Investigation on fouling mechanisms for recombinant human growth hormone sterile filtration

Journal of Pharmaceutical Sciences

Volumn 87, Issue 7, 1998, Pages 808-812

  Maa, Yuh Fun ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE;

ADSORPTION; ARTICLE; DRUG FORMULATION; MICROFILTRATION; SHEAR STRESS;

EID: 0031822593     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980114x     Document Type: Article

References (14)

1. Maa, Y. F.; Hsu C. C. Membrane fouling in sterile-filtration of recombinant, human growth hormone. Biotechnol. Bioeng. 1996, 50, 319-328.
2. Pitt, A. M. The nonspecific protein binding of polymeric microporous membranes. J. Parenteral Sci., Technol. 1987, 41, 110-113.
3. Wong, H. J.; Quinn, J. L. In Colloid and Interface Science; Kerker, M., Ed.; Academic Press: New York, 1976, Vol. 5, pp 169-180.
4. Zeman, L. J. Adsorption effects in rejection of macromolecules by ultrafiltration membranes. J. Membr. Sci. 1981, 15, 1213-230.
5. Robertson, B. C.; Zydney, A. L. Hindered protein diffusion in asymmetric ultrafiltration membranes with highly constricted pores. J. Membr. Sci. 1990, 49, 287-303.
6. Robertson, B. C.; Zydney, A. L. Protein adsorption in asymmetric ultrafiltration membranes with highly constricted pores. J. Colloid Interface Sci. 1990, 134, 563-575.
7. Bowen, W. R.; Gan, Q. Properties of microfiltration membranes: Flux loss during constant pressure permeation of bovine serum albumin. Biotechnol. Bioeng. 1991, 38, 688-696.
8. Mochizuki, S.; Zydney, A. L. Effect of protein adsorption on the transport characteristics of asymmetric ultrafiltration membranes. Biotechnol. Prog. 1992, 8, 553-561.
9. Nilsson J. L.; Hallstrom, B. Deviation in the fouling resistance of UF membrane due to clean membrane permeability variations. J. Membr. Sci. 1992, 67, 177-189.
10. Maa, Y.-F.; Hsu, C. Effect of high shear on proteins. Biotechnol. Bioeng. 1996, 51, 458-465.
11. Maa, Y.-F.; Hsu, C. C. Protein denaturation by combined effect of shear and air-liquid interface. Biotech. Bioeng. 1997, 54, 503-512.
12. Maa, Y.-F.; Nguyen, P.-A.; Hsu, S. W. Spray drying of air-liquid interface sensitive recombinant human growth hormone. J. Pharm. Sci. 1998, 87, 152-159.
13. Franken, A. C. M.; Sluys, J. T. M.; Chen, V.; Fane, A. G.; Fell, A. G. In Proceedings of the Fifth World Filtration Congress; Nice, France, 1990; Vol. 1, p 207.
14. Steadman, B. L.; Thompson, K. C.; Midaugh, R.; Mastrsno, K.; Vrona, S.; Lawtson, E. Q.; Lewis, R. L.The effect of surface adsorption onthe thermal stability of proteins. Biotechnol. Bioeng. 1992, 40, 8-15.