The C-terminal domain of apolipoprotein A-I is involved in ABCA1-driven phospholipid and cholesterol efflux

Biochemical and Biophysical Research Communications

Volumn 299, Issue 5, 2002, Pages 801-805

  Favari, Elda ^a   Bernini, Franco ^a   Tarugi, Patrizia ^b   Franceschini, Guido ^c   Calabresi, Laura ^c  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

ABCA1 transporter; Apolipoprotein A I; Cholesterol efflux; Phospholipid efflux

Indexed keywords

ABC TRANSPORTER A1; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN; APOLIPOPROTEIN A1; CHOLESTEROL; PHOSPHOLIPID; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL STIMULATION; CELL SURFACE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FIBROBLAST; MACROPHAGE; MOUSE; NONHUMAN; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELLS, CULTURED; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; MACROPHAGES; MICE; PEPTIDE FRAGMENTS; PHOSPHOLIPIDS; PROTEIN STRUCTURE, TERTIARY; RATS; TUMOR CELLS, CULTURED;

EID: 0036925992     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02745-6     Document Type: Article

References (31)

1. C.J. Fielding, P.E. Fielding, Molecular physiology of reverse cholesterol transport, J. Lipid Res. 36 (1995) 211-228.
2. W.J. Johnson, F.H. Mahlberg, G.H. Rothblat, M.C. Phillips, Cholesterol transport between cells and high-density lipoproteins, Biochim. Biophys. Acta 1085 (1991) 273-298.
3. J.F. Oram, S. Yokoyama, Apolipoprotein-mediated removal of cellular cholesterol and phospholipids, J. Lipid Res. 37 (1996) 2473-2491.
4. G.H. Rothblat, M. Llera-Moya, E. Favari, P.G. Yancey, G. Kellner-Weibel, Cellular cholesterol flux studies: Methodological considerations, Atherosclerosis 163 (2002) 1-8.
5. M.C. Phillips, W.J. Johnson, G.H. Rothblat, Mechanisms and consequences of cellular cholesterol exchange and transfer, Biochim. Biophys. Acta 906 (1987) 223-276.
6. G. Kellner-Weibel, M. Llera-Moya, M.A. Connelly, G. Stoudt, A.E. Christian, M.P. Haynes, D.L. Williams, G.H. Rothblat, Expression of scavenger receptor BI in COS-7 cells alters cholesterol content and distribution, Biochemistry 39 (2000) 221-229.
7. B. Jian, M. de la Llera-Moya, Y. Ji, N. Wang, M.C. Phillips, J.B. Swaney, A.R. Tall, G.H. Rothblat, Scavenger receptor class B type I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptors, J. Biol. Chem. 273 (1998) 5599-5606.
8. P.G. Yancey, M. Llera-Moya, S. Swarnakar, P. Monzo, S.M. Klein, M.A. Connelly, W.J. Johnson, D.L. Williams, G.H. Rothblat, High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI, J. Biol. Chem. 275 (2000) 36596-36604.
9. A.D. Attie, J.P. Kastelein, M.R. Hayden, Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis, J. Lipid Res. 42 (2001) 1717-1726.
10. R.M. Lawn, D.P. Wade, M.R. Garvin, X. Wang, K. Schwartz, J.G. Porter, J.J. Seilhamer, A.M. Vaughan, J.F. Oram, The Tangier disease gene product ABC1 controls the cellular apoli-poprotein-mediated lipid removal pathway, J. Clin. Invest. 104 (1999) R25-R31.
11. A.E. Bortnick, G.H. Rothblat, G. Stoudt, K.L. Hoppe, L.J. Royer, J. McNeish, O.L. Francone, The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines, J. Biol. Chem. 275 (2000) 28634-28640.
12. K. Schwartz, R.M. Lawn, D.P. Wade, ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR, Biochem. Biophys. Res. Commun. 274 (2000) 794-802.
13. J.F. Oram, Molecular basis of cholesterol homeostasis: Lessons from Tangier disease and ABCA1, Trends Mol. Med. 8 (2002) 168-173.
14. A.T. Remaley, J.A. Stonik, S.J. Demosky, E.B. Neufeld, A.V. Bocharov, T.G. Vishnyakova, T.L. Eggerman, A.P. Patterson, N.J. Duverger, S. Santamarina-Fojo, H.B. Brewer Jr., Apolipoprotein specificity for lipid efflux by the human ABCAI transporter, Biochem. Biophys. Res. Commun. 280 (2001) 818-823.
15. R.W. Mahley, T.L. Innerarity, S.C. Rall Jr., K.H. Weisgraber, Plasma lipoproteins: Apolipoprotein structure and function, J. Lipid Res. 25 (1984) 1277-1294.
16. A. Jonas, Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteins, Biochim. Biophys. Acta 1084 (1991) 205-220.
17. G.H. Rothblat, F.H. Mahlberg, W.J. Johnson, M.C. Phillips, Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux, J. Lipid Res. 33 (1992) 1091-1097.
18. K.N. Liadaki, T. Liu, S. Xu, B.Y. Ishida, P.N. Duchateaux, J.P. Krieger, J. Kane, M. Krieger, V.I. Zannis, Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and ApoA-I mutations on receptor binding, J. Biol. Chem. 275 (2000) 21262-21271.
19. P.G. Frank, D. N'Guyen, V. Franklin, T. Neville, M. Desforges, E. Rassart, D.L. Sparks, Y.L. Marcel, Importance of central α-helices of human apolipoprotein A-I in the maturation of high-density lipoproteins, Biochemistry 37 (1998) 13902-13909.
20. Y. Ji, A. Jonas, Properties of an N-terminal proteolytic fragment of apolipoprotein AI in solution and in reconstituted high density lipoproteins, J. Biol. Chem. 270 (1995) 11290-11297.
21. J.W. Burgess, P.G. Frank, V. Franklin, P. Liang, D.C. McManus, M. Desforges, E. Rassart, Y.L. Marcel, Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage, Biochemistry 38 (1999) 14524-14533.
22. F. Bernini, L. Calabresi, G. Bonfadini, G. Franceschini, The molecular structure of apolipoprotein A-II modulates the capacity of HDL to promote cell cholesterol efflux, Biochim. Biophys. Acta 1299 (1996) 103-109.
23. Milano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant, J. Biol. Chem. 260 (1985) 16321-16325.
24. S.W. Sakr, D.L. Williams, G.W. Stoudt, M.C. Phillips, G.H. Rothblat, Induction of cellular cholesterol efflux to lipid-free apolipoprotein A-I by cAMP, Biochim. Biophys. Acta 1438 (1999) 85-98.
25. P.G. Yancey, J.K. Bielicki, W.J. Johnson, S. Lund Katz, M.N. Palgunachari, G.M. Anantharamaiah, J.P. Segrest, M.C. Phillips, G.H. Rothblat, Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides, Biochemistry 34 (1995) 7955-7965.
26. J.J. Repa, S.D. Turley, J.M. Lobaccaro, J. Medina, L. Li, K. Lusting, R.A. Shan, J. Heyman, J.M. Dietschy, D.J. Mengelsdorf, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers, Science 289 (2002) 1524-1529.
27. D. Sviridov, L.E. Pyle, N. Fidge, Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutants, J. Biol. Chem. 271 (1996) 33277-33283.
28. N. Wang, D.L. Silver, P. Costet, A.R. Tall, Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1, J. Biol. Chem. 275 (2000) 33053-33058.
29. M.L. Fitzgerald, A.L. Morris, J.S. Rhee, L.P. Andersson, A.J. Mendez, M.W. Freeman, Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interac-tionwithapolipoproteinA-I, J. Biol. Chem. 277(2002)33178-33187.
30. O. Chambenoit, Y. Hamon, D. Marguet, H. Rigneault, M. Rosseneu, G. Chimini, Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter, J. Biol. Chem. 276 (2001) 9955-9960.
31. P.E. Fielding, K. Nagao, H. Hakamata, G. Chimini, C.J. Fielding, A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1, Biochemistry 39 (2000) 14113-14120.