Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc

Journal of Controlled Release

Volumn 156, Issue 2, 2011, Pages 161-169

  Forbes, Claire J ^a   Lowry, Deborah ^a   Geer, Leslie ^b   Veazey, Ronald S ^c   Shattock, Robin J ^d   Klasse, Per Johan ^e   Mitchnick, Mark ^b   Goldman, Laurie ^b   Doyle, Lara A ^c   Muldoon, Brendan C O ^a   Woolfson, A David ^a   Moore, John P ^e   Malcolm, R Karl ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Particle Sciences   (United States)

^c TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Macaque pharmacokinetics; Rheology; Silicone elastomer gel; Slug mucosal irritation; Sustained release; Vaginal HIV microbicide

Indexed keywords

CARBOPOL; CLINICAL PERFORMANCE; DELIVERY SYSTEMS; ENHANCED PERFORMANCE; GEL PRODUCTS; HISTORY OF USE; HYDROXYETHYLCELLULOSE; IN-VITRO; MICROBICIDES; NON-AQUEOUS; PHARMACOKINETIC STUDIES; POLYACRYLIC ACIDS; POLYMERIC GELS; SEMI-SOLIDS; SILICONE ELASTOMERS; SILICONE GELS; SINGLE-DOSE; SLUG MODELS; SLUG MUCOSAL IRRITATION; SUSTAINED RELEASE; VAGINAL DELIVERY; VAGINAL DRUG DELIVERY; VAGINAL HIV MICROBICIDE;

DRUG DELIVERY; DRUG PRODUCTS; ELASTOMERS; ORGANIC ACIDS; PHARMACOKINETICS; PLASTICS; RHEOLOGY; SILICONES; TISSUE;

GELS;

HYDROXYETHYLCELLULOSE; MARAVIROC; SILICONE GEL;

ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; VAGINA DISCHARGE;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; CYCLOHEXANES; DELAYED-ACTION PREPARATIONS; FEMALE; GELS; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; MACACA MULATTA; SILICONE ELASTOMERS; TRIAZOLES; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 81255157679     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.08.006     Document Type: Article

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