Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone

Journal of Controlled Release

Volumn 77, Issue 3, 2001, Pages 323-332

  Valenta, Claudia ^a   Kast, Constantia E ^a   Harich, Irene ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Carbopol cysteine conjugate; Oscillatory rheometry; Progesterone; Thiomers

Indexed keywords

ADHESIVE AGENT; CARBOMER; CARBOPOL 974P; CELLULOSE; CYANAMIDE; CYSTEINE DERIVATIVE; DRUG CARRIER; ELCEMA; POLYACRYLIC ACID; POLYMER; PROGESTERONE; THIOL;

ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; COVALENT BOND; COW; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG DELIVERY SYSTEM; ELASTICITY; IN VITRO STUDY; NONHUMAN; OSCILLATION; PH; PRIORITY JOURNAL; TABLET; TENSILE STRENGTH; VAGINA MUCOSA; VISCOSITY;

ACRYLATES; ADHESIVES; ANIMALS; CATTLE; CYSTEINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FEMALE; MUCOUS MEMBRANE; POLYMERS; PROGESTERONE; VAGINA;

EID: 0035856812     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00520-X     Document Type: Article

References (22)

1. The vaginal route of peptide and protein drug delivery
2. Intravaginal administration of conjugated estrogens in postmenopausal women
3. Studies on vaginal bioadhesive tablets of acyclovir
4. Swelling-controlled release system for the vaginal delivery of miconazole
5. Vaginal delivery of calcitonin by hyaluronic acid formulations
6. N,O-Carboxymethylchitosan as a mucoadhesive for vaginal delivery of levonorgestrel
7. Polymers with thiol groups: A new generation of mucoadhesive polymers?
8. Use of local electrostatic environments of cysteine to enhance formation of a desired species in a reversible disulfide exchange reaction
9. Synthesis and characterisation of mucoadhesive thiolated polymers
10. Development of controlled drug release systems based on thiolated polymers
11. Mucoadhesive polymers for peroral peptide delivery: Synthesis and evaluation of chitosan-EDTA conjugates
12. Thiolated polymers-thiomers: Development and in vitro evaluation of chitosan-thioglycolic acid conjugates
13. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine
14. Thiolated polymers: Development and evaluation of transdermal delivery systems for progesterone
15. An investigation of mucus-polymer rheological synergism using synthesised and characterised poly(acrylic acid)s
16. Pharmacokinetics of progesterone-containing vaginal tablet and its use in assisted reproduction
17. Principle and investigation of the bioadhesion mechanism of solid dosage forms
18. The luteal phase defect
19. Biliary excretion and intestinal metabolism of progesterone and estrogens in man
20. Vaginal delivery of progesterone in donor oocyte therapy
21. Spreading and retention of vaginal formulations in post-menopausal women as assessed by gamma-scintigraphy