The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the rabbit vaginal irritation test

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 60, Issue 3, 2005, Pages 419-425

  Dhondt, Marijke M M ^a   Adriaens, Els ^a   Roey, Jens Van ^b   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

^b TIBOTEC BVBA   (Belgium)

Author keywords

Alternative test; Local tolerance; Mucosal irritation; Vaginal formulation

Indexed keywords

DAPIVIRINE; NONOXINOL 9; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG FORMULATION; DRUG TOLERANCE; ENZYME RELEASE; EVALUATION; FEMALE; GEL; LABORATORY TEST; MUCUS SECRETION; NONHUMAN; PREDICTION; PROTEIN SECRETION; RABBIT; UTERINE CERVIX MUCOSA; VAGINA MUCOSA;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; DRUG EVALUATION, PRECLINICAL; FEMALE; IRRITANTS; MUCOUS MEMBRANE; PYRIMIDINES; RABBITS; SNAILS; SPERMATOCIDAL AGENTS; TOXICITY TESTS; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 21544451416     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.01.012     Document Type: Article

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