Rheological properties of vaginal hydrophilic polymer gels

Current Drug Delivery

Volumn 6, Issue 1, 2009, Pages 83-92

  Das Neves, José ^a   Da Silva, Marta Vázquez ^a   Gonçalves, Maria Pilar ^a   Amaral, Maria Helena ^a   Bahia, Maria Fernanda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Gels; Polymeric drug delivery systems; Rheology; Thixotropy; Vagina; Viscoelasticity; Yield stress

Indexed keywords

CARBOPOL 974P; CARBOXYMETHYLCELLULOSE; ESSENTIAL OIL; NONOXINOL 9; PLACEBO; POLYCARBOPHIL; REPHRESH; UNCLASSIFIED DRUG;

ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLOW KINETICS; FLOW MEASUREMENT; GEL; OSCILLATION; PRIORITY JOURNAL; SHEAR RATE; THIXOTROPY; VAGINAL GEL; VISCOELASTICITY; VISCOSITY;

ACRYLIC RESINS; BIOMECHANICS; CARBOXYMETHYLCELLULOSE; LIPIDS; OILS, VOLATILE; THYMUS PLANT; VAGINAL CREAMS, FOAMS, AND JELLIES; VISCOSITY;

EID: 61849103596     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720109787048294     Document Type: Article

References (37)

1. Barnes, H.A.; Hutton, J.F.; Walters, K. An Introduction to Rheology, Elsevier: Amsterdam, 1989.
2. Tamburic, S.; Craig, D.Q.M. The effects of ageing on the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. Pharm. Res. 1996, 13, 279-83.
3. Jones, D.S. Dynamic mechanical analysis of polymeric systems of pharmaceutical and biomedical significance. Int. J. Pharm. 1999, 179, 167-78.
4. das Neves, J.; Bahia, M.F. Gels as vaginal drug delivery systems. Int. J. Pharm. 2006, 318, 1-14.
5. das Neves, J.; Amaral, M.H.; Bahia, M.F. Performance of an in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental parameters. Eur. J. Pharm. Biopharm. 2008, 69, 622-32.
6. Garg, A.; Aggarwal, D.; Garg, S.; Singla, A.K. Spreading of semisolid formulations: an update. Pharm. Tech. 2002, 26, 84-105.
7. Owen, D.H.; Peters, J.J.; Katz, D.F. Rheological properties of contraceptive gels. Contraception 2000, 62, 321-6.
8. Owen, D.H.; Peters, J.J.; Lavine, M.L.; Katz, D.F. Effect of temperature and pH on contraceptive gel viscosity. Contraception 2003, 67, 57-64.
9. Owen, D.H.; Peters, J.J.; Kieweg, S.L.; Geonnotti, A.R.; Schnaare, R.L.; Katz, D.F. Biophysical analysis of prototype microbicidal gels. J. Pharm. Sci. 2007, 96, 661-9.
10. Gupta, K.M.; Barnes, S.R.; Tangaro, R.A.; Roberts, M.C.; Owen, D.H.; Katz, D.F.; Kiser, P.F. Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. J. Pharm. Sci. 2007, 96, 670-81.
11. Henderson, M.H.; Couchman, G.M.; Walmer, D.K.; Peters, J.J.; Owen, D.H.; Brown, M.A.; Lavine, M.L.; Katz, D.F. Optical imaging and analysis of human vaginal coating by drug delivery gels. Contraception 2007, 75, 142-51.
12. Pina-Vaz, C.; Gonçalves Rodrigues, A.; Pinto, E.; Costa-de-Oliveira, S.; Tavares, C.; Salgueiro, L.; Cavaleiro, C.; Gonçalves, M.J.; Martinez-de-Oliveira, J. Antifungal activity of Thymus oils and their major compounds. J. Eur. Acad. Dermatol. Venereol. 2004, 18, 73-8.
13. das Neves, J.; Pinto, E.; Amaral, M.H.; Bahia, M.F. Antifungal activity of a gel containing Thymus vulgaris essential oil against Candida species commonly involved in vulvovaginal candidosis. Pharm. Biol. 2009. in press.
14. Chang, J.Y.; Oh, Y.K.; Choi, H.G.; Kim, Y.B.; Kim, C.K. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int. J. Pharm. 2002 241, 155-63.
15. Rudraraju, V.S.; Wyandt, C.M. Rheology of microcrystalline cellulose and sodiumcarboxymethyl cellulose hydrogels using a controlled stress rheometer: part II. Int. J. Pharm. 2005, 292, 63-73.
16. Park, N.A.; Irvine Jr, T.F. Anomalous viscosity-temperature behavior of aqueous Carbopol solutions. J. Rheol. 1997, 41, 167-73.
17. Lai, B.E.; Xie, Y.Q.; Lavine, M.L.; Szeri, A.J.; Owen, D.H.; Katz, D.F. Dilution of microbicide gels with vaginal fluid and semen simulants: Effect on rheological properties and coating flow. J. Pharm. Sci. 2008, 97, 1030-8.
18. Cox, W.P.; Merz, E.H. Correlation of dynamic and steady flow viscosities. J. Polymer. Sci. 1958, 28, 619-22.
19. Herh, P.; Tkachuk, J.; Wu, S.; Bernzen, M.; Rudolph, B. The rheology of pharmaceutical and cosmetic semisolids. Am. Lab. 1998, 30, 12-4.
20. Kim, J.Y.; Song, J.Y.; Lee, E.J.; Park, S.K. Rheological properties and microstructures of Carbopol gel network system. Colloid. Polym. Sci. 2003, 281, 614-23.
21. A-sasutjarit, R.; Sirivat, A.; Vayumhasuwan, P. Viscoelastic properties of Carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. Pharm. Res. 2005, 22, 2134-40.
22. Almdal, K.; Dyre, J.; Hvidt, S.; Kramer, O. Towards a phenomenological definition of the term 'gel'. Polym. Gels Netw. 1993, 1, 5-17.
23. Kavanagh, G.M.; Ross-Murphy, S.B. Rheological characterisation of polymer gels. Prog. Polym. Sci. 1998, 23, 533-62.
24. Barnes, H.A. Thixotropy - a review. J. Non-Newtonian Fluid Mech. 1997, 70, 1-33.
25. Barnes, H.A.; Walters, K. The yield stress myth? Rheol. Acta. 1985, 24, 323-6.
26. Kieweg, S.L.; Geonnotti, A.R.; Katz, D.F. Gravity-induced coating flows of vaginal gel formulations: in vitro experimental analysis. J. Pharm. Sci. 2004, 93, 2941-52.
27. Kieweg, S.L.; Katz, D.F. Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. J. Pharm. Sci. 2007, 96, 835-50.
28. Islam, M.T.; Rodriguez-Hornedo, N.; Ciotti, S.; Ackermann, C. Rheological characterization of topical carbomer gels neutralized to different pH. Pharm. Res. 2004, 21, 1192-9.
29. Ghannam, M.T.; Esmail, M.N. Rheological properties of carboxymethyl cellulose. J. Appl. Polym. Sci. 1997, 64, 289-301.
30. Tamburic, S.; Craig, D.Q.M. An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J. Control. Release. 1995, 37, 59-68.
31. Barreiro-Iglesias, R.; Alvarez-Lorenzo, C.; Concheiro, A. Incorporation of small quantities of surfactants as a way to improve the rheological and diffusional behavior of carbopol gels. J. Control. Release. 2001, 77, 59-75.
32. Kristmundsdottir, T.; Sigurdsson, P.; Thormar, H. Effect of buffers on the properties of microbicidal hydrogels containing monoglyceride as the active ingredient. Drug Dev. Ind. Pharm. 2003, 29, 121-9.
33. Baudonnet, L.; Grossiord, J.L.; Rodriguez, F. Effect of dispersion stirring speed on the particle size distribution and rheological properties of three carbomers. J. Disp. Sci. Technol. 2004, 25, 183-92.
34. Jones, D.S.; Woolfson, A.D.; Brown, A.F. Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels. Pharm. Res. 1997, 14, 450-7.
35. Tamburic, S.; Craig, D.Q.M.; Vuleta, G.; Milic, J. A comparison of electrical and rheological techniques for the characterisation of creams. Int. J. Pharm. 1996, 137, 243-8.
36. Bates, M.A.; Frenkel, D. Phase behavior of model mixtures of colloidal disks and polymers. Phys. Rev. E. 2000, 62, 5225-9.
37. Owen, D.H.; Peters, J.J.; Katz, D.F. Comparison of the rheological properties of Advantage-S and Replens. Contraception 2001, 64, 393-6.