach allergen by electrospray mass spectrometry and MALDI imaging. J. Mass Spectrom. 2009, 44:891-897.
16. Cavatorta V., et al. In vitro gastrointestinal digestion of the major peach allergen Pru p 3, a lipid transfer protein: molecular characterization of the products and assessment of their IgE binding abilities. Mol. Nutr. Food Res. 2010, 54:1452-1457.
17. Ciardiello M.A., et al. Biochemical, immunological and clinical characterization of a cross-reactive nonspecific lipid transfer protein 1 from mulberry. Allergy 2010, 65:597-605.
18. Egger M., Hauser M., Mari A., Ferreira F., Gadermaier G. The role of lipid transfer proteins in allergic diseases. Curr. Allergy Asthma Rep. 2010, 10:326-335.
19. Fernandez-Rivas M., van Ree R., Cuevas M. Allergy to Rosaceae fruits without related pollinosis. J. Allergy Clin. Immunol. 1997, 100:728-733.
20. Fernandez-Rivas M., Cuevas M. Peels of Rosaceae fruits have a higher allergenicity than pulps. Clin. Exp. Allergy 1999, 29:1239-1247.
21. Gadermaier G., et al. Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks. Mol. Nutr. Food Res. 2011, 55:568-577.
22. Gaier S., et al. Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. Mol. Nutr. Food Res. 2008, 52(Suppl 2):S220-S229.
23. Gao Z.S., et al. Linkage map positions and allelic diversity of two Mal d 3 (non-specific lipid transfer protein) genes in the cultivated apple (Malus domestica). Theor. Appl. Genet. 2005, 110:479-491.
24. Garcia-Casado G., et al. Identification of IgE-binding epitopes of the major peach allergen Pru p 3. J. Allergy Clin. Immunol. 2003, 112:599-605.
25. Gomar J., et al. Solution structure and lipid binding of a nonspecific lipid transfer protein extracted from maize seeds. Protein Sci. 1996, 5:565-577.
26. Gouet P., Courcelle E., Stuart D.I., Metoz F. ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics 1999, 15:305-308.
27. Kader J.C. Lipid-transfer proteins in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 1996, 47:627-654.
28. Krause S., et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. J. Allergy Clin. Immunol. 2009, 124(771-778):e775.
29. Liu W., et al. Discovery, identification and comparative analysis of non-specific lipid transfer protein (nsLtp) family in Solanaceae. Genomics Proteomics Bioinformatics 2010, 8:229-237.
30. Lullien-Pellerin V., et al. Production in Escherichia coli and site-directed mutagenesis of a 9-kDa nonspecific lipid transfer protein from wheat. Eur. J. Biochem. 1999, 260:861-868.
31. Nieuwland J., et al. Lipid transfer proteins enhance cell wall extension in tobacco. Plant Cell 2005, 17:2009-2019.
32. Pace C.N., Vajdos F., Fee L., Grimsley G., Gray T. How to measure and predict the molar absorption coefficient of a protein. Protein Sci. 1995, 4:2411-2423.
33. Pacios L.F., et al. Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. Mol. Immunol. 2008, 45:2269-2276.
34. Palacin A., et al. Wheat lipid transfer protein is a major allergen associated with baker's asthma. J. Allergy Clin. Immunol. 2007, 120:1132-1138.
35. Pasquato N., et al. Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens. J. Mol. Biol. 2006, 356:684-694.
36. Pastorello E.A., et al. The maize major allergen, which is responsible for food-induced allergic reactions, is a lipid transfer protein. J. Allergy Clin. Immunol. 2000, 106:744-751.
37. Pastorello E.A., et al. Lipid transfer protein and vicilin are important walnut allergens in patients not allergic to pollen. J. Allergy Clin. Immunol. 2004, 114:908-914.
38. Salcedo G., Sanchez-Monge R., Barber D., Diaz-Perales A. Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochim. Biophys. Acta 2007, 1771:781-791.
39. Salcedo G., Sanchez-Monge R., Barber D., Diaz-Perales A. Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochim. Biophys. Acta 2007, 1771:781-791.
40. San Miguel-Moncin M., et al. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy 2003, 58:511-517.
41. Sancho A.I., et al. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy 2005, 60:1262-1268.
42. Scheurer S., et al. Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion. J. Allergy Clin. Immunol. 2004, 114:900-907.
43. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22:4673-4680.
44. Tordesillas L., et al. Molecular basis of allergen cross-reactivity: non-specific lipid transfer proteins from wheat flour and peach fruit as models. Mol. Immunol. 2009, 47:534-540.
45. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U. S. A. 1979, 76:4350-4354.
46. van Ree R. Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem. Soc. Trans. 2002, 30:910-913.
47. Vignols F., Wigger M., Garcia-Garrido J.M., Grellet F., Kader J.C., Delseny M. Rice lipid transfer protein (LTP) genes belong to a complex multigene family and are differentially regulated. Gene 1997, 195:177-186.