The origin and metabolism of a nascent pre-β high density lipoprotein involved in cellular cholesterol efflux

Acta Biochimica Polonica

Volumn 58, Issue 3, 2011, Pages 275-285

  Wróblewska, Małgorzata ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Abca1; Apo A I; Hdl; Pre HDL

Indexed keywords

DISCOIDAE;

EID: 81355139801     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2011_2237     Document Type: Review

References (169)

1. Abbott RD, Wilson PW, Kannel WB, Castelli WP (1988) High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study. Arteriosclerosis 8: 207-211.
2. Anderson DW, Nichols AV, Forte TM, Lindgren FT (1977) Particle distribution of human serum high density lipoproteins. Biochim Biophys Acta 493: 55-68.
3. Andersen RV, Wittrup HH, Tybjaerg-Hansen A, Steffensen R, Schnohr P, Nordestgaard BG (2003) Hepatic lipase mutations, elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol 41: 1972-1982.
4. Aouizerat BE, Engler MB, Natanzon Y, Kulkarni M, Song J, Eng C, Huuskonen J, Rivera C, Poon A, Bensley M, Sehnert A, Zellner C, Malloy M, Kane J, Pullinger CR (2006) Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. J Lipid Res 47: 787-793.
5. Arai T, Tsukada T, Murase T, Matsumoto K (2000) Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency. Clin Chim Acta 301: 103-117.
6. Asztalos BF, Sloop CH, Wong L, Roheim PS (1993) Two-dimensional electrophoresis of plasma lipoproteins: recognition of new apo A-Icontaining subpopulations. Biochim Biophys Acta 1169: 291-300.
7. Asztalos BF, Horvath KV, Kajinami K, Nartsupha C, Cox CE, Batista M, Schaefer EJ, Inazu A, Mabuchi H (2004) Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency. J Lipid Res 45: 448-455.
8. Asztalos BF, Schaefer EJ, Horvath KV, Yamashita S, Miller M, Franceschini G, Calabresi L (2007) Role of LCAT in HDL remodeling: investigation of LCAT deficiency states. J Lipid Res 48: 592-599.
9. Atkinson D, Small DM (1986) Recombinant lipoproteins: implications for structure and assembly of native lipoproteins. Annu Rev Biophys Biophys Chem 15: 403-456.
10. Attie AD (2007) ABCA1: at the nexus of cholesterol, HDL and atherosclerosis. Trends Biochem Sci 32: 172-179.
11. Azuma Y, Takada M, Shin HW, Kioka N, Nakayama K, Ueda K (2009) Retroendocytosis pathway of ABCA1/ApoA-I contributes to HDL formation. Genes Cells 14: 191-204.
12. Banerjee D, Redman CM (1983) Biosynthesis of high density lipoprotein by chicken liver: nature of nascent intracellular high density lipoprotein. J Cell Biol 96: 651-660.
13. Barrans A, Collet X, Barbaras R, Jaspard B, Manent J, Vieu C, Chap H, Perret B (1994) Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem 269: 11572-11577.
14. Barrans A, Jaspard B, Barbaras R, Chap H, Perret B, Collet X (1996) Pre-beta HDL: structure and metabolism. Biochim Biophys Acta 1300: 73-85.
15. Bekaert ED, Alaupovic P, Knight-Gibson C, Norum RA, Laux MJ, Ayrault-Jarrier M (1992) Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma. Biochim Biophys Acta 1126: 105-113.
16. Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ES, Otvos JD, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM (2007) Apolipoprotein A-II is inversely associated with risk of future coronary artery disease. Circulation 116: 2029-2035.
17. Blanche PJ, Gong EL, Forte TM, Nichols AV (1981) Characterization of human high-density lipoproteins by gradient gel electrophoresis. Biochim Biophys Acta 665: 408-419.
18. Blanco-Vaca F, Escola-Gil JC, Martin-Campos JM, Julve J (2001) Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein. J Lipid Res 42: 1727-1739.
19. Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, Diederich W, Drobnik W, Barlage S, Buchler C, Porsch-Ozcurumez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G (1999) The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 22: 347-351.
20. Boucher J, Ramsamy TA, Braschi S, Sahoo D, Neville TA, Sparks DL (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-858.
21. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 22: 336-345.
22. Brouillette CG, Anantharamaiah GM (1995) Structural models of human apolipoprotein A-I. Biochim Biophys Acta 1256: 103-129.
23. Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR (2006) Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116: 1052-1062.
24. Castro GR, Fielding CJ (1988) Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry 27: 25-29.
25. Chao WT, Tsai SH, Lin YC, Lin WW, Yang VC (2005) Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation. Biochem Biophys Res Commun 332: 743-749.
26. Chau P, Nakamura Y, Fielding CJ, Fielding PE (2006) Mechanism of prebeta-HDL formation and activation. Biochemistry 45: 3981-3987.
27. Chetiveaux M, Ouguerram K, Zair Y, Maugere P, Falconi I, Nazih H, Krempf M (2004) New model for kinetic studies of HDL metabolism in humans. Eur J Clin Invest 34: 262-267.
28. Chisholm JW, Burleson ER, Shelness GS, Parks JS (2002) ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipidpoor ApoA-I and intracellularly assembled nascent HDL. J Lipid Res 43: 36-44.
29. Clay MA, Barter PJ (1996) Formation of new HDL particles from lipid-free apolipoprotein A-I. J Lipid Res 37: 1722-1732.
30. Clay MA, Newnham HH, Barter PJ (1991) Hepatic lipase promotes a loss of apolipoprotein A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro. Arterioscler Thromb 11: 415-422.
31. Clay MA, Newnham HH, Forte TM, Barter PI (1992) Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo A-I from HDL and subsequent formation of discoidal HDL. Biochim Biophys Acta 1124: 52-58.
32. Clay MA, Pyle DH, Rye KA, Barter PJ (2000) Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. J Biol Chem 275: 9019-9025.
33. Cuchel M, Rader DJ (2006) Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation 113: 2548-2555
34. Daerr WH, Minzlaff U, Greten H (1986) Quantitative determination of apolipoprotein A-I in high-density lipoproteins and 'free' apolipoprotein A-I by two-dimensional agarose gel lipoprotein-'rocket' immunoelectrophoresis of human serum. Biochim Biophys Acta 879: 134-139.
35. Davidson WS, Sparks DL, Lund-Katz S, Phillips MC (1994) The molecular basis for the difference in charge between pre-beta-and alpha-migrating high density lipoproteins. J Biol Chem 269: 8959-8965.
36. Davidson WS, Silva RA (2005) Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Curr Opin Lipidol 16: 295-300.
37. Davidson WS Thompson TB (2007) The structure of apolipoprotein A-I in high density lipoproteins. J Biol Chem 282: 22249-22253.
38. de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH (2010) The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol 30: 796-801.
39. Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J (2004a) Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles. J Biol Chem 279: 41529-41536.
40. Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J, Jr (2004b) Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). J Biol Chem 279: 7384-7394.
41. Dullens SP, Plat J, Mensink RP (2007) Increasing ApoA-I production as a target for CHD risk reduction. Nutr Metab Cardiovasc Dis 17: 616-628.
42. Duong PT, Weibel GL, Lund-Katz S, Rothblat GH, Phillips MC (2008) Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I. J Lipid Res 49: 1006-1014.
43. Favari E, Bernini F, Tarugi P, Franceschini G, Calabresi L (2002) The C-terminal domain of apolipoprotein A-I is involved in ABCA1-driven phospholipid and cholesterol efflux. Biochem Biophys Res Commun 299: 801-805.
44. Favari E, Calabresi L, Adorni MP, Jessup W, Simonelli S, Franceschini G, Bernini F (2009) Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1. Biochemistry 48: 11067-11074.
45. Fielding CJ, Fielding PE (2000) Cholesterol and caveolae: structural and functional relationships. Biochim Biophys Acta 1529: 210-222.
46. Fielding CJ, Shore VG, Fielding PE (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun 46: 1493-1498.
47. Fielding PE, Nagao K, Hakamata H, Chimini G, Fielding CJ (2000) A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. Biochemistry 39: 14113-14120.
48. Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW (2002) Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem 277: 33178-33187.
49. Fitzgerald ML, Morris AL, Chroni A, Mendez AJ, Zannis VI, Freeman MW (2004) ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux. J Lipid Res 45: 287-294.
50. Forte TM, Bielicki JK, Goth-Goldstein R, Selmek J, McCall MR (1995) Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT. J Lipid Res 36: 148-157.
51. Fournier N, Cogny A, Atger V, Pastier D, Goudouneche D, Nicoletti A, Moatti N, Chambaz J, Paul JL, Kalopissis AD (2002) Opposite effects of plasma from human apolipoprotein A-II transgenic mice on cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells. Arterioscler Thromb Vasc Biol 22: 638-643.
52. Francis GA, Knopp RH, Oram JF (1995) Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease. J Clin Invest 96: 78-87.
53. Francone OL, Gurakar A, Fielding C (1989) Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol. J Biol Chem 264: 7066-7072.
54. Francone OL, Royer L, Haghpassand M (1996) Increased prebeta-HDL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprotein A-I (apoA-I) transgenes. J Lipid Res 37: 1268-1277.
55. Frank PG, Marcel YL (2000) Apolipoprotein A-I: structure-function relationships. J Lipid Res 41: 853-872.
56. Fredrickson DS (1964) The inheritance of high density lipoprotein deficiency (Tangier disease). J Clin Invest 43: 228-236.
57. Gao X, Yuan S, Jayaraman S, Gursky O (2009) Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition. J Mol Biol 387: 628-638.
58. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W (2004) Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J 18: 574-576.
59. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, Cartland S, Packianathan M, Kritharides L, Jessup W (2006) ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol 26: 534-540.
60. Gillard BK, Lin HY, Massey JB, Pownall HJ (2009) Apolipoproteins A-I, A-II and E are independently distributed among intracellular and newly secreted HDL of human hepatoma cells. Biochim Biophys Acta 1791: 1125-1132.
61. Gillotte KL, Davidson WS, Lund-Katz S, Rothblat GH, Phillips MC (1998) Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. J Lipid Res 39: 1918-1928.
62. Gonzalez MC, Toledo JD, Tricerri MA, Garda HA (2008) The central type Y amphipathic alpha-helices of apolipoprotein AI are involved in the mobilization of intracellular cholesterol depots. Arch Biochem Biophys 473: 34-41.
63. Gotto AM Jr (2001) Low high-density lipoprotein cholesterol as a risk factor in coronary heart disease: a working group report. Circulation 103: 2213-2218.
64. Gotto AM Jr, Brinton EA (2004) Assessing low levels of high-density lipoprotein cholesterol as a risk factor in coronary heart disease: a working group report and update. J Am Coll Cardiol 43: 717-724.
65. Guerra R, Wang J, Grundy SM, Cohen JC (1997) A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 94: 4532-4537.
66. Hamilton RL, Williams MC, Fielding CJ, Havel RJ (1976) Discoidal bilayer structure of nascent high density lipoproteins from perfused rat liver. J Clin Invest 58: 667-680.
67. Hara H, Yokoyama S (1991) Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol. J Biol Chem 266: 3080-3086.
68. Hassan HH, Denis M, Lee DY, Iatan I, Nyholt D, Ruel I, Krimbou L, Genest J (2007) Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis. J Lipid Res 48: 2428-2442.
69. Havel RJ, Eder HA, Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345-1353.
70. Hime NJ, Drew KJ, Wee K, Barter PJ, Rye KA (2006) Formation of high density lipoproteins containing both apolipoprotein A-I and A-II in the rabbit. J Lipid Res 47: 115-122.
71. Hirano K, Yamashita S, Nakajima N, Arai T, Maruyama T, Yoshida Y, Ishigami M, Sakai N, Kameda-Takemura K, Matsuzawa Y (1997) Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol 17: 1053-1059.
72. Hodoglugil U, Williamson DW, Mahley RW (2010) Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population. J Lipid Res 51: 422-430.
73. Hopkins GJ, Barter PJ (1986) Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins. J Lipid Res 27: 1265-1277.
74. Horowitz BS, Goldberg IJ, Merab J, Vanni TM, Ramakrishnan R, Ginsberg HN (1993) Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol. J Clin Invest 91: 1743-1752.
75. Hu YW, Zheng L, Wang Q (2010) Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes. Biochim Biophys Acta 1801: 100-105.
76. Ishida BY, Frolich J, Fielding CJ (1987) Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer. J Lipid Res 28: 778-786.
77. Jauhiainen M, Metso J, Pahlman R, Blomqvist S, van Tol A, Ehnholm C (1993) Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J Biol Chem 268: 4032-4036.
78. Jiang XC, Bruce C, Mar J, Lin M, Ji Y, Francone OL, Tall AR (1999) Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest 103: 907-914.
79. Jonas A (1986) Synthetic substrates of lecithin: cholesterol acyltransferase. J Lipid Res 27: 689-698.
80. Jonas A (2000) Lecithin cholesterol acyltransferase. Biochim Biophys Acta 1529: 245-256.
81. Jonas A, Kezdy KE, Wald JH (1989) Defined apolipoprotein A-I conformations in reconstituted high density lipoprotein discs. J Biol Chem 264: 4818-4824.
82. Jonas A, Wald JH, Toohill KL, Krul ES, Kezdy KE (1990) Apolipoprotein A-I structure and lipid properties in homogeneous, reconstituted spherical and discoidal high density lipoproteins. J Biol Chem 265: 22123-22129.
83. Kawano M, Miida T, Fielding CJ, Fielding PE (1993) Quantitation of pre beta-HDL-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid. Biochemistry 32: 5025-5028.
84. Kennedy MA, Barrera GC, Nakamura K, Baldan A, Tarr P, Fishbein MC, Frank J, Francone OL, Edwards PA (2005) ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 1: 121-131.
85. Kielar D, Dietmaier W, Langmann T, Aslanidis C, Probst M, Naruszewicz M, Schmitz G (2001) Rapid quantification of human ABCA1 mRNA in various cell types and tissues by real-time reverse transcription-PCR. Clin Chem 47: 2089-2097.
86. Kiss RS, McManus DC, Franklin V, Tan WL, McKenzie A, Chimini G, Marcel YL (2003) The lipidation by hepatocytes of human apolipoprotein A-I occurs by both ABCA1-dependent and -independent pathways. J Biol Chem 278: 10119-10127.
87. Klucken J, Buchler C, Orso E, Kaminski WE, Porsch-Ozcurumez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97: 817-822.
88. Kosek AB, Durbin D, Jonas A (1999) Binding affinity and reactivity of lecithin cholesterol acyltransferase with native lipoproteins. Biochem Biophys Res Commun 258: 548-551.
89. Krimbou L, Marcil M, Chiba H, Genest J Jr (2003) Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles. J Lipid Res 44: 884-892.
90. Krimbou L, Hajj Hassan H, Blain S, Rashid S, Denis M, Marcil M, Genest J (2005) Biogenesis and speciation of nascent apoA-I-containing particles in various cell lines. J Lipid Res 46: 1668-1677.
91. Kuivenhoven JA, Pritchard H, Hill J, Frohlich J, Assmann G, Kastelein J (1997) The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. J Lipid Res 38: 191-205.
92. Kunitake ST, La Sala KJ, Kane JP (1985) Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility. J Lipid Res 26: 549-555.
93. Kunitake ST, Mendel CM, Hennessy LK (1992) Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities. J Lipid Res 33: 1807-1816.
94. Lamarche B, Uffelman KD, Carpentier A, Cohn JS, Steiner G, Barrett PH, Lewis GF (1999) Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men. J Clin Invest 103: 1191-1199.
95. Lee JY, Timmins JM, Mulya A, Smith TL, Zhu Y, Rubin EM, Chisholm JW, Colvin PL, Parks JS (2005) HDLs in ApoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney. J Lipid Res 46: 2233-2245.
96. Liang HQ, Rye KA, Barter PJ (1994) Dissociation of lipid-free apolipoprotein A-I from high density lipoproteins. J Lipid Res 35: 1187-1199.
97. Liang HQ, Rye KA, Barter PJ (1995) Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools. Biochim Biophys Acta 1257: 31-37.
98. Liang HQ, Rye KA, Barter PJ (1996) Remodelling of reconstituted high density lipoproteins by lecithin: cholesterol acyltransferase. J Lipid Res 37: 1962-1970.
99. Lindgren FT, Elliott HA, Gofman JW (1951) The ultracentrifugal characterization and isolation of human blood lipids and lipoproteins, with applications to the study of atherosclerosis. J Phys Colloid Chem 55: 80-93.
100. Liu L, Bortnick AE, Nickel M, Dhanasekaran P, Subbaiah PV, LundKatz S, Rothblat GH, Phillips MC (2003) Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem 278: 42976-42984.
101. Luo G, Zhang X, Nilsson-Ehle P, Xu N (2004) Apolipoprotein M. Lipids Health Dis 3: 21.
102. Lusa S, Jauhiainen M, Metso J, Somerharju P, Ehnholm C (1996) The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion. Biochem J 313 (Part 1): 275-282.
103. Marcel YL, Kiss RS (2003) Structure-function relationships of apolipoprotein A-I: a flexible protein with dynamic lipid associations. Curr Opin Lipidol 14: 151-157.
104. Maric J, Kiss RS, Franklin V, Marcel YL (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-39949.
105. Marques-Vidal P, Jauhiainen M, Metso J, Ehnholm C (1997) Transformation of high density lipoprotein 2 particles by hepatic lipase and phospholipid transfer protein. Atherosclerosis 133: 87-95.
106. Martin DD, Budamagunta MS, Ryan RO, Voss JC, Oda MN (2006) Apolipoprotein A-I assumes a "looped belt" conformation on reconstituted high density lipoprotein. J Biol Chem 281: 20418-20426.
107. Martinez LO, Agerholm-Larsen B, Wang N, Chen W, Tall AR (2003) Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem 278: 37368-37374.
108. Masson D, Jiang XC, Lagrost L, Tall AR (2009) The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis. J Lipid Res 50 (Suppl): S201-6.
109. McCall MR, Forte TM, Shore VG (1988) Heterogeneity of nascent high density lipoproteins secreted by the hepatoma-derived cell line, Hep G2. J Lipid Res 29: 1127-1137.
110. McIntyre N (1988) Familial LCAT deficiency and fish-eye disease. J Inherit Metab Dis 11 (Suppl 1): 45-56.
111. Mendez AJ, Lin G, Wade DP, Lawn RM, Oram JF (2001) Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway. J Biol Chem 276: 3158-3166.
112. Mulya A, Lee JY, Gebre AK, Thomas MJ, Colvin PL, Parks JS (2007) Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1. Arterioscler Thromb Vasc Biol 27: 1828-1836.
113. Mulya A, Seo J, Brown AL, Gebre AK, Boudyguina E, Shelness GS, Parks JS (2010) Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1. J Lipid Res 51: 514-524.
114. Murtomaki S, Tahvanainen E, Antikainen M, Tiret L, Nicaud V, Jansen H, Ehnholm C (1997) Hepatic lipase gene polymorphisms influence plasma HDL levels. Results from Finnish EARS participants. European Atherosclerosis Research Study. Arterioscler Thromb Vasc Biol 17: 1879-1884.
115. Nakamura Y, Kotite L, Gan Y, Spencer TA, Fielding CJ, Fielding PE (2004) Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase. Biochemistry 43: 14811-14820.
116. Neary RH, Gowland E (1987) Stability of free apolipoprotein A-1 concentration in serum, and its measurement in normal and hyperlipidemic subjects. Clin Chem 33: 1163-1169.
117. Neary R, Bhatnagar D, Durrington P, Ishola M, Arrol S, Mackness M (1991) An investigation of the role of lecithin:cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of prebeta high density lipoproteins. Atherosclerosis 89: 35-48.
118. Neufeld EB, Remaley AT, Demosky SJ, Stonik JA, Cooney AM, Comly M, Dwyer NK, Zhang M, Blanchette-Mackie J, Santamarina-Fojo S, Brewer HB Jr (2001) Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem 276: 27584-27590.
119. Neufeld EB, Stonik JA, Demosky SJ Jr, Knapper CL, Combs CA, Cooney A, Comly M, Dwyer N, Blanchette-Mackie J, Remaley AT, Santamarina-Fojo S, Brewer HB Jr (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem 279: 15571-15578.
120. Nielsen LB, Christoffersen C, Ahnstrom J, Dahlback B (2009) ApoM: gene regulation and effects on HDL metabolism. Trends Endocrinol Metab 20: 66-71.
121. Nolte RT, Atkinson D (1992) Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism. Biophys J 63: 1221-1239.
122. O'Connor PM, Zysow BR, Schoenhaus SA, Ishida BY, Kunitake ST, Naya-Vigne JM, Duchateau PN, Redberg RF, Spencer SJ, Mark S, Mazur M, Heilbron DC, Jaffe RB, Malloy MJ, Kane JP (1998) Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender. J Lipid Res 39: 670-678.
123. Okuhira K, Tsujita M, Yamauchi Y, Abe-Dohmae S, Kato K, Handa T, Yokoyama S (2004) Potential involvement of dissociated ApoA-I in the ABCA1-dependent cellular lipid release by HDL. J Lipid Res 45: 645-652.
124. Oram JF, Heinecke JW (2005) ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol Rev 85: 1343-1372.
125. Oram JF, Albers JJ, Cheung MC, Bierman EL (1981) The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity. J Biol Chem 256: 8348-8356.
126. Oram JF, Lawn RM, Garvin MR, Wade DP (2000) ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem 275: 34508-34511.
127. Patsch JR, Prasad S, Gotto AM Jr, Patsch W (1987) High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J Clin Invest 80: 341-347.
128. Phillips JC, Wriggers W, Li Z, Jonas A, Schulten K (1997) Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks. Biophys J 73: 2337-2346.
129. Pownall HJ, Hosken BD, Gillard BK, Higgins CL, Lin HY, Massey JB (2007) Speciation of human plasma high-density lipoprotein (HDL): HDL stability and apolipoprotein A-I partitioning. Biochemistry 46: 7449-7459.
130. Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, Clerc M, Dumon MF, Fairwell T, Zech L (1994) Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease. J Clin Invest 93: 321-330.
131. Rashid S, Marcil M, Ruel I, Genest J (2009) Identification of a novel human cellular HDL biosynthesis defect. Eur Heart J 30: 2204-2212.
132. Remaley AT, Thomas F, Stonik JA, Demosky SJ, Bark SE, Neufeld EB, Bocharov AV, Vishnyakova TG, Patterson AP, Eggerman TL, Santamarina-Fojo S, Brewer HB (2003) Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway. J Lipid Res 44: 828-836.
133. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duverger N, Denefle P, Assmann G (1999) Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 22: 352-355.
134. Rye KA, Barter PJ (2004) Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I. Arterioscler Thromb Vasc Biol 24: 421-428.
135. Rye KA, Hime NJ, Barter PJ (1997) Evidence that cholesteryl ester transfer protein-mediated reductions in reconstituted high density lipoprotein size involve particle fusion. J Biol Chem 272: 3953-3960.
136. Rye KA, Wee K, Curtiss LK, Bonnet DJ, Barter PJ (2003) Apolipoprotein A-II inhibits high density lipoprotein remodeling and lipidpoor apolipoprotein A-I formation. J Biol Chem 278: 22530-22536.
137. Saito H, Dhanasekaran P, Nguyen D, Holvoet P, Lund-Katz S, Phillips MC (2003) Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model. J Biol Chem 278: 23227-23232.
138. Saito H, Lund-Katz S, Phillips MC (2004) Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Prog Lipid Res 43: 350-380.
139. Sankaranarayanan S, Oram JF, Asztalos BF, Vaughan AM, Lund-Katz S, Adorni MP, Phillips MC, Rothblat GH (2009) Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res 50: 275-284.
140. Segrest JP, Jones MK, De Loof H, Brouillette CG, Venkatachalapathi YV, Anantharamaiah GM (1992) The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J Lipid Res 33: 141-166.
141. Segrest JP, Jones MK, Klon AE, Sheldahl CJ, Hellinger M, De Loof H, Harvey SC (1999) A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein. J Biol Chem 274: 31755-31758.
142. Shah PK (2007) High-density lipoprotein mimetics: focus on synthetic high-density lipoprotein. Am J Cardiol 100: S62-S67.
143. Shih AY, Sligar SG, Schulten K (2009) Maturation of high-density lipoproteins. J R Soc Interface 6: 863-871.
144. Silva RA, Schneeweis LA, Krishnan SC, Zhang X, Axelsen PH, Davidson WS (2007) The structure of apolipoprotein A-II in discoidal high density lipoproteins. J Biol Chem 282: 9713-9721.
145. Sparks DL, Frank PG, Braschi S, Neville TA, Marcel YL (1999) Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles. Biochemistry 38: 1727-1735.
146. Takahashi Y, Smith JD (1999) Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc Natl Acad Sci USA 96: 11358-11363.
147. Tall AR, Green PH (1981) Incorporation of phosphatidylcholine into spherical and discoidal lipoproteins during incubation of egg phosphatidylcholine vesicles with isolated high density lipoproteins or with plasma. J Biol Chem 256: 2035-2044.
148. Tall AR, Krumholz S, Olivecrona T, Deckelbaum RJ (1985) Plasma phospholipid transfer protein enhances transfer and exchange of phospholipids between very low density lipoproteins and high density lipoproteins during lipolysis. J Lipid Res 26: 842-851.
149. Tang C, Vaughan AM, Anantharamaiah GM, Oram JF (2006) Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1. J Lipid Res 47: 107-114.
150. Thomas MJ, Bhat S, Sorci-Thomas MG (2008) Three-dimensional models of HDL apoA-I: implications for its assembly and function. J Lipid Res 49: 1875-1883.
151. Thuren T (2000) Hepatic lipase and HDL metabolism. Curr Opin Lipidol 11: 277-283.
152. Timmins JM, Lee JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS (2005) Targeted inactivation of hepatic ABCA1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 115: 1333-1342.
153. van Tornout P, Caster H, Lievens MJ, Rosseneu M, Assmann G (1981) In vitro interaction of human HDL with human apolipoprotein A-II. Synthesis of apolipoprotein A-II-rich HDL. Biochim Biophys Acta 663: 630-636.
154. Vaughan AM, Oram JF (2005) ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipiddepleted apolipoproteins. J Biol Chem 280: 30150-30157.
155. Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Saito H, Rothblat GH, Lund-Katz S, Phillips MC (2007a) Mechanism of ATP-binding
156. Vedhachalam C, Ghering AB, Davidson WS, Lund-Katz S, Rothblat GH, Phillips MC (2007b) ABCA1-induced cell surface binding sites for ApoA-I. Arterioscler Thromb Vasc Biol 27: 1603-1609.
157. von Eckardstein A, Jauhiainen M, Huang Y, Metso J, Langer C, Pussinen P, Wu S, Ehnholm C, Assmann G (1996) Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL. Biochim Biophys Acta 1301: 255-262.
158. Wang N, Silver DL, Thiele C, Tall AR (2001) ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem 276: 23742-23747.
159. Wang N, Chen W, Linsel-Nitschke P, Martinez LO, Agerholm-Larsen B, Silver DL, Tall AR (2003) A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest 111: 99-107.
160. Wang N, Lan D, Chen W, Matsuura F, Tall AR (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci USA 101: 9774-9779.
161. Wilson PW, Abbott RD, Castelli WP (1988) High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis 8: 737-741.
162. Wolfrum C, Poy MN, Stoffel M (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11: 418-422.
163. Wróblewska M, Kortas-Stempak B, Szutowicz A, Badzio T (2009) Phospholipids mediated conversion of HDLs generates specific apoA-II pre-beta mobility particles. J Lipid Res 50: 667-675.
164. Wróblewska M, Czyżewska M, Wolska A, Kortas-Stempak B, Szutowicz A (2010) Apo A-II participates in HDL-liposome interaction by the formation of new pre-beta mobility particles and the modification of liposomes. Biochim Biophys Acta 1801: 1323-1329.
165. Wu AL, Windmueller HG (1979) Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J Biol Chem 254: 7316-7322.
166. Wu Z, Wagner MA, Zheng L, Parks JS, Shy JM 3rd, Smith JD, Gogonea V, Hazen SL (2007) The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat Struct Mol Biol 14: 861-868.
167. Xu N, Dahlback B (1999) A novel human apolipoprotein (apoM). J Biol Chem 274: 31286-31290.
168. Xu Y, Fu M (2003) Alterations of HDL subclasses in hyperlipidemia. Clin Chim Acta 332: 95-102.
169. Zarubica A, Plazzo AP, Stockl M, Trombik T, Hamon Y, Muller P, Pomorski T, Herrmann A, Chimini G (2009) Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma membrane: a biophysical study. FASEB J 23: 1775-1785.