Inverse relationship of protein concentration and aggregation

Pharmaceutical Research

Volumn 19, Issue 4, 2002, Pages 511-516

  Treuheit, Michael J ^a   Kosky, Andrew A ^a   Brems, David N ^a  

^a AMGEN INC   (United States)

Author keywords

Aggregation; Agitation; Polysorbate; Protein; Shelf life; Stability

Indexed keywords

POLYSORBATE 20;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROCESSING; PROTEIN STABILITY; SURFACE TENSION; VIBRATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GLYCOPROTEINS; GRANULOCYTE COLONY-STIMULATING FACTOR; OSTEOPROTEGERIN; POLYETHYLENE GLYCOLS; POLYSORBATES; PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; THROMBOPOIETIN;

EID: 0036111474     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015108115452     Document Type: Article

References (33)

1. Stability of protein pharmaceuticals
2. The development of stable protein formulations: A close look at protein aggregation, deamidation, and oxidation
3. Inhibition of stress-induced aggregation of protein therapeutics
4. Films of protein in biologic processes
5. Physicochemical and biologic aspects of proteins at interfaces
6. Amyloid, prions, and other protein aggregates
7. Protein aggregation: Folding aggregates, inclusion bodies and amyloid
8. Protein folding at the air-water interface studied with X-ray reflectivity
9. Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20C of a recombinant hemoglobin
10. Conformation changes of proteins
11. Reconstitution of lactic dehydrogenase
12. Compositions and methods for stimulating megakaryocyte growth and differentiation
13. The surface coagulation of proteins during shaking
14. Kinetics of protein denaturation at gas-liquid interfaces
15. Spread monolayers of proteins
16. Fibronectin in a surface-adsorbed state: Insolubilization and self-assembly
17. Protein denaturation by combined effect of shear and air-liquid interface
18. The use of surface tension measurements in the design of antibody-based product formulations
19. Protein nebulization II. Stabilization of G-CSF to air-jet nebulization and the role of protectants
20. Foaming behavior of EDTA-treated α-lactalbumin
21. Spray-drying of trypsin, surface characterisation and activity preservation
22. Interaction of lysozyme and sodium dodecyl sulfate at the air-liquid interface
23. The formulation of recombinant factor IX: Stability, robustness, and convenience
24. Spray-drying of air-liquid interface sensitive recombinant human growth hormone
25. Use of poloxamer polymers to stabilize recombinant human growth hormone against various processing stresses
26. Techniques for assessing the effects of pharmaceutical excipients on the aggregation of porcine growth hormone
27. Evidence for a self-associating equilibrium intermediate during folding of human growth hormone
28. Molten globule intermediate of recombinant human growth hormone: Stabilization with surfactants
29. Tween protects recombinant human growth hormone agitation-induced damage via hydrophobic interactions
30. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces
31. Mechanism of insulin aggregation and stabilization in agitated aqueous solutions