메뉴 건너뛰기




Volumn 32, Issue 12, 2011, Pages 589-594

Impact of Ca2+ signaling on B cell function

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM ION; CD19 ANTIGEN; CD22 ANTIGEN; CD40 ANTIGEN; FC RECEPTOR IIB; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE SHP 1; STROMAL INTERACTION MOLECULE 1; STROMAL INTERACTION MOLECULE 2; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR NFAT; CALCIUM;

EID: 81355127403     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2011.09.004     Document Type: Review
Times cited : (64)

References (71)
  • 1
    • 0038125598 scopus 로고    scopus 로고
    • Calcium: calcium signalling: dynamics, homeostasis and remodelling
    • Berridge M.J., et al. Calcium: calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 2003, 4:517-529.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 517-529
    • Berridge, M.J.1
  • 2
    • 34548233165 scopus 로고    scopus 로고
    • Calcium signalling in lymphocyte activation and disease
    • Feske S. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 2007, 7:690-702.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 690-702
    • Feske, S.1
  • 3
    • 0035064074 scopus 로고    scopus 로고
    • Calcium signaling mechanisms in T lymphocytes
    • Lewis R.S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001, 19:497-521.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 497-521
    • Lewis, R.S.1
  • 4
    • 57849148942 scopus 로고    scopus 로고
    • Calcium signaling in immune cells
    • Vig M., Kinet J.-P. Calcium signaling in immune cells. Nat. Immunol. 2009, 10:21-27.
    • (2009) Nat. Immunol. , vol.10 , pp. 21-27
    • Vig, M.1    Kinet, J.-P.2
  • 5
    • 77950020321 scopus 로고    scopus 로고
    • B cell signaling and fate decision
    • Kurosaki T., et al. B cell signaling and fate decision. Annu. Rev. Immunol. 2009, 28:21-25.
    • (2009) Annu. Rev. Immunol. , vol.28 , pp. 21-25
    • Kurosaki, T.1
  • 6
    • 77950070632 scopus 로고    scopus 로고
    • Effector and regulatory B cells: modulators of CD4(+) T cell immunity
    • Lund F.E., Randall T.D. Effector and regulatory B cells: modulators of CD4(+) T cell immunity. Nat. Rev. Immunol. 2010, 4:236-247.
    • (2010) Nat. Rev. Immunol. , vol.4 , pp. 236-247
    • Lund, F.E.1    Randall, T.D.2
  • 7
    • 37849044394 scopus 로고    scopus 로고
    • The 'short' history of regulatory B cells
    • Mauri C., Ehrenstein M.R. The 'short' history of regulatory B cells. Trends Immunol. 2008, 29:34-40.
    • (2008) Trends Immunol. , vol.29 , pp. 34-40
    • Mauri, C.1    Ehrenstein, M.R.2
  • 8
    • 49249136452 scopus 로고    scopus 로고
    • Regulatory B cells as inhibitors of immune responses and inflammation
    • Bouaziz J.-D., et al. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol. Rev. 2008, 224:201-214.
    • (2008) Immunol. Rev. , vol.224 , pp. 201-214
    • Bouaziz, J.-D.1
  • 9
    • 0036584284 scopus 로고    scopus 로고
    • Regulation of B-cell signal transduction by adaptor proteins
    • Kurosaki T. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol. 2002, 2:354-363.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 354-363
    • Kurosaki, T.1
  • 10
    • 15544368216 scopus 로고    scopus 로고
    • Store-operated calcium channels
    • Parekh A.B., Putney J.W. Store-operated calcium channels. Physiol. Rev. 2005, 85:757-810.
    • (2005) Physiol. Rev. , vol.85 , pp. 757-810
    • Parekh, A.B.1    Putney, J.W.2
  • 11
    • 0022575011 scopus 로고
    • A model for receptor-regulated calcium entry
    • Putney J.W. A model for receptor-regulated calcium entry. Cell Calcium 1986, 7:1-12.
    • (1986) Cell Calcium , vol.7 , pp. 1-12
    • Putney, J.W.1
  • 12
    • 21044439334 scopus 로고    scopus 로고
    • STIM1, an essential and conserved component of store-operated Ca2+ channel function
    • Roos J., et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J. Cell Biol. 2005, 169:435-445.
    • (2005) J. Cell Biol. , vol.169 , pp. 435-445
    • Roos, J.1
  • 13
    • 21844432686 scopus 로고    scopus 로고
    • STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    • Liou J., et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr. Biol. 2005, 15:1235-1241.
    • (2005) Curr. Biol. , vol.15 , pp. 1235-1241
    • Liou, J.1
  • 14
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • Feske S., et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006, 441:179-185.
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1
  • 15
    • 33744479684 scopus 로고    scopus 로고
    • CRACM1 Is a plasma membrane protein essential for store-operated Ca2+ entry
    • Vig M. CRACM1 Is a plasma membrane protein essential for store-operated Ca2+ entry. Science 2006, 312:1220-1223.
    • (2006) Science , vol.312 , pp. 1220-1223
    • Vig, M.1
  • 16
    • 70349136626 scopus 로고    scopus 로고
    • Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells
    • Baba Y., Kurosaki T. Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. Immunol. Rev. 2009, 231:174-188.
    • (2009) Immunol. Rev. , vol.231 , pp. 174-188
    • Baba, Y.1    Kurosaki, T.2
  • 17
    • 33750940411 scopus 로고    scopus 로고
    • Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
    • Baba Y., et al. Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:16704-16709.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 16704-16709
    • Baba, Y.1
  • 18
    • 77950377028 scopus 로고    scopus 로고
    • Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
    • Hogan P.G., et al. Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu. Rev. Immunol. 2010, 28:491-533.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 491-533
    • Hogan, P.G.1
  • 19
    • 78449245269 scopus 로고    scopus 로고
    • Calcium signaling by STIM and Orai: intimate coupling details revealed
    • pe42-pe42
    • Wang Y., et al. Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci. Signal. 2010, 3. pe42-pe42.
    • (2010) Sci. Signal. , vol.3
    • Wang, Y.1
  • 20
    • 0026587743 scopus 로고
    • CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes
    • Carter R.H., Fearon D.T. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 1992, 256:105-107.
    • (1992) Science , vol.256 , pp. 105-107
    • Carter, R.H.1    Fearon, D.T.2
  • 21
    • 0035976940 scopus 로고    scopus 로고
    • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation
    • Fujimoto M., et al. CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. J. Biol. Chem. 2001, 276:44820-44827.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44820-44827
    • Fujimoto, M.1
  • 22
    • 0036669937 scopus 로고    scopus 로고
    • CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses
    • Tedder T.F., et al. CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses. Biochem. Soc. Trans. 2002, 30:807-811.
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 807-811
    • Tedder, T.F.1
  • 23
    • 33646347921 scopus 로고    scopus 로고
    • An antibody-deficiency syndrome due to mutations in the CD19 gene
    • van Zelm M.C., et al. An antibody-deficiency syndrome due to mutations in the CD19 gene. N. Engl. J. Med. 2006, 354:1901-1912.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1901-1912
    • van Zelm, M.C.1
  • 24
    • 0027169534 scopus 로고
    • CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
    • Tuveson D.A., et al. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 1993, 260:986-989.
    • (1993) Science , vol.260 , pp. 986-989
    • Tuveson, D.A.1
  • 25
    • 0028932411 scopus 로고
    • Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1
    • D'Ambrosio D., et al. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 1995, 268:293-297.
    • (1995) Science , vol.268 , pp. 293-297
    • D'Ambrosio, D.1
  • 26
    • 0029835940 scopus 로고    scopus 로고
    • Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB
    • Ono M., et al. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 1996, 383:263-266.
    • (1996) Nature , vol.383 , pp. 263-266
    • Ono, M.1
  • 27
    • 0031080328 scopus 로고    scopus 로고
    • CD22 is a negative regulator of B-cell receptor signalling
    • Nitschke L., et al. CD22 is a negative regulator of B-cell receptor signalling. Curr. Biol. 1997, 7:133-143.
    • (1997) Curr. Biol. , vol.7 , pp. 133-143
    • Nitschke, L.1
  • 28
    • 0032487425 scopus 로고    scopus 로고
    • The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling
    • Liu Q., et al. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J. Exp. Med. 1998, 188:1333-1342.
    • (1998) J. Exp. Med. , vol.188 , pp. 1333-1342
    • Liu, Q.1
  • 29
    • 2942657414 scopus 로고    scopus 로고
    • CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity
    • Chen J., et al. CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity. Nat. Immunol. 2004, 5:651-657.
    • (2004) Nat. Immunol. , vol.5 , pp. 651-657
    • Chen, J.1
  • 30
    • 34247219775 scopus 로고    scopus 로고
    • Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
    • Miller A.T., et al. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nat. Immunol. 2007, 8:514-521.
    • (2007) Nat. Immunol. , vol.8 , pp. 514-521
    • Miller, A.T.1
  • 31
    • 8444230017 scopus 로고    scopus 로고
    • Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes
    • Stork B., et al. Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Immunity 2004, 21:681-691.
    • (2004) Immunity , vol.21 , pp. 681-691
    • Stork, B.1
  • 32
    • 79956348707 scopus 로고    scopus 로고
    • Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction
    • Jang I.K., et al. Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:7926-7931.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 7926-7931
    • Jang, I.K.1
  • 33
    • 79954986185 scopus 로고    scopus 로고
    • Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling
    • Ackermann J.A., et al. Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO J. 2011, 30:1621-1633.
    • (2011) EMBO J. , vol.30 , pp. 1621-1633
    • Ackermann, J.A.1
  • 34
    • 70350393859 scopus 로고    scopus 로고
    • The B-lymphoid Grb2 interaction code
    • Neumann K., et al. The B-lymphoid Grb2 interaction code. Immunol. Rev. 2009, 232:135-149.
    • (2009) Immunol. Rev. , vol.232 , pp. 135-149
    • Neumann, K.1
  • 35
    • 34247392757 scopus 로고    scopus 로고
    • IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta
    • Waisman A., et al. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J. Exp. Med. 2007, 204:747-758.
    • (2007) J. Exp. Med. , vol.204 , pp. 747-758
    • Waisman, A.1
  • 36
    • 34247340435 scopus 로고    scopus 로고
    • Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
    • Horikawa K., et al. Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J. Exp. Med. 2007, 204:759-769.
    • (2007) J. Exp. Med. , vol.204 , pp. 759-769
    • Horikawa, K.1
  • 37
    • 69049105207 scopus 로고    scopus 로고
    • Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells
    • Engels N., et al. Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nat. Immunol. 2009, 10:1018-1025.
    • (2009) Nat. Immunol. , vol.10 , pp. 1018-1025
    • Engels, N.1
  • 38
    • 0028183406 scopus 로고
    • X-linked agammaglobulinemia: new approaches to old questions based on the identification of the defective gene
    • Conley M.E., et al. X-linked agammaglobulinemia: new approaches to old questions based on the identification of the defective gene. Immunol. Rev. 1994, 138:5-21.
    • (1994) Immunol. Rev. , vol.138 , pp. 5-21
    • Conley, M.E.1
  • 39
    • 0033521148 scopus 로고    scopus 로고
    • An essential role for BLNK in human B cell development
    • Minegishi Y., et al. An essential role for BLNK in human B cell development. Science 1999, 286:1954-1957.
    • (1999) Science , vol.286 , pp. 1954-1957
    • Minegishi, Y.1
  • 40
    • 36949028518 scopus 로고    scopus 로고
    • Novel mutations in a Japanese patient with CD19 deficiency
    • Kanegane H., et al. Novel mutations in a Japanese patient with CD19 deficiency. Genes Immun. 2007, 8:663-670.
    • (2007) Genes Immun. , vol.8 , pp. 663-670
    • Kanegane, H.1
  • 41
    • 0030764557 scopus 로고    scopus 로고
    • Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency
    • Shultz L.D., et al. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997, 15:302-307.
    • (1997) Trends Biotechnol. , vol.15 , pp. 302-307
    • Shultz, L.D.1
  • 42
    • 0033583479 scopus 로고    scopus 로고
    • Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
    • O'Keefe T.L., et al. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J. Exp. Med. 1999, 189:1307-1313.
    • (1999) J. Exp. Med. , vol.189 , pp. 1307-1313
    • O'Keefe, T.L.1
  • 43
    • 18844424394 scopus 로고    scopus 로고
    • The role of CD22 and other inhibitory co-receptors in B-cell activation
    • Nitschke L. The role of CD22 and other inhibitory co-receptors in B-cell activation. Curr. Opin. Immunol. 2005, 17:290-297.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 290-297
    • Nitschke, L.1
  • 44
    • 0033695963 scopus 로고    scopus 로고
    • Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis
    • Bolland S., Ravetch J.V. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity 2000, 13:277-285.
    • (2000) Immunity , vol.13 , pp. 277-285
    • Bolland, S.1    Ravetch, J.V.2
  • 45
    • 0034747097 scopus 로고    scopus 로고
    • Defective FcγRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus
    • Enyedy E.J., et al. Defective FcγRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus. Clin. Immunol. 2001, 101:130-135.
    • (2001) Clin. Immunol. , vol.101 , pp. 130-135
    • Enyedy, E.J.1
  • 46
    • 20244380494 scopus 로고    scopus 로고
    • Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry
    • Yu P., et al. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 2005, 22:451-465.
    • (2005) Immunity , vol.22 , pp. 451-465
    • Yu, P.1
  • 47
    • 65649088588 scopus 로고    scopus 로고
    • STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity
    • Picard C., et al. STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N. Engl. J. Med. 2009, 360:1971-1980.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1971-1980
    • Picard, C.1
  • 48
    • 77950629297 scopus 로고    scopus 로고
    • Immunodeficiency due to mutations in ORAI1 and STIM1
    • Feske S., et al. Immunodeficiency due to mutations in ORAI1 and STIM1. Clin. Immunol. 2010, 135:169-182.
    • (2010) Clin. Immunol. , vol.135 , pp. 169-182
    • Feske, S.1
  • 49
    • 79956303933 scopus 로고    scopus 로고
    • The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production
    • Matsumoto M., et al. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity 2011, 34:703-714.
    • (2011) Immunity , vol.34 , pp. 703-714
    • Matsumoto, M.1
  • 50
    • 37349073896 scopus 로고    scopus 로고
    • Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    • Baba Y., et al. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat. Immunol. 2008, 9:81-88.
    • (2008) Nat. Immunol. , vol.9 , pp. 81-88
    • Baba, Y.1
  • 51
    • 40949123088 scopus 로고    scopus 로고
    • Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
    • Oh-hora M., et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat. Immunol. 2008, 9:432-443.
    • (2008) Nat. Immunol. , vol.9 , pp. 432-443
    • Oh-hora, M.1
  • 52
    • 30744458329 scopus 로고    scopus 로고
    • A case for regulatory B cells
    • Mizoguchi A., Bhan A.K. A case for regulatory B cells. J. Immunol. 2006, 176:705-710.
    • (2006) J. Immunol. , vol.176 , pp. 705-710
    • Mizoguchi, A.1    Bhan, A.K.2
  • 53
    • 0029851762 scopus 로고    scopus 로고
    • Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
    • Timmerman L.A., et al. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 1996, 383:837-840.
    • (1996) Nature , vol.383 , pp. 837-840
    • Timmerman, L.A.1
  • 54
    • 0029761681 scopus 로고    scopus 로고
    • Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
    • Shibasaki F., et al. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 1996, 382:370-373.
    • (1996) Nature , vol.382 , pp. 370-373
    • Shibasaki, F.1
  • 55
    • 0030888186 scopus 로고    scopus 로고
    • Differential activation of transcription factors induced by Ca2+ response amplitude and duration
    • Dolmetsch R.E., et al. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 1997, 386:855-858.
    • (1997) Nature , vol.386 , pp. 855-858
    • Dolmetsch, R.E.1
  • 56
    • 0030966218 scopus 로고    scopus 로고
    • Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
    • Healy J.I., et al. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997, 6:419-428.
    • (1997) Immunity , vol.6 , pp. 419-428
    • Healy, J.I.1
  • 57
    • 0036795531 scopus 로고    scopus 로고
    • B cells regulate autoimmunity by provision of IL-10
    • Fillatreau S., et al. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 2002, 3:944-950.
    • (2002) Nat. Immunol. , vol.3 , pp. 944-950
    • Fillatreau, S.1
  • 58
    • 78650219406 scopus 로고    scopus 로고
    • Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection
    • Neves P., et al. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 2010, 33:777-790.
    • (2010) Immunity , vol.33 , pp. 777-790
    • Neves, P.1
  • 59
    • 0023729241 scopus 로고
    • Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
    • Goodnow C.C., et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988, 334:676-682.
    • (1988) Nature , vol.334 , pp. 676-682
    • Goodnow, C.C.1
  • 60
    • 0034331995 scopus 로고    scopus 로고
    • Antibody regulation of B cell development
    • Meffre E., et al. Antibody regulation of B cell development. Nat. Immunol. 2000, 1:379-385.
    • (2000) Nat. Immunol. , vol.1 , pp. 379-385
    • Meffre, E.1
  • 62
    • 79955004049 scopus 로고    scopus 로고
    • STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
    • Limnander A., et al. STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat. Immunol. 2011, 12:425-433.
    • (2011) Nat. Immunol. , vol.12 , pp. 425-433
    • Limnander, A.1
  • 63
    • 77953224467 scopus 로고    scopus 로고
    • Gazing into a crystal ball to predict kidney transplant outcome
    • Schroppel B., Heeger P.S. Gazing into a crystal ball to predict kidney transplant outcome. J. Clin. Invest. 2010, 120:1803-1806.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1803-1806
    • Schroppel, B.1    Heeger, P.S.2
  • 64
    • 74649083783 scopus 로고    scopus 로고
    • CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
    • Blair P.A., et al. CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010, 32:129-140.
    • (2010) Immunity , vol.32 , pp. 129-140
    • Blair, P.A.1
  • 65
    • 42649124913 scopus 로고    scopus 로고
    • Not always the bad guys: B cells as regulators of autoimmune pathology
    • Fillatreau S., et al. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol. 2008, 8:391-397.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 391-397
    • Fillatreau, S.1
  • 66
    • 79751527363 scopus 로고    scopus 로고
    • To B or not to B: B cells and the Th2-type immune response to helminths
    • Harris N., Gause W.C. To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol. 2011, 32:80-88.
    • (2011) Trends Immunol. , vol.32 , pp. 80-88
    • Harris, N.1    Gause, W.C.2
  • 67
    • 0036197923 scopus 로고    scopus 로고
    • Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    • Mizoguchi A., et al. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002, 16:219-230.
    • (2002) Immunity , vol.16 , pp. 219-230
    • Mizoguchi, A.1
  • 68
    • 34548319119 scopus 로고    scopus 로고
    • CD19 expression in B cells is important for suppression of contact hypersensitivity
    • Watanabe R., et al. CD19 expression in B cells is important for suppression of contact hypersensitivity. Am. J. Pathol. 2007, 171:560-570.
    • (2007) Am. J. Pathol. , vol.171 , pp. 560-570
    • Watanabe, R.1
  • 69
    • 34250179766 scopus 로고    scopus 로고
    • Novel suppressive function of transitional 2 B cells in experimental arthritis
    • Evans J.G., et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J. Immunol. 2007, 178:7868-7878.
    • (2007) J. Immunol. , vol.178 , pp. 7868-7878
    • Evans, J.G.1
  • 70
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba K., et al. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008, 28:639-650.
    • (2008) Immunity , vol.28 , pp. 639-650
    • Yanaba, K.1
  • 71
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • Matsushita T., et al. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J. Clin. Invest. 2008, 118:3420-3430.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3420-3430
    • Matsushita, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.