A provisional transport mechanism for a chloride channel-type Cl -/H+ exchanger

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 364, Issue 1514, 2009, Pages 175-180

  Miller, Christopher ^a   Nguitragool, Wang ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

Antiporter; Chloride channel; Conformational cycle; Transporter

Indexed keywords

CATION; CHEMICAL BINDING; CHLORIDE; COLIFORM BACTERIUM; ION EXCHANGE; PROTEIN; STOICHIOMETRY;

ESCHERICHIA COLI;

CHLORIDE; CHLORIDE CHANNEL; CLC PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; HYDROGEN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; ESCHERICHIA COLI; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

BINDING SITES; CHLORIDE CHANNELS; CHLORIDES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN; ION CHANNEL GATING; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

EID: 61449558440     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2008.0138     Document Type: Article

References (28)

1. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Iwata, S. & Kaback, H. R. 2003 The lactose permease of Escherichia colt: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett. 555, 96-101. (doi:10.1016/S0014-5793(03) 01087-1)
2. - channels. Nature 427, 803-807. (doi:10.1038/nature02314)
3. - channels. J. Gen. Physiol. 123, 109-119. (doi:10.1085/jgp. 200308935)
4. + exchanger. J. Gen. Physiol. 126, 563-570. (doi:10.1085/jgp. 200509417)
5. Accardi, A., Lobet, S., Williams, C., Miller, C. & Dutzler, R. 2006 Synergism between halide binding and proton transport in a CLC-type exchanger. J. Mol. Biol. 362, 691-699. (doi:10.1016/j.jmb.2006.07.081)
6. + antiporting. Science 317, 799-803. (doi:10.1126/science.1142824)
7. Armstrong, C. M. & Neyton, J. 1991 Ion permeation through calcium channels. A one-site model. Ann. NY Acad. Sci. 635, 18-25. (doi:10.1111/j.1749-6632.1991.tb36477.x)
8. Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T. & MacKinnon, R. 2002 X-ray structure of a CLC chloride channel at 3.0 C reveals the molecular basis of anion selectivity. Nature 415, 287-294. (doi:10.1038/415287a)
9. Dutzler, R., Campbell, E. B. & MacKinnon, R. 2003 Gating the selectivity filter in CLC chloride channels. Science 300, 108-112. (doi:10.1126/science.1082708)
10. + channels from Streptomyces lividans: functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114, 551-560. (doi: 10.1085/jgp.114.4.551)
11. Huang, Y., Lemieux, M. J., Song, J., Auer, M. & Wang, D. N. 2003 Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301, 616-620. (doi:10.1126/science. 1087619)
12. Iyer, R., Iverson, T. M., Accardi, A. & Miller, C. 2002 A biological role for prokaryotic CLC chloride channels. Nature 419, 715-718. (doi:10.1038/nature01000)
13. + exchanger. Proc. Natl Acad. Sci. USA 105, 11194-11199. (doi:10.1073/pnas. 0804503105)
14. Knauf, P. A., Lae, F. Y., Leung, T. W., Gehret, A. U. & Perez, M. L. 2002 Substrate-dependent reversal of anion transport site orientation in the human red blood cell anion-exchange protein, AE1. Proc. Natl Acad. Sci. USA 99, 10 861-10 864. (doi:10.1073/pnas.162402399)
15. Lobet, S. & Dutzler, R. 2005 Ion binding properties of the CLC chloride selectivity filter. EMBO J. 25, 24-33. (doi: 10.1038/sj.emboj.7600909)
16. Ludewig, U., Pusch, M. & Jentsch, T. J. 1996 Two physically distinct pores in the dimeric CLC-0 chloride channel. Nature 383, 340-343. (doi:10.1038/383340a0)
17. Matulef, K. & Maduke, M. 2005 Side-dependent inhibition of a prokaryotic ClC by DIDS. Biophys. J. 89, 1721-1730. (doi:10.1529/biophysj.105.066522)
18. Middleton, R. E., Pheasant, D. J. & Miller, C. 1994 Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry 33, 13 189-13 198. (doi:10.1021/bi00249a005)
19. Middleton, R. E., Pheasant, D. J. & Miller, C. 1996 Homodimeric architecture of a CLC-type chloride ion channel. Nature 383, 337-340. (doi:10.1038/383337a0)
20. Miller, C. 2006 CLC chloride channels viewed through a transporter lens. Nature 440, 484-489. (doi:10.1038/nature04713)
21. + exchange transporter by polyatomic anions. J. Mol. Biol. 362, 682-690. (doi:10.1016/j.jmb.2006.07. 006)
22. + transporters constrained by covalent cross-linking. Proc Natl. Acad Sci USA 104, 20 659-20 665. (doi:10.1073/pnas.07086 39104)
23. Park, C. S. & Miller, C. 1992 Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry 31, 7749-7755. (doi: 10.102 1/bi00149a002)
24. Soskine, M., Adam, Y & Schuldiner, S. 2004 Direct evidence for substrate-induced proton release in detergent-solubilized EmrE, a multidrug transporter. J. Biol. Chem. 279, 9951-9955. (doi:10.1074/jbc.M312 853200)
25. + exchanger. J. Gen. Physiol. 129, 317-329. (doi:10.1085/jgp.200709756)
26. Zdebik, A. A., Zifarelli, G., Bergsdorf, E. Y., Soliani, P., Scheel, O., Jentsch, T. J. & Pusch, M. 2008 Determinants of anion-proton coupling in mammalian endosomal CLC proteins. J. Biol. Chem. 283, 4219-4227. (doi:10.1074/jbc. M708368200)
27. + selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J. Mol. Biol. 333, 965-975. (doi:10. 1016/j.jmb.2003.09.022)
28. Zifarelli, G. & Pusch, M. 2007 CLC chloride channels and transporters: a biophysical and physiological perspective. Rev. Physiol. Biochem. Pharmacol. 158, 23-76. (doi:10. 1007/112-2006-0605)