Molecular basis of allergen cross-reactivity: Non-specific lipid transfer proteins from wheat flour and peach fruit as models

Molecular Immunology

Volumn 47, Issue 2-3, 2009, Pages 534-540

  Tordesillas, Leticia ^a   Pacios, Luis F ^b   Palacin, Arancha ^a   Quirce, Santiago ^c   Armentia, Alicia ^d   Barber, Domingo ^e   Salcedo, Gabriel ^a   Diaz Perales, Araceli ^a  

^a Electrotechnical Section   (Spain)

^b Technical University of Madrid   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^e ALK ABELLÓ   (Denmark)

Author keywords

Cross reactivity; Electrostatic potential; IgE epitopes; Mimotopes; Non specific lipid transfer protein; Pru p 3; Tri a 14

Indexed keywords

EPITOPE; IMMUNOGLOBULIN E; LIPID TRANSFER PROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROSS REACTION; ELECTRIC POTENTIAL; FOOD ALLERGY; HUMAN; MOLECULAR RECOGNITION; OCCUPATIONAL ASTHMA; PEACH; PHAGE DISPLAY; PRIORITY JOURNAL; WHEAT;

PRUNUS PERSICA; TRITICUM AESTIVUM;

EID: 70450224457     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.07.028     Document Type: Article

References (41)

1. Aalberse R.C. Structural biology of allergens. J. Allergy Clin. Immunol. 106 (2000) 228-238
2. Armentia A., Sanchez-Monge R., Gomez L., Barber D., and Salcedo G. In vivo allergenic activities of eleven purified members of a major allergen family from wheat and barley flour. Clin. Exp. Allergy 23 (1993) 410-415
3. Asero R., Antonicelli L., Arena A., Bommarito L., Caruso B., Crivellaro M., De Carli M., Della Torre E., Della Torre F., Heffler E., Lodi Rizzini F., Longo R., Manzotti G., Marcotulli M., Melchiorre A., Minale P., Morandi P., Moreni B., Moschella A., Murzilli F., Nebiolo F., Poppa M., Randazzo S., Rossi G., and Senna G.E. EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. Clin. Exp. Allergy 39 (2009) 547-555
4. Barber D., de la Torre F., Feo F., Florido F., Guardia P., Moreno C., Quiralte J., Lombardero M., Villalba M., Salcedo G., and Rodriguez R. Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy 63 (2008) 1550-1558
5. Brant A. Baker's asthma. Curr. Opin. Allergy Clin. Immunol. 7 (2007) 152-155
6. Christensen L.H., Holm J., Lund G., Riise E., and Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J. Allergy Clin. Immunol. 122 (2008) 298-304
7. Davies J.M., O'Hehir R.E., and Suphioglu C. Use of phage display technology to investigate allergen-antibody interactions. J. Allergy Clin. Immunol. 105 (2000) 1085-1092
8. Diaz-Perales A., Lombardero M., Sanchez-Monge R., Garcia-Selles F.J., Pernas M., Fernandez-Rivas M., Barber D., and Salcedo G. Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. Clin. Exp. Allergy 30 (2000) 1403-1410
9. Diaz-Perales A., Sanz M.L., Garcia-Casado G., Sanchez-Monge R., Garcia-Selles F.J., Lombardero M., Polo F., Gamboa P.M., Barber D., and Salcedo G. Recombinant Pru p 3 and natural Pru p 3, a major peach allergen, show equivalent immunologic reactivity: a new tool for the diagnosis of fruit allergy. J. Allergy Clin. Immunol. 111 (2003) 628-633
10. Dolinsky T.J., Nielsen J.E., McCammon J.A., and Baker N.A. PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res. 32 (2004) W665-W667
11. Fernandez-Rivas M., Gonzalez-Mancebo E., Rodriguez-Perez R., Benito C., Sanchez-Monge R., Salcedo G., Alonso M.D., Rosado A., Tejedor M.A., Vila C., and Casas M.L. Clinically relevant peach allergy is related to peach lipid transfer protein, Pru p 3, in the Spanish population. J. Allergy Clin. Immunol. 112 (2003) 789-795
12. Folgori A., Tafi R., Meola A., Felici F., Galfre G., Cortese R., Monaci P., and Nicosia A. A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J. 13 (1994) 2236-2243
13. Ganglberger E., Grunberger K., Sponer B., Radauer C., Breiteneder H., Boltz-Nitulescu G., Scheiner O., and Jensen-Jarolim E. Allergen mimotopes for 3-dimensional epitope search and induction of antibodies inhibiting human IgE. FASEB J. 14 (2000) 2177-2184
14. Garcia-Casado G., Pacios L.F., Diaz-Perales A., Sanchez-Monge R., Lombardero M., Garcia-Selles F.J., Polo F., Barber D., and Salcedo G. Identification of IgE-binding epitopes of the major peach allergen Pru p 3. J. Allergy Clin. Immunol. 112 (2003) 599-605
15. Garcia B.E., Lombardero M., Echechipia S., Olaguibel J.M., Diaz-Perales A., Sanchez-Monge R., Barber D., Salcedo G., and Tabar A.I. Respiratory allergy to peach leaves and lipid-transfer proteins. Clin. Exp. Allergy 34 (2004) 291-295
16. Gincel E., Simorre J.P., Caille A., Marion D., Ptak M., and Vovelle F. Three-dimensional structure in solution of a wheat lipid-transfer protein from multidimensional 1H-NMR data. A new folding for lipid carriers. Eur. J. Biochem. 226 (1994) 413-422
17. Jacobs J.H., Meijster T., Meijer E., Suarthana E., and Heederik D. Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers. Allergy 63 (2008) 1597-1604
18. Jensen-jarolim E., Leitner A., Kalchhauser H., Zurcher A., Ganglberger E., Bohle B., Scheiner O., Boltz-nitulescu G., and Breiteneder H. Peptide mimotopes displayed by phage inhibit antibody binding to Bet v 1, the major birch pollen allergen, and induce specific IgG response in mice. FASEB J. 12 (1998) 1635-1642
19. Jensen-Jarolim E., Wiedermann U., Ganglberger E., Zurcher A., Stadler B.M., Boltz-Nitulescu G., Scheiner O., and Breiteneder H. Allergen mimotopes in food enhance type I allergic reactions in mice. FASEB J. 13 (1999) 1586-1592
20. Lauer I., Miguel-Moncin M.S., Abel T., Foetisch K., Hartz C., Fortunato D., Cistero-Bahima A., Vieths S., and Scheurer S. Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid-transfer protein, Pru p 3. Clin. Exp. Allergy 37 (2007) 261-269
21. Lombardero M., Garcia-Selles F.J., Polo F., Jimeno L., Chamorro M.J., Garcia-Casado G., Sanchez-Monge R., Diaz-Perales A., Salcedo G., and Barber D. Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. Clin. Exp. Allergy 34 (2004) 1415-1421
22. Luzzago A., Felici F., Tramontano A., Pessi A., and Cortese R. Mimicking of discontinuous epitopes by phage-displayed peptides. I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene 128 (1993) 51-57
23. Mittag D., Batori V., Neudecker P., Wiche R., Friis E.P., Ballmer-Weber B.K., Vieths S., and Roggen E.L. A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients. Mol. Immunol. 43 (2006) 268-278
24. Myers M.A., Davies J.M., Tong J.C., Whisstock J., Scealy M., Mackay I.R., and Rowley M.J. Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling. J. Immunol. 165 (2000) 3830-3838
25. Pacios L.F. Arvomol/contour: molecular surface areas and volumes on personal computers. Comput. Chem. 18 (1994) 377-385
26. Pacios L.F. Distinct molecular surfaces and hydrophobicity of amino acid residues in proteins. J. Chem. Inf. Comput. Sci. 41 (2001) 1427-1435
27. Pacios L.F., Tordesillas L., Cuesta-Herranz J., Compes E., Sanchez-Monge R., Palacin A., Salcedo G., and Diaz-Perales A. Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. Mol. Immunol. 45 (2008) 2269-2276
28. Palacin A., Quirce S., Armentia A., Fernandez-Nieto M., Pacios L.F., Asensio T., Sastre J., Diaz-Perales A., and Salcedo G. Wheat lipid transfer protein is a major allergen associated with baker's asthma. J. Allergy Clin. Immunol. 120 (2007) 1132-1138
29. Palacin A., Varela J., Quirce S., del Pozo V., Tordesillas L., Barranco P., Fernandez-Nieto M., Sastre J., Diaz-Perales A., and Salcedo G. Recombinant lipid transfer protein Tri a 14: a novel heat and proteolytic resistant tool for the diagnosis of baker's asthma. Clin Exp Allergy. 39 (2009) 1267-1276
30. Partidos C.D., and Steward M.W. Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics. Comb. Chem. High Throughput Screen 5 (2002) 15-27
31. Pasquato N., Berni R., Folli C., Folloni S., Cianci M., Pantano S., Helliwell J.R., and Zanotti G. Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens. J. Mol. Biol. 356 (2006) 684-694
32. Pastorello E.A., Farioli L., Conti A., Pravettoni V., Bonomi S., Iametti S., Fortunato D., Scibilia J., Bindslev-Jensen C., Ballmer-Weber B., Robino A.M., and Ortolani C. Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. Int. Arch. Allergy Immunol. 144 (2007) 10-22
33. Quirce S., Fernandez-Nieto M., Escudero C., Cuesta J., de Las Heras M., and Sastre J. Bronchial responsiveness to bakery-derived allergens is strongly dependent on specific skin sensitivity. Allergy 61 (2006) 1202-1208
34. Riemer A., Scheiner O., and Jensen-Jarolim E. Allergen mimotopes. Methods 32 (2004) 321-327
35. Salcedo G., Sanchez-Monge R., Barber D., and Diaz-Perales A. Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochim. Biophys. Acta 1771 (2007) 781-791
36. Sharav T., Wiesmuller K.H., and Walden P. Mimotope vaccines for cancer immunotherapy. Vaccine 25 (2007) 3032-3037
37. Tatham A.S., and Shewry P.R. Allergens to wheat and related cereals. Clin. Exp. Allergy 38 (2008) 1712-1726
38. Tordesillas L., Cuesta-Herranz J., Gonzalez-Munoz M., Pacios L.F., Compes E., Garcia-Carrasco B., Sanchez-Monge R., Salcedo G., and Diaz-Perales A. T-cell epitopes of the major peach allergen, Pru p 3: identification and differential T-cell response of peach-allergic and non-allergic subjects. Mol. Immunol. 46 (2009) 722-728
39. van Ree R. Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem. Soc. Trans. 30 (2002) 910-913
40. Wang J., Breslin M.J., Coleman P.J., Duggan M.E., Hunt C.A., Hutchinson J.H., Leu C.T., Rodan S.B., Rodan G.A., Duong le T., and Hartman G.D. Non-peptide alpha beta 3 antagonists. Part 7: 3-substituted tetrahydro-naphthyridine derivatives. Bioorg. Med. Chem. Lett. 14 (2004) 1049-1052
41. Zuidmeer L., and van Ree R. Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. Curr. Opin. Allergy Clin. Immunol. 7 (2007) 269-273