FTIR and nDSC as analytical tools for high-concentration protein formulations

Pharmaceutical Research

Volumn 23, Issue 6, 2006, Pages 1350-1363

  Matheus, Susanne ^a   Friess, Wolfgang ^b   Mahler, Hanns Christian ^a,c  

^a MERCK KGAA   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

DSC; Formulation development; FTIR; High concentration protein formulation; Melting temperature

Indexed keywords

BETA LACTOGLOBULIN; BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN G1; LYSOZYME; PROTEIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; INFRARED SPECTROSCOPY; MELTING POINT; PRIORITY JOURNAL; PROTEIN FOLDING; SIGNAL NOISE RATIO; THERMODYNAMICS; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; ENZYME STABILITY; IMMUNOGLOBULIN G; LACTOGLOBULINS; MURAMIDASE; NANOTECHNOLOGY; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SERUM ALBUMIN, BOVINE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS; TRANSITION TEMPERATURE;

EID: 33745384433     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-0142-8     Document Type: Article

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