Comparison of different protein concentration techniques within preformulation development

International Journal of Pharmaceutics

Volumn 421, Issue 1, 2011, Pages 120-129

  Eppler, Annette ^a,b   Weigandt, Markus ^a   Schulze, Sandra ^a   Hanefeld, Andrea ^a   Bunjes, Heike ^b  

^a Merck Serono GmbH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Aggregation; Antibody; Protein concentration; Protein formulation; Tangential flow filtration; Ultrafiltration

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY;

ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSIS; DRUG MANUFACTURE; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ISOELECTRIC FOCUSING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREFORMULATION DEVELOPMENT; PRIORITY JOURNAL; PROTEIN STABILITY; TANGENTIAL FLOW FILTRATION; TURBIDITY; ULTRAFILTRATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTIBODIES, MONOCLONAL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DIALYSIS; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNOGLOBULIN G; ISOELECTRIC FOCUSING; MEMBRANES, ARTIFICIAL; NEPHELOMETRY AND TURBIDIMETRY; POLYMERS; SULFONES; ULTRAFILTRATION;

EID: 81155139112     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.09.028     Document Type: Article

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