The coupled proton transport in the ClC-ec1 Cl -/H + antiporter

Biophysical Journal

Volumn 101, Issue 10, 2011, Pages

  Zhang, Yong ^a   Voth, Gregory A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; CHLORIDE CHANNEL; CLC EC1 PROTEIN, E COLI; CLC-EC1 PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; GLUTAMIC ACID; MUTANT PROTEIN; PROTON;

ARTICLE; CHEMISTRY; ESCHERICHIA COLI; ION TRANSPORT; METABOLISM; MOLECULAR DYNAMICS; THERMODYNAMICS;

ANTIPORTERS; CHLORIDE CHANNELS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUTAMIC ACID; ION TRANSPORT; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; PROTONS; THERMODYNAMICS;

EID: 81255164758     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.10.021     Document Type: Article

References (22)

1. T.J. Jentsch, I. Neagoe, and O. Scheel CLC chloride channels and transporters Curr. Opin. Neurobiol. 15 2005 319 325
2. - channels Nature 427 2004 803 807
3. R. Dutzler, and E.B. Campbell R. MacKinnon X-ray structure of a ClC chloride channel at 3.0 reveals the molecular basis of anion selectivity Nature 415 2002 287 294
4. + transporters constrained by covalent cross-linking Proc. Natl. Acad. Sci. USA 104 2007 20659 20665
5. F.L. Gervasio, and M. Parrinello M.L. Klein Exploring the gating mechanism in the ClC chloride channel via metadynamics J. Mol. Biol. 361 2006 390 398
6. J.D. Faraldo-Gómez, and B. Roux Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli J. Mol. Biol. 339 2004 981 1000
7. D.L. Bostick, and M.L. Berkowitz Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel Biophys. J. 87 2004 1686 1696
8. + in ClC-ec1 from normal-mode analysis Biophys. J. 98 2010 999 1008
9. G. Kieseritzky, and E.-W. Knapp Charge transport in the ClC-type chloride-proton anti-porter from Escherichia coli J. Biol. Chem. 286 2011 2976 2986
10. + exchanger J. Gen. Physiol. 126 2005 563 570
11. + antiporter Biophys. J. 97 2009 121 131
12. R. Dutzler, E.B. Campbell, and R. MacKinnon Gating the selectivity filter in ClC chloride channels Science 300 2003 108 112
13. J. Cohen, and K. Schulten Mechanism of anionic conduction across ClC Biophys. J. 86 2004 836 845
14. E.A. Bykova, and X.-D. Zhang J. Zheng Large movement in the C terminus of CLC-0 chloride channel during slow gating Nat. Struct. Mol. Biol. 13 2006 1115 1119
15. X.-Q. Wang, and T. Yu X. Zou A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel Biophys. J. 99 2010 464 471
16. Y. Jian, and Z. Kuang T.L. Beck Ion transit pathways and gating in ClC chloride channels Proteins Struct. Funct. Bioinform. 57 2004 414 421
17. + exchange transporter J. Gen. Physiol. 129 2007 317 329
18. + exchanger J. Gen. Physiol. 133 2009 131 138
19. A. Accardi, and S. Lobet R. Dutzler Synergism between halide binding and proton transport in a CLC-type exchanger J. Mol. Biol. 362 2006 691 699
20. + exchanger Philos. Trans. R. Soc. Lond. B Biol. Sci. 364 2009 175 180
21. T.J.F. Day, and A.V. Soudackov G.A. Voth A second generation multistate empirical valence bond model for proton transport in aqueous systems J. Chem. Phys. 117 2002 5839 5849
22. L. Feng, and E.B. Campbell R. MacKinnon Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle Science 330 2010 635 641