Role of apoA-II in lipid metabolism and atherosclerosis: Advances in the study of an enigmatic protein

Journal of Lipid Research

Volumn 42, Issue 11, 2001, Pages 1727-1739

  Blanco Vaca, F ^a   Escola Gil J C ^a   Martin Campos J M ^a   Julve, J ^a  

^a Ser Bioq l'Hosp St Crue Sant Pau   (Spain)

Author keywords

apoA I; apoB; HDL; Hyperlipidemia; Hypertriglyceridemia; Insulin resistance; Triglycerides; Type 2 diabetes; VLDL

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CUBILIN; FATTY ACID; HEAT SHOCK PROTEIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; INSULIN; LIPID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL MODEL; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; DISEASE PREDISPOSITION; DNA MODIFICATION; FATTY ACID METABOLISM; GENE LOCUS; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOPROTEIN SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; APOLIPOPROTEIN A-II; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; BIOLOGICAL TRANSPORT; CHOLESTEROL; CHOLESTEROL, HDL; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIPID METABOLISM; LIPID PEROXIDATION; LIPOPROTEINS, VLDL; MICE; MICE, TRANSGENIC; TRIGLYCERIDES;

EID: 0035195675     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (113)

1. The apolipoprotein multigene family: Biosynthesis, structure-function relationship, and evolution
2. Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins
3. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
4. The human apolipoprotein AII gene: Structural organization and sites of expression
5. A splice-junction mutation responsible for familial apolipoprotein A-II deficiency
6. DNA polymorphisms in linkage disequilibrium at the 3′ end of the human APO AII gene: Relationships with lipids, apolipoproteins and coronary heart disease
7. High-density lipoprotein composition is altered by a common DNA polymorphism adjacent to apoprotein AII gene in man
8. Intracellular modification of human apolipoprotein (apoA-II) and sites of apoA-II synthesis: Comparison of apoA-II with apoC-II and apoC-III isoproteins
9. Transcriptional regulation of the human apolipoprotein genes
10. The -911/+29 sequence of human apolipoprotein A-II promoter is sufficient to confer liver restricted expression, developmental changes and response to a high fat diet in transgenic mice
11. Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene region
12. Promoter elements and factors required for hepatic transcription of the human apoA-II gene
13. Regulation of the human apoA-II gene by the synergistic action of factors binding to the proximal and distal regulatory elements
14. Transcription of the human apolipoprotein A-II is down-regulated by the first intron of its gene
15. Cooperative binding of upstream stimulatory factor and hepatic nuclear factor 4 drives the transcription of the human apolipoprotein A-II gene
16. Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription
17. Transcriptional regulation of human apolipoprotein genes apoB, apoCIII and apoAII by members of the steroid hormone receptor superfamily HNF,4 ARP-1, EAR-2 and EAR-3
18. Retinoids increase human apolipoprotein A-II expression through activation of the retinoid X receptor but not the retinoic acid receptor
19. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
20. SREBP-1 binds to multiple sites and transactivates the human apoA-II promoter in vitro: SREBP-1 mutants defective in DNA binding or transcriptional activation repress the apoA-II promoter activity
21. DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter
22. Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans
23. Genotype/phenotype is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein (a), and triglyceride levels
24. Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states
25. Amino acid sequence of human apoLp-GlnII (apoA-II), an apolipoprotein isolated from the high density lipoprotein
26. Apoprotein (E-A-II) complex of human plasma lipoproteins. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction
27. Distribution of apolipoprotein E between the free and apoA-II complexed forms in very-low- And high-density lipoproteins: Functionl implications
28. Characterization of disulfide-linked heterodimers containing apolipoprotein D in human plasma lipoproteins
29. The amphipathic helix in the exchangable apolipoproteins: A review of secondary structure and function
30. O-linked glycosylation modifies the association of apolipoprotein A-II to high density lipoproteins
31. Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: Evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci
32. Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II-B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia
33. Apolipoprotein A-containing lipoprotein particles: Physiological role, quantification, and clinical significance
34. Isolation and partial characterization of lipoprotein A-II (LP A-II) particles of human plasma
35. A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition
36. Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin: Cholesterol acyltransferase
37. Comparative analysis of mammalian plasma lipoproteins
38. Contrasting in vivo effects of murine and human apolipoprotein A-II
39. Primary structure of apolipoprotein A-II from inbred mouse strain BALB/c
40. Effect of apolipoprotein A-II on the structure of high density lipoproteins: Relationship to the activity of lecithin:cholesterol acyltransferase
41. Displacement of apoA-I from HDL by apoA-II or its C-terminal helix promotes the formation of pre-β1 migrating particles and decreases LCAT activation
42. Lipid-free apolipoproteins A-I and A-II promote remodelling of reconstituted high density lipoproteins and alter their reactivity with lecithin: Cholesterol acyltransferase
43. Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice
44. Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II
45. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses
46. Influence of mouse apolipoprotein A-I1 on plasma lipoproteins in transgenic mice
47. Dramatically decreased high density lipoprotein cholesterol increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility
48. Cell cholesterol efflux: Integration of old and new observations provides new insights
49. Molecular physiology of reverse cholesterol transport
50. Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: Formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT
51. Overexpression of apolipoprotein A-II in transgenic mice converts high density lipoproteins to proinflammatory particles
52. Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin:cholesterol acyltransferase deficiency
53. Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice
54. Cholesterol efflux, lecithin: Cholesterol acyltransferase activity, and pre-beta particle formation by serum from human apolipoprotein A-I/apolipoprotein A-II transgenic mice consistent with the latter being less effective for reverse cholesterol transport
55. Human apolipoproteins A-I and A-II in cell cholesterol efflux. Studies with transgenic mice
56. Apolipoprotein specificity for lipid efflux by the human ABCAI transporter
57. Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer protein activity
58. The influence of apolipoproteins on the structure and function of spheroidal, reconstituted high density lipoproteins
59. Differential interaction of the human cholesteryl ester transfer protein with plasma high density lipoproteins (HDLs) from humans, control mice, and transgenic mice to human HDL apolipoproteins
60. Human apoA-II inhibits the hydrolysis of HDL triglycerides and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice
61. ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance
62. Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: Location of a PLTP binding domain in the amino terminal region of apoA-I
63. Functional expression of human and mouse plasma phospholipid transfer protein: Effect of recombinant and plasma PTLP on HDL subspecies
64. ApoA-II/ apoA-I molar ratio in the HDL particle influences phospholipid transfer protein-mediated HDL interconversion
65. The effect of apolipoprotein A-II on the structure and function of apolipoprotein A-I in a homogeneous reconstituted high density lipoprotein particle
66. Apolipoprotein A-I-containing lipoproteins and atherosclerosis
67. Expression of human lecithin: Cholesterol acyltransferase in transgenic mice: Effect of human apolipoprotein AI and human apolipoprotein AII on plasma lipoprotein cholesterol metabolism
68. Hepatic lipase and HDL metabolism
69. The influence of apolipoproteins on the hepatic lipase-mediated hydrolysis of high density lipoprotein phospholipid and triglyceride
70. Evidence that apolipoprotein A-I facilitates hepatic lipase-mediated phospholipid hydrolysis in reconstituted HDL containing apolipoprotein A-II
71. Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: Evidence of a potentially relevant species-specific interaction with diet
72. In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions
73. ApoA-II maintains HDL levels in part by inhibition of hepatic lipase: Studies in apoA-II and hepatic lipase double knockout mice
74. Different reactivities of high density lipoprotein 2 subfractions with hepatic lipase
75. High density lipoprotein receptors, binding proteins, and ligands
76. Selective uptake of cholesteryl esters from high-density lipoprotein derived LpA-I and LpA-I:A-II particles by hepatic cells in culture
77. Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake
78. D.R. Apolipoprotein A-II modulates the binding and selective uptake of reconstituted HDL by scavenger receptor BI
79. Cubilin, a high-density lipoprotein receptor
80. Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein
81. High density lipoproteins (HDL) and the oxidative hypothesis of atherosclerosis
82. A DNA polymorphism of the apolipoprotein A-II gene
83. MspI polymorphism of the apolipoprotein A-II gene, serum lipids, and apolipoproteins in Chinese from Singapore
84. Association between apolipoprotein A2 MspI polymorphism and hypertriglyceridemia in Koreans
85. Plasma lipoprotein lipids in relation to the MspI polymorphism of the apolipoprotein A-II gene in Caucasian men
86. The MspI restriction fragment length polymorphism 3′ to the apolipoprotein gene: Relationship with lipids, apolipoproteins, and premature coronary artery disease
87. The Msp I polymorphism of the apolipoprotein A-II gene as a modulator of the dyslipidemic state found in visceral obesity
88. Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms
89. Variability of plasma apolipoprotein (apo) A-II levels associated with an apoA-II gene polymorphism in monozygotic twin pairs
90. Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans
91. How much of variability in apolipoprotein A-II concentration is explained by polymorphism adjacent to apoA-II gene?
92. Relationships between the metabolism of high density and very-low density lipoproteins in man: Studies of apolipoprotein kinetics and adipose tissue lipoprotein lipase activity
93. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
94. A genome-wide search for type 2 susceptibility gene in Utah Caucasians
95. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
96. Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia
97. Overexpression of human apolipoprotein A-II induces hypertriglyceridemia due to defective very low density lipoprotein hydrolyis
98. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II
99. Studies with transgenic mice indicate a role for HDLs in adiposity and insulin resistance
100. Increased production of very-low-density lipoproteins in transgenic mice overexpressing human apolipoprotein A-II and fed with a high-fat diet
101. A 700-bp fragment of the human antithrombin III promoter is sufficient to confer high, tissue-specific expression on human apolipoprotein A-II in transgenic mice
102. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
103. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates
104. Decreased HDL2 and HDL3 cholesterol, apo A-I and apo A-II, and increased risk of myocardial infarction
105. The role of lipoprotein A-I and lipoprotein A-I/A-II in predicting coronary artery disease
106. The role of triglyceride-rich lipoprotein families in the progression of atherosclerotic lesions as determined by sequential coronary angiography from a controlled clinical trial
107. Intravascular free tissue factor pathway inhibitor is inversely correlated with HDL cholesterol and postheparin lipoprotein lipase but proportional to apolipoprotein A-II
108. Interstitial fluid apolipoprotein A-II: An association with the occurrence of myocardial infarction
109. Protein composition determines the anti-atherogenic properties of HDL in transgenic mice
110. Influence of the apoA-II locus on HDL levels and fatty acid streak development in mice
111. Moderate red wine consumption in healthy vohmteers reduced plasma clearance of apolipoprotein AII
112. Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II
113. High-density lipoprotein binding to scavenger-BI activates endothelial nitric oxide synthase